14,743 results match your criteria conflicting reports


RBL2 bi-allelic truncating variants cause severe motor and cognitive impairment without evidence for abnormalities in DNA methylation or telomeric function.

J Hum Genet 2021 May 13. Epub 2021 May 13.

The Genetics Institute, Rambam Health Care Campus, Haifa, Israel.

RBL2/p130, a member of the retinoblastoma family of proteins, is a key regulator of cell division and propagates irreversible senescence. RBL2/p130 is also involved in neuronal differentiation and survival, and eliminating Rbl2 in certain mouse strains leads to embryonic lethality accompanied by an abnormal central nervous system (CNS) phenotype. Conflicting reports exist regarding a role of RBL2/p130 in transcriptional regulation of DNA methyltransferases (DNMTs), as well as the control of telomere length. Read More

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Radiological changes in sagittal parameters after C1-C2 arthrodesis and their clinical correlation: Is there a difference between traumatic and non-traumatic causes?

Int J Neurosci 2021 May 12:1-10. Epub 2021 May 12.

Department of Spine Service, Indian Spinal Injuries Centre, Vasant Kunj, New Delhi, India.

: Compensatory changes in cervical sagittal alignment after C1-C2 arthrodesis have been reported in a few studies. No studies have explored the differences in these compensatory changes between traumatic and non-traumatic pathologies. Conflicting reports exist on the correlation between cervical sagittal parameters and neck pain or function. Read More

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Tri-tubular penile fracture: A case of complete rupture of urethra and bilateral corpus cavernosa.

IJU Case Rep 2021 May 19;4(3):143-145. Epub 2021 Feb 19.

Division of Surgical Specialties and Anaesthetics Lyell McEwin Hospital Elizabeth Vale South Australia Australia.

Introduction: Tri-tubular penile fracture is a very rare subset of penile fractures, typically due to high-energy trauma to the erect penis.

Case Presentation: A 26-year-old healthy man presents with a triad of audible crack, immediate detumescence, and hematoma formation, following blunt trauma sustained during vaginal sexual intercourse. A diagnosis of penile fracture is made, with intraoperative finding of a complete traumatic transection of the urethra with total bilateral corpus cavernosa disruption. Read More

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Wanted: A vocabulary for talking about involuntary behaviors associated with Lesch-Nyhan disease.

JIMD Rep 2021 May 23;59(1):26-31. Epub 2021 Mar 23.

Psychological Services Matheny Medical and Educational Center Peapack New Jersey USA.

Lesch-Nyhan disease (LND) is a rare genetic disorder with an unusual behavioral phenotype that includes severe and involuntary self-injury requiring the near constant use of protective devices and, for some individuals, dental extraction. Often, the person with LND also engages in emotional self-injury in the form of both self-sabotage and behaviors directed toward others that will have a negative social consequence. When these self-destructive behaviors present themselves, it is sometimes challenging for caregivers, professionals, or other observers to fully recognize their lack of volition. Read More

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Full-Thickness Macular Hole Progressing from Lamellar Macular Hole with Epiretinal Proliferation.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):134-141. Epub 2021 Apr 12.

Burjeel Speciality Hospital, Sharjah, United Arab Emirates.

Foveoschisis in association with contractile epiretinal membrane is frequently misdiagnosed as lamellar macular hole (LMH). The progression of true LMH with associated epiretinal proliferation to full-thickness macular hole (FTMH) is probably underestimated. We report a case of bilateral FTMH progressing from LMH with epiretinal proliferation. Read More

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Post-Surgery Subcutaneous Seeding of Laryngeal Squamous Cell Carcinoma: A Rare Case.

Case Rep Oncol 2021 Jan-Apr;14(1):568-572. Epub 2021 Mar 22.

Department of Otolaryngology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Laryngeal squamous cell carcinoma (LSCC) is the most common malignant head and neck cancer, with a 40% recurrence rate in the first 3 years after radical treatment. Recurrence of LSCC mostly comprises lymphogenous metastasis, hematogenic metastasis, and locoregional recurrence, while LSCC seeding is rarest: there are only 4 cases reported in PubMed, and none of them is one of subcutaneous seeding. We report a case with post-surgery subcutaneous seeding of LSCC. Read More

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The Environment, Leiomyomas, Latinas, and Adiposity Study (ELLAS): Rationale and Design.

Am J Obstet Gynecol 2021 May 8. Epub 2021 May 8.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan. Electronic address:

Background: Uterine leiomyomas, commonly known as fibroids, are benign tumors in postmenarchal females. By the age of 35, approximately 30% of females will have fibroids, and by age 50 the prevalence approaches 70% with some studies reporting >85% prevalence in African-American females. Prior studies evaluating the prevalence of fibroids have largely relied on self-reported fibroid diagnoses, which could have falsely underestimated prevalence because many females with fibroids are asymptomatic. Read More

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The diagnostic predictive value of neutrophil-to-lymphocyte ratio in thyroid cancer adjusted for tumor size.

PLoS One 2021 11;16(5):e0251446. Epub 2021 May 11.

Department of Otorhinolaryngology-Head & Neck Surgery, Inje University College of Medicine, Ilsan Paik Hospital, Goyang-Si, Korea.

The role of systemic inflammation has not been clearly defined in thyroid cancers. There have been conflicting reports on whether systemic inflammatory markers have predictive value for thyroid cancers. We aimed to evaluate the association between systemic inflammatory markers and clinicopathological factors in thyroid cancers and to assess their predictive value for thyroid cancers in detail. Read More

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Nurses' and Physicians' Distress, Burnout, and Coping Strategies During COVID-19: Stress and Impact on Perceived Performance and Intentions to Quit.

J Contin Educ Health Prof 2021 May 10. Epub 2021 May 10.

Dr. Lou: Postdoctoral Fellow, Research Institute of the McGill University Health Centre, Montreal, CA. Dr. Montreuil: Assistant professor, Department of Educational and Counselling Psychology, McGill University, Montreal, CA; Associate Member, Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, CA; and Associate Investigator, Research Institute of the McGill University Health Centre, Montreal, CA. Dr. Feldman: Professor and Chair, Department of Surgery, Faculty of Medicine and Health Sciences, and Chair, The Steinberg-Bernstein Centre for Minimally Invasive Surgery, McGill University, Montreal, CA. Dr. Fried: Professor, Department of Surgery, Faculty of Medicine and Health Sciences, Director, Steinberg Centre for Simulation and Interactive Learning, McGill University, Montreal, CA. Dr. Lavoie-Tremblay: Associate Professor, Ingram School of Nursing, McGill University, Montreal, CA. Dr. Bhanji: Director of Education, Steinberg Centre for Simulation and Interactive Learning, Professor, Department of Pediatrics, Faculty of Medicine and Health Sciences, and Associate member, Institute for Health Sciences Education, McGill University, Montreal, CA. Ms. Kaneva: Program coordinator, The Steinberg-Bernstein Centre for Minimally Invasive Surgery, McGill University, Montreal, CA. Ms. Kennedy: Doctoral student, Department of Educational and Counselling Psychology, Faculty of Education, McGill University, Montreal, CA. Dr. Harley: Assistant professor, Department of Surgery, Faculty of Medicine and Health Sciences, McGill University, Montreal, CA, Scientist, Research Institute of the McGill University Health Centre, Montreal, CA; Associate Member, Department of Educational and Counselling Psychology; Director of Research, Steinberg Centre for Simulation and Interactive Learning; and Associate Member, Institute for Health Sciences Education, McGill University, Montreal, CA.

Introduction: Health care providers (HCPs) have experienced more stress and burnout during COVID-19 than before. We compared sources and levels of stress, distress, and approaches to coping between nurses and physicians, and examined whether coping strategies helped mitigate the negative impact of stress and intentions to quit.

Methods: Using a cross-sectional study design, burnout was measured with the Maslach Burnout Inventory. Read More

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Associations of sleep apnoea with glaucoma and age-related macular degeneration: an analysis in the United Kingdom Biobank and the Canadian Longitudinal Study on Aging.

BMC Med 2021 May 11;19(1):104. Epub 2021 May 11.

Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Nedlands, Western Australia, Australia.

Background: Sleep apnoea, a common sleep-disordered breathing condition, is characterised by upper airway collapse during sleep resulting in transient hypoxia, hypoperfusion of the optic nerve, and spike in intracranial pressure. Previous studies have reported conflicting findings on the association of sleep apnoea with glaucoma, and there are limited reports on the link between sleep apnoea and age-related macular degeneration (AMD).

Methods: Middle-aged and older participants from the longitudinal United Kingdom (UK) Biobank (n = 502,505) and the Canadian Longitudinal Study on Aging (CLSA; n = 24,073) were included in this analysis. Read More

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Exploring the association of early life physical activity and risk of dementia: a systematic review.

Minerva Med 2021 May 10. Epub 2021 May 10.

NESMOS Department, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.

Introduction: Physical activity has been included in the list of twelve modifiable risk factors for dementia, despite conflicting results from observational and controlled studies. In particular it is not clear whether physical inactivity near the time of dementia diagnosis is a consequence or cause of dementia. We review all available studies reporting the possible association between having engaged in PA before 60 years of age and the risk of dementia. Read More

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What Psychological Factors Make Individuals Believe They Are Infected by Coronavirus 2019?

Front Psychol 2021 22;12:667722. Epub 2021 Apr 22.

Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway.

We previously showed, by means of an online-based survey, that the belief of being infected by coronavirus disease 2019 (COVID-19) acted as a nocebo and predicted higher perception of symptoms similar to COVID-19 symptoms. However, there is little known about the psychological mechanisms that give rise to beliefs such as certainty of being infected by COVID-19, and this was investigated in the present study. Using the same data from the previous online survey with the same research team, we further investigated whether certainty of being infected by COVID-19 is associated with age, sex, health anxiety, and/or personality traits. Read More

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Organizing Psycho-Oncological Care for Cancer Patients: The Patient's Perspective.

Front Psychol 2021 22;12:625117. Epub 2021 Apr 22.

Department of Clinical, Neuro and Developmental Psychology, Faculty of Behavioral and Movement Sciences, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

Background: Cancer patients often suffer from psychological distress during or after cancer treatment, but the use of psycho-oncological care among cancer patients is limited. One of the reasons might be that the way psycho-oncological care is organized, does not fit patients' preferences. This study aimed to obtain detailed insight into cancer patients' preferences regarding the organization of psycho-oncological care. Read More

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Telehealth and Research in Orthopedics: New Means of Care Invites New Barriers to Evidence.

HSS J 2021 Feb 21;17(1):115-118. Epub 2021 Feb 21.

Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY, USA.

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February 2021

The Virtual Shoulder Physical Exam.

HSS J 2021 Feb 21;17(1):59-64. Epub 2021 Feb 21.

Sports Medicine Institute, Hospital for Special Surgery, New York City, NY, USA.

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February 2021

An Overview of Telehealth in Total Joint Arthroplasty.

HSS J 2021 Feb 21;17(1):51-58. Epub 2021 Feb 21.

Adult Reconstruction and Joint Replacement Service, Hospital for Special Surgery, New York, NY, USA.

With the increase in technological advances over the years, telehealth services in orthopedic surgery have gained in popularity, yet adoption among surgeons has been slow. With the onset of the COVID-19 pandemic, however, orthopedic surgery practices nationwide have accelerated adaptation to telemedicine. Telehealth can be effectively applied to total joint arthroplasty, with the ability to perform preoperative consultations, postoperative follow-up, and telerehabilitation in a virtual, remote manner with similar outcomes to in-person visits. Read More

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February 2021

Telehealth Can Be Implemented Across a Musculoskeletal Service Line Without Compromising Patient Satisfaction.

HSS J 2021 Feb 21;17(1):36-45. Epub 2021 Feb 21.

Department of Orthopaedic Surgery, Emory University, Atlanta, GA, USA.

The COVID-19 pandemic has led to changes to in-office orthopedic care, with a rapid shift to telemedicine. Institutions' lack of established infrastructure for these types of visits has posed challenges requiring attention to confidentiality, safety, and patient satisfaction. : The aim of this study was to analyze the feasibility of telemedicine in orthopedics during the pandemic and its effect on efficiency and patient satisfaction. Read More

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February 2021

Perspective of Attending Physicians on the Use of Telemedicine in an Outpatient Arthroplasty Setting During the COVID-19 Pandemic.

HSS J 2021 Feb 21;17(1):31-35. Epub 2021 Feb 21.

Hospital for Special Surgery, New York, NY, USA.

: During the worldwide COVID-19 pandemic, physicians had to improvise and adapt new ways to provide care to patients. : The purpose of this study was to assess physicians' sentiments regarding telemedicine and its use in orthopedic practices. : We performed a cross-sectional study of attending orthopedic physicians, the majority of whom integrated telemedicine into their practices from March to October 2020. Read More

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February 2021

Telemedicine in an Outpatient Arthroplasty Setting During the COVID-19 Pandemic: Early Lessons from New York City.

HSS J 2021 Feb 21;17(1):25-30. Epub 2021 Feb 21.

Hospital for Special Surgery, New York, NY, USA.

The early months of the coronavirus disease 19 (COVID-19) pandemic in New York City led to a rapid transition of non-essential in-person health care, including outpatient arthroplasty visits, to a telemedicine context. Based on our initial experiences with telemedicine in an outpatient arthroplasty setting, we sought to determine early lessons learned that may be applicable to other providers adopting or expanding telemedicine services. A cross-sectional study was performed by surveying all patients undergoing telemedicine visits with 8 arthroplasty surgeons at 1 orthopedic specialty hospital in New York City from April 8 to May 19, 2020. Read More

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February 2021

Good Comes From Evil: COVID-19 and the Advent of Telemedicine in Orthopedics.

HSS J 2021 Feb 21;17(1):7-13. Epub 2021 Feb 21.

Sports Medicine Institute, Hospital for Special Surgery, New York, NY, USA.

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February 2021

A Novel Lid Hygiene Detergent Successfully Eliminated Demodex Mites, a Common PRefractory Obstructive Meibomian Gland Dysfunction.

J Oleo Sci 2021 May 7. Epub 2021 May 7.

Department of Ophthalmology, Keio University School of Medicine.

Introduction: Demodex mites are microscopic arthropods that have been shown to be responsible for chronic blepharitis. Although many reports have demonstrated positive effects of lid hygiene on demodicosis, some have produced conflicting results. We retrospectively evaluated the effect of lid margin cleansing with a novel lid hygiene detergent, Eye Shampoo, in patients with ocular demodicosis. Read More

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Enhanced targeted DNA methylation with dCas9-DNMT3A3L of the CMV and endogenous promoters entails distinct subsequent histone modification changes in CHO cells.

Metab Eng 2021 May 6. Epub 2021 May 6.

BOKU University of Natural Resources and Life Sciences, Vienna, Austria; Austrian Center for Industrial Biotechnology GmbH, Vienna, Austria. Electronic address:

With the emergence of new CRISPR/dCas9 tools that enable site specific modulation of DNA methylation and histone modifications, more detailed investigations of the contribution of epigenetic regulation to the precise phenotype of cells in culture, including recombinant production subclones, is now possible. These also allow a wide range of applications in metabolic engineering once the impact of such epigenetic modifications on the chromatin state is available. In this study, enhanced DNA methylation tools were targeted to a recombinant viral promoter (CMV), an endogenous promoter that is silenced in its native state in CHO cells, but had been reactivated previously (β-galactoside α-2,6-sialyltransferase 1) and an active endogenous promoter (α-1,6-fucosyltransferase), respectively. Read More

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Uncommon Pigmented Carcinoma In Situ: Case Report and Brief Review.

Clin Pathol 2021 Jan-Dec;14:2632010X211009819. Epub 2021 Apr 20.

Department of Pathology, School of Medicine, State University of Campinas (UNICAMP), Campinas, Brazil.

Pigmented lesions of the oral mucosa encompass several benign and malignant conditions that may be a matter of concern under both clinical and histopathological views. We reported a case of a 62-year-old woman, presenting with an asymptomatic, deeply pigmented lesion on the soft palate. On examination, it appeared asymmetrical, with irregular borders and an area of ulceration. Read More

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A case of spontaneous pneumomediastinum in a patient with severe SARS-CoV-2 and a review of the literature.

SAGE Open Med Case Rep 2021 21;9:2050313X211010021. Epub 2021 Apr 21.

Department of Internal Medicine, Harbor-University of California, Los Angeles (UCLA) Medical Center, Torrance, CA, USA.

Spontaneous pneumomediastinum is defined as having an etiology that is not related to surgery, trauma, or mechanical ventilation. Precipitating causes of spontaneous pneumomediastinum include coughing, exercise, vomiting, infection, underlying lung diseases such as asthma, and illicit drugs. Symptoms include chest pain, shortness of breath, and dysphagia. Read More

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Application of high-flow nasal oxygenation as a rescue therapy in difficult videolaryngoscopic intubation.

SAGE Open Med Case Rep 2021 20;9:2050313X211010015. Epub 2021 Apr 20.

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, South Korea.

In difficult airway situations, the next step of the airway management method is selected according to the prior presence of difficulties in mask ventilation and endotracheal intubation. It is important for the practitioner to be calm, quick in judgment, and take action in cases of difficult intubation. Recently, high-flow nasal oxygenation has been rapidly introduced into the anesthesiology field. Read More

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Supra-massive transfusion and interdisciplinary approach to cesarean hysterectomy due to complex placenta percreta: Case report.

SAGE Open Med Case Rep 2021 20;9:2050313X211010011. Epub 2021 Apr 20.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Medical College of Georgia at Augusta University, Augusta, GA, USA.

Placenta accreta spectrum encompasses a group of conditions of abnormal placental infiltration of the uterine wall and surrounding tissues. It is associated with significant blood loss, perioperative morbidity, and risk of death. A coordinated interdisciplinary approach to these complex cases and early resuscitation with blood products are critical factors in the successful management of patients affected by this disease. Read More

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