416,941 results match your criteria connective tissue


Sulfated alginate/polycaprolactone double-emulsion nanoparticles for enhanced delivery of heparin-binding growth factors in wound healing applications.

Colloids Surf B Biointerfaces 2021 Sep 15;208:112105. Epub 2021 Sep 15.

Biomedical Engineering Program, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut 1107 2020, Lebanon. Electronic address:

Diabetic foot ulcers (DFUs) that are not effectively treated could lead to partial or complete lower limb amputations. The lack of connective tissue growth factor (CTGF) and insulin-like growth factor (IGF-I) in DFUs results in limited matrix deposition and poor tissue repair. To enhance growth factor (GF) availability in DFUs, heparin (HN)-mimetic alginate sulfate/polycaprolactone (AlgSulf/PCL) double emulsion nanoparticles (NPs) with high affinity and sustained release of CTGF and IGF-I were synthesized. Read More

View Article and Full-Text PDF
September 2021

A call for evidence in connective tissue diseases-associated interstitial lung disease.

Joint Bone Spine 2021 Sep 15:105274. Epub 2021 Sep 15.

National Reference Centre for Rare Pulmonary Diseases, Louis Pradel Hospital, Hospices Civils de Lyon; IVPC, INRAE, Claude Bernard University Lyon 1; member of ERN-LUNG, 28 avenue Doyen Lepine, 69677 Lyon cedex, Lyon, France.

View Article and Full-Text PDF
September 2021

Engineered glove to evaluate hand disability in rheumatoid arthritis: a pilot-study.

Joint Bone Spine 2021 Sep 15:105272. Epub 2021 Sep 15.

Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine and Specialties - DIMI, University of Genova, Italy - IRCCS Rheumatology Unit, San Martino Polyclinic, Viale Benedetto XV, n°6 -, 16132 Genova, Italy. Electronic address:

Objective: The Hand Test System (HTS) is an engineered-sensorized glove that has been originally developed in the neuroscientific field for the evaluation of hand fingers' speed movement. This pilot study aimed to evaluate the reproducibility of HTS analysis in rheumatoid arthritis (RA), correlating glove-derived parameters with clinical disease activity indexes, self-reported disability-related questionnaires and hand strength.

Methods: Fifty-five RA patients and fifty age and sex matched healthy controls (HCs) performed HTS analysis. Read More

View Article and Full-Text PDF
September 2021

The physiologic and physiopathologic roles of perivascular adipose tissue and its interactions with blood vessels and the renin-angiotensin system.

Pharmacol Res 2021 Sep 15:105890. Epub 2021 Sep 15.

Division of Pharmacology & Toxicology, Office of Cardiology, Hematology, Endocrinology, and Nephrology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA.

The perivascular adipose tissue (PVAT) refers to an ectopic local deposit of connective tissue that anatomically surrounds most of the blood vessels. While it was initially known only as a structural support for vasculature, the landmark findings of Soltis and Cassis (1991), first demonstrating that PVAT reduces the contractions of norepinephrine in the isolated rat aorta, brought the potential vascular role of PVAT into the limelight. This seminal work implied the potential ability of PVAT to influence vascular responsiveness. Read More

View Article and Full-Text PDF
September 2021

Vascularization of Microvascular Fragment Isolates from Visceral and Subcutaneous Adipose Tissue of Mice.

Tissue Eng Regen Med 2021 Sep 18. Epub 2021 Sep 18.

Institute for Clinical and Experimental Surgery, Saarland University, 66421, Homburg, Germany.

Background: Adipose tissue-derived microvascular fragments (MVF) represent effective vascularization units for tissue engineering. Most experimental studies in rodents exclusively use epididymal adipose tissue as a visceral fat source for MVF isolation. However, in future clinical practice, MVF may be rather isolated from liposuctioned subcutaneous fat tissue of patients. Read More

View Article and Full-Text PDF
September 2021

Gingival recession treatment with enamel matrix derivative associated with coronally advanced flap and subepithelial connective tissue graft: a split-mouth randomized controlled clinical trial with molecular evaluation.

Clin Oral Investig 2021 Sep 18. Epub 2021 Sep 18.

Periodontics and Biomaterials, Faculty of Dental Medicine at the Universidade Católica Portuguesa, Viseu, Portugal.

Objectives: The goal of this study was to evaluate the impact of enamel matrix derivative (EMD) on periodontal healing after root coverage (RC) surgery, involving CAF in combination with SCTG, and to assess the molecular profile, verifying the inflammation level in early stage (1 and 2 weeks).

Materials And Methods: Thirty-two recessions (RT1) were submitted to periodontal surgery with (test) or without (control) EMD. The clinical parameters analyzed on the day of surgery and 6 months after the surgical procedure were as follows: recession height and width, keratinized tissue height, percentual root coverage, and the gingival thickness of keratinized tissue. Read More

View Article and Full-Text PDF
September 2021

IgG anti-Pentraxin 3 antibodies are a novel biomarker of ANCA-associated vasculitis and better identify patients with eosinophilic granulomatosis with polyangiitis.

J Autoimmun 2021 Sep 14;124:102725. Epub 2021 Sep 14.

Division of Rheumatology, Department of Medicine DIMED, University of Padova, Italy. Electronic address:

Objective: To investigate prevalence of anti-Pentraxin 3 (PTX3) antibodies in sera of anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) patients.

Methods: Anti-PTX3 and PTX3 levels were analysed by enzyme-linked immunosorbent assays in sera from unselected patients with AAV and compared with patients with systemic lupus erythematosus (SLE, n = 130), other connective tissue diseases (CTDs, n = 97) and matched healthy controls (n = 97). Optical density (OD) cut-off for positive anti-PTX3 antibodies was determined by ROC curve analysis and set as 0. Read More

View Article and Full-Text PDF
September 2021

Relapsing polychondritis: state-of-the-art review with three case presentations.

Postgrad Med 2021 Sep 17. Epub 2021 Sep 17.

Department of Rheumatology, Rehabilitation and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.

Background: relapsing polychondritis (rpc) is a complex immune-mediated systemic disease affecting cartilaginous tissue and proteoglycan-rich organs. The most common and earliest clinical features are intermittent inflammation involving the auricular and nasal regions, although all cartilage types can be potentially affected. The life-threatening effects of rpc involve the tracheobronchial tree and cardiac connective components. Read More

View Article and Full-Text PDF
September 2021

CTGF promotes cell-to-cell communication in human periodontal ligament stem cells via MAPK and PI3K pathway.

J Periodontol 2021 Sep 17. Epub 2021 Sep 17.

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Purposes: Cell-cell communication is an essential process to respond to biological stimuli and sustain the microenvironmental homeostasis of human periodontal ligament stem cells (hPDLSCs). Connective tissue growth factor (CTGF), a critical secreted matrix protein, exhibits significant tasks in regulating the cell-cell and cell-matrix interactions. This study aimed to explore the relationship between CTGF and cell communication and the underlying mechanism. Read More

View Article and Full-Text PDF
September 2021

A novel variant in fibrillin-1 is responsible for early-onset familial thoracic aortic aneurysms in Marfan patients.

Ann Transl Med 2021 Aug;9(15):1240

Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, China.

Background: Marfan syndrome (MFS) is an inherited connective tissue disorder that affects the skeletal, ocular, and cardiovascular system. The disease's severity and clinical manifestations vary greatly due to pathogenic variants which, combined with a lack of research on the correlation between MFS's genotype and phenotype, make MFS a challenging disease to diagnose. This study aims to further the understanding of MFS by shedding light on the clinical manifestation of a novel variant in fibrillin-1 ()-the protein responsible for the genetic defects that lead to MFS. Read More

View Article and Full-Text PDF

Boost Tendon/Ligament Repair With Biomimetic and Smart Cellular Constructs.

Front Bioeng Biotechnol 2021 31;9:726041. Epub 2021 Aug 31.

Department of Orthopedics Trauma and Hand Surgery & Guangxi Key Laboratory of Regenerative Medicine, International Joint Laboratory on Regeneration of Bone and Soft Tissue, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Tendon and ligament are soft connective tissues that play essential roles in transmitting forces from muscle to bone or bone to bone. Despite significant progress made in the field of ligament and tendon regeneration over the past decades, many strategies struggle to recapitulate basic structure-function criteria of native ligament/tendon. The goal here is to provide a fundamental understanding of the structure and composition of ligament/tendon and highlight few key challenges in functional regeneration of these connective tissues. Read More

View Article and Full-Text PDF

Association of Adult-Onset Bartter Syndrome With Undifferentiated Connective Tissue Disorder.

Cureus 2021 Aug 13;13(8):e17140. Epub 2021 Aug 13.

internal Medicine/Nephrology, Shifa International Hospital, Islamabad, PAK.

Bartter syndrome is a rare autosomal recessive, salt-losing disorder characterized by hypokalemic hypochloremic metabolic alkalosis. We are reporting a case of 21 years old patient, who presented with lower limb weakness, marked hypokalemia, proteinuria, and renal impairment detected on laboratory evaluation. The diagnosis of Bartter syndrome was suspected by marked hypokalemia and was supported by renal biopsy which showed evidence of Juxtaglomerular (JG) hyperplasia. Read More

View Article and Full-Text PDF

Prediction of top round beef meat tenderness as a function of marinating time based on commonly evaluated parameters and regression equations.

Food Sci Nutr 2021 Sep 7;9(9):5006-5015. Epub 2021 Jul 7.

Department of Food Science and Technology Damghan Branch Islamic Azad University Damghan Iran.

This study investigates the influence of 24-hr marination (with different plant extracts and vinegar) at refrigerated conditions on commonly evaluated physicochemical and textural attributes, including pH, water-holding capacity (WHC), collagen solubility, moisture, drip loss, and shear force values of beef meat. The results reflected the appropriate correlation between each pair and indicated the efficiency of the household marination procedure to acquire more palatability and tender beef meat. Therefore, to predict beef meat tenderness by applying the Warner-Bratzler shear force (WBSF), a strong positive correlation with the drip loss ( < . Read More

View Article and Full-Text PDF
September 2021

The Nature of Finger Enslaving: New Results and Their Implications.

Motor Control 2021 Sep 16:1-24. Epub 2021 Sep 16.

Department of Kinesiology, The Pennsylvania State University, University Park, PA,USA.

We present a review on the phenomenon of unintentional finger action seen when other fingers of the hand act intentionally. This phenomenon (enslaving) has been viewed as a consequence of both peripheral (e.g. Read More

View Article and Full-Text PDF
September 2021

Two-stage approach for class II mandibular furcation defect with insufficient keratinized mucosa: a case report with 3 years' follow-up.

J Int Med Res 2021 Sep;49(9):3000605211044595

Oral Diagnosis and General Dentistry, Dental Hospital, 13100Tokyo Medical and Dental University, Tokyo Medical and Dental University, Tokyo, Japan.

Periodontal regenerative treatment is useful for intrabony defects and furcation involvement, but is difficult when there is insufficient keratinized mucosa to cover and maintain the regenerative material, particularly in the mandibular molar region. We report the case of a 27-year-old woman who underwent a two-stage surgical approach for a class II furcation defect with gingival recession and insufficient keratinized mucosal width (KMW) and vestibular depth at the mandibular left first molar. We first improved the KMW and keratinized mucosal thickness using an epithelial embossed connective tissue graft with enamel matrix derivative, and then focused on periodontal regeneration at the furcation defect using an enamel matrix derivative and a bovine-derived xenograft. Read More

View Article and Full-Text PDF
September 2021

Baculoviral inhibitor of apoptosis family of proteins repeat-containing 5 gene methylation status in peripheral blood mononuclear cells and plasma survivin levels in patients with Behçet's disease.

Arch Rheumatol 2021 Jun 14;36(2):185-191. Epub 2021 Jan 14.

Department of Internal Medicine, Connective Tissue Diseases Research Center, Tabriz, Iran.

Objectives: This study aims to evaluate the baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) gene methylation in the peripheral blood mononuclear cells (PBMCs) in patients with Behçet's disease (BD) compared to healthy controls and the association of survivin with BD activity.

Patients And Methods: A cross-sectional study was conducted on 43 BD patients (22 males, 21 females; mean age 36.6±10. Read More

View Article and Full-Text PDF

Frontonasal glioma - diagnostic difficulties.

Med Pharm Rep 2021 Aug 10;94(Suppl No 1):S33-S35. Epub 2021 Aug 10.

Clinical Hospital, Cluj-Napoca, Romania.

Nasal glioma or nasal glial heterotopia represents a rare rare benign tumor of the median line. Prenatal and even postnatal imagingc diagnosis of congenital frontonasal masses is difficult. We describe the case of an infant presenting with a lateral nasal mass. Read More

View Article and Full-Text PDF

Cardiovascular manifestations in Marfan syndrome.

Med Pharm Rep 2021 Aug 10;94(Suppl No 1):S25-S27. Epub 2021 Aug 10.

Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Marfan syndrome (MFS) is an autosomal dominant inherited disease of the connective tissue with multiorgan involvement (skeleton, cardiovascular, eyes, skin, lungs). Cardiovascular involvement is variable and represents the major cause of morbidity and mortality in Marfan syndrome. We provide a comprehensive description of cardiovascular manifestations in Marfan syndrome, genotype-phenotype correlations and assessment of cardiovascular abnormalities and complications. Read More

View Article and Full-Text PDF

Systematic review and meta-analysis of aortic valve-sparing surgery versus replacement surgery in ascending aortic aneurysms and dissection in patients with Marfan syndrome and other genetic connective tissue disorders.

J Thorac Dis 2021 Aug;13(8):4830-4844

Editorial Department, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico.

Background: Aortic aneurysm and dissection are important causes of morbimortality in patients with Marfan syndrome (MFS) and other connective tissue diseases that affect the cardiovascular tissues. Timely intervention through different surgical techniques improves the prognosis. Both sparing and replacement-type interventions of the aortic valve are used, but selection depends on the condition of the patient at the time of diagnosis, the patient's emergency condition, surgeon preference and hospital resources. Read More

View Article and Full-Text PDF

Porcine Acellular Dermal Matrix: An Alternative to Connective Tissue Graft-A Narrative Review.

Authors:
Shashi Dadlani

Int J Dent 2021 1;2021:1652032. Epub 2021 Sep 1.

Section of Periodontology, Faculty of Health Sciences, University Clinic of Dentistry, Oviedo university, Spain.

Porcine acellular dermal matrix has recently been introduced in dentistry as an alternative to the gold standard connective tissue graft especially for the use in gingival recession treatments and soft tissue augmentation in implant surgery. Connective tissue grafts are inconvenient and require a second surgical site leading to greater morbidity, longer surgical procedures, and a more painful postoperative phase for the patient. Other options such as allografts have ethical concerns and are less available in Europe. Read More

View Article and Full-Text PDF
September 2021

Requirement of Histone Deacetylase 6 for Interleukin-6 Induced Epithelial-Mesenchymal Transition, Proliferation, and Migration of Peritoneal Mesothelial Cells.

Front Pharmacol 2021 30;12:722638. Epub 2021 Aug 30.

Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Influenced by microenvironment, human peritoneal mesothelial cells (HPMCs) acquired fibrotic phenotype, which was identified as the protagonist for peritoneal fibrosis. In this study, we examined the role of histone deacetylase 6 (HDAC6) for interleukin-6 (IL-6) induced epithelial-mesenchymal transition (EMT), proliferation, and migration of HPMCs. The role of HDAC6 in IL-6-elicited EMT of HPMCs was tested by morphological observation of light microscope, immunoblotting, and immune-fluorescence assay; and the function of HDAC6 in proliferation and migration of HPMCs was examined by CCK-8 assay, wound healing experiment, and immunoblotting. Read More

View Article and Full-Text PDF

Hydrogen Sulfide Prevents Mesenteric Adipose Tissue Damage, Endothelial Dysfunction, and Redox Imbalance From High Fructose Diet-Induced Injury in Aged Rats.

Front Pharmacol 2021 30;12:693100. Epub 2021 Aug 30.

Department of Physiology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.

A high fructose diet (HFD) and advanced age are key factors for the gradual loss of physiological integrity of adipose tissue. Endogenous hydrogen sulfide (HS) has beneficial effects on cytoprotection and redox balance. But its interactive effects on age-related damage of mesenteric vessels and connective and adipose tissues (MA) during HFD which could be the base of the development of effective physiological-based therapeutic strategy are unknown. Read More

View Article and Full-Text PDF

Predictive Factors for Pneumomediastinum During Management of Connective Tissue Disease-related Interstitial Lung Disease: A Retrospective Study.

Intern Med 2021 15;60(18):2887-2897. Epub 2021 Sep 15.

Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan.

Objective To identify factors associated with pneumomediastinum during management of connective tissue disease (CTD)-related interstitial lung disease (ILD). Methods Patients diagnosed with pneumomediastinum after the initiation of corticosteroid therapy for their CTD-ILD were enrolled. The baseline characteristics of patients who developed pneumomediastinum after the initiation of corticosteroid therapy (n=13, all occurring within 120 days) were compared to those of patients who did not develop pneumomediastinum (n=49). Read More

View Article and Full-Text PDF
September 2021

A Reflection on How Carcinoma-Associated Fibroblasts Were Recognized as Active Participants of Epithelial Tumorigenesis.

Authors:
Edna Cukierman

Cancer Res 2021 Sep;81(18):4668-4670

Cancer Signaling and Epigenetics, Marvin and Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania.

Today's view of cancer as a systemic disease was facilitated by studies accentuating the local as well as the systemic role that non-tumorigenic cells, such as carcinoma-associated fibroblasts, play in cancer onset, development, and progression. The study highlighted in this Landmark was instrumental for supporting the idea that cancer is a full-body disease that depends on reciprocal interactions between cancer cells and the tumor microenvironment. Fibroblasts are mesenchymal cells of the connective tissue and are responsible for maintaining tissue homeostasis. Read More

View Article and Full-Text PDF
September 2021

Relationship between Chest CT scan Findings with SOFA score, CRP, Comorbidity, and Mortality in ICU Patients with COVID-19.

Int J Clin Pract 2021 Sep 15:e14869. Epub 2021 Sep 15.

Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Objective: This study aimed to investigate the relationship between chest computed tomography (CT) scan findings with sequential organ failure assessment (SOFA) score, C-reactive protein (CRP), comorbidity, and mortality in intensive care unit (ICU) patients with coronavirus disease 19 (COVID-19).

Method: Adult patients (≥18 years old) with COVID-19 who were consecutively admitted to the Imam-Reza Hospital, Tabriz, East-Azerbaijan Province, North-West of Iran between March 2020 and August 2020 were screened and total of 168 patients were included. Demographic, clinical, and mortality data were gathered. Read More

View Article and Full-Text PDF
September 2021

Treatment of Palindromic Rheumatism: A systematic review.

Int J Clin Pract 2021 Sep 15:e14868. Epub 2021 Sep 15.

Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Objectives: Palindromic rheumatism (PR) characterized by self-resolving attacks of arthritis and peri-arthritis that may progresses to other autoimmune connective tissue diseases (CTD). The aim of this systematic review was to analyze the effectiveness of different treatments on PR.

Methods: Articles were collected from Cochrane, PubMed, Science Direct, Scopus, ProQuest, Ebsco, Google Scholar, MEDLINE, EMBASE. Read More

View Article and Full-Text PDF
September 2021

Patients with Ehlers-Danlos syndrome on the diagnostic odyssey: Rethinking complexity and difficulty as a hero's journey.

Am J Med Genet C Semin Med Genet 2021 Sep 15. Epub 2021 Sep 15.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Patients with hypermobile Ehlers-Danlos syndrome, an hereditary disorder of the connective tissue, often face a long and difficult diagnostic odyssey in pursuit of a name for their condition. Clinicians may dismiss subjective symptoms of chronic pain, thus prolonging patients' odysseys and worsening their care and satisfaction and creating antagonisms in the patient-provider relationship. A greater understanding of patient experiences is necessary in order to decrease burdens of this relationship and to improve care. Read More

View Article and Full-Text PDF
September 2021

Risk Factors and Outcomes for Gastroparesis After Lung Transplantation.

Dig Dis Sci 2021 Sep 15. Epub 2021 Sep 15.

Division of Digestive and Liver Diseases, Department of Medicine, New York Presbyterian Columbia University Medical Center, 622 West 168th Street, New York, NY, USA.

Background: Gastroparesis is common after lung transplantation and is associated with worse transplant outcomes, including the development of chronic lung allograft dysfunction (CLAD). This study sought to identify the prevalence, risk factors, and outcomes associated with a new diagnosis of gastroparesis after lung transplantation.

Methods: This was a single-center retrospective study of patients who underwent lung transplantation in 2008-2018. Read More

View Article and Full-Text PDF
September 2021

The effect of transverse fascia inversion on postoperative seroma in direct hernias treated with laparoscopic TAPP procedure.

Ann Ital Chir 2021 ;92:384-389

Aim: This study aims to reveal the results of the transverse fascia inversion technique applied in laparoscopic transabdominal preperitoneal (TAPP) procedure to reduce the risk of seroma in direct hernias.

Marial And Methods: Patients who underwent elective inguinal hernia repair with the laparoscopic TAPP procedure were retrospectively evaluated. Indirect inguinal or femoral hernias and emergency operations were excluded, and only patients with direct or indirect + direct inguinal hernia were included in the study. Read More

View Article and Full-Text PDF
September 2021

Idiopathic spontaneous liver hemorrhage A report of two cases and a review of the literature.

Ann Ital Chir 2021 ;92:361-364

Spontaneous liver hemorrhage (SLH) is a serious, extremely rare, and life-threatening occurrence requiring a multidisciplinary approach. Since diagnosis might be difficult, a high mortality rate is reported. Survival depends on a prompt diagnosis followed by an appropriate management. Read More

View Article and Full-Text PDF
September 2021