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Hypophosphatemia in critically ill pediatric patients receiving enteral and oral nutrition.

JPEN J Parenter Enteral Nutr 2021 Jul 21. Epub 2021 Jul 21.

State University of Campinas, Unicamp, Faculty of Medical Sciences, 126 Tessália Vieira de Camargo St., Barão Geraldo, Campinas, SP, Zip Code: 13083-887, Brazil.

Background: Hypophosphatemia (HP) is related to several comorbidities in pediatric intensive care units (PICUs). This study aimed to evaluate the incidence of HP in severely ill pediatric patients under oral and/or enteral nutrition. The secondary objectives were to investigate the association between HP and the inflammatory state, prolonged PICU length stay, severity, mortality, nutritional status, and protein, energy, calcium, vitamin D and phosphate intake METHODS: : A prospective, observational cohort study was conducted in a PICU of a quaternary hospital. Read More

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Liver Protection Mechanism and Absorption Promotion Technology of Silybin Based on Intelligent Medical Analysis.

J Healthc Eng 2021 3;2021:9968016. Epub 2021 Jul 3.

Zhucheng People's Hospital, Zhucheng 262200, Shandong, China.

With the continuous popularization of smart medicine, the protective effect of silibinin in the liver has attracted much attention. This study mainly explores the liver protection mechanism and absorption promotion technology of silybin based on intelligent medical analysis. Refining of silibinin: accurately weigh 1. Read More

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Respiratory Events After Intensive Care Unit Discharge in Trauma Patients: Epidemiology, Outcomes, and Risk factors.

J Trauma Acute Care Surg 2021 Jul 20. Epub 2021 Jul 20.

Surgical Outcomes Research Center, Department of Surgery, University of Washington, Seattle, WA Department of Surgery, Harborview Medical Center, Seattle, WA Department of Surgery, University of California San Francisco, San Francisco, CA.

Background: Respiratory complications are associated with significant morbidity and mortality in trauma patients. The care transition from the intensive care unit (ICU) to the acute care ward is a vulnerable time for injured patients. There is a lack of knowledge about the epidemiology of respiratory events and their outcomes during this transition. Read More

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Assessment of Pressure Injuries Following Surgery: A Descriptive Study.

Wound Manag Prev 2021 Jun;67(6):27-40

Manisa Celal Bayar University, Faculty of Health Science Department of Surgical Nursing, Manisa, Turkey.

Background: Pressure injury is a common problem for patients undergoing surgery and is a significant quality indicator for perioperative care.

Purpose: To determine the rate of intraoperative pressure injuries and evaluate risk factors in surgical patients.

Methods: A descriptive study was conducted from May to December 2019 among consecutive patients older than 18 years of age undergoing a nonemergent (planned) surgical procedure lasting longer than 2 hours in a hospital in Turkey. Read More

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Artificial Long Estrus Protocols Administered Prior to Progesterone Increase Endometrial Uterocalin Expression in Anestrous Mares.

J Equine Vet Sci 2021 Aug 6;103:103669. Epub 2021 Jun 6.

Letur, Albacete, Spain. Electronic address:

Uterocalin (P19) is a lipocalin protein that has binding activity for the provisioning of the embryo with lipids, including those essential for morphogenesis and pattern formation. Therefore, it is thought that P19 plays an important role in supporting the survival of the early embryo. Previous research has shown that the endometrium from acyclic mares expressed more P19 following a simulated long estrus: treatment of 8 mg of estradiol benzoate (EB) split over five consecutive days, followed by long-acting progesterone administration (LA-P4) 72 hours later, when compared to a single 2. Read More

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Early discharge after thoracoscopic anatomical pulmonary resection for non-small-cell lung cancer.

Interact Cardiovasc Thorac Surg 2021 Jul 19. Epub 2021 Jul 19.

Service of Thoracic Surgery, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Objectives: Although video-assisted thoracic surgery (VATS) has shortened hospitalization duration for non-small-cell lung cancer (NSCLC) patients, the factors associated with early discharge remain unclear. This study aimed to identify patients eligible for a 72-h stay after VATS anatomical resection.

Methods: Monocentric retrospective study including all consecutive patients undergoing VATS anatomical resection for NSCLC between February 2010 and December 2019. Read More

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Loss of nocturnal dipping pattern of skin sympathetic nerve activity during and following an extended-duration work shift in residents in training.

J Cardiol 2021 Jul 16. Epub 2021 Jul 16.

Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, 1665 Kongjiang Road, Shanghai 200092, China. Electronic address:

Background: Extended-duration work shifts (EDWSs) might affect the health of physician residents, causing autonomic alteration. Skin sympathetic nerve activity (SKNA) recorded by noninvasive neuro-electrocardiography (neuECG) is used to estimate cardiac sympathetic tone. In this study, we aim to evaluate the impact of EDWSs on nocturnal SKNA assessed in resident doctors. Read More

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Association between Early Antibiotic Therapy and In-Hospital Mortality among Older Patients with SARS-CoV-2 Pneumonia.

J Gerontol A Biol Sci Med Sci 2021 Jul 17. Epub 2021 Jul 17.

Department of Clinical Research, Troyes Hospital Centre, Troyes, France.

Background: It is uncertain whether antibiotic therapy should be started in SARS CoV-2 pneumonia. We aimed to investigate the association between early antibiotic therapy and the risk of in-hospital mortality in older patients.

Methods: We performed a retrospective international cohort study (ANTIBIOVID) in five COVID-19 geriatric units in France and Switzerland. Read More

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Acute Central Retinal Artery Occlusion Seen within 24 Hours at a Tertiary Institution.

J Stroke Cerebrovasc Dis 2021 Jul 13;30(9):105988. Epub 2021 Jul 13.

Department of Ophthalmology, Emory University School of Medicine, 1365-B Clifton Road NE, Suite B4500, Atlanta, GA 30322, United States; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, United States. Electronic address:

Objective: Acute central retinal artery occlusion (CRAO) is an emergency with poor visual outcome. Intravenous thrombolysis within 4.5 h of vision loss is safe and may improve vision, but is rarely administered because of frequent delays in presentation. Read More

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Intraoperative Neurophysiology and Transcranial Doppler for Detection of Cerebral Ischemia and Hyperperfusion during Carotid Endarterectomy.

World Neurosurg 2021 Jul 13. Epub 2021 Jul 13.

Department of Neurosurgery, Cangzhou Central Hospital, Hebei province, China.

Objective: To evaluate and compare the efficacy of intraoperative neurophysiological monitoring (IONM) and intraoperative transcranial Doppler (TCD) techniques for identification of hypoperfusion during carotid artery (CA) clamp and hyperperfusion after release of occlusion during carotid endarterectomy (CEA).

Methods: A retrospective, consecutive case series of 152 patients undergoing CEA between June 2018 and March 2020 were reviewed. Monitoring of somatosensory evoked potentials (SEPs), motor evoked potentials (MEPs), electroencephalogram (EEG) and TCD were investigated. Read More

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Comparison of efficacy of two different doses of tranexamic acid in prevention of post operative blood loss in patients with congenital cyanotic heart disease undergoing cardiac surgery.

Ann Card Anaesth 2021 Jul-Sep;24(3):339-344

Department of Anesthesiology and Critical Care, Aster Medicity, Kochi, Kerala, India.

Background: The optimal dose of tranexamic acid in minimizing perioperative bleeding is uncertain. We compared efficacy of two different doses of tranexamic acid in reducing post-operative blood loss and its side effects in patients with congenital cyanotic heart disease undergoing cardiac surgery.

Settings And Design: Prospective observational study at a pediatric cardiac center in South India. Read More

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Low dose intraoperative ketamine infusion with multilevel paravertebral block for pain after video-assisted thoracic surgery: a randomized-controlled study.

Ann Palliat Med 2021 Jul 6. Epub 2021 Jul 6.

Department of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Intraoperative low-dose ketamine infusion has been reported to be an effective adjuvant to opioids for postoperative pain control without major side effects, but it has not been tested in videoassisted thoracic surgery (VATS). The aim of this study was to examine the effect of low-dose intraoperative intravenous ketamine infusion on 24-hour morphine requirement and acute postoperative pain following VATS for lung resection.

Methods: This study was a single center, randomized, double-blind, placebo-controlled study. Read More

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Minocycline Activates the Nucleus of the Solitary Tract-associated Network to Alleviate Lipopolysaccharide-induced Neuroinflammation.

Chin Med Sci J 2021 Jun 30. Epub 2021 Jun 30.

State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China.

Objective To examine the neuroanatomical substrates underlying the effects of minocycline on alleviating LPS-induced neuroinflammation. Methods Forty C57BL/6 male mice were randomly and equally divided into eight groups. Over three consecutive days, saline was administered to four groups of mice and minocycline to the other four groups. Read More

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Factors Associated With Prolonged Mechanical Ventilation in Patients With Subarachnoid Hemorrhage-The RAISE Score.

Crit Care Med 2021 Jul 2. Epub 2021 Jul 2.

1 Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria. 2 Institute of Medical Informatics, UMIT: University for Health Sciences, Medical Informatics and Technology, Hall in Tirol, Austria.

Objectives: Patients suffering from spontaneous subarachnoid hemorrhage frequently require mechanical ventilation. Here, we aimed to identify factors associated with prolonged mechanical ventilation in subarachnoid hemorrhage patients and to create a new predictive score for prolonged mechanical ventilation.

Design: Prospective cohort study with retrospective data analysis. Read More

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Effect of arachidonic acid cascade inhibitors on body temperature and cognitive functions in rats in the Morris water maze after acute cold injury.

Pharmazie 2021 Jul;76(7):313-316

Educational and Scientific Institute of Applied Pharmacy, National University of Pharmacy, Kharkiv, Ukraine.

: The aim of the study was to evaluate the effect of arachidonic acid cascade inhibitors on body temperature and cognitive functions of rats (spatial memory, learning ability) in the Morris water maze test (MWM) after acute cold injury (CI). Animals were trained to find an escape platform in the MWM for two consecutive days. On the third day, rats were treated with saline (10 ml/kg), diclofenac sodium (7 mg/kg), etoricoxib (5 mg/kg), darbufelone mesylate (20 mg/kg) or montelukast (1 mg/kg) intragastrically (i. Read More

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Injectable Anesthesia With Medetomidine, Ketamine, and Butorphanol in Captive Humboldt Penguins ().

J Avian Med Surg 2021 Jul;35(2):167-179

Tieraerztliche Praxis für Exoten, D-86167 Augsburg, Germany.

The effects of an injectable anesthesia with 0.05 mg/kg medetomidine, 5 mg/kg ketamine, and 0.5 mg/kg butorphanol administered together intramuscularly were evaluated in 22 captive Humboldt penguins (, 10 male and 12 female), with a mean age of 8. Read More

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Pharmacokinetics of direct oral anticoagulants in emergency situations - Results of the prospective observational RADOA-registry.

Thromb Haemost 2021 Jul 13. Epub 2021 Jul 13.

Med. Klinik III, Johann-Wolfgang-Goethe-Universitätsklinik Frankfurt, Frankfurt, Germany.

Background Direct oral anticoagulants (DOAC) are increasingly used worldwide. Little is known so far about their pharmacokinetics in emergency situations. Methods A prospective, observational registry was performed to determine the clinical course in consecutive patients with major bleeding or urgent surgery treated with DOACs. Read More

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Combining C reactive protein and serum albumin to predict 90-day mortality in systemic lupus erythematosus with serious community-acquired infections.

Lupus Sci Med 2021 07;8(1)

Department of Emergency, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, China

Objective: Serious infections in SLE are common and have emerged as the major cause of death. However, effective methods to identify poor prognosis are still lacking. Therefore, we aimed to determine the predictive value of C reactive protein (CRP) plus albumin (ALB) in SLE with serious infections. Read More

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Effect of Anemia on the Prognosis of Patients with Ventricular Tachyarrhythmias.

Am J Cardiol 2021 Jul 8. Epub 2021 Jul 8.

First Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Germany. Electronic address:

This study evaluates the prognostic impact of anemia in patients presenting with ventricular tachyarrhythmias. The present longitudinal, observational, registry-based, monocentric cohort study included retrospectively all consecutive patients presenting with ventricular tachyarrhythmias on admission from 2002 to 2016. Anemic patients (hemoglobin levels <12. Read More

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Incidence and influencing factors of post-intensive care cognitive impairment.

Intensive Crit Care Nurs 2021 Jul 7:103106. Epub 2021 Jul 7.

School of Nursing, Lanzhou University, Lanzhou, Gansu Province 730000, China; Department of Intensive Care Unit, The First Hospital of Lanzhou University, Lanzhou, Gansu Province 730000, China. Electronic address:

Objective: To evaluate the incidence and risks factors of short-term post-intensive care (ICU) cognitive impairment.

Design: Prospective, observational study.

Setting: Closed university-affiliated intensive care unit. Read More

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Does the time interval from the end of sperm processing to intrauterine insemination (lab-to-uterus time) affect treatment outcome?

Andrology 2021 Jul 10. Epub 2021 Jul 10.

Infertility and IVF Unit, Helen Schneider Hospital for Women, Rabin Medical Center - Beilinson Hospital, Petach Tikva, 4941492, Israel.

Background: Intra-uterine insemination (IUI) is an essential component in the treatment of infertility. Success rates are dependent on clinical factors of the female partner, sperm quality and preparation technique. The effect of the time interval between the end of sperm preparation in the lab, and its injection into the uterine cavity (lab-to-uterus time) is yet to be determined. Read More

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Population Coding of Capsaicin Concentration by Sensory Neurons Revealed Using Ca Imaging of Dorsal Root Ganglia Explants from Adult pirt-GCaMP3 Mouse.

Cell Physiol Biochem 2021 Jul;55(4):428-448

International Centre for Neurotherapeutics, Dublin City University, Glasnevin, Dublin, Ireland.

Background/aims: Nociceptors detect noxious capsaicin (CAPS) via the transient receptor potential vanilloid 1 (TRPV1) ion channel, but coding mechanisms for relaying CAPS concentration [CAPS] remain obscure. Prolonged (up to 1h.) exposure to CAPS is used clinically to desensitise sensory fibres for treatment of neuropathic pain, but its signalling has typically been studied in cultures of dissociated sensory neurons employing low cell numbers and very short exposure times. Read More

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Early glottic cancer treatment with concurrent chemoradiotherapy with once-daily orally administered S-1.

Nagoya J Med Sci 2021 May;83(2):251-258

Department of Radiology, Nagoya University Graduate School of Medicine,Nagoya, Japan.

Glottic carcinoma is the most common laryngeal cancer. The outcomes for T1 bulky Glottic carcinoma and T2N0 Glottic carcinoma after radiation therapy alone are unsatisfactory. This study was conducted to evaluate the efficacy and safety of unique concurrent chemoradiotherapy regimen using S-1 for early glottic cancer. Read More

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An NP-led pilot telehealth programme to facilitate guideline-directed medical therapy for heart failure with reduced ejection fraction during the COVID-19 pandemic.

N Z Med J 2021 07 9;134(1538):77-88. Epub 2021 Jul 9.

Senior Improvement Advisor, Ko Awatea.

Aims: Heart failure with reduced ejection fraction (HFrEF) is associated with poor outcomes. While several medications are beneficial, achieving optimal guideline-directed medical therapy (GDMT) is challenging. COVID-19 created a need to explore new ways to deliver care. Read More

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Characteristics of Gut Microbiome After Traumatic Brain Injury.

J Neurosurg Anesthesiol 2021 Jul 8. Epub 2021 Jul 8.

Department of Neuroanaesthesiology and Critical Care Department of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Center Department of Biostatistics, All India Institute of Medical Sciences (AIIMS), New Delhi Department of Anaesthesia and Intensive Care, Government Medical College, Chandigarh, India.

Background: Preclinical studies have reported significant changes in the gut microbiome after traumatic brain injury (TBI). We hypothesized that TBI induces the growth of Proteobacteria in the human gut. Our primary outcome was to study the profile of the human fecal microbiome after TBI and the secondary outcome was to identify colonization with colistin-resistant and multidrug-resistant pathogens. Read More

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Intraoperative Versus Postoperative Vault Measurement After Implantable Collamer Lens Implantation in a Large Cohort of Patients.

J Refract Surg 2021 Jul 1;37(7):477-483. Epub 2021 Jul 1.

Purpose: To compare intraoperative and postoperative central vault measurement after implantable Collamer lens (ICL; STAAR Surgical) implantation using optical coherence tomography (OCT).

Methods: A total of 574 eyes of 338 consecutive patients undergoing myopic ICL implantation were evaluated (mean age of 30.8 ± 5. Read More

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Neutrophil Gelatinase-Associated Lipocalin as an Early Predictor of Contrast-Induced Nephropathy Following Endovascular Aortic Repair for Abdominal Aortic Aneurysm.

Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211025618

Department of Vascular Surgery, The First Affiliated Hospital of Xi'an JiaoTong University, Xi'an, Shanxi, China.

To investigate serum neutrophil gelatinase-associated lipocalin (sNGAL) and urine neutrophil gelatinase-associated lipocalin (uNGAL) as early predictors of contrast-associated acute kidney injury(contrast-induced nephropathy)following endovascular aortic repair for abdominal aortic aneurysm. Prospective cohort study. Subjects included 202 consecutive patients with abdominal aortic aneurysm diagnosed between February 2016 and October 2018. Read More

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Knowledge and Practice of Health Care Providers Towards Proper Face Mask Utilization to Minimize the Extent of COVID-19 Infection in Amhara Region Referral Hospitals, Ethiopia.

J Multidiscip Healthc 2021 28;14:1583-1591. Epub 2021 Jun 28.

Department of Midwifery, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.

Introduction: The novel coronavirus disease (COVID-19) pandemic began in early 2020, causing tens of thousands of deaths, over a million cases, and widespread socioeconomic disruption.

Objective: The aim of the study was to assess health care workers' knowledge and practice of proper face mask utilization to prevent the spread of COVID-19 infection in Amhara region referral hospitals, Ethiopia.

Methods: A cross-sectional institutional-based quantitative study design was conducted from May 15 to 30/2020 using pre-tested self-administrated questionnaire and analyzed by using SPSS version 20. Read More

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Systemic Immune-Inflammation Index Is a Predictor of Contrast-Induced Nephropathy in Patients With ST-Segment Elevation Myocardial Infarction.

Angiology 2021 Jul 7:33197211029094. Epub 2021 Jul 7.

Department of Cardiology, University of Health Sciences, Dr. Siyami Ersek Training and Research Hospital, Istanbul, Turkey.

We evaluated the predictive value of admission systemic immune-inflammation index (SII) for the risk of contrast-induced nephropathy (CIN) in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and SII (platelet × NLR) levels were calculated in 1621 consecutive patients with STEMI. The relationship of these parameters with CIN development within 72 hours of pPCI was analyzed. Read More

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Feasibility, outcomes, and safety of tele-hepatology services during the COVID-19 pandemic.

Hepatol Commun 2021 Apr 21. Epub 2021 Apr 21.

Departments of Hepatology Post Graduate Institute of Medical Education and Research Sector 12 Chandigarh-160012 India.

Background & Aims: COVID-19 has hampered health-care delivery globally. We evaluated the feasibility, outcomes, and safety of tele-hepatology in delivering quality-care amidst the pandemic.

Approach And Results: A telemedicine setup using smartphones by hepatologists was organized at our tertiary-care centre after pilot testing. Read More

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