Stem Cell Res Ther 2021 May 29;12(1):307. Epub 2021 May 29.
Sports Medicine Department of the Institution of Peking University Third Hospital, Beijing Key Laboratory of Sports Injuries, No. 49 North Garden Road, Beijing, 100191, China.
Background: The stem cells of the stem cell banks have prominent problems for insufficient sources, easy contamination, unstable biological characteristics after serial subcultivations, and high cost.
Methods: After collecting the construction processes of the existing stem cell banks and suggestions from authoritative experts in the past 10 years, 230 reference principles were obtained, and finally, the principles of "5C" for the establishment of modern standardized stem cell banks were summarized, and their related applications on the management of sports injuries were reviewed as well.
Results: The basic principles of "5C" for the establishment of modern standardized stem cell banks include (1) principle of informed consent, (2) confidentiality principle, (3) conformity principle, (4) contamination-free principle, and (5) commonweal principle. Read More