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Resting-state brain connectivity in healthy young and middle-aged adults at risk of progressive Alzheimer's disease.

Neurosci Biobehav Rev 2021 Jul 23. Epub 2021 Jul 23.

Edinburgh Dementia Prevention and Centre for Clinical Brain Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom.

Functional brain connectivity of the resting-state networks has gained recent attention as a possible biomarker of Alzheimer's Disease (AD). In this paper, we review the literature of functional connectivity differences in young adults and middle-aged cognitively intact individuals with non-modifiable risk factors of AD (n = 17). We focus on three main intrinsic resting-state networks: The Default Mode network, Executive network, and the Salience network. Read More

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The significance of imaging examinations during follow-up for malignant melanoma.

Eur J Dermatol 2021 Jun;31(3):357-363

Department of Dermatology, Venerology and Oncodermatology, Medical School, Clinical Center - University of Pécs, 1. Akac Street, P.O.B.: H-7632 Pécs, Hungary.

Currently, there is a general lack of consensus regarding optimal strategy and imaging during follow-up for patients suffering from melanoma. Our aim was to analyse the utility of various imaging procedures, in particular CT scans, during the follow-up of patients with different stages of melanoma. A retrospective analysis of the medical records of patients suffering from melanoma diagnosed between 2001 and 2011 was carried out at the Department of Dermatology, University of Pécs. Read More

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Successful diagnosis and treatment of jejunal diverticular haemorrhage by full-thickness enterotomy: A case report.

World J Clin Cases 2021 Jul;9(19):5232-5237

Department of General Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

Background: Jejunal diverticula are the rarest of all small bowel diverticula and usually have no classic clinical symptoms. Jejunal diverticular haemorrhage (JDH) is a rare complication and can be difficult to identify and manage, hence it always resulting in a diagnostic delay and unsatisfactory clinical outcomes. Although with the advances in endoscopic technology, no consensus have been reached on the diagnosis and management of JDH, the conventional surgical intervention still remains the mainstream for the management of JDH. Read More

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Morphological, Structural, and Functional Networks Highlight the Role of the Cortical-Subcortical Circuit in Individuals With Subjective Cognitive Decline.

Front Aging Neurosci 2021 9;13:688113. Epub 2021 Jul 9.

Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Subjective cognitive decline (SCD) is considered the earliest stage of the clinical manifestations of the continuous progression of Alzheimer's Disease (AD). Previous studies have suggested that multimodal brain networks play an important role in the early diagnosis and mechanisms underlying SCD. However, most of the previous studies focused on a single modality, and lacked correlation analysis between different modal biomarkers and brain regions. Read More

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A FAUSTIAN BARGAIN THAT UNDERMINES RESEARCH PARTICIPANTS' PRIVACY RIGHTS AND RETURN OF RESULTS.

Fla Law Rev 2019 Sep;71(5):1281-1345

Consortium on Law and Values in Health, Environment & the Life Sciences, University of Minnesota.

A 2018 committee report published by the highly respected National Academies of Science, Engineering, and Medicine (the Report) recommends stripping research participants of crucial data privacy rights and discarding decades of carefully deliberated consensus guidelines for the ethical return of results and data from research. This Article traces these disturbing recommendations to three root causes: (1) a statement of task that blocked careful and impartial analysis of a disputed legal matter central to the Report; (2) a piecemeal legal analysis that omitted relevant strands of law; and (3) the inappropriate conflation of two distinct concepts-the return of individual research results (the stated subject of the Report) and privacy-enabling individual access rights, which have a nearly fifty-year legal history long predating the modern debate about return of results. The Report's recommendations would erect new barriers to the return of results and, simultaneously, dial back a core data privacy right that Americans-including many research participants-currently enjoy. Read More

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September 2019

Assessing the role of urban green spaces for human well-being: a systematic review.

GeoJournal 2021 Jul 20:1-19. Epub 2021 Jul 20.

HOD Geography Department, University of Malaya, Kuala Lumpur, Malaysia.

Human has been evolving in a natural environment over a long time; thus, he is habitual to adapt it. Green spaces are obligatory landscapes in an urban structure that provide a natural environment and accelerate other life events. In contrast, unplanned urbanization, and conversion from green to grey structures have damaged natural environmental resources. Read More

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Invasive Multimodal Neuromonitoring in Aneurysmal Subarachnoid Hemorrhage: A Systematic Review.

Stroke 2021 Jul 26:STROKEAHA121034633. Epub 2021 Jul 26.

Department of Neurosurgery, RWTH Aachen University Hospital, Aachen, Germany (M.A., W.A., M.W., A.H., H.C., G.A.S.).

Background And Purpose: Aneurysmal subarachnoid hemorrhage is a devastating disease leaving surviving patients often severely disabled. Delayed cerebral ischemia (DCI) has been identified as one of the main contributors to poor clinical outcome after subarachnoid hemorrhage. The objective of this review is to summarize existing clinical evidence assessing the diagnostic value of invasive neuromonitoring (INM) in detecting DCI and provide an update of evidence since the 2014 consensus statement on multimodality monitoring in neurocritical care. Read More

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Infections and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society.

Rev Neurol (Paris) 2021 Jul 21. Epub 2021 Jul 21.

URC2A, Cote d'Azur University, CRCSEP-Côte d'Azur, neurologie, Hôpital Pasteur2, CHU Nice, France.

Introduction: Viral, bacterial, or fungal infections are suspected of triggering multiple sclerosis (MS) and promoting relapses of the disease and are likely to be promoted by immune-active treatments. This raises questions about the infectious workup and preventive treatment of these infections prior to their initiation.

Objectives: To establish recommendations on infections and MS. Read More

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Evaluation of the LI-RADS treatment response algorithm in hepatocellular carcinoma after trans-arterial chemoembolization.

Clin Imaging 2021 Jun 24;80:117-122. Epub 2021 Jun 24.

Weill Cornell Medical College, Division of Liver Transplantation and Hepatobiliary Surgery, United States of America.

Purpose: To evaluate the diagnostic performance of LI-RADS treatment response algorithm (LR-TRA) and modified RECIST (mRECIST) for the detection of viable hepatocellular carcinoma (HCC) on MRI after trans-arterial chemoembolization (TACE).

Materials And Methods: This retrospective study includes cirrhotic patients that underwent trans-arterial chemoembolization prior to liver transplantation from 2013 to 2017 with a pre- and post-treatment MRI available. Three blinded readers assigned a LR-TRA and mRECIST category to each lesion. Read More

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Evolution of Type 2 Diabetes Management from a Glucocentric Approach to Cardio-Renal Risk Reduction: The New Paradigm of Care.

Drugs 2021 Jul 24. Epub 2021 Jul 24.

Cardiology Unit, Department of Medicine K2, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

For many years, clinical studies could not show that lowering glucose in patients with type 2 diabetes leads to better macrovascular outcomes. In the past few years, new data have shown that treatment with two classes of dugs developed as "glucose-lowering agents," SGLT2 inhibitors and GLP-1 receptor agonists, can reduce macrovascular and renal complications. These studies have prompted debate about the main aim of type 2 diabetes management. Read More

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Wild plants used by the Lhoba people in Douyu Village, characterized by high mountains and valleys, in southeastern Tibet, China.

J Ethnobiol Ethnomed 2021 Jul 23;17(1):46. Epub 2021 Jul 23.

Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.

Background: Douyu Village, inhabited by the Lhoba people, is situated within the Eastern Himalayas, in southeastern Tibet, China. The village is located among high mountains and valleys, which feature complex terrain with cold and dry climates and distinctive vegetation types and species. The Lhoba people in this village are isolated from other groups in China. Read More

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QTL Mapping and Diurnal Transcriptome Analysis Identify Candidate Genes Regulating Flowering Time.

Int J Mol Sci 2021 Jul 15;22(14). Epub 2021 Jul 15.

National Key Laboratory of Crop Genetic Improvement, Hongshan Laboratory, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.

Timely flowering is important for seed formation and maximization of rapeseed () yield. Here, we performed flowering-time quantitative trait loci (QTL) mapping using a double haploid (DH) population grown in three environments to study the genetic architecture. Brassica 60 K Illumina Infinium™ single nucleotide polymorphism (SNP) array and simple sequence repeat (SSR) markers were used for genotyping of the DH population, and a high-density genetic linkage map was constructed. Read More

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The effects of genetic polymorphisms on benzene-exposed workers: A systematic review.

Health Sci Rep 2021 Sep 16;4(3):e327. Epub 2021 Jul 16.

Bacterias & Cáncer Group, Microbiology and Parasitology, Faculty of Medicine Universidad de Antioquia Medellín Colombia.

Background And Aims: Benzene is a group I carcinogen, which has been associated with leukemia and myelodysplastic syndrome. Moreover, it has been proposed that polymorphisms in benzene metabolizing genes influence the outcomes of benzene exposure in the human body. This systematic review aims to elucidate the existent relationship between genetic polymorphisms and the risk of developing adverse health effects in benzene-exposed workers. Read More

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September 2021

mA Regulator-Mediated Methylation Modification Model Predicts Prognosis, Tumor Microenvironment Characterizations and Response to Immunotherapies of Clear Cell Renal Cell Carcinoma.

Front Oncol 2021 6;11:709579. Epub 2021 Jul 6.

Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.

Background: This study aims to establish an N6-methyladenosine (mA) RNA methylation regulators-mediated methylation model and explore its role in predicting prognostic accuracy of immune contexture and characterizations of clear cell renal cell carcinoma (ccRCC).

Methods: The mA modification subclasses (mAMS) were identified by unsupervised cluster analysis and three clusters were determined by consensus clustering algorithm in a discovering cohort. Testing and real-world validation cohorts were used to identify predictive responses for immune checkpoint therapies (ICTs) of mAMS. Read More

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Endoscopic surveillance for bladder cancer: a systematic review of contemporary worldwide practices.

Transl Androl Urol 2021 Jun;10(6):2750-2761

Department of Urology, Guy's and St. Thomas NHS Foundation Trust, London, UK.

Background: The aim of this systematic review was to identify the current endoscopic surveillance strategies in use across the world and to determine whether these were sufficient or if any recommendations for changes in the guidelines could be made. This review focused on the cystoscopic follow-up of non-muscle invasive bladder cancer (NMIBC) patients and muscle invasive bladder cancer (MIBC) patients who had undergone bladder sparing treatments.

Methods: A literature search was carried out on Medline and Embase using OVID gateway according to a pre-defined protocol. Read More

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UK Vessel Health and Preservation (VHP) Framework: a commentary on the updated VHP 2020.

J Infect Prev 2021 Jul 14;22(4):147-155. Epub 2020 Dec 14.

The Christie NHS Foundation Trust, Manchester, UK.

Background: In 2016, a UK vessel health and preservation (VHP) framework was developed to support healthcare staff to select the most appropriate vascular access device for patients requiring intravenous therapy. The VHP framework was based on available evidence and expert consensus. The VHP was based on available evidence and expert consensus. Read More

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The efficacy of virtual distance training of intensive therapy and anaesthesiology among fifth-year medical students during the COVID-19 pandemic: a cross-sectional study.

BMC Med Educ 2021 Jul 22;21(1):393. Epub 2021 Jul 22.

Department of Anaesthesiology and Intensive Therapy, Semmelweis University, P.O.B. 2, H-1428, Budapest, Hungary.

Background: The coronavirus disease (COVID-19) brought several challenges in medical education. The aim of our study was to investigate whether virtual distance trainings (VDT) organized during the COVID-19 pandemic at our university were effective in replacing in-person bed-side education in intensive therapy and anaesthesiology among fifth-year medical students, both from students' and instructors' perspectives.

Methods: This was a cross-sectional study consisting of three parts: a 20-item students' questionnaire filled out by students participating in VDT, a 22-item instructors' questionnaire filled out by instructors taking part in virtual distance education and a 20-item knowledge test completed by students participating in VDT, as well as by students visiting bed-side trainings (BT) during the same semester, before COVID-19 pandemic. Read More

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Fine dissection of limber pine resistance to Cronartium ribicola using targeted sequencing of the NLR family.

BMC Genomics 2021 Jul 23;22(1):567. Epub 2021 Jul 23.

Canadian Forest Service, Natural Resources Canada, 506 West Burnside Road, Victoria, BC, V8Z 1M5, Canada.

Background: Proteins with nucleotide binding site (NBS) and leucine-rich repeat (LRR) domains (NLR) make up one of most important resistance (R) families for plants to resist attacks from various pathogens and pests. The available transcriptomes of limber pine (Pinus flexilis) allow us to characterize NLR genes and related resistance gene analogs (RGAs) in host resistance against Cronartium ribicola, the causal fungal pathogen of white pine blister rust (WPBR) on five-needle pines throughout the world. We previously mapped a limber pine major gene locus (Cr4) that confers complete resistance to C. Read More

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Randomised clinical trials of patients with acute myocardial infarction-related cardiogenic shock: a systematic review of used cardiogenic shock definitions and outcomes.

Kardiol Pol 2021 Jul 22. Epub 2021 Jul 22.

Department of Cardiology Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Background: Cardiogenic shock (CS) is a critical complication to acute myocardial infarction (AMI), with short-term mortality rates exceeding 40%. However, no international consensus of a CS definition exists. This may compromise interstudy comparability. Read More

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Ethnoveterinary botanical survey of medicinal plants used in Pashto, Punjabi and Saraiki communities of Southwest Pakistan.

Vet Med Sci 2021 Jul 22. Epub 2021 Jul 22.

Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan.

Medicinal plants are highly used in the ethnoveterinary practice as considerable livestock resources in remote areas. The aim of the present study is to explore the ethnoveterinary medicinal practices in three different communities and discuss the cross-cultural consensus on the usage of medicinal plants for the treatment of animals. The field survey was conducted by the animal healers of the area during the different seasons of plant growth. Read More

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COMP: A Potential Early Biomarker of RAS After Lung Transplantation.

Transplant Direct 2021 Aug 19;7(8):e730. Epub 2021 Jul 19.

Department of Internal Medicine/Respiratory Medicine and Allergology, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.

Background: Chronic rejection, defined as chronic lung allograft dysfunction (CLAD), is the major factor limiting long-term survival after lung transplantation (LTx). A specific subgroup of CLAD is restrictive allograft syndrome (RAS). CLAD's pathogenesis is largely unknown, but previous findings suggest that it is associated with increased fibrosis in the transplanted lung. Read More

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Identification of the mA RNA Methylation Regulators WTAP as a Novel Prognostic Biomarker and Genomic Alterations in Cutaneous Melanoma.

Front Mol Biosci 2021 5;8:665222. Epub 2021 Jul 5.

Department of Plastic Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.

The purpose of our research was to establish a gene signature and determine the prognostic value of mA methylation regulators in cutaneous melanoma and WTAP as a protective gene in cutaneous melanoma prognosis, we also evaluated gene mutations in cutaneous melanoma. We downloaded the RNA-seq transcriptome data and the clinical information for cutaneous melanoma patients from the GTEx and TCGA databases. Consensus clustering analysis was applied to divide the samples into two groups. Read More

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Knowledge, attitudes, and practices regarding vector-borne diseases in central Mexico.

J Ethnobiol Ethnomed 2021 Jul 21;17(1):45. Epub 2021 Jul 21.

Laboratorio de Cultura y Educación Ambiental, Facultad de Ciencias Biológicas, Benemérita Universidad Autónoma de Puebla, Blvd. Valsequillo y Av. San Claudio. Edificio BIO I, Ciudad Universitaria, Col. Jardines de San Manuel, C. P. 72570, Puebla, México.

Background: While vector-borne diseases (VBDs) pose an important public health problem worldwide, there is a limited and conflicting knowledge about such illnesses in rural or urban settings. The present study aimed to explore the social representations (SRs) held by people in the state of Puebla, Mexico on insects and the diseases they transmit. Understood as the group of ideas held and shared by a group of human beings which enable them to understand and interpret the world, SRs constitute what could be called a collective science or knowledge of everyday life. Read More

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Robust and efficient software for reference-free genomic diversity analysis of GBS data on diploid and polyploid species.

Mol Ecol Resour 2021 Jul 20. Epub 2021 Jul 20.

Department of Systems and Computing Engineering, Universidad de los Andes, Bogotá, Colombia.

Genotyping-by-Sequencing (GBS) is a widely used and cost-effective technique for obtaining large numbers of genetic markers from populations by sequencing regions adjacent to restriction cut sites. Although a standard reference-based pipeline can be followed to analyze GBS reads, a reference genome is still not available for a large number of species. Hence, reference-free approaches are required to generate the genetic variability information that can be obtained from a GBS experiment. Read More

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Increased gene expression variability in BRCA1-associated and basal-like breast tumours.

Breast Cancer Res Treat 2021 Jul 21. Epub 2021 Jul 21.

Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.

Purpose: Inherited variants in the cancer susceptibility genes, BRCA1 and BRCA2 account for up to 5% of breast cancers. Multiple gene expression studies have analysed gene expression patterns that maybe associated with BRCA12 pathogenic variant status; however, results from these studies lack consensus. These studies have focused on the differences in population means to identified genes associated with BRCA1/2-carriers with little consideration for gene expression variability, which is also under genetic control and is a feature of cellular function. Read More

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Histological Patterns of Skin Lesions in Tuberous Sclerosis Complex: A Panorama.

Dermatopathology (Basel) 2021 Jul 4;8(3):236-252. Epub 2021 Jul 4.

Reference Center for Genodermatoses (MAGEC Center), Department of Pathology, Necker-Enfants Malades Hospital, Paris Centre University, 75015 Paris, France.

Tuberous Sclerosis Complex (TSC) is a multisystem genetic disease characterized by cutaneous and extracutaneous hamartomas. The diagnosis is based on the association of major and minor criteria, defined by a consensus conference updated in 2012. The clinical examination of the skin is crucial because seven diagnostic criteria are dermatological: four major (hypomelanotic macules, angiofibroma or fibrous cephalic plaques, ungual fibromas, shagreen patches) and three minor criteria (confetti skin lesions, dental enamel pits, intraoral fibromas). Read More

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Current Evidence for Stereotactic Body Radiotherapy in Lung Metastases.

Curr Oncol 2021 Jul 15;28(4):2560-2578. Epub 2021 Jul 15.

Princess Margaret Cancer Centre, Radiation Medicine Program, University Health Network, Toronto, ON M5G2M9, Canada.

Lung metastases are the second most common malignant neoplasms of the lung. It is estimated that 20-54% of cancer patients have lung metastases at some point during their disease course, and at least 50% of cancer-related deaths occur at this stage. Lung metastases are widely accepted to be oligometastatic when five lesions or less occur separately in up to three organs. Read More

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PRISMA-S: an extension to the PRISMA statement for reporting literature searches in systematic reviews.

J Med Libr Assoc 2021 Apr;109(2):174-200

Emerging Technology and Innovation Strategist, University of Minnesota, Minneapolis, MN.

Background: Literature searches underlie the foundations of systematic reviews and related review types. Yet, the literature searching component of systematic reviews and related review types is often poorly reported. Guidance for literature search reporting has been diverse and, in many cases, does not offer enough detail to authors who need more specific information about reporting search methods and information sources in a clear, reproducible way. Read More

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The recurring features of molecular subtypes in distinct gastrointestinal malignancies-A systematic review.

Crit Rev Oncol Hematol 2021 Jul 17;164:103428. Epub 2021 Jul 17.

Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental and Molecular Medicine (CEMM), Cancer Center Amsterdam and Amsterdam Gastroenterology and Metabolism, Amsterdam University Medical Centers, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands; Oncode Institute, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. Electronic address:

In colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDAC) and gastric cancer (GC) multiple studies of inter-tumor heterogeneity have identified molecular subtypes, which correlate with clinical features. Our aim was to investigate the attributes of molecular subtypes across three different gastrointestinal cancer types. We performed a systematic search for publications on molecular subtypes or classifications in PDAC and GC and compared the described subtypes with the established consensus molecular subtypes of CRC. Read More

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Expert Consensus to Finalize a Universal Evaluator Rubric to Assess Pharmacy Students' Patient Communication Skills.

Am J Pharm Educ 2020 Dec 2;84(12):848016. Epub 2020 Oct 2.

University of Iowa College of Pharmacy, Iowa City, Iowa.

To use an expert consensus-building process to develop a rubric used by multiple evaluator types to assess Doctor of Pharmacy students' patient communication skills. Faculty and staff members from six schools and colleges of pharmacy collaborated on a multi-step expert consensus-building process to create the final version of a communication rubric. First, faculty and patient content experts evaluated each item in the rubric for its relevance, criticality, and global comprehensiveness using a five-point Likert scale (0=not at all, 4=to a high extent). Read More

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December 2020