8,941 results match your criteria congenital diaphragmatic


The Outcome of Operated Neonates with an Isolated Congenital Diaphragmatic Hernia in a Limited Resource Scenario: A Critical Analysis.

J Indian Assoc Pediatr Surg 2021 Jan-Feb;26(1):32-37. Epub 2021 Jan 11.

Department of Paediatric Surgery, SAT Hospital, Government Medical College, Thiruvananthapuram, Kerala, India.

Introduction: Congenital diaphragmatic hernia (CDH) is one of the most common neonatal emergencies, and the ideal current therapy requires high standards of neonatal care and advanced facilities. However, majority of neonates born with CDH are treated in public sector hospitals, with limitations in resources and workforce.

Objectives: The aim of the study was to review and analyze the outcome of operated neonates with isolated CDH in a public sector hospital and medical college where a standard protocol of management was followed, considering the need for optimization of therapy in view of the resource constraints. Read More

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January 2021

Top 100 Most Influential Manuscripts in Congenital Abdominal Pediatric Surgery: A Bibliometric Analysis.

J Indian Assoc Pediatr Surg 2021 Jan-Feb;26(1):6-10. Epub 2021 Jan 11.

Department of Cardiothoracic Surgery, University Hospitals, Coventry and Warwickshire, Coventry, UK.

Bibliometric analysis identifies the most influential manuscripts that shape our understanding of various congenital gastrointestinal pathologies. This study sets out to analyse the 100 most cited manuscripts on congenital gastrointestinal surgery. The Thomson Reuters Web of Science database was searched for all manuscripts relevant to paediatric congenital gastrointestinal surgery. Read More

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January 2021

Influence of Gestational Age and Mode of Delivery on Neonatal Outcomes in Prenatally Diagnosed Isolated Congenital Diaphragmatic Hernia.

Fetal Diagn Ther 2021 May 5:1-9. Epub 2021 May 5.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Aim: The optimal gestational age (GA) at delivery and mode of delivery (MoD) for pregnancies with fetal congenital diaphragmatic hernia (CDH) is undetermined. The impact of early term (37-38 weeks 6 days) versus full term (39-40 weeks 6 days) and MoD on immediate neonatal outcomes in prenatally diagnosed isolated CDH cases was evaluated.

Material And Methods: A retrospective chart review of pregnancies evaluated and delivered with the prenatal diagnosis of CDH between July 1, 2008, and December 31, 2018. Read More

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Open abdomen in the management of complicated diaphragmatic hernia: a case report.

Acta Biomed 2021 Apr 30;92(S1). Epub 2021 Apr 30.

Emergency Surgery Unit, Parma University Hospital.

Diaphragmatic hernia (DH) can be congenital or acquired. DH is a potentially life-threatening condition and the management in emergency setting remain unclear. Nonspecific symptoms can delay the diagnosis. Read More

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The Effect of an Interval Training on Skill Retention of High-Complex Low-Volume Minimal Invasive Pediatric Surgery Skills: A Pilot Study.

J Laparoendosc Adv Surg Tech A 2021 Apr 30. Epub 2021 Apr 30.

Department of Pediatric Surgery, Radboud University Medical Center, Amalia Children's Hospital, Nijmegen, The Netherlands.

Current training programs for complex pediatric minimal invasive surgery (MIS) are usually bulk training, consisting of 1- or 2-day courses. The aim of this study was to examine the effects of bulk training versus interval training on the preservation of high-complex, low-volume MIS skills. Medical students, without prior surgical experience, were randomly assigned to either a bulk or interval training program for complex MIS (congenital diaphragmatic hernia [CDH] and esophageal atresia [EA] repair). Read More

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Outcomes of home mechanical ventilation with tracheostomy after congenital heart surgery.

Cardiol Young 2021 May 4:1-5. Epub 2021 May 4.

Department of Cardiovascular Surgery, Acıbadem Mehmet Ali Aydınlar University, School of Medicine, Istanbul, Turkey.

Objective: After congenital heart surgery, some patients may need long-term mechanical ventilation because of chronic respiratory failure. In this study, we analysed outcomes of the patients who need tracheostomy and home mechanical ventilation.

Methods: Amongst 1343 patients who underwent congenital heart surgery between January, 2014 and June, 2018, 45 needed tracheostomy and HMV. Read More

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Diaphragmatic eventration as a first sign of Scimitar syndrome.

Cardiol Young 2021 May 4:1-3. Epub 2021 May 4.

Neonatology Department, Hospital Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal.

Diaphragmatic eventration is an anomaly of the diaphragm. In Scimitar syndrome, a curved-shaped anomalous pulmonary venous drainage is seen. Association between these conditions is rare. Read More

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Case Report: Late-Presenting Congenital Diaphragmatic Hernia With Tension Gastrothorax.

Front Pediatr 2021 14;9:618596. Epub 2021 Apr 14.

Train and Help Babies Organization, Dallas, TX, United States.

A congenital diaphragmatic hernia (CDH) occurs when the abdominal contents protrude into the thoracic cavity through an opening in the diaphragm. The main pathology lies in the maldevelopment or defective fusion of the pleuroperitoneal membranes. Delayed diagnosis in later childhood as in the index case reported here can lead to life-threatening complications such as tension gastrothorax and gastric volvulus. Read More

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Pediatric living-donor lobar lung transplantation in postpneumonectomy-like anatomy caused by pulmonary hypoplasia with congenital diaphragmatic hernia.

Am J Transplant 2021 May 2. Epub 2021 May 2.

Department of Thoracic Surgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

When performing living-donor lobar lung transplantation on small children of height 100 cm or under, accommodation of an oversized adult lobar graft is problematic, sometimes necessitating single lobar transplantation in combination with contralateral pneumonectomy. We here report a unique case of living-donor lobar lung transplantation in a 9-year-old boy with congenital pulmonary hypoplasia. Although he was 104 cm tall, and the available adult lower lobe graft appeared to be oversized, his right lung was hypoplastic, resulting in his mediastinum being shifted to the right and thus already showing "postpneumonectomy-like" anatomy. Read More

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ISOLATED CONGENITAL DIAPHRAGM HERNIA ASSOCIATED WITH HOMOZYGOUS SLIT3 GENE VARIANT IN DIZYGOUS TWINS.

Eur J Med Genet 2021 Apr 29:104215. Epub 2021 Apr 29.

, Eskişehir Osmangazi University Faculty of Medicine, Deparment of Neonatology, Eskişehir/Turkey.

Congenital diaphragmatic hernia (CDH) is a serious life-threatening birth defect characterized by abnormal development in the muscular or tendinous portion of the diaphragm during embryogenesis. Despite its high incidence, the etiology of CDH hasn't been fully understood. Genetic factors are important in pathogenesis; however, few single genes have been definitively implicated in human CDH. Read More

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Efficacy of Intact Cord Resuscitation Compared to Immediate Cord Clamping on Cardiorespiratory Adaptation at Birth in Infants with Isolated Congenital Diaphragmatic Hernia (CHIC).

Children (Basel) 2021 Apr 26;8(5). Epub 2021 Apr 26.

ULR2694 Metrics‑Perinatal Environment and Health, University of Lille, 59000 Lille, France.

Resuscitation at birth of infants with Congenital Diaphragmatic Hernia (CDH) remains highly challenging because of severe failure of cardiorespiratory adaptation at birth. Usually, the umbilical cord is clamped immediately after birth. Delaying cord clamping while the resuscitation maneuvers are started may: (1) facilitate blood transfer from placenta to baby to augment circulatory blood volume; (2) avoid loss of venous return and decrease in left ventricle filling caused by immediate cord clamping; (3) prevent initial hypoxemia because of sustained uteroplacental gas exchange after birth when the cord is intact. Read More

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Erratum: Romero-Lopez et al. Lung Metabolomics Profiling of Congenital Diaphragmatic Hernia in Fetal Rats. 2021, , 177.

Metabolites 2021 Apr 9;11(4). Epub 2021 Apr 9.

Center for Fetal and Placental Research, Division of Pediatric General and Thoracic Surgery, Cincinnati Chidren's Hospital Medical Center (CCHMC), Cincinnati, OH 45229, USA.

The authors wish to make the following corrections to this paper [... Read More

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Morphometric Analysis of Brain in Newborn with Congenital Diaphragmatic Hernia.

Brain Sci 2021 Apr 2;11(4). Epub 2021 Apr 2.

Medical Physics Department, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.

Congenital diaphragmatic hernia (CDH) is a severe pediatric disorder with herniation of abdominal viscera into the thoracic cavity. Since neurodevelopmental impairment constitutes a common outcome, we performed morphometric magnetic resonance imaging (MRI) analysis on CDH infants to investigate cortical parameters such as cortical thickness (CT) and local gyrification index (LGI). By assessing CT and LGI distributions and their correlations with variables which might have an impact on oxygen delivery (total lung volume, TLV), we aimed to detect how altered perfusion affects cortical development in CDH. Read More

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Stereological Lung Parameters After Fetoscopic Abdominal Decompression of Congenital Diaphragmatic Hernia in an Ovine Model: A Pilot Study.

J Laparoendosc Adv Surg Tech A 2021 Apr 28. Epub 2021 Apr 28.

Department of Pediatric Surgery, Ostschweizer Children's Hospital, St.Gallen, Switzerland.

Fetoscopic endoluminal tracheal occlusion (FETO) improves lung maturation in severe cases of congenital diaphragmatic hernia (CDH) but it does not ameliorate lung compression by herniated abdominal organs. Surgically opening the fetal abdomen (abdominal decompression [AD]) reduces the intrathoracic pressure by diverting the abdominal organs into the amniotic cavity-a probable causal therapy for lung hypoplasia and pulmonary hypertension in CDH. Open surgical abdominal decompression has been reported: we describe a minimally invasive approach in an ovine model of CDH as a probable fetoscopic intervention. Read More

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Right sided Bochdalek diaphragmatic hernia appeared as a life-threatening event in an infant: a case report.

Pan Afr Med J 2021 10;38:150. Epub 2021 Feb 10.

Department of Paediatric Surgery, Medical School, Aristotle University of Thessaloniki, General Hospital of "Papageorgiou", Thessaloniki, Greece.

We report a case of a 5-month-old female infant who presented with a cardiorespiratory distress and shock. After thoracic computed tomography (CT) scan, a right sided Bochdalek hernia was diagnosed with massive herniation of the abdominal viscera causing mediastinal shift. The girl underwent emergency laparotomy, which confirmed the right sided diaphragmatic hernia with herniation of small bowel and colon. Read More

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Transpleural systemic artery-pulmonary artery communications in the absence of chronic inflammatory lung disease. A case series and review of the literature.

Clin Radiol 2021 Apr 23. Epub 2021 Apr 23.

Imaging Department, Hammersmith Hospital, Imperial College Healthcare NHS Trust, Du Cane Road, London, W12 0HS, UK.

Aim: To describe the causes and computed tomography (CT) and angiographic appearances of transpleural systemic artery-pulmonary artery shunts in patients without chronic inflammatory lung disease and determine their best management.

Materials And Methods: All patients referred to a tertiary referral unit between January 2013 and January 2020 in whom a diagnosis of a systemic-pulmonary artery communication without underlying chronic inflammatory lung disease was subsequently made have been included in this report. Medical records and imaging findings were reviewed retrospectively. Read More

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Late Complication of Congenital Diaphragmatic Hernia Repair: Recurrent Small Bowel Obstruction.

Pediatr Emerg Care 2021 Jan 15. Epub 2021 Jan 15.

From the *Faculty of Medicine, University of Toronto, Toronto †Faculty of Health Sciences, McMaster University, Hamilton ‡Department of Pediatrics, Faculty of Medicine, Hospital for Sick Children, University of Toronto, Toronto, Canada §Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.

Congenital diaphragmatic hernia (CDH) is associated with high early mortality. However, advances in newborn care have led to improved survival into adolescence and early adulthood. We report a 17-year-old adolescent boy with recurrent small bowel obstruction after CDH repair at 2 days of age. Read More

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January 2021

Achieving adequate growth in infants with congenital diaphragmatic hernia prior to discharge.

J Pediatr Surg 2021 Mar 26. Epub 2021 Mar 26.

Division of Neonatology, The Children's Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, 3401 Civic Center Boulevard, Philadelphia, PA 19104, United States.

Background/purpose: To evaluate the enteral feeding requirements, including caloric provisions, of infants with CDH in relation to growth patterns.

Methods: A retrospective observational study was conducted on infants with CDH between August 2012 and March 2017. Electronic medical records were reviewed to extract detailed infant feeding data and anthropometric measurements at monthly intervals until discharge. Read More

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Extracardiac Complications in Intensive Care Units after Surgical Repair for Congenital Heart Disease: Imaging Review with a Focus on Ultrasound and Radiography.

J Pediatr Intensive Care 2021 Jun 9;10(2):85-105. Epub 2020 Sep 9.

Department of Radiology, Saitama Children's Medical Center, Saitama, Japan.

Pediatric patients show various extracardiac complications after cardiovascular surgery, and radiography and ultrasound are routinely performed in the intensive care unit to detect and evaluate these complications. This review presents images of these complications, sonographic approach, and timing of occurrence that are categorized based on their extracardiac locations and include complications pertaining to the central nervous system, mediastinum, thorax and lung parenchyma, diaphragm, liver and biliary system, and kidney along with pleural effusion and iatrogenic complications. This pictorial review will make it easier for medical doctors in intensive care units to identify and manage various extracardiac complications in pediatric patients after cardiovascular surgery. Read More

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Fetal lung underdevelopment is rescued by administration of amniotic fluid stem cell extracellular vesicles in rodents.

Sci Transl Med 2021 Apr;13(590)

Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, M5G 0A4, Canada.

Fetal lung underdevelopment, also known as pulmonary hypoplasia, is characterized by decreased lung growth and maturation. The most common birth defect found in babies with pulmonary hypoplasia is congenital diaphragmatic hernia (CDH). Despite research and clinical advances, babies with CDH still have high morbidity and mortality rates, which are directly related to the severity of lung underdevelopment. Read More

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Treatment for congenital diaphragmatic hernia: clinical guidelines.

Authors:
Etsuji Ukiyama

Pediatr Int 2021 Apr;63(4):369-370

Department of Pediatric Surgery, Faculty of Medicine, Kyorin University, Tokyo, Japan.

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Caecal volvulus associated with complex small bowel malrotation and congenital bands: A case report and literature review.

J Surg Case Rep 2021 Apr 13;2021(4):rjab040. Epub 2021 Apr 13.

Department of General Surgery, Worthing Hospital, Worthing, UK.

Caecal volvulus is an uncommon condition and represents only 10% of all colonic volvulus. The mechanism is due to hypermobile cecum twisting around it is own mesentery. A 40-year-old female who was previously fit and well-attended hospital with 2 days history of intermittent abdominal pain, mild distention and constipation. Read More

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Cardiac energy metabolism may play a fundamental role in congenital diaphragmatic hernia-associated ventricular dysfunction.

J Mol Cell Cardiol 2021 Apr 18;157:14-16. Epub 2021 Apr 18.

Department of Pediatric Surgery, McGovern Medical School at the University of Texas Health Science Center and Children's Memorial Hermann Hospital, Houston, TX, United States of America. Electronic address:

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Thoracoscopic repair of congenital diaphragmatic hernia in neonates: findings of a multicenter study in Japan.

Surg Today 2021 Apr 20. Epub 2021 Apr 20.

Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

Purpose: We compared the efficacy of thoracoscopic repair (TR) with that of open repair (OR) for neonatal congenital diaphragmatic hernia (CDH).

Methods: The subjects of this multicenter retrospective cohort study were 524 infants with left-sided isolated CDH, diagnosed prenatally, and treated at one of 15 participating hospitals in Japan between 2006 and 2018. The outcomes of infants who underwent TR and those who underwent OR were compared, applying propensity score matching. Read More

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First Trimester Cystic Hygroma: Herald to Early Diagnosis of Congenital Diaphragmatic Hernia.

P R Health Sci J 2021 Mar;40(1):53-55

Maternal- Fetal Medicine Specialists of South Florida, LLC; Herbert Wertheim College of Medicine, Florida International University. Miami, Florida.

The early diagnosis of in utero congenital diaphragmatic hernia (CDH) allows a thorough evaluation for other morbidities that may be associated with CDH. Our patient was referred to us with a fetus at 13 weeks gestational age with a thick nuchal translucency. Our team performed a transvaginal ultrasound that revealed a large ystic hygroma, a heart displaced to the right, and a heterogeneous mass with peristalsis in the left chest. Read More

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Respiratory muscle function in the newborn: a narrative review.

Pediatr Res 2021 Apr 19. Epub 2021 Apr 19.

Department of Paediatrics, University of Patras, Patras, Greece.

Our aim was to summarise the current evidence and methods used to assess respiratory muscle function in the newborn, focusing on current and future potential clinical applications. The respiratory muscles undertake the work of breathing and consist mainly of the diaphragm, which in the newborn is prone to dysfunction due to lower muscle mass, flattened shape and decreased content of fatigue-resistant muscle fibres. Premature infants are prone to diaphragmatic dysfunction due to limited reserves and limited capacity to generate force and avoid fatigue. Read More

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ATS Core Curriculum 2020. Pediatric Pulmonary Medicine.

ATS Sch 2020 Dec 30;1(4):456-475. Epub 2020 Dec 30.

Beth Israel Deaconess Medical Center, Boston, Massachusetts.

The American Thoracic Society Core Curriculum updates clinicians annually in adult and pediatric pulmonary disease, medical critical care, and sleep medicine, in a 3- to 4-year recurring cycle of topics. These topics will be presented at the 2020 International Conference. Below is the pediatric pulmonary medicine core, including pediatric hypoxemic respiratory failure; modalities in noninvasive management of chronic respiratory failure in childhood; surgical and nonsurgical management of congenital lung malformations; an update on smoke inhalation lung injury; an update on vaporizers, e-cigarettes, and other electronic delivery systems; pulmonary complications of sarcoidosis; pulmonary complications of congenital heart disease; and updates on the management of congenital diaphragmatic hernia. Read More

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December 2020

Spectral Doppler, tissue Doppler, and speckle-tracking echocardiography for the evaluation of fetal cardiac function: an update.

Radiol Bras 2021 Mar-Apr;54(2):99-106

Department of Obstetrics, Escola Paulista de Medicina da Universidade Federal de São Paulo (EPM-Unifesp), São Paulo, SP, Brazil.

The functional assessment of the fetal heart has been incorporated into cardiac ultrasound screening as a routine procedure, encompassing fetuses with and without structural heart diseases. It has long been known that various cardiac and extracardiac conditions, such as fetal growth restriction, fetal tumors, twin-to-twin transfusion syndrome, fetal anemia, diaphragmatic hernia, arteriovenous fistula with high cardiac output, and congenital heart diseases (valvular regurgitation and primary myocardial disease), can alter hemodynamic status and fetal cardiac function. Several ultrasound and Doppler echocardiographic parameters of fetal cardiovascular disease have been shown to correlate with perinatal mortality. Read More

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Transamniotic Stem Cell Therapy for Experimental Congenital Diaphragmatic Hernia: Structural, Transcriptional, and Cell Kinetics Analyses in the Nitrofen Model.

Fetal Diagn Ther 2021 Apr 14:1-11. Epub 2021 Apr 14.

Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Purpose: We examined select pulmonary effects and donor cell kinetics after transamniotic stem cell therapy (TRASCET) in a model of congenital diaphragmatic hernia (CDH).

Methods: Pregnant dams (n = 58) received nitrofen on gestational day 9.5 (E9) to induce fetal CDH. Read More

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Early, Postnatal Pulmonary Hypertension Severity Predicts Inpatient Outcomes in Congenital Diaphragmatic Hernia.

Neonatology 2021 Apr 13:1-8. Epub 2021 Apr 13.

John P. and Katherine G. McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, Texas, USA.

Introduction: Pulmonary hypertension (PH) is the major pathophysiologic consequence of congenital diaphragmatic hernia (CDH). We aimed to evaluate the association between early CDH-associated PH (CDH-PH) and inpatient outcomes.

Methods: The CDH Study Group registry was queried for infants born 2015-2019 with echocardiograms before 48h of life. Read More

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