156,389 results match your criteria considered cases


Safety and Performance of Transbronchial Cryobiopsy for Parenchymal Lung Lesions.

Chest 2021 May 7. Epub 2021 May 7.

Johns Hopkins Department of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, MD, USA. Electronic address:

Background: Despite advances in technology, the bronchoscopic diagnosis of parenchymal pulmonary lesions (PPL) remains difficult to achieve. Transbronchial Lung Cryobiopsy (TLCB) offers the potential for larger samples with improved diagnostic yield, however, there remains a paucity of data describing its safety and utility for the diagnosis of PPL RESEARCH QUESTION: What is the safety profile of TLCB for PPL?

Study Design And Methods: An observational, retrospective, multicenter cohort study enrolling patients without endobronchial disease undergoing TLCB of PPL from 2015-2019. All procedures were performed using both rigid and flexible bronchoscopy with a flexible cryoprobe. Read More

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Genomic correlates of response and resistance to immune checkpoint inhibitors in carcinomas of unknown primary.

Eur J Clin Invest 2021 May 10:e13583. Epub 2021 May 10.

University of Ioannina, Ioannina, Greece.

Background: Cancers of unknown primary (CUP) are highly aggressive tumours with limited molecular characterization. These tumours can be particularly sensitive to immune checkpoint inhibitors (ICI) by mounting a seemingly more effective anti-tumour immune response. Unlike other tumour lineages, the biological basis and clinical efficacy of ICI in CUP remain largely unknown. Read More

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Surgical considerations for atrial functional regurgitation of the mitral and tricuspid valves based on the etiological mechanism.

Gen Thorac Cardiovasc Surg 2021 May 10. Epub 2021 May 10.

Department of Cardiology, Osaka City General Hospital, 2-13-22, Miyakojima Hondori, Miyakojima, Osaka, 534-0021, Japan.

Atrial functional mitral regurgitation is a hot research topic in the field of mitral valve disease. Atrial functional mitral regurgitation is distinctly different from ventricular functional mitral regurgitation. The surgical indications for atrial functional mitral regurgitation have not been well established because of the small amount of evidence gathered to date. Read More

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Characteristic of IgA and IgG antibody response to SARS-CoV-2 infection in an Italian referral COVID-19 Hospital.

Intern Emerg Med 2021 May 10. Epub 2021 May 10.

Department of Laboratory Sciences and Infectious Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Introduction: Antibody response plays a fundamental role in the natural history of infectious disease. A better understanding of the immune response in patients with SARS-CoV-2 infection could be important for identifying patients at greater risk of developing a more severe form of disease and with a worse prognosis.

Methods: We performed a cross-sectional analysis to determine the presence and the levels of both anti-SARS-CoV-2 IgG and IgA in a cohort of hospitalized patients with confirmed infection at different times in the natural history of the disease. Read More

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Metals toxicity and its correlation with the gene expression in Alzheimer's disease.

Mol Biol Rep 2021 May 10. Epub 2021 May 10.

Geriatric Mental Health Department, KGMU, Lucknow, India.

Alzheimer's disease is a common neurodegenerative disease in the elderly population and a leading cause of dementia. Genetics and environmental risk factors were considered to play a major role in the onset of the disease. This study aimed to examine the correlation between different metals levels and the gene expression in Alzheimer's patients with age-matched control subjects. Read More

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Aortic valve surgery: management and outcomes in the paediatric population.

Eur J Pediatr 2021 May 10. Epub 2021 May 10.

Department of Paediatric Cardiac Surgery, Alder Hey Children's Hospital, Liverpool, UK.

Congenital anomalies of the aortic valve frequently necessitate intervention in childhood. The most common aortic valve pathologies present in childhood are aortic stenosis and insufficiency. Presentation of aortic valve disease depends on severity and presence of concomitant syndromes and valvular disorders. Read More

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Preeclampsia Prevalence, Risk Factors, and Pregnancy Outcomes in Sweden and China.

JAMA Netw Open 2021 May 3;4(5):e218401. Epub 2021 May 3.

Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.

Importance: Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality worldwide. Within-country studies have reported racial differences in the presentation and outcome, but little is known about differences between countries.

Objective: To compare preeclampsia prevalence, risk factors, and pregnancy outcomes between the Swedish and Chinese populations. Read More

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Right aortic arch forming a true vascular ring: a clinical review.

Eur J Cardiothorac Surg 2021 May 10. Epub 2021 May 10.

Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, Netherlands.

Objectives: This review aims at presenting and summarizing the current state of literature on the presentation and surgical management of a right-sided aortic arch with a left-sided ligamentum forming a complete vascular ring around the oesophagus and trachea.

Methods: A systematic database search for appropriate literature was conducted on PubMed/MEDLINE. Articles were considered relevant when providing details on the presentation, diagnosis and surgical treatment of this specific congenital arch anomaly in human beings. Read More

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A mixed methods study on the manifestations of behavioural symptoms of dementia among veterans with and without posttraumatic stress disorder.

J Adv Nurs 2021 May 10. Epub 2021 May 10.

School of Nursing, Duke University, Durham, NC, USA.

Aims: To explore how behavioural symptoms of dementia are manifested among veterans in residential long-term care settings, in the context of personal, interpersonal/social and environmental triggers and how the manifestations differ between veterans with and without posttraumatic stress disorder.

Design: Secondary analysis using a mixed methods approach.

Methods: We analysed text data from a stratified random sample of 66 cases derived from the programme evaluation dataset of the Staff Training in Assisted Living Residences-Veterans Health Administration (STAR-VA) intervention from 2013 to 2016, using framework analysis. Read More

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Case report and literature review: antenatal diagnosis of a fetal anaplastic astrocytoma.

J Matern Fetal Neonatal Med 2021 May 9:1-7. Epub 2021 May 9.

Department of Ultrasound, The School of Clinical Medicine, Fujian Medical University, Fuzhou, China.

Objectives: To describe the ultrasonographic appearance of congenital anaplastic astrocytoma, so as to provide diagnostic clues for it. An updated review of the literature was also carried out.

Results: There was a case of fetal anaplastic astrocytoma detected by ultrasound at 37 + 1 weeks of gestation. Read More

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A case series with literature review on adjunctive usage of intravitreal ceftazidime in ocular syphilis with human immunodeficiency virus infection.

Int J STD AIDS 2021 May 8:9564624211011917. Epub 2021 May 8.

University Malaya Eye Research Centre, Department of Ophthalmology, Faculty of Medicine, University of Malaya, Malaysia.

Background: Penicillin is the conventional treatment for all stages of syphilis, including ocular and neurosyphilis, according to the recommendations by the Centre for Disease Control and Prevention Sexually Transmitted Disease. This case series highlighted three cases of ocular syphilis which showed prompt treatment response as early as 24 h after the adjunctive intravitreal ceftazidime injection.

Methods: Case Series. Read More

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Unusual cutaneous manifestations of dracunculiasis: Two rare case reports.

Indian J Dermatol Venereol Leprol 2021 Apr 23:1-4. Epub 2021 Apr 23.

Department of Dermatology, KEM Hospital, Mumbai, Maharashtra, India.

A nematode parasite, Dracunculus medinensis, causes dracunculiasis. Despite being non-fatal, this condition causes significant morbidity. Dracunculiasis is considered an eradicated disease in India since 1999. Read More

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Perspectives of Black women in the United States on salon-based intervention to promote the uptake of pre-exposure prophylaxis (PrEP) for HIV.

J Clin Nurs 2021 May 9. Epub 2021 May 9.

Duke University School of Nursing, Durham, North Carolina, USA.

Aims And Objectives: To understand Black women's perspectives on a pre-exposure prophylaxis (PrEP) education intervention in a salon setting.

Background: Black women have a significant lifetime risk of acquiring HIV. Pre-exposure prophylaxis (PrEP) is an effective prevention approach in reducing that risk. Read More

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SARS-CoV-2 RNAaemia in children: an Iranian referral hospital-based study.

J Med Virol 2021 May 10. Epub 2021 May 10.

Department of Infectious Diseases, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Although SARS-CoV-2 RNA is generally detected in nasopharyngeal swabs, viral RNA can be found in other samples including blood. Recently, associations between SARS-CoV-2 RNAaemia and disease severity and mortality have been reported in adults, while no reports are available in pediatric patients with COVID-19. The aim of this study was to evaluate the mortality, severity, clinical and laboratory findings of SARS-CoV-2 RNA detection in blood in 96 pediatric patients with confirmed COVID-19. Read More

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Coronavirus Disease 2019 (COVID-19): A Systematic Review of 133 Children Presented with Kawasaki-like Multisystem Inflammatory Syndrome.

J Med Virol 2021 May 10. Epub 2021 May 10.

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Kawasaki-like disease (KLD) and multisystem inflammatory syndrome in children (MIS-C) are considered as challenges for pediatric patients under the age of 18 infected with coronavirus disease 2019 (COVID-19).

Methods: A systematic search was performed on July 2, 2020, and updated on December 1, 2020, to identify studies on KLD/MIS-C associated with COVID-19. The databases of Scopus, PubMed, Web of Science, Embase, and Scholar were searched. Read More

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Detection of SARS-CoV-2 infection by RT-PCR test: factors influencing interpretation of results.

Virusdisease 2021 May 3:1-3. Epub 2021 May 3.

Genetic Research Centre, ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai, 400012 India.

In this current pandemic of coronavirus disease 2019 (COVID-19), prompt interventions in terms of early detection and clinical management along with isolation of positive cases is of utmost importance. This helps to limit not only the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections but also the morbidity and mortality associated with it. Different strategies for screening of COVID-19 in containment zones and non-containment areas include testing of symptomatic patients and their contacts in fever clinics, hospital-based testing, testing on demand and population-based screening. Read More

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Laparoscopic uncontained power morcellation-induced dissemination of ovarian endodermal sinus tumors: A case report.

World J Clin Cases 2021 May;9(13):3212-3218

Department of Obstetrics and Gynecology, Wonkwang University Hospital, Iksan 54645, Jeollabuk-do, South Korea.

Background: Endodermal sinus tumors (ESTs), which arise primarily in children and adolescents, account for 20% of malignant ovarian germ cell tumors, but constitute only 1% of all ovarian malignancies. Treatment of ESTs consists of surgical staging with fertility-sparing surgery and chemotherapy.

Case Summary: A 15-year-old nulliparous patient was diagnosed with disseminated ovarian ESTs after laparoscopic unilateral salpingo-oophorectomy using uncontained power morcellation for treatment of a ruptured solid adnexal mass in another hospital. Read More

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Sarcomatoid carcinoma of the pancreas - multimodality imaging findings with serial imaging follow-up: A case report and review of literature.

World J Clin Cases 2021 May;9(13):3102-3113

Department of Pathology, Cancer Research Institute, College of Medicine, Chungnam National University, Daejeon 35015, South Korea.

Background: Sarcomatoid carcinoma of the pancreas is extremely rare and has an extremely poor prognosis. Although a few cases of sarcomatoid carcinoma of pancreas have been reported, most are focused on a histopathological review. To the best of our knowledge, there are no reports documenting multimodality imaging characteristics and chronological changes with emphasis on radiologic features. Read More

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Spontaneous coronary dissection should not be ignored in patients with chest pain in autosomal dominant polycystic kidney disease: A case report.

World J Clin Cases 2021 May;9(13):3095-3101

Department of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.

Background: When autosomal dominant polycystic kidney disease (ADPKD) presents with acute coronary syndrome (ACS), the possibility of spontaneous coronary artery dissection (SCAD) should be highly considered. In some cases, SCAD is considered an extrarenal manifestation of ADPKD depending on the pathological characteristics of the unstable arterial wall in ADPKD.

Case Summary: Here, we report a 46-year-old female patient with ADPKD who presented with ACS. Read More

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Prognostic value of hemodynamic indices in patients with sepsis after fluid resuscitation.

World J Clin Cases 2021 May;9(13):3008-3013

Department of Emergency Medicine, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University, Haikou 570311, Hainan Province, China.

Background: Sepsis usually causes hemodynamic abnormalities. Hemodynamic index is one of the factors to identify the severity of sepsis and an important parameter to guide the procedure of fluid resuscitation. The present study investigated whether the assessment of hemodynamic indices can predict the outcomes of septic patients undergoing resuscitation therapy. Read More

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Torsades de pointes episode in a woman with high-grade fever and inflammatory activation: A case report.

World J Clin Cases 2021 Apr;9(12):2899-2907

Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

Background: QT interval prolongation can induce torsades de pointes (TdP), a potentially fatal ventricular arrhythmia. Recently, an increasing number of non-cardiac drugs have been found to cause QT prolongation and/or TdP onset. Moreover, recent findings have demonstrated the key roles of systemic inflammatory activation and fever in promoting long-QT syndrome (LQTS) and TdP development. Read More

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Detection of fusion in cell-free DNA of a patient with advanced gastric cancer: A case report.

World J Clin Cases 2021 Apr;9(12):2884-2889

Department of Laboratory Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, South Korea.

Background: Gastric cancer is the fifth most diagnosed cancer worldwide and the third most common cause of cancer-related death. In recent decades, increasing application of next-generation sequencing has enabled detection of molecular aberrations, including fusions. In cases where tissue is difficult to obtain, cell-free DNA (cfDNA) is used for detecting mutations to identify the molecular profile of cancer. Read More

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Pulmonary alveolar proteinosis complicated with nocardiosis: A case report and review of the literature.

World J Clin Cases 2021 Apr;9(12):2874-2883

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, Zhejiang Province, China.

Background: Pulmonary alveolar proteinosis (PAP) is a pulmonary syndrome wherein large volumes of phospholipid and protein-rich surfactants accumulate within the alveoli. PAP forms include primary (auto-immune PAP), secondary, and congenital. Nocardiosis is a form of suppurative disease induced upon infection with bacteria of the genus. Read More

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Intramuscular hematoma in rhabdomyolysis patients treated with low-molecular-weight heparin: Report of two cases.

World J Clin Cases 2021 Apr;9(12):2838-2844

Department of Critical Care Medicine, Nanping First Hospital Affiliated to Fujian Medical University, Nanping 353000, Fujian Province, China.

Background: Rhabdomyolysis is a serious complication of heat stroke. Unlike that in acute kidney injury, the risk of muscle bleeding in rhabdomyolysis is often ignored and can substantially increase the widespread use of anticoagulants, leading to the formation of intramuscular hematoma.

Case Summary: During the summer, a middle-aged man and an elderly man were diagnosed with heat stroke, rhabdomyolysis, and acute renal impairment. Read More

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Unresectable esophageal cancer treated with multiple chemotherapies in combination with chemoradiotherapy: A case report.

World J Clin Cases 2021 Apr;9(12):2801-2810

Department of Surgery, Hiratsuka City Hospital, Kanagawa 2540065, Japan.

Background: Definitive chemoradiotherapy (dCRT) using cisplatin plus 5fluorouracil (CF) with radiation is considered the standard treatment for unresectable locally advanced T4 esophageal squamous cell carcinoma (ESCC). Recently, induction chemotherapy has received attention as an effective treatment strategy.

Case Summary: We report a successful case of a 59-year-old female with unresectable locally advanced T4 ESCC treated by two additional courses of chemotherapy with CF after induction chemotherapy with docetaxel, cisplatin and fluorouracil (DCF) followed by dCRT. Read More

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Predictive risk factors for recollapse of cemented vertebrae after percutaneous vertebroplasty: A meta-analysis.

World J Clin Cases 2021 Apr;9(12):2778-2790

Department of Spine Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China.

Background: As one of the most common complications of osteoporosis, osteoporotic vertebral compression fracture (OVCF) increases the risk of disability and mortality in elderly patients. Percutaneous vertebroplasty (PVP) is considered to be an effective, safe, and minimally invasive treatment for OVCFs. The recollapse of cemented vertebrae is one of the serious complications of PVP. Read More

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Paradoxical relationship between proton pump inhibitors and COVID-19: A systematic review and meta-analysis.

World J Clin Cases 2021 Apr;9(12):2763-2777

Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.

Background: The proton pump inhibitors (PPIs), used to reduce gastric acid secretion, represent one of the most widely used pharmaceutical classes in the world. Their consumption as a risk factor for the evolution of severe forms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been investigated as well as the mortality of these patients. These risks also appear to be linked to the duration and the dosage. Read More

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Emergomycosis, an Emerging Systemic Mycosis in Immunocompromised Patients: Current Trends and Future Prospects.

Front Med (Lausanne) 2021 23;8:670731. Epub 2021 Apr 23.

Department of Microbiology, All India Institute of Medical Sciences, Jodhpur, India.

Recently, the global emergence of emergomycosis, a systemic fungal infection caused by a novel dimorphic fungus species has been observed among immunocompromised individuals. Though initially classified under the genus , a taxonomic revision in 2017 based on DNA sequence analyses placed five -like fungi under a separate genus . These include , and . Read More

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Long-Read Sequencing to Unravel Complex Structural Variants of Leading to Cone-Rod Dystrophy and Hearing Loss.

Front Cell Dev Biol 2021 21;9:664317. Epub 2021 Apr 21.

Center for Medical Genetics Ghent, Ghent University Hospital, Ghent, Belgium.

Inactivating variants as well as a missense variant in the centrosomal gene have been identified in autosomal recessive cone-rod dystrophy with hearing loss (CRDHL), a rare syndromic inherited retinal disease distinct from Usher syndrome. Apart from this, a complex structural variant (SV) implicating has been reported in CRDHL. Here we aimed to expand the genetic architecture of typical CRDHL by the identification of complex SVs of the region and characterization of their underlying mechanisms. Read More

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The Impact of Universal Mask Use on SARS-COV-2 in Victoria, Australia on the Epidemic Trajectory of COVID-19.

Front Public Health 2021 21;9:625499. Epub 2021 Apr 21.

The Biosecurity Program, The Kirby Institute, University of New South Wales, Kensington, NSW, Australia.

To estimate the impact of universal community face mask use in Victoria, Australia along with other routine disease control measures in place. A mathematical modeling study using an age structured deterministic model for Victoria, was simulated for 123 days between 1 June 2020 and 1 October 2020, incorporating lockdown, contact tracing, and case findings with and without mask use in varied scenarios. The model tested the impact of differing scenarios of the universal use of face masks in Victoria, by timing, varying mask effectiveness, and uptake. Read More

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