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The majority of conversion total hip arthroplasties can be considered primary replacements - a matched cohort study.

Acta Orthop Belg 2021 Mar;87(1):17-23

The success of conversion Total Hip Arthroplasty (THA) among primary THA and revision THA re- mains unclear. We hypothesized that most conversion THAss can be performed using primary implants and will have an uncomplicated post-operative course. Thirty-six patients (23 females, mean age 68,0y) who underwent conversion THA for failed interventions for proximal femur fractures in the period 2006-2018 were matched sequentially against patients of the same sex and age who underwent primary THA or revision THA. Read More

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Assessment of the hydrochemistry, water quality, and human health risk of groundwater in the northwest of Nansi Lake Catchment, north China.

Environ Geochem Health 2021 Jun 15. Epub 2021 Jun 15.

801 Institute of Hydrogeology and Engineering Geology, Shandong Provincial Bureau of Geology & Mineral Resources, Jinan, 250014, China.

In this study, the formation mechanism and water quality of groundwater in the northwest of Nansi Lake Catchment (NNLC) were analyzed through mathematical statistics, hydrochemical analysis and entropy weighted water quality index (EWQI), and the human health risk of nitrate was also evaluated. To this end, 89 wells in the NNLC were sampled, and the groundwater samples were divided into three groups (I, II, and III) according to cluster analysis results and spatial distribution. The main results are as follows: Topographically, Groups I, II, and III correspond to the alluvial plains, apron plain, and low hills and its front margin, respectively. Read More

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Synthesis and screening of 6-alkoxy purine analogs as cell type-selective apoptotic inducers in Jurkat cells.

Arch Pharm (Weinheim) 2021 Jun 15:e2100095. Epub 2021 Jun 15.

Department of Medicinal & Organic Chemistry and Excellence Research Unit of "Chemistry Applied to Biomedicine and the Environment", Faculty of Pharmacy, University of Granada, Granada, Spain.

Purines are ubiquitous structures in cell biology involved in a multitude of cellular processes, because of which substituted purines and analogs are considered excellent scaffolds in drug design. In this study, we explored the key structural features of a purine-based proapoptotic hit, 8-tert-butyl-9-phenyl-6-benzyloxy-9H-purine (1), by setting up a library of 6-alkoxy purines with the aim of elucidating the structural requirements that govern its biological activity and to study the cell selectivity of this chemotype. This was done by a phenotypic screening approach based on cell cycle analysis of a panel of six human cancer cell lines, including T cell leukemia Jurkat cells. Read More

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Tacrolimus-loaded chitosan nanoparticles for enhanced skin deposition and management of plaque psoriasis.

Carbohydr Polym 2021 Sep 23;268:118238. Epub 2021 May 23.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address:

Tacrolimus is a natural macrolide that exhibits an anti-proliferative action by T-lymphocytic cells inhibition. Hence, it was tested as a potential topical treatment to improve and control psoriatic plaques. In this study, for the first time the lipophilic tacrolimus in chitosan nanoparticles was used to achieve the desired response and dermal retention of the drug using a modified ionic gelation technique. Read More

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September 2021

Quality of life evaluation in Mexican patients with severe obesity before and after bariatric surgery.

Gac Med Mex 2021 ;157(1):64-69

Endocrinology Department, Specialty Hospital, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social.

Introduction: In Mexico, neither the 36-item Short Form Health Survey (SF-36) nor the Bariatric Analysis and Reporting Outcome System (BAROS) instruments have been used to assess quality of life (QoL) before and after bariatric surgery (BS).

Objective: To describe changes in QoL using the SF-36 and BAROS questionnaires in patients with severe obesity before and after BS.

Methods: Clinical and anthropometric data of patients undergoing bariatric surgery between 2015 and 2016 were collected. Read More

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January 2021

Case Report: Giant Biatrial Myxoma Mimicking Malignant Cardiac Tumor in a Patient With a Hepatic Angiomatous Mass.

Front Cardiovasc Med 2021 28;8:676807. Epub 2021 May 28.

Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.

Cardiac myxomas, primarily originating from the left atrium, are the most prevalent types of benign cardiac tumors; however, biatrial myxomas are extremely rare. Herein, we present a rare case of a 55-year old male with exertional dyspnea and intermittent chest discomfort due to a giant biatrial mass with concomitant atrial fibrillation and hepatic hemangioma. The giant tumor with its peduncle at the interatrial septum involved both atria; however, bulging through the tricuspid valve to the right ventricle during systole. Read More

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Super and Selective Adsorption of Cationic Dyes onto Carboxylate-Modified Passion Fruit Peel Biosorbent.

Front Chem 2021 26;9:646492. Epub 2021 May 26.

Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area, Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology for Science and Education Combined with Science and Technology Innovation Base, Guilin University of Technology, Guilin, China.

The carboxylate-functionalized passion fruit peel (PFPCS) was an efficient and rapid biosorbent for wastewater treatment. The PFPCS exhibited excellent selectivity to the cationic dyes, where the maximum adsorption capacities for methylene blue (MB) and methyl violet (MV) were 1,775.76 mg g and 3,756. Read More

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Comparison of effects of six main gastrectomy procedures on patients' quality of life assessed by Postgastrectomy Syndrome Assessment Scale-45.

World J Gastrointest Surg 2021 May;13(5):461-475

Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

Background: The effects of various gastrectomy procedures on the patient's quality of life (QOL) are not well understood. Thus, this nationwide multi-institutional cross-sectional study using the Postgastrectomy Syndrome Assessment Scale-45 (PGSAS-45), a well-established questionnaire designed to clarify the severity and characteristics of the postgastrectomy syndrome, was conducted.

Aim: To compare the effects of six main gastrectomy procedures on the postoperative QOL. Read More

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Synthesis of Thiol-Modified Hemicellulose, Its Biocompatibility, Studies, and Appraisal as a Sustained Release Carrier of Ticagrelor.

Front Pharmacol 2021 19;12:550020. Epub 2021 May 19.

Department of Chemistry, University of Sargodha, Sargodha, Pakistan.

Nature has always been considered as the primary source of pharmaceutical ingredients. A variety of hemicelluloses, as well as their modified forms, have been under investigation. Herein, a study was designed to explore the biocompatibility of hemicellulose and its modified form (thiolated hemicellulose) as well as its potential as a pharmaceutical excipient. Read More

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Structure-based investigation of MARK4 inhibitory potential of Naringenin for therapeutic management of cancer and neurodegenerative diseases.

J Cell Biochem 2021 Jun 14. Epub 2021 Jun 14.

Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, India.

MAP/microtubule affinity-regulating kinase 4 (MARK4) is a member of serine/threonine kinase family and considered an attractive drug target for many diseases. Screening of Indian Medicinal Plants, Phytochemistry, and Therapeutics (IMPPAT) using virtual high-throughput screening coupled with enzyme assay suggested that Naringenin (NAG) could be a potent inhibitor of MARK4. Structure-based molecular docking analysis showed that NAG binds to the critical residues found in the active site pocket of MARK4. Read More

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Metal shrapnel causing psoas abscess: The first case report.

Int J Surg Case Rep 2021 Jun 8;84:106092. Epub 2021 Jun 8.

Faculty of Medicine, University of Aleppo, Aleppo, Syria.

Introduction And Importance: Iliopsoas abscess is defined as the accumulation of suppurative fluid within the fascia surrounding the psoas and iliac muscles. Although some cases reported psoas abscess due to foreign body, to the best of our knowledge this is the first case of metal shrapnel causing psoas abscess.

Case Presentation: A 41 years old male presented to our center after a landmine explosion. Read More

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Minimally-invasive tubular retraction ports for intracranial neurosurgery: History and future perspectives.

J Clin Neurosci 2021 Jul 6;89:97-102. Epub 2021 May 6.

University of Minnesota Medical School Department of Neurosurgery, United States.

Brain retraction is a necessary yet potentially damaging requirement of accessing lesions located in deep structures. The development of minimally-invasive tubular retractors (MITRs) provides the theoretical advantage of maximizing visualization of and access to deep-seated lesions, all while minimizing collateral tissue damage. These advantages make MITRs preferable to traditional bladed retractors in the majority of deep-seated lesions. Read More

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Multi-layer oil-resistant food serving containers made using cellulose nanofiber coated wood flour composites.

Carbohydr Polym 2021 Sep 19;267:118221. Epub 2021 May 19.

School of Forest Resources and Advanced Structures and Composites Center, University of Maine, Orono, ME, USA.

Cost-effective, eco-friendly, and oil and grease-resistant food serving containers were made from wood flour with cellulose nanofibrils (CNF) or lignin-containing cellulose nanofibrils (LCNF) coating layers on the surface and in the bulk. The multi-layer wet-on-wet cellulose nanofiber composites were developed using a vacuum filtration process. All composites showed excellent oil/grease resistivity according to the "kit" test passing #12, the highest possible. Read More

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September 2021

Synthesis of magnetic chitosan biopolymeric spheres and their adsorption performances for PFOA and PFOS from aqueous environment.

Carbohydr Polym 2021 Sep 7;267:118165. Epub 2021 May 7.

Department of Environmental Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea. Electronic address:

Due to numerous applications and excellent environmental stability, long-chain perfluorinated chemicals (PFCs) are ubiquitous in water across the world and adversely affect the living organisms. Thus, this study focused on the mitigation of the most frequently used long-chain PFCs namely perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) from water using reduced graphene oxide modified zinc ferrite immobilized chitosan beads ([email protected]) as an adsorbent. The results from the adsorption isotherm and kinetic studies revealed that the adsorption data fitted well to the Langmuir and the pseudo-second-order models. Read More

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September 2021

How and When Should Tetralogy of Fallot be Palliated Prior to Complete Repair?

Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2021 ;24:77-84

Hospital for Sick Children, Department of Surgery, Division of Cardiovascular Surgery, Toronto, Ontario, Canada.

The controversy regarding the best or ideal surgical management of Tetralogy of Fallot (ToF) stems from the recognition of there being a spectrum of morphology and associated lesions, each of which require a different approach to achieve the three goals of minimizing mortality preserving right ventricular function long-term and minimizing reinterventions. A one-size-fits-all approach to ToF needs to be replaced by a considered and personalized approach in order to yield the best outcomes possible for individual patients. The great majority of patients with ToF undergo primary complete repair between age 3-9 months with excellent outcomes. Read More

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January 2021

Assessment of rapidly advancing bone age during puberty on elbow radiographs using a deep neural network model.

Eur Radiol 2021 Jun 11. Epub 2021 Jun 11.

Department of Orthopedic Surgery, Korea University Anam Hospital, 73, Goryeodae-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.

Objectives: Bone age is considered an indicator for the diagnosis of precocious or delayed puberty and a predictor of adult height. We aimed to evaluate the performance of a deep neural network model in assessing rapidly advancing bone age during puberty using elbow radiographs.

Methods: In all, 4437 anteroposterior and lateral pairs of elbow radiographs were obtained from pubertal individuals from two institutions to implement and validate a deep neural network model. Read More

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Arthroscopic bankart repair for the management of anterior shoulder instability: Mid- and long-term results.

Rev Esp Cir Ortop Traumatol 2021 Jul-Aug;65(4):255-263

Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.

Introduction: Arthroscopic stabilisation is a well-recognised surgical technique with a variable rate of failure reported between 0-35%. The aim of this study was to evaluate the outcome of this technique and our second aim was to identify risk factors that could be associated to recurrence rate.

Material And Methods: 41 patients that underwent arthroscopic shoulder stabilisation for glenohumeral instability between 2001-2015 were included. Read More

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Design and Construction of Photochromic and Antileakage Reinforced Wood-Based Cellulose Microframework/Hexadecanol-Coconut Oil Composite Phase Change Material.

Langmuir 2021 Jun 10. Epub 2021 Jun 10.

School of Resources, Environment and Materials, Guangxi University, Nanning 530004, China.

The development of high-performance shape-stable phase change material composites (SPCMs) with high phase change enthalpy and high conversion efficiency, especially with good photochromic properties, is essential for thermal energy storage. Here, we report that one type of SPCMs with both photochromic and phase change energy storage is obtained by incorporating organic binary composite PCMs (hexadecanol/coconut oil, H/C) and photochromic phosphotungstic acid (PA) into Ochroma pyramidale wood-based cellulose microframe (DOW) through simple vacuum impregnation. When the ratio of hexadecanol to coconut oil is 3:7 and the ratio of phosphotungstic acid to ,-dimethylacetamide is 4:13. Read More

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Circulating growth differentiation factor-15 as a novel biomarker in heart transplant.

ESC Heart Fail 2021 Jun 10. Epub 2021 Jun 10.

Division of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Rd, Pathumwan, Bangkok, 10330, Thailand.

Aims: This study aimed to examine (i) whether circulating growth differentiation factor-15 (GDF-15) is associated with acute cellular cardiac allograft rejection (ACR); (ii) a longitudinal trend of GDF-15 after heart transplantation; and (iii) the prognostic value of GDF-15 in predicting a composite outcome of severe primary graft dysfunction (PGD) and 30 day mortality post-transplant.

Methods And Results: Serum samples were collected before heart transplantation and at every endomyocardial biopsy (EMB) post-heart transplantation in de novo transplant patients. A total of 60 post-transplant serum samples were matched to the corresponding EMBs. Read More

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Diagnostic Performance of Various Methodologies for Group B S Screening in Pregnant Woman in China.

Front Cell Infect Microbiol 2021 24;11:651968. Epub 2021 May 24.

Clinical Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Maternal vaginal/rectal colonization of group B streptococcus (GBS) is a main risk for neonatal invasive infection. Efficient determination of GBS colonization in pregnant women is crucial. This study aimed to investigate the prevalence of GBS carriage and evaluate the diagnostic performance of six methodologies for GBS screening conducted in China, including blood agar plate, liquid chromogenic medium, and loop-mediated isothermal amplification (LAMP) without pre-enrichment, chromogenic agar plate with pre-enrichment, and GBS antigen detection without and with pre-enrichment in comparison with the standard reference method (Lim broth-enriched subculture with plating on 5% sheep blood agar). Read More

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Functional prediction of environmental variables using metabolic networks.

Sci Rep 2021 Jun 9;11(1):12192. Epub 2021 Jun 9.

Sorbonne University, 75005, Paris, France.

In this manuscript, we propose a novel approach to assess relationships between environment and metabolic networks. We used a comprehensive dataset of more than 5000 prokaryotic species from which we derived the metabolic networks. We compute the scope from the reconstructed graphs, which is the set of all metabolites and reactions that can potentially be synthesized when provided with external metabolites. Read More

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Rheumatologist perspective of the Brazilian consensus for detection of auto antibodies in HEp-2 CELLS.

Adv Rheumatol 2021 Jun 9;61(1):32. Epub 2021 Jun 9.

Pontifícia Universidade Católica de Goiás (PUC Goiás), Escola de Ciências Médicas, Farmacêuticas e Biomédicas, Avenida Universitária 1.440, Setor Universitário, Goiânia, GO, Brazil.

Objective: To evaluate the perception of rheumatologists regarding the recommendations of the Brazilian Consensus for detection of Autoantibodies (BCA) on HEp-2 Cells by Indirect Immunofluorescence assay (IFA) and how BCA recommendations help in clinical practice.

Methodology: A structured questionnaire regarding the BCA recommendations for detection and interpretations of autoantibodies in HEp-2 cells was applied to randomly selected rheumatologists. The results were tabulated using the Microsoft® Excel program, expressed as a simple percentage and the dichotomous data were analyzed using the Chi-square test and the Epi Info® program. Read More

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High-efficient photocatalytic degradation of commercial drugs for pharmaceutical wastewater treatment prospects: A case study of Ag/g-CN/ZnO nanocomposite materials.

Chemosphere 2021 Jun 1;282:130971. Epub 2021 Jun 1.

Faculty of Materials Science and Technology, University of Science, VNU-HCM, 227 Nguyen Van Cu Street, District 5, Ho Chi Minh City, 700000, Viet Nam; Vietnam National University-Ho Chi Minh City, Linh Trung Ward, Thu Duc District, Ho Chi Minh City, 700000, Viet Nam. Electronic address:

Pharmaceutical drugs' removal from wastewater by photocatalytic oxidation process is considered as an attractive approach and environmentally friendly solution. This report aims to appraise the practical application potential of Ag/g-CN/ZnO nanorods toward the wastewater treatment of the pharmaceutical industry. The catalysts are synthesized by straightforward and environmentally-friendly strategies. Read More

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Molten Salt Assisted Annealing for Making Colloidal ZnGa2O4:Cr Nanocrystals with High Persistent Luminescence.

Chemistry 2021 Jun 9. Epub 2021 Jun 9.

Illinois Institute of Technology College of Science, Chemistry, 3101 S Dearborn Street, Pritzker Science Center 136, 60616, Chicago, UNITED STATES.

Persistent luminescent nanocrystals (PLNCs) in sub-10 nm domain are considered most fascinating inventions in lighting technology owing to their excellent performance in anti-counterfeiting, luminous paints, bioimaging, security applications, etc. Further improvement of persistent luminescence (PersL) intensity and lifetime is needed to achieve the desired success while keeping uniform sub-10 nm size of PLNCs. In this work, we have introduced the concept of molten salt confinement to thermally anneal as-synthesized ZnGa 2 O 4 :Cr 3+ (ZGOC) colloidal NCs (CNCs) in a molten salt media at 650 o C for the first time. Read More

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High-Throughput Discovery of Ni(IN) for Ethane/Ethylene Separation.

Adv Sci (Weinh) 2021 Jun 1;8(11):e2004940. Epub 2021 Apr 1.

Department of Chemistry, Korea University, Seoul, 02841, Republic of Korea.

Although ethylene (C H ) is one of the most critical chemicals used as a feedstock in artificial plastic chemistry fields, it is challenging to obtain high-purity C H gas without any trace ethane (C H ) by the oil cracking process. Adsorptive separation using C H -selective adsorbents is beneficial because it directly produces high-purity C H in a single step. Herein, Ni(IN) (HIN = isonicotinic acid) is computationally discovered as a promising adsorbent with the assistance of the multiscale high-throughput computational screening workflow and Computation-Ready, Experimental (CoRE) metal-organic framework (MOF) 2019 database. Read More

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MXene-Based Materials for Electrochemical Sodium-Ion Storage.

Adv Sci (Weinh) 2021 Jun 15;8(11):e2003185. Epub 2021 Mar 15.

Pillar of Engineering Product Development, Singapore University of Technology and Design, 8 Somapah Road, Singapore, 487372, Singapore.

Advanced architecture and rational design of electrode materials for electrochemical sodium-ion storage are well developed by researchers worldwide. MXene-based materials are considered as one of the most potential electrode materials for sodium-ion-based devices, such as sodium-ion batteries (SIBs), sodium-sulfur batteries (SSBs), and sodium-ion capacitors (SICs), because of the excellent physicochemical characteristics of MXenes. Here, in this review, the recent research work and progress, both theoretical and experimental, on MXene-based materials including pure MXenes and MXene-based composites in application of SIBs, SSBs, and SICs are comprehensively summarized. Read More

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Lifestyle Habits and Wellbeing Among Physicians in Pakistan: A Cross-Sectional Study.

Cureus 2021 May 6;13(5):e14875. Epub 2021 May 6.

Surgery, Darul Sehat Hospital, Karachi, PAK.

Introduction Physicians' attitude towards a healthy lifestyle is important as it determines their extent of acceptance of these habits leading to overall well-being. Physicians with healthy lifestyle habits are more confident in advocating the same to their patients and their patients are keener in adopting lifestyle modifications. This study aimed to evaluate the lifestyle habits, wellbeing, and mental health of physicians in Pakistan. Read More

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Pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: state-of-the-art 2020.

Michael M Madani

Pulm Circ 2021 Apr-Jun;11(2):20458940211007372. Epub 2021 May 24.

Cardiovascular and Thoracic Surgery, University of California San Diego, La Jolla, CA, USA.

Pulmonary endarterectomy is the treatment of choice for patients with operable chronic thromboembolic pulmonary hypertension (CTEPH) as it is potentially curative. In expert centers that conduct > 50 pulmonary endarterectomy procedures per year, peri- and post-surgical mortality rates are very low and long-term outcomes are excellent, with three-year post-operative survival of > 80%. Therapeutic decisions in CTEPH are based largely on the location of the arterial obstruction, with pulmonary endarterectomy for obstructions in main, lobar, and segmental vessels, and balloon pulmonary angioplasty and medical therapy for small-vessel disease. Read More

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Aortic size in children: Systolic measurements are different from diastolic measurements.

Ann Pediatr Cardiol 2021 Apr-Jun;14(2):165-169. Epub 2021 Mar 26.

Department of Cardiology, Nicklaus Children's Hospital, Miami, FL, USA.

Background: Current guidelines recommended aortic measurements during diastole in adults and during systole in children. Recent studies in adults have demonstrated noteworthy differences in aortic measurements during systole and diastole in the same subjects. In the present study, we aimed to characterize systolic and diastolic differences in aortic measurements in healthy children. Read More

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Clinical imaging factors of excellent outcome after thrombolysis in large-vessel stroke: a THRACE subgroup analysis.

Stroke Vasc Neurol 2021 Jun 8. Epub 2021 Jun 8.

Department of Neurology-Stroke Unit, CIC-P 1433, INSERMU1116, Université de Lorraine, Nancy Regional University Hospital Center, Nancy, France

Background: For patients with stroke with large-vessel occlusion (LVO), study of factors predicting response to intravenous thrombolysis (IVT) would allow identifying subgroups with high expected gain, and those for whom it could be considered as futile, and even detrimental. From patients included in the Mechanical Thrombectomy After Intravenous Alteplase vs Alteplase Alone After Stroke trial, we investigated clinical-imaging factors associated with optimal response to IVT.

Methods: We included patients receiving IVT alone. Read More

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