103,549 results match your criteria configuration g3-p[10]-i8-r3-c3-m3-a9-n3-t3-e3-h6

Paper-based mediatorless enzymatic microfluidic biofuel cells.

Biosens Bioelectron 2021 Jun 9;190:113391. Epub 2021 Jun 9.

Dept. of Mechanical Engineering, BK21 FOUR ERICA-ACE Center, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, South Korea. Electronic address:

In this study, eco-friendly and disposable paper-based membraneless microfluidic enzymatic fuel cells (EFCs) were developed without any mediators to reduce the toxicity and cost of EFCs. Glucose oxidase and laccase were immobilized on multi-walled carbon nanotube electrodes to catalyze the redox reaction of glucose and oxygen. Micromachining techniques well-suited for mass production were used to precisely fabricate micro-scale Y-shaped and cross-shaped EFCs. Read More

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Design, synthesis, and biological evaluation of novel sulindac derivatives as partial agonists of PPARγ with potential anti-diabetic efficacy.

Eur J Med Chem 2021 May 24;222:113542. Epub 2021 May 24.

School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian, 361102, China; High Throughput Drug Screening Platform, Xiamen University, Xiamen, Fujian, 361102, China. Electronic address:

Peroxisome proliferator-activated receptor gamma (PPARγ) is a valuable drug target for diabetic treatment and ligands of PPARγ have shown potent anti-diabetic efficacy. However, to overcome the severe side effects of current PPARγ-targeted drugs, novel PPARγ ligands need to be developed. Sulindac, an identified ligand of PPARγ, is widely used in clinic as a non-steroidal anti-inflammatory drug. Read More

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Investigating the potential of Sentinel-2 configuration to predict the quality of Mediterranean permanent grasslands in open woodlands.

Sci Total Environ 2021 May 29;791:148101. Epub 2021 May 29.

Department of Forest Engineering, ETSIAM, University of Cordoba, Ctra. Madrid, Km 396, 14071 Córdoba, Spain. Electronic address:

The assessment of pasture quality in permanent grasslands is essential for their conservation and management, as it can contribute to making real-time decisions for livestock management. In this study, we assessed the potential of Sentinel-2 configuration to predict forage quality in high diverse Mediterranean permanent grasslands of open woodlands. We evaluated the performance of Partial Least Squares Regression (PLS) models to predict crude protein (CP), neutral detergent fibre (NDF), acid detergent fibre (ADF) and enzyme digestibility of organic matter (EDOM) by using three different reflectance datasets: (i) laboratory measurements of reflectance of dry and ground pasture samples re-sampled to Sentinel-2 configuration (Spec-lab) (ii) field in-situ measurements of grasslands canopy reflectance resampled to Sentinel-2 configuration (Spec-field); (iii) and Bottom Of Atmosphere Sentinel-2 imagery. Read More

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Accelerometry-derived respiratory index estimating apnea-hypopnea index for sleep apnea screening.

Comput Methods Programs Biomed 2021 May 31;207:106209. Epub 2021 May 31.

Grenoble Alpes University, CNRS, CHU Grenoble Alpes, Grenoble INP, TIMC, Grenoble, France. Electronic address:

Background And Objective: Sleep Apnea Syndrome (SAS) is a multimorbid chronic disease with individual and societal deleterious consequences. Polysomnography (PSG) is the multi-parametric reference diagnostic tool that allows a manual quantification of the apnea-hypopnea index (AHI) to assess SAS severity. The burden of SAS is affecting nearly one billion people worldwide explaining that SAS remains largely under-diagnosed and undertreated. Read More

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Characterization of chitin-glucan complex from Tremella fuciformis fermentation residue and evaluation of its antibacterial performance.

Int J Biol Macromol 2021 Jun 9. Epub 2021 Jun 9.

College of Food and Light Industry, Nanjing Tech University, Nanjing 211800, PR China.

Submerged fermentation of fungi is an efficient way to obtain extracellular polysaccharides, however, in this process, excess discarded biomass is produced. In this study, Tremella fuciformis mycelia were reused as the raw material to isolate a novel fungal chitin-glucan complex (CGC-TFM) using alkaline extraction. Characteristic analysis revealed that the CGC-TFM consisted of glucosamine/acetylglucosamine and glucose (GlcN:Glc = 26:74 mol%), indicating a reference to the β polymorphism of chitin-glucan complex, with the molecular weight and crystallinity index of 256 ± 3. Read More

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Adapting the listening time for micro-electrode recordings in deep brain stimulation interventions.

Int J Comput Assist Radiol Surg 2021 Jun 11. Epub 2021 Jun 11.

Laboratoire Traitement du Signal et de l'Image (LTSI - INSERM UMR 1099), Université de Rennes 1, Rennes, France.

Purpose: Deep brain stimulation (DBS) is a common treatment for a variety of neurological disorders which involves the precise placement of electrodes at particular subcortical locations such as the subthalamic nucleus. This placement is often guided by auditory analysis of micro-electrode recordings (MERs) which informs the clinical team as to the anatomic region in which the electrode is currently positioned. Recent automation attempts have lacked flexibility in terms of the amount of signal recorded, not allowing them to collect more signal when higher certainty is needed or less when the anatomy is unambiguous. Read More

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Modeling the hydroxylation of estragole via human liver cytochrome P450.

J Mol Model 2021 Jun 11;27(7):199. Epub 2021 Jun 11.

Molecular Modeling Lab, Department of Physics, School of Physical and Decision Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, UP, 226025, India.

Natural compounds derived from plants are generally regarded safe and devoid of adverse effects. However, there are individual ingredients that possess toxic, genotoxic, and carcinogenic activities. These compounds when exposed at specific level become hazardous to health. Read More

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Impact of A1 Asymmetry on the Woven EndoBridge Device in Anterior Communicating Artery Aneurysms.

AJNR Am J Neuroradiol 2021 Jun 11. Epub 2021 Jun 11.

Department of Interventional Neuroradiology (J. Cortese, J. Caroff, J.-B.G., C.M., G.A., A.E., L.I., S.G., A.O., V.C., J.M., L.S.), NEURI Brain Vascular Center, Bicêtre Hospital, APHP, Paris Saclay University, Le Kremlin-Bicêtre, France.

Background And Purpose: Woven EndoBridge (WEB) devices are increasingly used to treat intracranial aneurysms. A1 asymmetry contributes to anterior communicating artery aneurysm formation and to treatment instability after coiling. We sought to evaluate whether A1 asymmetry had an impact on angiographic outcome in anterior communicating artery aneurysms treated with the WEB. Read More

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A facile and one-pot aqueous phase transfer of oleylamine capped Au NP with aminophenylboronic acid used as transfer and targeting ligand.

Enzyme Microb Technol 2021 Aug 25;148:109810. Epub 2021 Apr 25.

Department of Analytical Chemistry, Faculty of Pharmacy, Erciyes University, 38039, Kayseri, Turkey. Electronic address:

Although various phase transfer techniques have been used to make hydrophobic nanoparticles (NPs) water-soluble. However, these techniques have been limited by inefficient surface modification strategy that often stable NPs in aqueous solutions. Herein, we report the use of 3-aminophenylboronic acid (3-APBA) as a hydrophilic ligand for phase transfer of oleylamine (OA) capped Au NPs ([email protected] NPs) from non-hydrolytic system into aqueous solutions. Read More

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MOF-enzyme hybrid nanosystem decorated 3D hollow fiber membranes for in-situ blood separation and biosensing array.

Biosens Bioelectron 2021 Jun 5;190:113413. Epub 2021 Jun 5.

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China. Electronic address:

Modified metal-organic frameworks (MOFs) doping with enzymes exhibit high enzyme stability and catalytic performance, which is a research hotspot in the field of enzyme-based sensing. Although the MOF-enzyme constitutes a 3D structure in the nanoscale, the macroscopic assembly configuration still stays in 1D or 2D structures, limiting sensing applications towards complex biological targets. Herein, the MOF-enzyme hybrid nanosystem was assembled into 3D porous conductive supports via a controllable physical embedding method, displaying high enzymatic loading, stability and cascade catalytic performance. Read More

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An interdomain hydrogen bond in the Rag GTPases maintains stable mTORC1 signaling in sensing amino acids.

J Biol Chem 2021 Jun 8:100861. Epub 2021 Jun 8.

Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St, Worcester, MA 01605, USA. Electronic address:

Cellular growth and proliferation are primarily dictated by the mechanistic target of rapamycin complex 1 (mTORC1), which balances nutrient availability against the cell's anabolic needs. Central to the activity of mTORC1 is the RagA-RagC GTPase heterodimer, which under favorable conditions recruits the complex to the lysosomal surface to promote its activity. The RagA-RagC heterodimer has a unique architecture in that both subunits are active GTPases. Read More

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Bioinspired Soft Robotic Fingers with Sequential Motion Based on Tendon-Driven Mechanisms.

Soft Robot 2021 Jun 11. Epub 2021 Jun 11.

School of Aeronautics and Astronautics, Sichuan University, Chengdu, China.

The conformability is yet a challenge for most soft robotic grippers due to the continuous motion and deformation of these machines under external force. Herein, inspired by the movement mechanism of human fingers, we propose a novel tendon-driven soft robotic finger with a preprogrammed bending configuration and a human finger like sequential motion that can be obtained by matching the stiffness gradient of the finger joints with three-dimensional (3D) printing technology. The contents of this article are organized as follows. Read More

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Selective Photoswitchable Allosteric Agonist of a G Protein-Coupled Receptor.

J Am Chem Soc 2021 Jun 11. Epub 2021 Jun 11.

Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, United States.

G protein-coupled receptors (GPCRs) are the most common targets of drug discovery. However, the similarity between related GPCRs combined with the complex spatiotemporal dynamics of receptor activation has hindered drug development. Photopharmacology offers the possibility of using light to control the location and timing of drug action by incorporating a photoisomerizable azobenzene into a GPCR ligand, enabling rapid and reversible switching between an inactive and active configuration. Read More

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Is a cross-connector beneficial for single level traditional or cortical bone trajectory pedicle screw instrumentation?

PLoS One 2021 11;16(6):e0253076. Epub 2021 Jun 11.

Department of Orthopaedics, Balgrist University Hospital, Zurich, Switzerland.

The cortical bone trajectory (CBT) has been introduced with the aim of better screw hold, however, screw-rod constructs with this trajectory might provide less rigidity in lateral bending (LB) and axial rotation (AR) compared to the constructs with the traditional trajectory (TT). Therefore, the addition of a horizontal cross-connector could be beneficial in counteracting this possible inferiority. The aim of this study was to compare the primary rigidity of TT with CBT screw-rod constructs and to quantify the effect of cross-connector-augmentation in both. Read More

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Rare Self-Luminous Mixed-Valence Eu-MOF with a Self-Enhanced Characteristic as a Near-Infrared Fluorescent ECL Probe for Nondestructive Immunodetection.

Anal Chem 2021 Jun 11. Epub 2021 Jun 11.

Collaborative Innovation Centre for Green Chemical Manufacturing and Accurate Detection School of Chemistry and Chemical Engineering, Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022 Shandong, China.

Steady and efficient sensitized emission of Eu to Eu can be achieved through a rare mixed-valence Eu-MOF (LEuEu). Compared with the sensitization of other substances, the similar ion radius and configuration of the extranuclear electron between Eu and Eu make sensitization easier and more efficient. The sensitization of Eu to Eu is of great assistance for the self-enhanced luminescence of LEuEu, the longer luminous time, and the more stable electrochemiluminescence (ECL) signal. Read More

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Many-Body Nonlocality as a Resource for Quantum-Enhanced Metrology.

Phys Rev Lett 2021 May;126(21):210506

Faculty of Physics, University of Warsaw, Ulica Pasteura 5, PL-02-093 Warszawa, Poland.

We demonstrate that the many-body nonlocality witnessed by a broad family of Bell inequalities is a resource for ultraprecise metrology. We formulate a general scheme which allows one to track how the sensitivity grows with the nonlocality extending over an increasing number of particles. We illustrate our findings with some prominent examples-a collection of spins forming an Ising chain and a gas of ultracold atoms in any two-mode configuration. Read More

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Conduction Band Energy-Level Engineering for Improving Open-Circuit Voltage in Antimony Selenide Nanorod Array Solar Cells.

Adv Sci (Weinh) 2021 Jun 10:e2100868. Epub 2021 Jun 10.

National-Local Joint Engineering Laboratory of New Energy Photoelectric Devices, College of Physics Science and Technology, Hebei University, Baoding, 071002, China.

Antimony selenide (Sb Se ) nanorod arrays along the [001] orientation are known to transfer photogenerated carriers rapidly due to the strongly anisotropic one-dimensional crystal structure. With advanced light-trapping structures, the Sb Se nanorod array-based solar cells have excellent broad spectral response properties, and higher short-circuit current density than the conventional planar structured thin film solar cells. However, the interface engineering for the Sb Se nanorod array-based solar cell is more crucial to increase the performance, because it is challenging to coat a compact buffer layer with perfect coverage to form a uniform heterojunction interface due to its large surface area and length-diameter ratio. Read More

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3D Anisotropic [email protected] Hemispherical Nanostructures as Efficient Electrocatalysts for Methanol, Ethanol, and Formic Acid Oxidation Reaction.

Adv Mater 2021 Jun 10:e2100713. Epub 2021 Jun 10.

Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu, 215123, P. R. China.

Anisotropic 3D nanostructures exhibit excellent electrocatalytic activity and stability due to their heterogeneous elemental distribution and unsymmetrical configuration. However, it is still a huge challenge to combine anisotropically distributed elements and anisotropic morphologies within one 3D nanostructure. Herein, 3D [email protected] hemispherical nanostructures ([email protected] H-Ss) are fabricated as highly efficient electrocatalysts for oxidation reaction, which present heterogenous element distribution and anisotropic morphology. Read More

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Regional patterning in tail vertebral form and function in chameleons (C. calyptratus).

Integr Comp Biol 2021 Jun 10. Epub 2021 Jun 10.

Evolutionary Morphology of Vertebrates, Ghent University, Belgium.

Previous studies have focused on documenting shape variation in the caudal vertebrae in chameleons underlying prehensile tail function. The goal of this study was to test the impact of this variation on tail function using multibody dynamic analysis (MDA). First, observations from dissections and 3D reconstructions generated from contrast-enhanced µCT-scans were used to document regional variation in arrangement of the caudal muscles along the antero-posterior axis. Read More

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Masking Emotions: Face Masks Impair How We Read Emotions.

Front Psychol 2021 25;12:669432. Epub 2021 May 25.

Unit for Visually Impaired People (U-VIP), Istituto Italiano di Tecnologia, Genova, Italy.

To date, COVID-19 has spread across the world, changing our way of life and forcing us to wear face masks. This report demonstrates that face masks influence the human ability to infer emotions by observing facial configurations. Specifically, a mask obstructing a face limits the ability of people of all ages to infer emotions expressed by facial features, but the difficulties associated with the mask's use are significantly pronounced in children aged between 3 and 5 years old. Read More

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Influence of Lenslet Configuration on Short-Term Visual Performance in Myopia Control Spectacle Lenses.

Front Neurosci 2021 25;15:667329. Epub 2021 May 25.

Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China.

This study aimed to evaluate short-term visual performance and optical quality of three different lenslet configurations on myopia control spectacle lenses. This study utilized a cross-over design. Distance visual acuity (VA) was measured in 50 myopic children; contrast sensitivity (CS) was measured in 36 myopic children. Read More

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Optical Trapping with Focused Surface Waves.

Ann Phys 2020 Apr 24;532(4). Epub 2020 Feb 24.

Department of Optics and Optical Engineering, Institute of Photonics, University of Science and Technology of China, Hefei, Anhui 230026, China.

Near-field optical trapping can be realized with focused evanescent waves that are excited at the water-glass interface due to the total internal reflection, or with focused plasmonic waves excited on the water-gold interface. Herein, the performance of these two kinds of near-field optical trapping techniques is compared using the same optical microscope configuration. Experimental results show that only a single-micron polystyrene bead can be trapped by the focused evanescent waves, whereas many beads are simultaneously attracted to the center of the excited region by focused plasmonic waves. Read More

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Small flexible automated system for monitoring Caenorhabditis elegans lifespan based on active vision and image processing techniques.

Sci Rep 2021 Jun 10;11(1):12289. Epub 2021 Jun 10.

Cell Biology Laboratory/ADM Nutrition/Biopolis SL/Archer Daniels Midland, Paterna, Valencia, Spain.

Traditionally Caenorhabditis elegans lifespan assays are performed by manually inspecting nematodes with a dissection microscope, which involves daily counting of live/dead worms cultured in Petri plates for 21-25 days. This manual inspection requires the screening of hundreds of worms to ensure statistical robustness, and is therefore a time-consuming approach. In recent years, various automated artificial vision systems have been reported to increase the throughput, however they usually provide less accurate results than manual assays. Read More

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Efficient facemask decontamination via forced ozone convection.

Sci Rep 2021 Jun 10;11(1):12263. Epub 2021 Jun 10.

Department of Mechanical Engineering, University of California Riverside, 900 University Ave, Riverside, CA, 92521, USA.

The COVID-19 crisis has taken a significant toll on human life and the global economy since its start in early 2020. Healthcare professionals have been particularly vulnerable because of the unprecedented shortage of Facepiece Respirators (FPRs), which act as fundamental tools to protect the medical staff treating the coronavirus patients. In addition, many FPRs are designed to be disposable single-use devices, creating an issue related to the generation of large quantities of non-biodegradable waste. Read More

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Three dimensional reconstruction of coronary artery stents from optical coherence tomography: experimental validation and clinical feasibility.

Sci Rep 2021 Jun 10;11(1):12252. Epub 2021 Jun 10.

Cardiovascular Biology and Biomechanics Laboratory, Cardiovascular Division, University of Nebraska Medical Center, 982265 Nebraska Medical Center, Omaha, NE, 68198, USA.

The structural morphology of coronary stents (e.g. stent expansion, lumen scaffolding, strut apposition, tissue protrusion, side branch jailing, strut fracture), and the local hemodynamic environment after stent deployment are key determinants of procedural success and subsequent clinical outcomes. Read More

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Tip-Induced β-Hydrogen Dissociation in an Alkyl Group Bound on Si(001).

J Phys Condens Matter 2021 Jun 10. Epub 2021 Jun 10.

Institute of Applied Physics, Justus Liebig University Giessen, Heinrich-Buff-Ring 16, Giessen, 35392, GERMANY.

Atomic-scale chemical modification of surface-adsorbed ethyl groups on Si(001) was induced and studied by means of scanning tunneling microscopy. Tunneling at sample bias > +1.5 V leads to tip-induced C-H cleavage of a β-hydrogen of the covalently bound ethyl configuration. Read More

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Opalescence Measurements: Improvements in Fundamental Knowledge, Identifying Sources of Analytical Biases, and Advanced Applications for the Development of Therapeutic Proteins.

J Pharm Sci 2021 Jun 7. Epub 2021 Jun 7.

Drug Product Development, Bristol Myers Squibb Company, New Brunswick, New Jersey, USA 08903.

Opalescence of biopharmaceutical solutions can indicate suboptimal colloidal stability and is therefore a generally undesirable attribute that requires investigation and potentially remediation. While there are numerous instrumentation options available for measuring opalescence, cross-instrument comparisons and detailed knowledge of analytical biases have been limited.  Here, we highlight key findings from a multi-instrument investigation where differences in reported opalescence values are explained with particular emphasis on how the optical configuration and detector properties of each instrument affect the response of the sample and the primary formazin standards required for instrument calibration. Read More

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Interplay of morphological configuration and language switching in numerical processing and word processing.

J Exp Psychol Learn Mem Cogn 2021 Jun 10. Epub 2021 Jun 10.

Institute of Psychology, RWTH Aachen University.

The aim of the present study was to examine the interplay of morphological configuration switching and language switching. The morphological configuration is present in word-formation whenever a word contains more than one free morpheme. The morphological configuration is variable both within and between languages for example in two-digit number names (is the decade named first as in twenty-one or the unit named first as in seventeen) and in compound words (is the modifier or the head named first). Read More

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The impact of the female genital tract microbiome in women health and reproduction: a review.

J Assist Reprod Genet 2021 Jun 10. Epub 2021 Jun 10.

IVIRMA Valencia, Plaza de la Policía Local, 3, 46015, Valencia, Spain.

Purpose: The aim of this review is to gather the available research focusing on female genital tract (FGT) microbiome. Research question focuses in decipher which is the role of FGT microbiota in eubiosis, assisted reproduction techniques (ARTs), and gynaecological disorders, and how microbiome could be utilised to improve reproduction outcomes and to treat fertility issues.

Methods: PubMed was searched for articles in English from January 2004 to April 2021 for "genital tract microbiota and reproduction", "endometrial microbiome", "microbiome and reproduction" and "microbiota and infertility". Read More

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Laparoscopic approach for symptomatic pelvic and para-aortic lymphoceles.

J Turk Ger Gynecol Assoc 2021 Jun 10. Epub 2021 Jun 10.

Department of Gynecology and Obstetrics, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Description of laparoscopic management for symptomatic pelvic lymphocele after surgical staging in gynecological cancer surgery and demonstrate its feasibility. Step-by-step description of the surgical procedure using pictures and an educational video. Informed consent was obtained for the use of images, and the full video article was approved by the Institutional Review Board of the Hospital of Sant Pau. Read More

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