46,344 results match your criteria congestive heart


Risk Factors Associated with Carbapenemase Producing Carbapenem-Resistant Enterobacteriaceae (CP-CRE) Positive Cultures in a Cohort of U.S. Veterans.

Clin Infect Dis 2021 May 11. Epub 2021 May 11.

Center of Innovation for Complex Chronic Healthcare (CINCCH), Hines Jr. Veterans Affairs Hospital, Hines, IL,USA.

Introduction: Carbapenem-resistant Enterobacterales (CRE) cause approximately 13,100 infections with 8% mortality in the United States annually. The subset of carbapenemase-producing CRE (CP-CRE) infections have much higher mortality rates (40% -50%). There has been little research on characteristics unique to CP-CRE. Read More

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Predictors of Mortality in Patients With Transcatheter Aortic Valve Implantation: A National Inpatient Sample Database Analysis.

Cureus 2021 Apr 7;13(4):e14344. Epub 2021 Apr 7.

Medicine, Mercy Health St. Vincent Medical Center, Toledo, USA.

Introduction In recent decades, transcatheter aortic valve implantation (TAVI) has become a treatment of choice for aortic stenosis. The purpose of this study was to evaluate predictors of mortality in patients undergoing TAVI. Methods The National Inpatient Sample database from the year 2011 to 2018 was used to identify all patients undergoing TAVI during the study period. Read More

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Association Between 5-Item Modified Frailty Index and Short-term Outcomes in Complex Head and Neck Surgery.

Otolaryngol Head Neck Surg 2021 May 11:1945998211010443. Epub 2021 May 11.

Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California, USA.

Objectives: To evaluate the impact of preoperative frailty on short-term outcomes following complex head and neck surgeries (HNSs).

Study Design: Cross-sectional database analysis.

Setting: American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database. Read More

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Anthracycline Treatment, Cardiovascular Risk Factors and the Cumulative Incidence of Cardiovascular Disease in a Cohort of Newly Diagnosed Lymphoma Patients from the Modern Treatment Era.

Am J Hematol 2021 May 10. Epub 2021 May 10.

Division of Hematology, Mayo Clinic, Rochester, MN, USA.

The development of cardiovascular disease (CVD) in long-term survivors of lymphoma is of increasing importance. Here, we characterize the cumulative incidence and risk factors for CVD in lymphoma patients diagnosed in the current treatment era. From 2002-2015, newly diagnosed lymphoma patients (>18 years) were enrollment into a prospective cohort study that captured incident CVD, consisting of congestive heart failure (CHF), acute coronary syndrome (ACS), valvular heart disease (VHD), and arrhythmia. Read More

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Fatal outcome of congenital aortopulmonary window with patent ductus arteriosus complicating pregnancy.

Autops Case Rep 2021 Apr 15;11:e2021265. Epub 2021 Apr 15.

Post Graduate Institute of Medical Education & Research (PGIMER), Departments of Histopathology, Chandigarh, India.

Aortopulmonary window (APW) is a rare congenital heart defect with abnormal communication between the ascending aorta and the pulmonary trunk with two separate semilunar valves. We present an autopsy case report wherein a young primigravida woman presented with progressive breathlessness and central cyanosis at 21 weeks of gestation. Echocardiography performed in the emergency room revealed elevated right-sided cardiac pressures suggestive of severe pulmonary hypertension; however, no structural cardiac defect was discernible. Read More

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Frequency of cardiac arrhythmias in older adults: Findings from the Subclinical Atrial Fibrillation and Risk of Ischemic Stroke (SAFARIS) study.

Int J Cardiol 2021 May 6. Epub 2021 May 6.

Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States of America. Electronic address:

Background: Prolonged monitoring of cardiac rhythm has been used to screen for subclinical atrial fibrillation (AF); little is known about other arrhythmias in the general population, especially in the elderly, who are at higher risk of arrhythmias.

Methods: We evaluated the frequency of arrhythmias in the tri-ethnic (white, Black, Hispanic), community-based Subclinical Atrial Fibrillation and Risk of Ischemic Stroke (SAFARIS) study using a patch-based recorder for up to 14 days in 527 participants free of AF, congestive heart failure (CHF) or history of stroke. Differences according to gender, age, ethnicity and presence of hypertension, diabetes and pertinent ECG and echocardiographic variables were examined. Read More

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Lefamulin efficacy and safety in a pooled phase 3 clinical trial population with community-acquired bacterial pneumonia and common clinical comorbidities.

BMC Pulm Med 2021 May 8;21(1):154. Epub 2021 May 8.

Olive View-UCLA Medical Center, Los Angeles, CA, USA.

Background: Lefamulin, a first-in-class pleuromutilin antibiotic approved for intravenous and oral use in adults with community-acquired bacterial pneumonia (CABP), was noninferior to moxifloxacin in the Lefamulin Evaluation Against Pneumonia (LEAP) 1 intravenous-to-oral switch study and the LEAP 2 oral-only study. Using pooled LEAP 1/2 data, we examined lefamulin efficacy/safety overall and within subgroups of patients presenting with comorbidities typical in CABP management.

Methods: In LEAP 1, adults with CABP were randomized to receive intravenous lefamulin (150 mg every 12 h) for 5‒7 days or moxifloxacin (400 mg every 24 h) for 7 days, with optional intravenous-to-oral switch if predefined improvement criteria were met. Read More

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Increased risk of secondary lung cancer in patients with tuberculosis: A nationwide, population-based cohort study.

PLoS One 2021 7;16(5):e0250531. Epub 2021 May 7.

Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Background: Tuberculosis (TB) presents a global threat in the world and the lung is the frequent site of metastatic focus. A previous study demonstrated that TB might increase primary lung cancer risk by two-fold for more than 20 years after the TB diagnosis. However, no large-scale study has evaluated the risk of TB and secondary lung cancer. Read More

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Use of average volume-assured pressure support as a therapeutic option in patients with central sleep apnea syndrome.

Sleep Breath 2021 May 7. Epub 2021 May 7.

Sleep Disorders Center, Division of Pulmonary and Critical Care, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

Purpose: Central sleep apnea (CSA) syndrome commonly occurs with other medical conditions such as congestive heart failure, opiate use, and brainstem disorders. Various treatment modalities have been used with varied effectiveness in an attempt to improve ventilation and reduce the apnea-hypopnea index (AHI) in patients with CSA. This study evaluated whether or not a bilevel positive airway pressure mode of noninvasive ventilation, average volume-assured pressure support (AVAPS) is effective in treating CSA. Read More

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Investigation of the relationships between sleep behaviors and risk of healthspan termination: a prospective cohort study based on 323,373 UK-Biobank participants.

Sleep Breath 2021 May 6. Epub 2021 May 6.

Department of Epidemiology and Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, 101 Longmian Road, Nanjing, 211166, China.

Objectives: To examine the associations between four sleep behaviors and the risk of healthspan termination.

Methods: This study included 323,373 participants, free of terminated healthspan at baseline, from the UK-Biobank (UKB). We applied multivariable-adjusted Cox regression models to estimate the risk of terminated healthspan based on four sleep behaviors (insomnia/sleeplessness, napping, daytime sleepiness, and difficulty getting up from bed), which were self-reported and measured on Likert scales from "usually" to "never/rarely" experiences. Read More

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Outpatient Total Shoulder Arthroplasty: A Systematic Review Evaluating Outcomes and Cost-Effectiveness.

JBJS Rev 2021 05 6;9(5). Epub 2021 May 6.

Department of Orthopaedics, The Ohio State University Wexner Medical Center, Columbus, Ohio.

Background: Orthopaedic surgical procedures are increasingly being performed in outpatient settings. The drive for cost reduction without compromising patient safety and outcomes has increased interest in outpatient total shoulder arthroplasty (TSA). The primary aim of this study was to perform a review of the evidence regarding the outcomes and cost-effectiveness of outpatient TSA. Read More

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Peripheral Gangerene, an Unusual Presentation of Infantile Kawasaki: A Case Report and Literature Review.

Case Rep Rheumatol 2021 13;2021:6629405. Epub 2021 Apr 13.

Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Diagnosing infantile Kawasaki disease with atypical symptoms is difficult, and it also has higher risk of coronary abnormalities which is one of the most common complications of KD. Other complications such as pericardial effusion, mitral insufficiency, congestive heart failure, myocardial systolic dysfunction, and systemic vasculitis were also reported. Peripheral gangrene and necrosis are among the rare complications of this systemic vasculitis. Read More

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Geographical variation of emergency hospital admissions for ambulatory care sensitive conditions in older adults in Ireland 2012-2016.

BMJ Open 2021 May 5;11(5):e042779. Epub 2021 May 5.

HRB Centre for Primary Care Research, Department of General Practice, Royal College of Surgeons in Ireland, Dublin, Ireland

Objective: Ambulatory care sensitive (ACS) conditions are those for which intensified primary care management could potentially prevent emergency admissions. This study aimed to quantify geographical variation in emergency admissions with ACS conditions in older adults and explore factors influencing variation.

Design: Repeated cross-sectional study. Read More

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A case report of COVID-19 in refractory myasthenia: Outcome with remdesivir and dexamethasone.

Medicine (Baltimore) 2021 May;100(18):e25701

Department of Neurology, University of Missouri Health Care, Missouri.

Rationale: Myasthenia gravis (MG) patients are at increased risk of COVID-19 infection and its complications due to chronic immunosuppression. COVID-19 infection can also increase the risk of myasthenia exacerbation.

Patient Concerns: The patient presented with respiratory distress, fever and chills and was diagnosed with COVID-19 pneumonia. Read More

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Carbohydrate antigen 125 in heart failure: congestive kidneys or beyond?

Eur Heart J Acute Cardiovasc Care 2021 May 5. Epub 2021 May 5.

Department of Cardiovascular Medicine, Kaufman Center for Heart Failure Treatment and Recovery, Cleveland Clinic, 9500 Euclid Avenue, Desk J3-4, Cleveland, OH 44195, USA.

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Novel therapies with precision mechanisms for type 2 diabetes mellitus.

Nat Rev Endocrinol 2021 May 4. Epub 2021 May 4.

Dallas Diabetes Research Center at Medical City, Dallas, TX, USA.

Type 2 diabetes mellitus (T2DM) is one of the greatest health crises of our time and its prevalence is projected to increase by >50% globally by 2045. Currently, 10 classes of drugs are approved by the US Food and Drug Administration for the treatment of T2DM. Drugs in development for T2DM must show meaningful reductions in glycaemic parameters as well as cardiovascular safety. Read More

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A comparison of revascularization methods for peripheral arterial disease in diabetics: Changing trends in lower extremity revascularization from 2008 to 2014.

Vascular 2021 May 4:17085381211012564. Epub 2021 May 4.

Department of Surgery, The University of Toledo College of Medicine and Life Sciences, Toledo, USA.

Objectives: This study examined the current demographic and outcome trends regarding endovascular and open revascularization for people with diabetes.

Methods: The National Inpatient Sample database was utilized to identify diabetic patients who underwent lower extremity revascularization and amputation procedures between 2008 and 2014. International Classification of Diseases 9th edition codes were used to identify the procedures, diagnoses, and comorbidities. Read More

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A prospective observational study of preoperative natriuretic peptide testing in adult non-cardiac surgical patients in hospitals in Western Cape Province, South Africa.

S Afr Med J 2021 03 31;111(4):338-342. Epub 2021 Mar 31.

Department of Anaesthesia and Perioperative Medicine, Groote Schuur Hospital and Faculty of Health Sciences, University of Cape Town, South Africa.

Background: International guidelines recommend risk stratification to identify high-risk non-cardiac surgical patients. It is also recommended that all patients aged ≥45 years with significant cardiovascular disease should have preoperative natriuretic peptide (NP) testing. Abnormal preoperative B-type NPs have a strong association with postoperative cardiac complications. Read More

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Postpartum maternal collapse-a first-time presentation of severe mitral stenosis: a case report.

J Med Case Rep 2021 May 4;15(1):225. Epub 2021 May 4.

Tulubolo General Hospital, Tulu Bolo, Ethiopia.

Background: Among cardiac causes for postpartum maternal collapse, severe mitral stenosis is not listed as a potential cause in current literature. We report a rare case of severe mitral stenosis that presented with severe hypoxia and maternal decompensation in early postpartum period for the first time. A 30-year-old para 2, abortus 1, Ethiopian woman developed severe hypoxia and rapid deterioration on her sixth postoperative day after cesarean delivery for fetal bradycardia with a good fetal outcome. Read More

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Windsock deformity of submitral left ventricular aneurysm communicating into left atrium - role of transesophageal echocardiography.

Ann Card Anaesth 2021 Jan-Mar;24(1):72-74

Department of Cardiothoracic and Vascular Surgery, Kerala Institute of Medical Sciences, Trivandrum, Kerala, India.

Submitral left ventricular aneurysm (SMLA) is a rare condition. We report here a 38-year-old male patient, presented with mitral regurgitation and features of congestive cardiac failure (CCF) with New York Heart Association (NYHA) function class III, diagnosed to have SMLA. We discuss here the etiology, types, clinical presentation, and management of SMLA and also the role of transesophageal echocardiography in diagnosis. Read More

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Sipuleucel-T associated inflammatory cardiomyopathy: a case report and observations from a large pharmacovigilance database.

ESC Heart Fail 2021 May 2. Epub 2021 May 2.

Department of Pharmacology, Regional Pharmacovigilance Centre, Pitié-Salpêtrière Hospital, Sorbonne Université, INSERM CIC-1901, AP-HP, Paris, France.

Aims: The major cardiovascular (CV) adverse effects observed with sipuleucel-T from large multi-institutional clinical trials included thromboembolic events, myocardial infarction, and congestive heart failure in up to 0.3% of patients with CV risk factors. The incidence, outcomes, and mechanisms in real-world clinical settings of these CV adverse effects to date have not been fully elucidated. Read More

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Deep Learning to Quantify Pulmonary Edema in Chest Radiographs.

Radiol Artif Intell 2021 Mar 6;3(2):e190228. Epub 2021 Jan 6.

Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215 (S.H., S.J.B.); Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Mass (R.L., P.G.); and Clinical Informatics Solutions and Services, Philips Research, Cambridge, Mass (X.W., S.D.).

Purpose: To develop a machine learning model to classify the severity grades of pulmonary edema on chest radiographs.

Materials And Methods: In this retrospective study, 369 071 chest radiographs and associated radiology reports from 64 581 patients (mean age, 51.71 years; 54. Read More

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Generative Adversarial Networks Improve the Reproducibility and Discriminative Power of Radiomic Features.

Radiol Artif Intell 2020 May 27;2(3):e190035. Epub 2020 May 27.

Service of Radiology, Department of Diagnostics, Geneva University Hospital, Rue Gabrielle Perret-Gentil 4, 1211 Geneva 14, Switzerland (S.M., J.H., S.P.M., X.M.); Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland (S.M., J.H., M.G.P., S.P.M., D.V.D.V., X.M.); and Institute of Bioengineering/Center for Neuroprosthetics, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (S.M., M.G.P., D.V.D.V.).

Purpose: To assess the contribution of a generative adversarial network (GAN) to improve intermanufacturer reproducibility of radiomic features (RFs).

Materials And Methods: The authors retrospectively developed a cycle-GAN to translate texture information from chest radiographs acquired using one manufacturer (Siemens) to chest radiographs acquired using another (Philips), producing fake chest radiographs with different textures. The authors prospectively evaluated the ability of this texture-translation cycle-GAN to reduce the intermanufacturer variability of RFs extracted from the lung parenchyma. Read More

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Diagnostic Accuracy with Total Adenosine Deaminase as a Biomarker for Discriminating Pleural Transudates and Exudates in a Population-Based Cohort Study.

Dis Markers 2021 10;2021:6648535. Epub 2021 Apr 10.

Department of Clinics, Faculty of Medical Sciences, Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil.

Background: An initial step in the evaluation of patients with pleural effusion syndrome (PES) is to determine whether the pleural fluid is a transudate or an exudate.

Objectives: To investigate total adenosine deaminase (ADA) as a biomarker to classify pleural transudates and exudates.

Methods: An assay of total ADA in pleural fluids (P-ADA) was observed using a commercial kit in a population-based cohort study. Read More

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Yield and Risk Factors for Advanced Colorectal Neoplasia and Long-term Outcomes in Veterans With 3 or More Nonadvanced Adenomas.

J Clin Gastroenterol 2021 Apr 30. Epub 2021 Apr 30.

Indiana University Roudebush VA Medical Center, Indianapolis, IN.

Background And Aims: Until recently, guidelines recommended a 3-year surveillance colonoscopy for persons with 3 to 10 nonadvanced adenomas (NAA). In this study, we quantify yield for metachronous advanced neoplasia (AN); attempt to identify risk factors for AN; and measure colorectal cancer (CRC) incidence and mortality.

Methods: We used natural language processing to screen an existing data set for Veterans with 3 to 10 NAA. Read More

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Early follow-up at outpatient care after discharge improves long-term heart failure readmission rate and prognosis.

ESC Heart Fail 2021 May 2. Epub 2021 May 2.

Division of Cardiology, Fukuoka Red Cross Hospital, 3-1-1, Okusu, Minami-ku, Fukuoka, 815-8555, Japan.

Aims: It has been reported that congestive heart failure (CHF) readmission has not decreased in the last decade. It is also reported that CHF readmission is likely to occur shortly after discharge. We investigated whether an early follow-up at outpatient care within 2 weeks after discharge affects the long-term readmission rate and prognosis. Read More

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Cerebral blood flow, cerebrovascular reactivity, and their influence on ventilatory sensitivity.

Exp Physiol 2021 May 1. Epub 2021 May 1.

Centre for Heart, Lung and Vascular Health, University of British Columbia - Okanagan Campus.

New Findings: What is the topic of this review? Cerebrovascular reactivity to CO is a principle factor in determining ventilatory responses to CO through the role reactivity plays in determining cerebral extra- and intra-cellular pH. What advances does it highlight? Recent animal evidence suggests central chemoreceptor vasculature may demonstrate regionally heterogenous cerebrovascular reactivity to CO , potentially as a protective mechanism against excessive CO washout from the central chemoreceptors, thereby allowing ventilation to reflect the systemic acid-base balance needs (respiratory changes in PaCO ) rather than solely the cerebral needs. Ventilation per se does not influence cerebrovascular reactivity independent of changes in PaCO . Read More

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Interstitial lung disease in lysosomal storage disorders.

Eur Respir Rev 2021 Jun 29;30(160). Epub 2021 Apr 29.

Service de Médecine Interne, Groupe Hospitalier Diaconesses Croix Saint-Simon, Paris, France.

Lysosomes are intracellular organelles that are responsible for degrading and recycling macromolecules. Lysosomal storage diseases (LSDs) are a group of inherited diseases caused by mutations affecting genes that encode the function of the lysosomal enzymes. Three LSDs are associated with lung involvement and/or interstitial lung disease (ILD): Gaucher disease (GD); Niemann-Pick disease, also known as acid sphingomyelinase deficiency (ASMD); and Fabry disease (FD). Read More

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Trends, Predictors, and Outcomes of Major Bleeding after Transcatheter Aortic Valve Implantation, From National Inpatient Sample (2011-2018).

Expert Rev Cardiovasc Ther 2021 Apr 29. Epub 2021 Apr 29.

West Virginia University, medicine, 1 Medical Center Dr, Morgantown, WV, 26505, USA.

Introduction: Major bleeding remains one of the most frequent complications seen in transcatheter aortic valve implantation (TAVI). The purpose of this study was to evaluate outcomes, trends, and predictors of major bleeding in patients undergoing TAVI.

Methods: We utilized the National Inpatient Sample (NIS) data from the year 2011 to 2018. Read More

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The Cardioprotective Mechanism of Phenylaminoethyl Selenides (PAESe) Against Doxorubicin-Induced Cardiotoxicity Involves Frataxin.

Front Pharmacol 2020 12;11:574656. Epub 2021 Apr 12.

Department of Drug, Discovery and Development, Harrison School of Pharmacy, Auburn University, Alabama, AL, United States.

Doxorubicin (DOX) is an anthracycline cancer chemotherapeutic that exhibits cumulative dose-limiting cardiotoxicity and limits its clinical utility. DOX treatment results in the development of morbid cardiac hypertrophy that progresses to congestive heart failure and death. Recent evidence suggests that during the development of DOX mediated cardiac hypertrophy, mitochondrial energetics are severely compromised, thus priming the cardiomyocyte for failure. Read More

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