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Body Fat Mass, Percent Body Fat, Fat-Free Mass, and Skeletal Muscle Mass Reference Curves for Czech Children Aged 6-11 Years.

Children (Basel) 2021 May 4;8(5). Epub 2021 May 4.

Department of Natural Sciences in Kinanthropology, Faculty of Physical Culture, Palacký University, 771 11 Olomouc, Czech Republic.

Background: Negative lifestyle trends are reflected in overweight and obese children, in which their lack of physical activity results in decreased muscle mass. This study aimed to define age- and sex-specific reference curves for body fat mass (BFM), skeletal muscle mass (SMM), fat-free mass (FFM), and percent body fat (%BF) in Czech children.

Methods: Body composition was measured by segmental bioelectrical impedance (BIA, InBody 720). Read More

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Principles for establishment of the stem cell bank and its applications on management of sports injuries.

Stem Cell Res Ther 2021 May 29;12(1):307. Epub 2021 May 29.

Sports Medicine Department of the Institution of Peking University Third Hospital, Beijing Key Laboratory of Sports Injuries, No. 49 North Garden Road, Beijing, 100191, China.

Background: The stem cells of the stem cell banks have prominent problems for insufficient sources, easy contamination, unstable biological characteristics after serial subcultivations, and high cost.

Methods: After collecting the construction processes of the existing stem cell banks and suggestions from authoritative experts in the past 10 years, 230 reference principles were obtained, and finally, the principles of "5C" for the establishment of modern standardized stem cell banks were summarized, and their related applications on the management of sports injuries were reviewed as well.

Results: The basic principles of "5C" for the establishment of modern standardized stem cell banks include (1) principle of informed consent, (2) confidentiality principle, (3) conformity principle, (4) contamination-free principle, and (5) commonweal principle. Read More

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"I want to perform and succeed more than those who are HIV-seronegative" Lived experiences of youth who acquired HIV perinetally and attend Zewditu Memorial Hospital ART clinic, Addis Ababa, Ethiopia.

PLoS One 2021 27;16(5):e0251848. Epub 2021 May 27.

Department of Preventive Medicine, School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia.

Background: In Ethiopian Human Immunodeficiency Virus (HIV) prevention program one of the focusing areas is prevention of mother-to-child transmission and decreasing morbidity and mortality among those who already acquired it. However, the needs and the sexual behavior of children who acquired HIV perinatally was not given due attention. Therefore, we conducted this study with the aim of exploring the lived experiences of youth who acquired HIV perinatally to contribute to HIV prevention and control program. Read More

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[The desire and the experience of participation among children and adolescents in inpatient mental healthcare].

Z Kinder Jugendpsychiatr Psychother 2021 May;49(5):213-226

Institut für Medizinische Psychologie und Medizinische Soziologie, Albert-Ludwigs-Universität Freiburg.

The desire and the experience of participation among children and adolescents in inpatient mental healthcare Children have the right to participate in decisions that affect them. However, the stages and domains of participation relevant within inpatient child and adolescent psychiatry have rarely been empirically investigated. The present study closes this research gap. Read More

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Guidance for ensuring fair and ethical broad consent for future use. A scoping review protocol.

F1000Res 2021 11;10:102. Epub 2021 Feb 11.

World Health Organization, TDR, the Special Programme for Research and Training in Tropical Diseases, Geneva, Switzerland.

Broad consent for future use is the reuse of data and/or samples collected by a study by researchers who may not be affiliated with the original study team for purposes that may differ from the objectives of the original study. Sharing participant-level data and samples collected from research participants facilitates reuse and transparency and can accelerate drug or vaccine development, research findings, and translation. Data reuse and synthesis help prevent unnecessary research, thereby respecting research participants time and efforts and building their trust in the research process. Read More

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Digital Health during COVID-19: Informatics Dialogue with the World Health Organization.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

eHealth Development Association, Amman, Jordan.

Background: On December 16, 2020 representatives of the International Medical Informatics Association (IMIA), a Non-Governmental Organization in official relations with the World Health Organization (WHO), along with its International Academy for Health Sciences Informatics (IAHSI), held an open dialogue with WHO Director General (WHO DG) Tedros Adhanom Ghebreyesus about the opportunities and challenges of digital health during the COVID-19 global pandemic.

Objectives: The aim of this paper is to report the outcomes of the dialogue and discussions with more than 200 participants representing different civil society organizations (CSOs).

Methods: The dialogue was held in form of a webinar. Read More

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Outcome of thrombolysis with streptokinase in patients with prosthetic valve thrombosis.

Pak J Med Sci 2021 Mar-Apr;37(2):325-330

Anjum Jalal, FCPS-CS, FRCS-CTh, Professor of Cardiac Surgery, Faisalabad Institute of Cardiology, Faisalabad, Pakistan.

Objective: To evaluate the outcome of thrombolysis in patients of prosthetic valve thrombosis.

Methods: This retrospective analysis was conducted on data of 84 patients of prosthetic valve thrombosis who presented to emergency room of Faisalabad Institute of Cardiology between July 2017 to December 2019. The diagnosis of prosthetic valve thrombosis was based on clinical suspicion and bed side transthoracic echocardiography done by a consultant cardiologist. Read More

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Clinical indications for total abdominal hysterectomy among women seen in Dar es Salaam regional referral hospitals, Tanzania: a prospective, observational hospital-based study.

Pan Afr Med J 2021 6;38:10. Epub 2021 Jan 6.

Clinical Research, H3 Research Unit of I-Katch Technology Limited, Dar es Salaam, Tanzania.

Total abdominal hysterectomy is among the commonest gynaecologic surgeries observed in Africa. However, there exists a gap in published data to support this hypothesis. Information on hysterectomies reported from sub-Saharan Africa reflects mostly obstetric indications. Read More

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Systemic inflammation and chronic kidney disease in a patient due to the RNASEH2B defect.

Pediatr Rheumatol Online J 2021 Jan 22;19(1). Epub 2021 Jan 22.

Department of Rheumatology and Immunology, Shenzhen Children's Hospital, 7019 Yitian Road, Shenzhen, 518038, China.

Introduction: Aicardi-Goutières (AGS) is a rare immune dysregulated disease due to mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, or IFIH1. Clinical features include basal ganglia calcifications, white matter abnormalities, and cerebral atrophy. Severe systemic inflammation and chronic kidney disease (CKD) are extremely rare in AGS. Read More

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January 2021

MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols.

Alzheimers Dement 2021 04 21;17(4):704-715. Epub 2021 Jan 21.

Alzheimer's Clinical and Translational Research Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.

The concept of vascular contributions to cognitive impairment and dementia (VCID) derives from more than two decades of research indicating that (1) most older individuals with cognitive impairment have post mortem evidence of multiple contributing pathologies and (2) along with the preeminent role of Alzheimer's disease (AD) pathology, cerebrovascular disease accounts for a substantial proportion of this contribution. Contributing cerebrovascular processes include both overt strokes caused by etiologies such as large vessel occlusion, cardioembolism, and embolic infarcts of unknown source, and frequently asymptomatic brain injuries caused by diseases of the small cerebral vessels. Cerebral small vessel diseases such as arteriolosclerosis and cerebral amyloid angiopathy, when present at moderate or greater pathologic severity, are independently associated with worse cognitive performance and greater likelihood of dementia, particularly in combination with AD and other neurodegenerative pathologies. Read More

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Growth-Promoting Therapies May Be Useful In Short Stature Patients With Nonspecific Skeletal Abnormalities Caused By Acan Heterozygous Mutations: Six Chinese Cases And Literature Review.

Endocr Pract 2020 Nov;26(11):1255-1268

Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medixcal College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.. Electronic address:

Objective: There are numerous reasons for short stature, including mutations in osteochondral development genes. ACAN, one such osteochondral development gene in which heterozygous mutations can cause short stature, has attracted attention from researchers in recent years. Therefore, we analyzed six cases of short stature with heterozygous ACAN mutations and performed a literature review. Read More

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November 2020

Effects of Shenqi compound on intestinal microbial metabolites in patients with type 2 diabetes: A protocol for systematic review and meta analysis.

Medicine (Baltimore) 2020 Nov;99(48):e23017

Yibin Hospital of Traditional Chinese Medicine, Yibin, Sichuan, China.

Introduction: According to the data from the 2017 Chinese Guidelines for the Prevention and Treatment of Type 2 Diabetes [Chin J Diabetes. 2017;20:81-117], in 2013, the incidence of T2DM in China was 10.4%, while nearly 63% of the patients did not receive standard diagnosis. Read More

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November 2020

Systematic Evaluation of Smartphone Applications for the Medical Management of Nephrolithiasis.

J Endourol 2021 Apr 9. Epub 2021 Apr 9.

The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

The aim of this study was to comprehensively evaluate the quality of patient-oriented, mobile health applications (apps) available for medical management of kidney stone disease (KSD). A systematic search was performed to identify apps from the Apple and Google Play app stores. Eligible apps were divided into two categories: (1) fluid apps and (2) dietary apps. Read More

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Artificial Intelligence in Plastic Surgery: Current Applications, Future Directions, and Ethical Implications.

Plast Reconstr Surg Glob Open 2020 Oct 29;8(10):e3200. Epub 2020 Oct 29.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Mayo Clinic, Phoenix, Ariz.

Background: Artificial intelligence (AI) in healthcare delivery has become an important area of research due to the rapid progression of technology, which has allowed the growth of many processes historically reliant upon human input. AI has become particularly important in plastic surgery in a variety of settings. This article highlights current applications of AI in plastic surgery and discusses future implications. Read More

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October 2020

A Practical Guideline for the Implementation of Shared Decision-making in Complex Ventral Incisional Hernia Repair.

J Surg Res 2021 03 15;259:387-392. Epub 2020 Oct 15.

Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.

Background: Although obtaining preoperative procedural consent is required to meet legal and ethical obligations, consent is often relegated to a unidirectional conversation between surgeons and patients. In contrast, shared decision-making (SDM) is a collaborative dialog that elicits patient preferences. Despite emerging interest in SDM, there is a paucity of literature on its application to ventral incisional hernia repair (VIHR). Read More

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Maternal-Neonatal Dyad Outcomes of Maternal COVID-19 Requiring Extracorporeal Membrane Support: A Case Series.

Am J Perinatol 2021 01 17;38(1):82-87. Epub 2020 Oct 17.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Los Angeles.

Objective: This study aimed to describe two cases of acute respiratory distress syndrome (ARDS) secondary to novel coronavirus disease 2019 (COVID-19) in pregnant women requiring extracorporeal membrane oxygenation (ECMO), and resulting in premature delivery.

Study Design: The clinical course of two women hospitalized with ARDS due to COVID-19 care in our intensive care (ICU) is summarized; both participants provided consent to be included in this case series.

Results: Both women recovered with no clinical sequelae. Read More

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January 2021

[Guideline on diagnosis, treatment, and follow-up of laryngeal cancer].

Authors:
F Bootz

Radiologe 2020 Nov;60(11):1052-1057

Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde, Universitätsklinikum Bonn (UKB), 53127, Bonn, Deutschland.

The German S3 guideline on diagnosis, treatment, and follow-up of laryngeal cancer was developed in 2019 as part of the oncology guideline program of the Association of the Scientific Medical Societies in Germany (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften, AWMF) of the German Cancer Society (Deutsche Krebsgesellschaft, DKG) and German Cancer Aid (Deutsche Krebshilfe, DKH), published under the leadership of the German Society for Otorhinolaryngology, Head and Neck Surgery. The guideline was funded by DKH as part of the oncology guideline program. Since guidelines are an important tool for quality assurance and quality management in oncology, they should be incorporated into everyday care in a targeted and sustainable manner. Read More

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November 2020

The MOMENTUM Study: An International Registry for the Evidence-Based Introduction of MR-Guided Adaptive Therapy.

Front Oncol 2020 7;10:1328. Epub 2020 Sep 7.

Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, Netherlands.

MR-guided Radiation Therapy (MRgRT) allows for high-precision radiotherapy under real-time MR visualization. This enables margin reduction and subsequent dose escalation which may lead to higher tumor control and less toxicity. The Unity MR-linac (Elekta AB, Stockholm, Sweden) integrates a linear accelerator with a 1. Read More

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September 2020

Reporting of key methodological and ethical aspects of cluster trials in hemodialysis require improvement: a systematic review.

Trials 2020 Aug 28;21(1):752. Epub 2020 Aug 28.

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Background: The hemodialysis setting is suitable for trials that use cluster randomization, where intact groups of individuals are randomized. However, cluster randomized trials (CRTs) are complicated in their design, analysis, and reporting and can pose ethical challenges. We reviewed CRTs in the hemodialysis setting with respect to reporting of key methodological and ethical issues. Read More

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Controlled substances in hospices after patient death: a cross-sectional survey of Ontario hospices.

Int J Clin Pharm 2020 Oct 19;42(5):1344-1353. Epub 2020 Aug 19.

University of Waterloo School of Pharmacy, 10 Victoria St S, Kitchener, ON, N2G 1C5, Canada.

Background Practices related to the handling of controlled substances (CS) in Ontario hospices have not been previously published and therefore, are unknown. Objective The objective of this study was to determine current practices, and policies, standard operating procedures (SOPs) and guidelines related to handling and disposal of CS at hospices across Ontario. Setting This study was a cross-sectional survey of hospices in Ontario. Read More

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October 2020

[Guideline on diagnosis, treatment, and follow-up of laryngeal cancer].

Authors:
F Bootz

HNO 2020 Oct;68(10):757-762

Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde, Universitätsklinikum Bonn (UKB), 53127, Bonn, Deutschland.

The German S3 guideline on diagnosis, treatment, and follow-up of laryngeal cancer was developed in 2019 as part of the oncology guideline program of the Association of the Scientific Medical Societies in Germany (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften, AWMF) of the German Cancer Society (Deutsche Krebsgesellschaft, DKG) and German Cancer Aid (Deutsche Krebshilfe, DKH), published under the leadership of the German Society for Otorhinolaryngology, Head and Neck Surgery. The guideline was funded by DKH as part of the oncology guideline program. Since guidelines are an important tool for quality assurance and quality management in oncology, they should be incorporated into everyday care in a targeted and sustainable manner. Read More

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October 2020

Assessing Parent Decisions About Child Participation in a Behavioral Health Intervention Study and Utility of Informed Consent Forms.

JAMA Netw Open 2020 07 1;3(7):e209296. Epub 2020 Jul 1.

Mary Ann & J. Milburn Smith Child Health Research, Outreach, and Advocacy Center; Stanley Manne Children's Research Institute; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

Importance: Obtaining informed consent is an important ethical obligation for clinical research participation that is imperfectly implemented. Research on improving consent processes often focuses on consent forms, but little is known about consent forms' influence on decision-making compared with other types of engagement.

Objective: To evaluate whether parents decide whether to enroll their children in research before or after they receive the consent form. Read More

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A cross-sectional study of awareness and practices regarding thalassemia among parents of thalassemic children.

J Family Med Prim Care 2020 Apr 30;9(4):1935-1938. Epub 2020 Apr 30.

Department of Community Medicine, Government Medical College, Patiala, Punjab, India.

Background: This cross-sectional study was carried out in thalassemia ward of Rajindra Hospital, Patiala, among the parents of thalassemic children to determine awareness about side effects and complications of blood transfusion therapy, other treatment options, nature of disease, and food practices of transfusion-dependent patients. The study was carried out using a predesigned questionnaire and 118 parents participated in the study. About 50. Read More

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GROWTH PROMOTING THERAPIES MAYBE USEFUL IN SHORT STATURE PATIENTS WITH NON-SPECIFIC SKELETAL ABNORMALITIES CAUSED BY HETEROZYGOUS MUTATIONS: SIX CHINESE CASES AND LITERATURE REVIEW.

Endocr Pract 2020 Jul 13. Epub 2020 Jul 13.

From: Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China.

There are numerous reasons for short stature, including mutations in osteochondral development genes. , one such osteochondral development gene whose heterozygous mutations can cause short stature, has attracted attention from researchers in recent years. Therefore, we analysed six cases of short stature with heterozygous mutations and performed a literature review. Read More

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Clinical features of 2019 novel coronavirus infection in Beijing.

J Thorac Dis 2020 May;12(5):2563-2568

Department of Emergency Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing 100730, China.

Background: A new coronavirus pneumonia caused by 2019 new coronavirus (2019-nCoV) is spreading in China. Here we summarized the patients we accepted in the fever outpatient department.

Methods: Patients with epidemiologic history, respiratory symptoms or fever were required to go to the fever clinic for screening. Read More

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The natural history of multiple osteochondromas in a large Italian cohort of pediatric patients.

Bone 2020 10 24;139:115499. Epub 2020 Jun 24.

Department of Medical Genetics and Rare Orthopedic Diseases and CLIBI Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. Electronic address:

Importance: Multiple osteochondromas is a rare hereditary skeletal disorder, characterized by bony protrusions arising from growth plates on long bones during skeletal development. The disorder frequently leads to diminished stature, deformities and functional limitations. Understanding of the natural history of multiple osteochondromas and its evolution in children and adolescents is limited. Read More

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October 2020

Efficacy and safety of bone marrow aspiration and biopsy using fluoroscopic guidance and a drill-powered needle: clinical experience from 775 cases.

Eur Radiol 2020 Nov 9;30(11):5964-5970. Epub 2020 Jun 9.

Mallinckrodt Institute of Radiology, Washington University in St. Louis, 510 South Kingshighway Boulevard, St. Louis, MO, 63110, USA.

Objectives: To evaluate the efficacy and safety of performing a fluoroscopically guided bone marrow aspiration and biopsy (BMAB) using a drill-powered needle in a large patient population.

Methods: This retrospective study received institutional review board approval with a waiver of patient informed consent. We identified all BMAB procedures from August 2012 through December 2016 performed at our institution using fluoroscopic guidance and a drill-powered needle. Read More

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November 2020

A Systematic Review of Minimally Invasive Trans-thoracic Liver Resection to Examine Intervention Description, Governance, and Outcome Reporting of an Innovative Technique.

Ann Surg 2021 05;273(5):882-889

Bristol Center for Surgical Research, Population Health Sciences, Bristol Medical School, Bristol, UK.

Introduction: The number of laparoscopic liver resections undertaken has increased. However, lesions located postero-superiorly are difficult to access. This may be overcome by the novel use of trans-thoracic port(s). Read More

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Rising dysmorphia among adolescents : A cause for concern.

J Family Med Prim Care 2020 Feb 28;9(2):567-570. Epub 2020 Feb 28.

Internal Medicine Patiala, Punjab, India.

Introduction: Body dysmorphic disorder is defined as a preoccupation with apparent defects in patient's appearance which causes significant distress and impairment. This study was conducted in 186 students who attended premedical preparation classes with the mean age of 16.81 years with the primary motive of determining body dysmorphia among adolescent age group. Read More

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February 2020