100,531 results match your criteria congenital heart


Exception Status Listing - A Critical Pathway to Heart Transplantation For Adults with Congenital Heart Diseases.

J Card Fail 2021 Oct 17. Epub 2021 Oct 17.

Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Adults with congenital heart diseases may not be candidates for conventional therapies for ventricular systolic dysfunction including MCS which moves potential heart transplantation recipients to a higher priority listing status. This results in longer wait list times and mortality. Exception status listing allows for one pathway for this complex and anatomically heterogenous group of patients to be listed for heart transplantation at appropriately high listing status. Read More

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October 2021

Whole genome sequencing in transposition of the great arteries and associations with clinically relevant heart, brain and laterality genes.: WGS in transposition of the great arteries.

Am Heart J 2021 Oct 17. Epub 2021 Oct 17.

Heart Centre for Children, The Children's Hospital at Westmead, Sydney, Australia; Sydney Medical School, The University of Sydney, Sydney, Australia; Victor Chang Cardiac Research Institute, Darlinghurst, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia; Cincinnati Children's Hospital Medical Center, Heart Institute, Cardiothoracic Surgery, Cincinnati, Ohio, United States of America. Electronic address:

Background: The most common cyanotic congenital heart disease (CHD) requiring management as a neonate is transposition of great arteries (TGA). Clinically, up to 50% of TGA patients develop some form of neurodevelopmental disability (NDD), thought to have a significant genetic component. A 'ciliopathy' and links with laterality disorders have been proposed. Read More

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October 2021

Cardiac Arrhythmias During Pregnancy.

Tex Heart Inst J 2021 Sep;48(4)

Department of Cardiology, Texas Heart Institute, Houston, Texas.

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September 2021

Emergency surgical treatment of total anomalous pulmonary venous connection.

J Card Surg 2021 Oct 20. Epub 2021 Oct 20.

Department of Pediatric Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Background: This study explored the strategy and effect of emergency surgical treatment for total anomalous pulmonary venous connection (TAPVC).

Methods: From March 2009 to February 2020, 78 patients with TAPVC underwent emergency surgical correction. There were 51 males and 27 females. Read More

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October 2021

The Comparative Effectiveness and Safety of Different Anticoagulation Strategies for Treatment of Left Atrial Appendage Thrombus in the Setting of Chronic Anticoagulation for Atrial Fibrillation or Flutter.

Cardiovasc Drugs Ther 2021 Oct 20. Epub 2021 Oct 20.

II Department of Heart Arrhythmia, National Institute of Cardiology, Alpejska 42, 04-628, Warsaw, Poland.

Purpose: To compare effectiveness of different treatments for atrial fibrillation (AF) patients who were scheduled for cardioversion (CV) or ablation (CA) presenting with left atrium appendage (LAA) thrombus despite chronic oral anticoagulation therapy (OAC).

Methods: This was a retrospective cohort study. We analyzed 2014-2019 medical records of patients scheduled for CV or CA of AF who were diagnosed with LAA thrombus despite optimal OAC and had a follow-up transesophageal echocardiogram (TOE). Read More

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October 2021

Incorporation of the CardioMEMS™ System During an Exercise Physiology Test in a Pediatric Congenital Heart Disease Patient Contributing to Medical Decision-Making.

Pediatr Cardiol 2021 Oct 20. Epub 2021 Oct 20.

Division of Pediatric Cardiology, Washington University School of Medicine, St. Louis, USA.

Exercise testing among the pediatric congenital heart disease population continues to transform and expand the way patients are evaluated and managed. We describe a case where a stress echocardiogram was performed while successfully collecting data from a previously implanted CardioMEMS™ HF system which helped guide decision-making. Read More

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October 2021

Anomalous Origin of the Right Pulmonary Artery From the Aorta and Congenital Tracheal Stenosis: Staged Repair in a Neonate.

World J Pediatr Congenit Heart Surg 2021 Oct 20:21501351211049384. Epub 2021 Oct 20.

National Children's Hospital, Hanoi, Vietnam.

Anomalous origin of the right pulmonary artery from the ascending aorta (AORPA), sometimes referred to as hemitruncus, is a rare malformation. We report a unique case of AORPA associated with Ebstein's anomaly and with congenital tracheal stenosis due to complete tracheal rings. The AORPA and tracheal stenosis were both successfully corrected in the neonatal period. Read More

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October 2021

Successful surgical repair of pulmonary dominant common arterial trunk without aortic arch obstruction in a neonate.

Ann Pediatr Cardiol 2021 Jul-Sep;14(3):416-418. Epub 2021 Aug 12.

Department of Radiology, Believers Church Medical College Hospital, Thiruvalla, Kerala, India.

The pulmonary dominant variant of the common arterial trunk has always been reported to be associated with aortic coarctation, or interruption of the aortic arch, along with a duct-dependent systemic circulation. This mandates a complex surgical repair with attendant high surgical mortality. We report a 23-day-old baby with a pulmonary dominant trunk with mild aortic hypoplasia but with an arch free of coarctation or interruption, who underwent successful surgical repair. Read More

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Transcatheter device closure of perimembranous ventricular septal defect associated with indirect Gerbode defect: A retrospective study.

Ann Pediatr Cardiol 2021 Jul-Sep;14(3):397-400. Epub 2021 Aug 26.

Department of Pediatric Cardiology, AMRI Hospitals Ltd., Kolkata, West Bengal, India.

Perimembranous ventricular septal defect (pmVSD) is a common congenital heart disease that is sometimes associated with indirect left ventricle (LV) to right atrium (RA) shunt (indirect Gerbode defect). This defect has a rare chance of spontaneous closure and therefore was usually closed surgically in the past, but more recently transcatheter closure has been reported by a few authors. In our study, we have described a series of 14 children (age ranging from 1. Read More

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The modified Senning operation - surgical aspects.

Ann Pediatr Cardiol 2021 Jul-Sep;14(3):382-387. Epub 2021 Aug 26.

Department of Pediatric & Congenital Heart Surgery, Fortis Escorts Heart Institute, New Delhi, India.

The advent of the arterial switch operation for the treatment of transposition of great arteries (TGA) made the atrial switch operation largely redundant and its use in the developed world is now confined to the atrial component of the double-switch operation for congenitally corrected TGA. In resource-limited countries, however, it remains relevant as a treatment option for patients presenting late with transposition and a regressed left ventricle. The operation is intricate with many potential pitfalls, and this "how I do it" article describes the operative steps in detail to enable surgeons to learn this procedure and make it a part of their surgical armamentarium. Read More

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Diagnosis and management of junctional ectopic tachycardia in children.

Ann Pediatr Cardiol 2021 Jul-Sep;14(3):372-381. Epub 2021 Aug 20.

Department of Pediatrics (Cardiology), Oregon Health and Science University, Portland, Oregon, USA.

Junctional ectopic tachycardia (JET) is more common in its postoperative form. A thorough understanding of its etiology, pathophysiology, and management strategies is essential. Classically, postoperative JET is considered to arise from surgical trauma. Read More

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Research in pediatric cardiac anesthesia and intensive care in low- and middle- income countries and low resource settings: Challenges and opportunities.

Ann Pediatr Cardiol 2021 Jul-Sep;14(3):356-358. Epub 2021 Aug 26.

Department of Pediatric and Congenital Heart Surgery, Fortis Escorts Heart Institute, New Delhi, India.

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Early multicenter experience of a new balloon expandable MyVal transcatheter heart valve in dysfunctional stenosed right ventricular outflow tract conduits.

Ann Pediatr Cardiol 2021 Jul-Sep;14(3):293-301. Epub 2021 Aug 26.

Department of Pediatric Cardiology, Lisie Hospital, Kochi, Kerala, India.

Background: Transcatheter pulmonary valve implantation (TPVI) is a surgical alternative for correcting dysfunctional right ventricular outflow tract conduits in previously operated patients. MyVal transcatheter heart valve (THV) (Meril Life Sciences, India), a new transcatheter valve designed for aortic position has not been used for TPVI.

Methods: Patients with stenosed dysfunctional conduits from the right ventricle to pulmonary artery (RV-PA) were prestented after initial computed tomography and balloon interrogation before the implantation of MyVal. Read More

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Outcome of COVID-19-positive children with heart disease and grown-ups with congenital heart disease: A multicentric study from India.

Ann Pediatr Cardiol 2021 Jul-Sep;14(3):269-277. Epub 2021 Aug 26.

Children's Heart Center, Kokilaben Dhirubhai Ambani Hospital, Mumbai, Maharashtra, India.

Background: Outcome data of children with heart disease who acquired COVID-19 infection are limited.

Aims: We sought to analyze outcome data and identify risk factors associated with mortality in children with heart disease and grown-ups with congenital heart disease (GUCH) who had a laboratory-confirmed COVID-19 infection.

Settings And Design: This is a retrospective, multicentric, observational study. Read More

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A pragmatic approach to risk assessment in pulmonary arterial hypertension using the 2015 European Society of Cardiology/European Respiratory Society guidelines.

Open Heart 2021 Oct;8(2)

Department of Experimental, Diagnostic and Specialty Medicine - DIMES, University of Bologna, Bologna, Italy.

Objective: To optimise treatment of patients with pulmonary arterial hypertension (PAH), the 2015 European Society of Cardiology/European Respiratory Society guidelines recommend using risk stratification, with the aim of patients achieving low-risk status. Previous analyses of registries made progress in using risk stratification approaches, however, the focus is often on patients with a low-risk prognosis, whereas most PAH patients are in intermediate-risk or high-risk categories. Using only six parameters with high prognostic relevance, we aimed to demonstrate a pragmatic approach to individual patient risk assessment to discriminate between patients at low risk, intermediate risk and high risk of death. Read More

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October 2021

Health care costs of hospitalization of young children for respiratory syncytial virus infections: a population-based matched cohort study.

CMAJ Open 2021 Oct-Dec;9(4):E948-E956. Epub 2021 Oct 19.

Department of Pediatrics (Thampi, McNally), Faculty of Medicine, University of Ottawa; CHEO Research Institute (Thampi, McNally); ICES uOttawa (Knight); Ottawa Hospital Research Institute (Knight, Thavorn); Clinical Research Unit, CHEO Research Institute (Knight, Webster); Ontario Child Health Support Unit (Knight, Webster); School of Epidemiology and Public Health (Thavorn, Hawken), University of Ottawa, Ottawa, Ont.; ICES Central (Thavorn, Hawken), Toronto, Ont.; Clinical Epidemiology Program (Thavorn), Ottawa, Ont.; Sunnybrook Research Institute (Lanctot), University of Toronto, Toronto, Ont.; Clinical Epidemiology Program (Hawken), Ottawa Hospital Research Institute, Ottawa, Ont.

Background: Respiratory syncytial virus (RSV) infection poses a substantial clinical burden among infants and young children. We sought to determine the health care costs of hospitalizations attributable to RSV in Ontario, Canada, from the health care payer perspective.

Methods: For this population-based matched cohort study, we identified children younger than 24 months who were or were not hospitalized with RSV infections in 2006-2016. Read More

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October 2021

Maternal mosaicism for a missense variant in the SMS gene that causes Snyder-Robinson syndrome.

Cold Spring Harb Mol Case Stud 2021 Oct 19. Epub 2021 Oct 19.

Nationwide Children's Hospital.

There is increasing recognition for the contribution of genetic mosaicism to human disease, particularly as high-throughput sequencing has enabled detection of sequence variants at very low allele frequencies. Here, we describe an infant male who presented at 9 months of age with hypotonia, dysmorphic features, congenital heart disease, hyperinsulinemic hypoglycemia, hypothyroidism, and bilateral sensorineural hearing loss. Whole-genome sequencing of the proband and the parents uncovered an apparent mutation in the X-linked gene. Read More

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October 2021

Bicuspid aortic valve and anomalous right coronary artery from the opposite coronary sinus.

Cardiol Young 2021 Oct 20:1-3. Epub 2021 Oct 20.

Department of Paediatric and Congenital Cardiac Surgery and Cardiology, Ospedali Riuniti, Ancona, Italy.

We report on a patient with bicuspid aortic valve and anomalous right coronary artery from the opposite sinus without evidence of intramural course. Different authors support the universal presence of intramural course in patients with origin of the right coronary artery from the opposite sinus of Valsalva in normal heart. The occurrence of both bicuspid aortic valve and the absence of intramural course may not be accidental. Read More

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October 2021

Disability Among Young Adults With Congenital Heart Defects: Congenital Heart Survey to Recognize Outcomes, Needs, and Well-Being 2016-2019.

J Am Heart Assoc 2021 Oct 20:e022440. Epub 2021 Oct 20.

National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention Atlanta GA.

Background Disabilities have implications for health, well-being, and health care, yet limited information is available on the percentage of adults with congenital heart defects (CHD) living with disabilities. We evaluated the prevalence of disability and associated characteristics among the 2016-2019 CH STRONG (Congenital Heart Survey to Recognize Outcomes, Needs, and Well-Being) population-based sample of 19- to 38-year-olds with CHD from 3 US locations. Methods and Results Prevalence of disability types (hearing, vision, cognition, mobility, self-care, living independently) were compared with similarly aged adults from the general population as estimated by the American Community Survey and standardized to the CH STRONG eligible population to reduce nonresponse bias and confounding. Read More

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October 2021

Correlation and prediction of oxygen index from oxygen saturation index in neonates with acute respiratory failure.

Am J Perinatol 2021 Oct 19. Epub 2021 Oct 19.

Pediatrics, Prince of Songkla University, Hat Yai, Thailand.

Objective: To evaluate the correlation between the oxygen index (OI) and the oxygen saturation index (OSI, measured by pulse oximetry and noninvasively) in neonates with acute respiratory failure and to predict the OI from the OSI.

Study Design: A retrospective cohort study was conducted in neonates requiring invasive mechanical ventilation who had arterial blood gas between 2018 to 2019 at a neonatal intensive care unit. The correlation between OI and OSI was analyzed by using the Pearson correlation coefficient. Read More

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October 2021

Change in Out-of-Hospital 12-lead ECG Diagnostic Classification Following Resuscitation from Cardiac Arrest.

Resuscitation 2021 Oct 16. Epub 2021 Oct 16.

Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI; Division of EMS Medicine, Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI. Electronic address:

Introduction: We evaluated the incidence of change in serial 12-lead electrocardiogram (ECG) diagnostic classifications in patients resuscitated from out-of-hospital (OH) cardiac arrest (OHCA) comparing OH to emergency department (ED) ECGs.

Methods: This retrospective case series included: 1) adults (≥ 18 years old), 2) resuscitated OHCA, 3) ≥ 1 OH and 1 ED ECG/patient, and 4) emergency medical services (EMS) transport to the study hospital. OH and ED ECGs were classified as: 1) STEMI (ST-segment Elevation Myocardial Infarction), 2) ischemia, and 3) non-ischemic. Read More

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October 2021

Implication of rare genetic variants of NODAL and ACVR1B in Congenital Heart Disease patients from Indian Population.

Exp Cell Res 2021 Oct 16:112869. Epub 2021 Oct 16.

Cytogenetics Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India. Electronic address:

NODAL signaling plays an essential role in vertebrate embryonic patterning and heart development. Accumulating evidences suggest that genetic mutations in TGF-β/NODAL signaling pathway can cause congenital heart disease in humans. To investigate the implication of NODAL signaling in isolated cardiovascular malformation, we have screened 300 non-syndromic CHD cases and 200 controls for NODAL and ACVR1B by Sanger sequencing and identified two rare missense (c. Read More

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October 2021

Isolated Coronary Artery Aneurysm in a 12-Year-Old Boy With Marfan Syndrome.

Tex Heart Inst J 2021 Sep;48(4)

College of Medicine, University of Central Florida, Orlando, Florida.

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September 2021

Physiologic Lead Placement with Electroanatomic Mapping: A Case Series.

J Cardiovasc Electrophysiol 2021 Oct 19. Epub 2021 Oct 19.

Northwestern University, Department of Cardiology, Chicago, IL.

Introduction: His bundle pacing (HBP) and left bundle branch area pacing (LBBAP) have emerged as attractive alternatives to traditional biventricular pacing in order to achieve cardiac resynchronization therapy. Early reported results have been inconsistent, particularly amongst patients in whom initial placement with traditional approaches has been unsuccessful or those with complex anatomy or congenital abnormalities. In this report, we describe the use of three-dimensional electroanatomic mapping (EAM) in five selected cases. Read More

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October 2021

Longitudinal Trends in Body Mass Index for Adults with Congenital Heart Disease.

Pediatr Cardiol 2021 Oct 19. Epub 2021 Oct 19.

Department of Pediatrics, Division of Pediatric Cardiology, Children's Hospital of Michigan, Central Michigan University School of Medicine, 3901 Beaubien Boulevard, Detroit, MI, 48201, USA.

Obesity is a modifiable, independent risk factor for adverse long-term outcomes in children and adults. Our objective was to determine the prevalence of overweight and obese status in a cohort of adults with congenital heart disease (CHD) as well as to assess longitudinal trends over a 20-year period. The study group consisted of patients 18 years of age and older followed at our adult CHD clinic. Read More

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October 2021

[Use of extracorporeal circulation (ECLS/ECMO) for cardiac and circulatory failure : Short version of the S3 guideline].

Med Klin Intensivmed Notfmed 2021 Oct 19. Epub 2021 Oct 19.

Department of Pediatric Surgery, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Deutschland.

In Germany, a remarkable increase regarding the usage of extracorporeal membrane oxygenation (ECMO) and extracorporeal life support (ECLS) systems has been observed in recent years with approximately 3000 ECLS/ECMO implantations annually since 2015. Despite the widespread use of ECLS/ECMO, evidence-based recommendations or guidelines are still lacking regarding indications, contraindications, limitations and management of ECMO/ECLS patients. Therefore in 2015, the German Society of Thoracic and Cardiovascular Surgery (GSTCVS) registered the multidisciplinary S3 guideline "Use of extracorporeal circulation (ECLS/ECMO) for cardiac and circulatory failure" to develop evidence-based recommendations for ECMO/ECLS systems according to the requirements of the Association of the Scientific Medical Societies in Germany (AWMF). Read More

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October 2021

[Use of extracorporeal circulation (ECLS/ECMO) for cardiac and circulatory failure : Short version of the S3 guideline].

Anaesthesist 2021 Oct 19. Epub 2021 Oct 19.

Department of Pediatric Surgery, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Deutschland.

In Germany, a remarkable increase regarding the usage of extracorporeal membrane oxygenation (ECMO) and extracorporeal life support (ECLS) systems has been observed in recent years with approximately 3000 ECLS/ECMO implantations annually since 2015. Despite the widespread use of ECLS/ECMO, evidence-based recommendations or guidelines are still lacking regarding indications, contraindications, limitations and management of ECMO/ECLS patients. Therefore in 2015, the German Society of Thoracic and Cardiovascular Surgery (GSTCVS) registered the multidisciplinary S3 guideline "Use of extracorporeal circulation (ECLS/ECMO) for cardiac and circulatory failure" to develop evidence-based recommendations for ECMO/ECLS systems according to the requirements of the Association of the Scientific Medical Societies in Germany (AWMF). Read More

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October 2021

In the Beginning… The Early Boston Years with Aldo Castañeda.

World J Pediatr Congenit Heart Surg 2021 Oct 19:21501351211051664. Epub 2021 Oct 19.

Hopital de la Timone Enfants, Bd J Moulin Thoracic and CV Surgery, France.

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October 2021