105,024 results match your criteria congenital cardiac


Transcatheter aortic valve replacement in bicuspid valves: The synergistic effects of eccentric and incomplete stent deployment.

J Mech Behav Biomed Mater 2021 Jun 7;121:104621. Epub 2021 Jun 7.

Department of Mechanical and Materials Engineering, University of Denver, Denver, CO, USA. Electronic address:

Bicuspid aortic valve is a congenital cardiac anomaly and common etiology of aortic stenosis. Given the positive outcomes of transcatheter aortic valve replacement (TAVR) in low-risk patients, TAVR will become more prevalent in the future in the treatment of severe bicuspid valve stenosis. However, asymmetrical bicuspid valve anatomy and calcification can prevent the circular and complete expansion of transcatheter aortic valves (TAVs). Read More

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Feasibility and accuracy of printed models of complex cardiac defects in small infants from cardiac computed tomography.

Pediatr Radiol 2021 Jun 15. Epub 2021 Jun 15.

Pediatric and Congenital Cardiology, Children's Hospital, CHU Toulouse, 330 avenue de Grande Bretagne, TSA 70034, 31059, Toulouse Cedex 9, France.

Background: Three-dimensional (3-D) printed models are increasingly used to enhance understanding of complex anatomy in congenital heart disease.

Objective: To assess feasibility and accuracy of 3-D printed models obtained from cardiac CT scans in young children with complex congenital heart diseases.

Materials And Methods: We included children with conotruncal heart anomalies who were younger than 2 years and had a cardiac CT scan in the course of their follow-up. Read More

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Current opinion on the pharmacogenomics of paclitaxel-induced toxicity.

Expert Opin Drug Metab Toxicol 2021 Jun 15. Epub 2021 Jun 15.

Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates.

: Paclitaxel is a microtubule stabilizer that is currently one of the most utilized chemotherapeutic agents. Its efficacy in breast, uterine, lung and other neoplasms made its safety profile enhancement a subject of great interest. Neurotoxicity is the most common paclitaxel-associated toxicities. Read More

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Aortic Root Dilation in Patients with 22q11.2 Deletion Syndrome Without Intracardiac Anomalies.

Pediatr Cardiol 2021 Jun 14. Epub 2021 Jun 14.

Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Aortic root dilation (ARD) has been reported in patients with 22q11.2 deletion syndrome (22q11.2DS) with and without congenital heart defects (CHDs). Read More

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Long-term outcomes after the paediatric Ross and Ross-Konno procedures.

Interact Cardiovasc Thorac Surg 2021 Jun 13. Epub 2021 Jun 13.

Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.

Objectives: The Ross procedure is an attractive option for the management of aortic valve disease in paediatric patients. We reviewed our experience with the paediatric Ross procedure to determine survival and freedom from reoperation in the third decade after surgery.

Methods: We reviewed the data of 124 paediatric patients [71% male, median age at time of surgery 11. Read More

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Procalcitonin and Early Postoperative Infection After Pediatric Cardiopulmonary Bypass Surgery.

J Cardiothorac Vasc Anesth 2021 May 14. Epub 2021 May 14.

Neonatal and Pediatric Intensive Care Unit, Department of Surgery and Critical Care, IRCCS Istituto Giannina Gaslini, Genova, Italy.

Objectives: Systemic inflammation and bacterial infections are critical occurrences after pediatric cardiac surgery. Elevated white blood cell count and C-reactive protein cannot discriminate between these two conditions in the early postoperative period. The aim of this study was to understand whether procalcitonin (PCT) values within 48 hours of surgery could be a useful marker of postoperative infection. Read More

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Risk factors for death or mechanical ventilation time after bidirectional cavopulmonary anastomosis in a developing country.

Cardiol Young 2021 Jun 15:1-5. Epub 2021 Jun 15.

Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Background: Glenn procedure is performed for patients with cyanotic CHD and univentricular physiology and has a survival rate above 90%.

Aim: To evaluate the risk factors associated with a poor outcome after Glenn procedure.

Methods: The data for this retrospective analysis were collected from a regional Brazilian registry of congenital heart surgeries (ASSIST initiative) from 2014 to 2019. Read More

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Association analysis of maternal MTHFR gene polymorphisms and the occurrence of congenital heart disease in offspring.

BMC Cardiovasc Disord 2021 Jun 14;21(1):298. Epub 2021 Jun 14.

Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Changsha, 410078, Hunan, China.

Background: Although many studies showed that the risk of congenital heart disease (CHD) was closely related to genetic factors, the exact pathogenesis is still unknown. Our study aimed to comprehensively assess the association of single nucleotide polymorphisms (SNPs) of maternal MTHFR gene with risk of CHD and its three subtypes in offspring.

Methods: A case-control study involving 569 mothers of CHD cases and 652 health controls was conducted. Read More

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Gender Disparities in Concerns of Cancer Research Participation During COVID-19 Climate.

Cancer Control 2021 Jan-Dec;28:10732748211024214

Department of Cardiothoracic Surgery, Liverpool Heart and Chest Hospital, Liverpool, United Kingdom.

The unprecedented threat of COVID-19 has taken its toll on the field of cancer research, with trial accrual rates seeing a sharp decline since the beginning of the pandemic. Recent evidence has suggested that decreased participation appears to be more pronounced in women than men, which raises concerns about an exacerbation of gender bias in research. The following manuscript is a commentary article to the recent study by Fox et al, who aimed at investigating the concerns of patients with regard to participating to cancer research, as well as examining potential gender disparities within their sample population. Read More

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[Efficacy of emergent systemic-pulmonary arterial anastomosis (Potts shunt) in a child with severe idiopathic pulmonary hypertension].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Jun;49(6):621-623

Department of Anesthesiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, National Children's Medical Center, Shanghai 200127, China.

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Effects of bisphenol A exposure during cardiac cell differentiation.

Environ Pollut 2021 Jun 9;286:117567. Epub 2021 Jun 9.

Department of Animal Reproduction, INIA, Av. Puerta de Hierro, 18, Madrid, Spain. Electronic address:

Heart development requires a precise temporal regulation of gene expression in cardiomyoblasts. Therefore, the transcriptional changes in differentiating cells can lead to congenital heart diseases. Although the genetic mutations underlie most of these alterations, exposure to environmental contaminants, such as bisphenol A (BPA), has been recently considered as a risk factor as well. Read More

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Redefining Palliative Surgery: the Congenital Cardiac Surgery Experience.

Ann Thorac Surg 2021 Jun 11. Epub 2021 Jun 11.

Department of Cardiovascular Surgery, Boston Children's Hospital, MA.

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Echocardiography during the coronavirus disease 2019 pandemic - the impact of the vaccination program. A 2021 update of the expert opinion of the Working Group on Echocardiography of the Polish Cardiac Society.

Kardiol Pol 2021 ;79(5):595-603

Department of Congenital Heart Disease, National Institute of Cardiology, Warszawa, Poland.

The coronavirus disease 2019 (COVID-19) pandemic resulted in an urgent need to reorganize the work of echocardiography laboratories in order to ensure the safety of patients and the protection of physicians, technicians, and other staff members. In the previous Expert Opinion of the Working Group on Echocardiography of Polish Cardiac Society we provided recommendations for the echocardiographic services, in order to ensure maximum possible safety and efficiency of imagers facing epidemic threat. Now, with much better knowledge and larger experience in treating COVID-19 patients and with introduction of vaccination programs, we present updated recommendations for performing transthoracic and transesophageal examinations, including information on the potential impact of personnel and the patient vaccination program, and growing numbers of convalescents on performance of echocardiographic laboratories, with the goal of their ultimate reopening. Read More

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Polish Multicenter Registry (Pol-LAS-SE registry). Stress echocardiography in low-gradient aortic stenosis in Poland: numbers, settings, results, complications and clinical practice.

Kardiol Pol 2021 ;79(5):517-524

Department of Cardiology, Wroclaw Medical University, Wrocław, Poland.

Background: The diagnostic workup of low-gradient aortic stenosis (LG AS) is a challenge in clinical practice.

Aims: Our goal was to assess the diagnostic value of stress echocardiography (SE) performed in patients with undefined LG AS with low and preserved ejection fraction (EF) and the impact of its result on therapeutic decisions in Polish third level of reference.

Methods: All the patients with LG AS and with SE performed were recruited in 16 Polish cardiology departments between 2016 and 2019. Read More

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Cardiac Biomarkers in Pediatrics: An Undervalued Resource.

Clin Chem 2021 Jun 14. Epub 2021 Jun 14.

CALIPER Program, Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.

Background: The clinical use of common cardiac biomarkers, such as brain natriuretic peptides and troponins, has traditionally been limited to adult populations in the assessment of heart failure and acute coronary syndrome, respectively. While many have discounted the value of these markers in pediatric populations, emerging evidence suggests they may be useful in the diagnosis and prognostication of many cardiac and noncardiac pathologies in neonates, children, and adolescents, and an increasing number of pediatric hospitals are routinely measuring cardiac markers in their clinical practice.

Content: This review summarizes and critically evaluates the current literature regarding the application of cardiac biomarkers for clinical decision-making in the pediatric population. Read More

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A simplified repair method for adult Ebstein's anomaly.

J Card Surg 2021 Jun 14. Epub 2021 Jun 14.

Department of Cardiovascular and Thoracic Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.

Ebstein's anomaly (EA) is a rare but difficult to manage congenital heart disease with a wide spectrum of clinical manifestations. We present a simplified repair method which combines the plication of the atrialized right ventricle, tricuspid leaflet repair and ring annuloplasty. This method is suitable for older adult EA patients with progressive right heart dysfunction symptoms. Read More

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Successful implantation of a leadless pacemaker in a patient with complete atrioventricular block and congenital absence of superior vena cava: a case report.

Eur Heart J Case Rep 2021 May 12;5(5):ytab167. Epub 2021 May 12.

Department Cardiovascular Medicine, Juntendo University Shizuoka Hospital, 1129 Nagaoka, Izunokuni-shi, Shizuoka-ken 410-2295, Japan.

Background: Congenital absence of superior vena cava (CASVC) is an extremely rare vascular anomaly often associated with conduction disturbances which makes implantation of a pacemaker difficult. We report a case of pacemaker implantation in a patient presenting with complete atrioventricular block (c-AVB) with bilateral absence of the SVC.

Case Summary: A 68-year-old man who had experienced dyspnoea on exertion by c-AVB was admitted to our hospital for treatment and management. Read More

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Successful coil embolization of a large right coronary artery-coronary sinus fistula causing a significant left-to-right shunt: a case report.

Eur Heart J Case Rep 2021 May 3;5(5):ytab121. Epub 2021 May 3.

DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, TX, USA.

Background: This case reviews a challenging but successful transcatheter coil embolization of a large congenital coronary artery fistula (CAF) causing a significant left-to-right shunt.

Case Summary: A 51-year-old female with no significant prior history presented with symptoms of dyspnoea and chest discomfort. Extensive evaluation revealed a large CAF between a tortuous right coronary artery (RCA) and the coronary sinus (CS) composed of three aneurysmal pseudochambers. Read More

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Neonatal arrhythmias in Turner syndrome: a case report and review of the literature.

Eur Heart J Case Rep 2021 Apr 30;5(4):ytab160. Epub 2021 Apr 30.

Boston University School of Medicine, 72 E Concord St, Boston, MA 02118, USA.

Background: While left-sided congenital heart defects have been well described in females with Turner syndrome (45, X), the literature is scarce regarding arrhythmias in this patient population.

Case Summary: A full-term neonate referred to cardiology was found to have a non-apex forming left ventricle and partial anomalous pulmonary venous return. During the echocardiogram, she developed atrial flutter, followed by orthodromic reentrant supraventricular tachycardia (SVT). Read More

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Surgical resection of a giant pericardial cyst: a case report.

Eur Heart J Case Rep 2021 Apr 12;5(4):ytab116. Epub 2021 Apr 12.

Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, 5-3-1 Chikami, Minami-ku, Kumamoto, Japan.

Background: Pericardial cysts are rare congenital mediastinal cysts. They are typically asymptomatic and are often discovered incidentally, although some patients may present with chest pain and dyspnoea. Asymptomatic patients are managed conservatively with multiple modalities, with surgical resection often recommended for symptomatic patients only. Read More

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Failing systemic right ventricle in a patient with dextrocardia and complex congenitally corrected transposition of the great arteries: a case report of successful transvenous cardiac resynchronization therapy.

Eur Heart J Case Rep 2021 Apr 12;5(4):ytab068. Epub 2021 Apr 12.

Department of Cardiology, Leiden Heart-Lung Center, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.

Background : Patients with congenitally corrected transposition of the great arteries (ccTGA) are prone to the development of advanced atrio-ventricular block requiring chronic ventricular pacing. The morphological right ventricle (RV) often develops systolic dysfunction as it is unable to withstand the chronic pressure overload it is exposed to when supporting the systemic circulation.

Case Summary : A 56-year-old woman with dextrocardia and complex ccTGA with a history of dual-chamber implantable cardioverter-defibrillator (DDD-ICD, high degree atrio-ventricular-block and syncopal ventricular tachycardia), presented with progressive heart failure and symptomatic atrial arrhythmias. Read More

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Left anterior descending/right coronary artery bifurcation angioplasty in a rare case of single coronary artery: a case report.

Eur Heart J Case Rep 2021 Apr 21;5(4):ytab047. Epub 2021 Apr 21.

Professor of Medicine & Interventional Cardiologist, Department of Cardiology, Military Hospital, Jaipur-302016, India.

Background: Single coronary artery (SCA) is a rare congenital coronary anomaly with incidence of 8-66 per 100 000 cases. Percutaneous coronary intervention (PCI) in patients with SCA is technically challenging. This is a case of bifurcation angioplasty involving left anterior descending/right coronary artery (LAD/RCA) in a patient with SCA and 1-year follow-up with computed tomography coronary angiography (CTCA). Read More

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Young athletes: Preventing sudden death by adopting a modern screening approach? A critical review and the opening of a debate.

Int J Cardiol Heart Vasc 2021 Jun 28;34:100790. Epub 2021 May 28.

Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA, USA.

Preventing sudden cardiac death (SCD) in athletes is a primary duty of sports cardiologists. Current recommendations for detecting high-risk cardiovascular conditions (hr-CVCs) are history and physical examination (H&P)-based. We discuss the effectiveness of H&P-based screening versus more-modern and accurate methods. Read More

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Molecular and Mechanical Mechanisms of Calcification Pathology Induced by Bicuspid Aortic Valve Abnormalities.

Front Cardiovasc Med 2021 26;8:677977. Epub 2021 May 26.

Section of Pediatric Cardiology, The Herma Heart Institute, Children's Wisconsin, Milwaukee, WI, United States.

Bicuspid aortic valve (BAV) is a congenital defect affecting 1-2% of the general population that is distinguished from the normal tricuspid aortic valve (TAV) by the existence of two, rather than three, functional leaflets (or cusps). BAV presents in different morphologic phenotypes based on the configuration of cusp fusion. The most common phenotypes are Type 1 (containing one raphe), where fusion between right coronary and left coronary cusps (BAV R/L) is the most common configuration followed by fusion between right coronary and non-coronary cusps (BAV R/NC). Read More

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Sexual Dimorphism of the Heart: Genetics, Epigenetics, and Development.

Front Cardiovasc Med 2021 26;8:668252. Epub 2021 May 26.

Lewis Katz School of Medicine, Fels Institute for Cancer Research, Temple University, Philadelphia, PA, United States.

The democratization of genomic technologies has revealed profound sex biases in expression patterns in every adult tissue, even in organs with no conspicuous differences, such as the heart. With the increasing awareness of the disparities in cardiac pathophysiology between males and females, there are exciting opportunities to explore how sex differences in the heart are established developmentally. Although sexual dimorphism is traditionally attributed to hormonal influence, expression and epigenetic sex biases observed in early cardiac development can only be accounted for by the difference in sex chromosome composition, i. Read More

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Prevalence of Growth Restriction at Birth for Newborns With Congenital Heart Defects: A Population-Based Prospective Cohort Study EPICARD.

Front Pediatr 2021 28;9:676994. Epub 2021 May 28.

Université de Paris, CRESS, INSERM, INRA, Paris, France.

Congenital heart defects (CHD) and growth restriction at birth are two major causes of childhood and adult morbidity and mortality. The aim of this study was to assess the overall risk of growth restriction at birth, as measured by its imperfect proxy small (< 10th percentile) for gestational age (SGA), for newborns with CHD. Using data from a population-based cohort of children born with CHD, we assessed the risk of growth restriction at birth using SGA and severe SGA (3rd percentile). Read More

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Technical Aspects: Coronary Artery Bypass Grafting in a Case of Dextrocardia With Situs Inversus.

Cureus 2021 May 10;13(5):e14932. Epub 2021 May 10.

Department of Cardiothoracic Surgery, Madras Medical Mission Hospital, Chennai, IND.

Dextrocardia with situs inversus is a rare congenital anomaly in which the heart and the abdominal organs orient themselves in a mirror-image reversal of the normal anatomy. Coronary artery disease incidence is similar to that of the normal population. Performing coronary artery bypass grafting in this subset of the population poses few difficulties. Read More

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Evaluation of cardiac function in children after percutaneous closure of atrial septal defect using speckle tracking echocardiography.

ARYA Atheroscler 2020 Nov;16(6):290-294

Assistant Professor, Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Atrial septal defect (ASD) is among the most common congenital anomalies that its neglect may cause severe right ventricular (RV)-associated cardiac dysfunction. Percutaneous closure of ASD is an efficient technique used commonly worldwide. Varieties of techniques have been used to assess postoperative changes of cardiac function. Read More

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November 2020

Case Report: Late Successful Thrombectomy for Ischemic Stroke in a 2-Year-Old Child.

Front Neurol 2021 28;12:670565. Epub 2021 May 28.

Department of Neuroradiology, Toulouse University Hospital, Université Toulouse III, Toulouse, France.

Despite extensive evidence of benefit of thrombectomy in adult ischemic stroke due to large-vessel occlusion in the 6-h window, its role remains uncertain in very young children. We describe hereafter the case of a 2-year-old female child who had a successful thrombectomy 9 h after stroke onset. The patient presented with right hemiplegia, central facial palsy, a normal level of consciousness, and speech difficulties. Read More

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