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Should temozolomide be used on the basis of O-methylguanine DNA methyltransferase status in patients with advanced neuroendocrine tumors? A systematic review and meta-analysis.

Cancer Treat Rev 2021 Jul 22;99:102261. Epub 2021 Jul 22.

IEO, European Institute of Oncology, IRCCS, Milan, Italy. Electronic address:

Background: Temozolomide (TEM) is an active treatment in metastatic neuroendocrine tumors (NETs). Patients affected by glioblastoma multiforme or advanced melanoma treated with TEM who have deficiency of O-methylguanine DNA methyltransferase (MGMT) have a better responses and survival. However, the predictive role of MGMT in patients with NETs treated with TEM is still debated. Read More

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Functional and oncological outcomes of renal surgery for hilar tumors: informing the decisions in risk-adapted management.

Urology 2021 Jul 28. Epub 2021 Jul 28.

Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

Objective: No consensus exists on whether renal hilar tumors should be considered for radical (RN) or partial nephrectomy (PN). In this study we aim to describe the safety and efficacy of PN for surgically managed renal hilar tumors MATERIALS AND METHODS: : we retrospectively reviewed institutional records of patients with a small (<5 cm) solitary renal (hilar or non-hilar) mass who underwent PN or RN between 2008 and 2018. Hilar tumors were defined as those at medial position, abutting the renal vessels. Read More

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Oral diadochokinetic rates across languages: Multilingual speakers comparison.

Int J Lang Commun Disord 2021 Jul 31. Epub 2021 Jul 31.

Department of Audiology and Speech-Language Pathology, Mackay Medical College, New Taipei City, Taiwan.

Background: It is unclear whether oral diadochokinetic rate (oral-DDK) performance is affected by different languages within a multilingual country.

Aims: This study investigated the effects of age, sex, and stimulus type (real word in L1, L2 vs. non-word) on oral-DDK rates among healthy Malaysian-Malay speakers in order to establish language- and age-sensitive norms. Read More

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Depiction of the genomic and genetic landscape identifies CCL5 as a protective factor in colorectal neuroendocrine carcinoma.

Br J Cancer 2021 Jul 30. Epub 2021 Jul 30.

Department of Medical Oncology, The First Affiliated Hospital Zhejiang, University School of Medicine, Hangzhou, China.

Background: Colorectal neuroendocrine carcinomas (CRNECs) are highly aggressive tumours with poor prognosis and low incidence. To date, the genomic landscape and molecular pathway alterations have not been elucidated.

Methods: Tissue sections and clinical information of CRNEC (n = 35) and CR neuroendocrine tumours (CRNETs) (n = 25) were collected as an in-house cohort (2010-2020). Read More

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The chest radiographic scoring system in initial diagnosis of COVID-19: Is a radiologist needed?

Adv Clin Exp Med 2021 Jul 30. Epub 2021 Jul 30.

Department of General Radiology, Interventional Radiology and Neuroradiology, Wroclaw Medical University, Poland.

Background: Lung imaging, next to a polymerase chain reaction (PCR) test, is a key diagnostic tool in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The degree of abnormalities correlates with clinical outcome. Imaging of the lungs using chest radiography (CXR) at the peak of a pandemic is considered a basic diagnostic tool at the triage stage. Read More

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Intergenerational educational mobility in Bangladesh.

PLoS One 2021 30;16(7):e0255426. Epub 2021 Jul 30.

Statistics Division, Bangladesh Bank, Dhaka, Bangladesh.

Introduction: Social mobility is considered as an important indicator of the economic development of a country. However, it varies widely across geographical regions and social groups in developing countries like Bangladesh. This paper intends to evaluate the intergenerational mobility in Bangladesh across generations. Read More

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Interaction of cesium bound fission product compounds (CsI and CsOH) with abundant inorganic compounds of atmosphere: Effect on hygroscopic growth properties.

J Hazard Mater 2021 Jun 9;418:126356. Epub 2021 Jun 9.

Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Mumbai 400085, India; Homi Bhabha National Institute, Anushaktinagar, Mumbai 400094, India.

Cesium compounds if present in atmosphere, can affect human health as well as the ecosystem due to their highly hazardous nature. Interaction of cesium compounds with abundantly available atmospheric salts can modify the hygroscopic behavior in sub-saturation relative humidity (RH) domain. Any marked modification in growth factor (GF) for the mixed particle state in comparison to the single particles ultimately affects the settling rates and hence the deposition flux. Read More

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Comparative cradle-to-grave life cycle assessment of bio-based and petrochemical PET bottles.

Sci Total Environ 2021 Jun 24;793:148642. Epub 2021 Jun 24.

Copernicus Institute of Sustainable Development, Utrecht University, Utrecht, the Netherlands.

This article presents a life cycle assessment of bio-based polyethylene terephthalate (PET) bottles with a cradle to grave scope and provides a comparison with petrochemical PET bottles for 13 environmental impact categories. Besides the baseline bio-based PET bottles, which are produced from Brazilian sugarcane reflecting status-quo, two alternative hypothetical bio-based product systems were considered: European wheat straw and European crops market mix composed of maize, wheat and sugar beet. The land-use change (LUC) impacts were assessed based on a deterministic model. Read More

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Liquid Biopsy Can Detect Brca2 Gene Variants In Female Dogs With Mammary Neoplasia.

Vet Comp Oncol 2021 Jul 30. Epub 2021 Jul 30.

Department of Molecular Biology, Cancer Molecular Research Laboratory (LIMC), FAMERP, São José do Rio Preto, Brazil.

Mammary tumors (MT) is one of the most prevalent malignancies in female dogs and women. Currently, molecular analyzes have shown that each tumor type presents its own genetic signature. In this context, liquid biopsy allows a comprehensive genetic characterization of the tumor, enabling early diagnosis and personalized treatment of patients. Read More

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The impact of an electronic hospital system on therapeutic drug monitoring.

J Clin Pharm Ther 2021 Jul 30. Epub 2021 Jul 30.

QIMR Berghofer Medical Research Institute, Herston, Qld, Australia.

What Is Known And Objective: Australian hospitals have undergone a transformation with both a review and expansion of traditional roles of healthcare professionals and the implementation of an ieMR. The implementation of an ieMR brings large scale organizational change within the health system especially for staff with direct patient contact. This is changing the future of healthcare and the roles of healthcare professionals. Read More

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Exercise for depression and depressive symptoms in older adults: an umbrella review of systematic reviews and Meta-analyses.

Aging Ment Health 2021 Jul 30:1-11. Epub 2021 Jul 30.

Department of Nephrology and Biostatistics, Universidade de Caxias do Sul (UCS), Caxias do Sul, Brazil.

Objectives: We aimed to gather and update the evidence on the impact of exercise on late-life depression.

Method: We conducted an umbrella review of meta-analyses of randomized controlled trials (RCTs) that assessed the effects of an exercise intervention for depression in older adults (e.g. Read More

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The risk of cardiometabolic disorders in lean non-alcoholic fatty liver disease: A longitudinal study.

Am J Prev Cardiol 2020 Dec 20;4:100097. Epub 2020 Oct 20.

Houston Methodist, Debakey Heart and Vascular Institute, Houston, TX, USA.

Background: Recent studies suggest that non-alcoholic fatty liver disease (NAFLD) in lean (BMI<25 ​kg/m) individuals presents a distinct phenotype. We sought to determine the cardiometabolic consequences of lean NAFLD in a population cohort of relatively young asymptomatic individuals who participated in a voluntary routine health promotion evaluation in Brazil.

Methods: We analyzed data in our population collected from 2004 to 2016. Read More

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December 2020

Risk Factors and Their Diagnostic Values for Ocular Metastases in Gastric Adenocarcinoma.

Cancer Manag Res 2021 23;13:5835-5843. Epub 2021 Jul 23.

Department of Geriatric Medicine and Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People's Republic of China.

Objective: Gastric adenocarcinoma originates from the glands in the superficial layer or mucosa of the stomach. It is prone to metastases, of which ocular metastasis (OM) is rare, but once it occurs the disease is considered more serious. The aim of this study was to investigate the risk factors for OM in gastric adenocarcinoma. Read More

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Patient reported psychosocial functioning following successful ptosis surgery.

Eye (Lond) 2021 Jul 29. Epub 2021 Jul 29.

Bristol Eye Hospital, Bristol, UK.

Background: Ptosis may result in increased anxiety, appearance-related distress and social avoidance, and impacts visual function. Previous work demonstrates the benefits of ptosis surgery for health-related quality of life, but there is a paucity of research comparing such outcomes before and after surgery. The aim of this study was to determine potential patient benefits in health-related quality of life, social dysfunction and anxiety following successful ptosis surgery using validated measures. Read More

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Yoga for treating low back pain: a systematic review and meta-analysis.

Pain 2021 Jul 28. Epub 2021 Jul 28.

Department of Internal and Integrative Medicine, Evang. Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany. National Centre for Naturopathic Medicine, Southern Cross University, Lismore, Australia. Australian Research Centre in Complementary and Integrative Medicine (ARCCIM), Faculty of Health, University of Technology Sydney, Sydney, Australia.

Abstract: Yoga is frequently used for back pain relief. However, evidence was judged to be of only low- or moderate. To assess the efficacy and safety of yoga in patients with low back pain a meta-analysis was performed. Read More

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Dedifferentiated Liposarcoma: A Comprehensive Historical Review With Proposed Evidence-based Guidelines Regarding a Diagnosis in Need of Further Clarification.

Adv Anat Pathol 2021 Jul 29. Epub 2021 Jul 29.

Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH.

Among all sarcoma types, liposarcoma is the most common sarcoma that develops "dedifferentiation." Since its initial description by Dr Harry Evans, the spectrum of what is now acceptably included under the rubric of "dedifferentiated liposarcoma" (DL) has expanded, sometimes supported by cytogenetic and molecular advances. Similarly, the range of morphologic appearances considered to represent the precursor of DL, atypical lipomatous tumor (ALT)/well-differentiated liposarcoma, also has broadened, not uncommonly creating variants with significant, almost indistinguishable, morphologic overlap with occasional forms of DL, especially problematic in small biopsy specimens. Read More

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Efficacy and safety of high flow nasal oxygen for children with bronchiolitis: systematic review and meta-analysis.

BMJ Open Respir Res 2021 Jul;8(1)

Children's Hospital for Wales, University of Wales Hospital, Cardiff, Cardiff, UK

Background: To assess the published evidence to establish the efficacy and safety of high flow oxygen cannula (HFNC) as respiratory support for children up to 24 months of age with bronchiolitis within acute hospital settings.

Methods: We searched eight databases up to March 2021. Studies including children up to 24 months of age with a diagnosis of bronchiolitis recruited to an randomised controlled trial were considered in the full meta-analysis. Read More

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Cardiac Output Measurement in Neonates and Children Using Noninvasive Electrical Bioimpedance Compared With Standard Methods: A Systematic Review and Meta-Analysis.

Crit Care Med 2021 Jul 29. Epub 2021 Jul 29.

Biomedical Research Centre, Imperial College London, London, United Kingdom. Department of Neonatology, Imperial College Healthcare NHS Trust, London, United Kingdom. Library Services, Imperial College London, London, United Kingdom. Institute of Reproductive and Developmental Biology, Imperial College London, London, United Kingdom. Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom.

Objective: To systematically review and meta-analyze the validity of electrical bioimpedance-based noninvasive cardiac output monitoring in pediatrics compared with standard methods such as thermodilution and echocardiography.

Data Sources: Systematic searches were conducted in MEDLINE and EMBASE (2000-2019).

Study Selection: Method-comparison studies of transthoracic electrical velocimetry or whole body electrical bioimpedance versus standard cardiac output monitoring methods in children (0-18 yr old) were included. Read More

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Immunogenicity of a recombinant Lactobacillus casei, surface-expressed HP mutant of Clostridium perfringens epsilon toxin and its protective responses in BALB/c mice.

Toxicon 2021 Jul 26. Epub 2021 Jul 26.

Graudated Student, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.

Epsilon toxin (Etx) is the most important virulence factor of type D C. perfringens in ruminants. The recombinant vaccines can be used against Etx intoxication. Read More

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Comparison of the suprainguinal fascia iliaca compartment block with continuous epidural analgesia in patients undergoing hip surgeries: a retrospective study.

Braz J Anesthesiol 2021 Jul 26. Epub 2021 Jul 26.

Mersin Üniversitesi Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Mersin, Turkey.

Background And Objective: Pain control is one of the major concerns after major hip surgeries. Suprainguinal fascia iliaca compartment block (S-FICB) is an alternative analgesic technique that can be considered as an effective and less invasive method than epidural analgesia (EA). In this retrospective study, we compared postoperative analgesic efficacy of single shot ultrasound guided S-FICB and EA after major hip surgery. Read More

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Efficacy of a Web App-Based Music Intervention During Cataract Surgery: A Randomized Clinical Trial.

JAMA Ophthalmol 2021 Jul 29. Epub 2021 Jul 29.

Department of Anesthesia and Intensive Care, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France.

Importance: Hypertensive events during cataract surgery may induce complications. Information and communication technologies applied to health are popular, but clinical evidence of its usefulness is rare and limited to treating anxiety without specific analysis. Recent publications have described the potential effects of personalized music choices as mobile-based intervention on pain but not on anxiety. Read More

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Enhanced stress-resilience training for surgical trainees.

BJS Open 2021 Jul;5(4)

Department of Surgery, Morriston Hospital, Swansea Bay University Health Board, Swansea, UK.

Introduction: Core surgical training programmes are associated with a high risk of burnout. This study aimed to assess the influence of a novel enhanced stress-resilience training (ESRT) course delivered at the start of core surgical training in a single UK statutory education body.

Method: All newly appointed core surgical trainees (CSTs) were invited to participate in a 5-week ESRT course teaching mindfulness-based exercises to develop tools to deal with stress at work and burnout. Read More

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Long-term Efficacy of Percutaneous Epidural Neurolysis of Adhesions in Chronic Lumbar Radicular Pain: 10 Year Follow-up of a Randomized Controlled Trial.

Pain Physician 2021 Aug;24(5):359-367

Dept. of Orthopedic Surgery and Traumatology, School of Medicine, Christian-Albrechts-University, Campus Kiel, Germany.

Background: No long-term follow-up data exist in any treatment for chronic radicular pain occurring with disc pathology and after failed back surgery. A previous randomized controlled trial (RCT) has proven efficacy in short-term follow-up as an evidence-based effective therapeutic option.

Objectives: Long term data is needed to determine the efficacy and cost- effectiveness of minimal invasive procedures. Read More

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Benefits of Transversus Abdominis Plane Block on Postoperative Analgesia after Bariatric Surgery: A Systematic Review and Meta-Analysis.

Pain Physician 2021 Aug;24(5):345-358

Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada.

Background: Patients undergoing bariatric surgery present unique analgesic challenges, including poorly controlled pain, increased prevalence of obstructive sleep apnea, and opioid-induced respiratory depression. The transversus abdominis plane (TAP) has been demonstrated to be a safe and effective component of multimodal analgesia for a variety of abdominal surgeries.

Objective: To determine the benefits of the TAP block on postoperative analgesia and recovery in patients undergoing bariatric surgery. Read More

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Quiescent-Interval Slice-Selective MRA Accurately Estimates Intravascular Stent Dimensions Prior to Intervention in Patients With Peripheral Artery Disease.

J Magn Reson Imaging 2021 Jul 29. Epub 2021 Jul 29.

Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina, USA.

Background: Quiescent-interval slice-selective (QISS) magnetic resonance angiography (MRA) is a non-contrast alternative for the pre-procedural assessment of patients with peripheral artery disease (PAD). However, the feasibility of pre-procedural stent size estimation using QISS MRA would merit investigation.

Purpose: To evaluate the feasibility of QISS MRA for pre-procedural stent size estimation in PAD patients compared to computed tomography angiography (CTA). Read More

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One step further: randomised single-centre trial comparing the direct and afterload techniques of embryo transfer.

Hum Reprod 2021 Jul 29. Epub 2021 Jul 29.

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT, USA.

Study Question: What are the differences in ease of use between two different embryo transfer (ET) techniques: the preload direct approach and the afterload approach.

Summary Answer: The afterload technique seems to reduce the rate of difficult ETs.

What Is Known Already: Numerous published trials now document that the ET procedure has an impact on pregnancy and delivery rates after IVF. Read More

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Electrocardiographic findings in migraineurs: results of the Finnish Health 2000 survey.

Acta Neurol Scand 2021 Jul 29. Epub 2021 Jul 29.

Department of Neurology, Helsinki University and Helsinki University Hospital, Helsinki, Finland.

Background: The precise relation between migraine and cardiovascular diseases remains unknown, but cardiac autonomic regulation as reflected by electrocardiography is poorly studied in migraineurs.

Aims Of The Study: To search whether electrocardiographic findings may elucidate the mechanisms linking migraine with cardiovascular diseases.

Methods: We compared electrocardiographic findings in headache-free subjects (n=5,317) and people with migraine (n=490) in a Finnish population cohort. Read More

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Liver Transplantation for Non-Resectable Liver Metastases from Colorectal Cancer: A Systematic Review and Meta-Analysis.

World J Surg 2021 Jul 28. Epub 2021 Jul 28.

Department of Hepato-Pancreato-Biliary Surgery, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Oxford Road, Manchester, M13 9WL, UK.

Backgrounds: Colorectal liver metastases were historically considered a contraindication to liver transplantation, but dismal outcomes for those with metastatic colorectal cancer and advancements in liver transplantation (LT) have led to a renewed interest in the topic. We aim to compare the current evidence for liver transplantation for non-resectable colorectal liver metastases (NRCLM) with the current standard treatment of palliative chemotherapy.

Methods: A systematic review and meta-analysis of proportions was conducted following screening of MEDLINE, EMBASE, SCOPUS and CENTRAL for studies reporting liver transplantation for colorectal liver metastases. Read More

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Relationship of pupils' quality of life and academic achievement with the employment status of their mothers.

J Prev Med Hyg 2021 Mar 29;62(1):E164-E169. Epub 2021 Apr 29.

Department of Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Introduction: One of the most important environmental factors affecting academic achievement and performance is the family especially mothers. The purpose of this study was to determine the relationship between quality of life (QOL) and the academic achievement of pupils with the employment status of their mothers.

Methods: This cross-sectional study was conducted on 9th-grade students in Shiraz. Read More

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The effect of adjunctive use of melatonin as a supplement on serum ferritin level in periodontal patients: A randomized, controlled trial.

Dent Res J (Isfahan) 2021 24;18:39. Epub 2021 May 24.

Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Ferritin is an acute-phase protein that is increased in inflammatory diseases. Melatonin has been studied due to its antioxidant effects and the elimination of free radicals. The aim of this study was to evaluate the effect of melatonin supplement as an adjunct to routine periodontal treatment on serum ferritin levels in patients with periodontitis. Read More

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