529,129 results match your criteria confidence interval

Long-term Safety and Efficacy of Avalglucosidase Alfa in Patients With Late-Onset Pompe Disease.

Neurology 2022 May 26. Epub 2022 May 26.

Friedrich-Baur-Institut, Department of Neurology Klinikum München, München, Germany.

Background And Objectives: Pompe disease is a rare, progressive neuromuscular disorder caused by deficiency of lysosomal acid α-glucosidase (GAA) and subsequent glycogen accumulation. Avalglucosidase alfa, a recombinant human GAA enzyme replacement therapy designed for increased cellular uptake and glycogen clearance, has been studied for long-term efficacy and safety in patients with late-onset Pompe disease (LOPD). Here we report up to 6. Read More

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Determinants of High Fat Mass Index in Preschoolers Living in Brazilian Urban Areas.

J Nutr Educ Behav 2022 Jun;54(6):532-539

Faculty of Physiotherapy, Federal University of the Jequitinhonha and Mucuri Valleys, Diamantina, Minas Gerais, Brazil.

Objective: Determine the social, environmental, and personal factors associated with high fat mass index in preschoolers.

Design: A quantitative, exploratory, and cross-sectional study.

Setting And Participants: Fifty-one Brazilian preschoolers from public schools living in urban areas. Read More

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Prevalence of depression and anxiety and their predictors among patients undergoing maintenance hemodialysis in Northern China: a cross-sectional study.

Ren Fail 2022 Dec;44(1):933-944

Department of Nephrology, the Attached Hospital of Inner Mongolia Medical University, Hohhot, China.

Objective: To investigate the prevalence of depression and anxiety in patients undergoing maintenance hemodialysis (MHD) in Hohhot, a large city on the northern border of China, and to identify independent risk factors for depression and anxiety in these patients.

Methods: Patients receiving MHD for >3 months were enrolled in the four largest hemodialysis centers between September 2020 and December 2020. Depression and anxiety were assessed using the Zung self-rated depression scale (SDS) and Zung self-rated anxiety scale (SAS), respectively, with demographic and other data collected for logistic regression analyses. Read More

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December 2022

Fracture Risk of Sodium-Glucose Cotransporter-2 Inhibitors in Chronic Kidney Disease.

Clin J Am Soc Nephrol 2022 May 26. Epub 2022 May 26.

Institute for Clinical and Evaluative Sciences (ICES), London, Ontario, Canada.

Background And Objectives: Sodium-glucose cotransporter-2 (SGLT2) inhibitors have been associated with a higher risk of skeletal fractures in some randomized, placebo-controlled trials. Secondary hyperparathyroidism and increased bone turnover (also common in CKD) may contribute to the observed fracture risk. We aimed to determine if SGLT2 inhibitor use associates with a higher risk of fractures compared with dipeptidyl peptidase-4 (DPP-4) inhibitors, which have no known association with fracture risk. Read More

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Postural Control Adaptations in Yoga Single-Leg Support Postures: Comparison Between Practitioners and Nonpractitioners.

Motor Control 2022 May 26:1-18. Epub 2022 May 26.

Biomedical Engineering Program, COPPE, Federal University of Rio de Janeiro, Rio de Janeiro, RJ,Brazil.

This paper investigates whether a group of regular Yoga practitioners shows postural control differences compared with healthy controls while performing single-leg Yoga postures. Ten Yoga practitioners were compared with a control group of 10 nonpractitioners performing two single-leg support Yoga postures: Vrksasana (tree posture) and Natarajasana (dancer posture). Rambling and trembling decomposition of the center of pressure trajectories was implemented using a genetic algorithm spectral optimization that avoids using horizontal forces and was validated with bipedal posture data. Read More

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Microvascular reactivity as a predictor of major adverse events in patients with on-pump cardiac surgery.

Korean J Anesthesiol 2022 May 27. Epub 2022 May 27.

Department of Anesthesia and Pain Medicine, Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.

Background: Microcirculatory disturbance occurs most seriously during cardiopulmonary bypass (CPB) in cardiac surgery. If microvascular reactivity compensates for microcirculatory disturbance during CPB, tissue hypoxemia may be minimized. The primary aim of this study was to assess whether microvascular reactivity during CPB can predict major adverse events (MAE) after cardiac surgery. Read More

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The effects of statin monotherapy on depressive symptoms: A systematic review and meta-analysis.

J Affect Disord 2022 May 23. Epub 2022 May 23.

University of Oxford, Department of Psychiatry, Warneford Hospital, Warneford Lane, Oxford, Oxfordshire OX3 7JX, United Kingdom.

Introduction: Statins have been proposed as a strategy for treating depression, but their benefit in the absence of concurrent antidepressant treatment is unclear. This meta-analysis investigated the antidepressant effects of statin monotherapy in the general population.

Methods: We conducted a literature search of randomised controlled trials using any statin monotherapy versus any control condition for depressive symptoms. Read More

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Exposure to greenspace and cancer incidence, prevalence, and mortality: A systematic review and meta-analyses.

Sci Total Environ 2022 May 23:156180. Epub 2022 May 23.

Univ Rennes, INSERM, EHESP, IRSET (Institut de Recherche en Santé, Environnement et Travail) - UMR_S 1085, F-35000 Rennes, France. Electronic address:

We conducted a systematic review and meta-analysis of the available literature on the association between greenspace exposure and all-sites and site-specific cancer incidence, prevalence, and mortality in adults. We searched PubMed, Scopus, and Web of Science for original articles published, without language restriction until September 2021. We assessed the risk of bias in each study and the overall quality of evidence for exposure-outcome pairs that were reported in two or more studies. Read More

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Psychological factors and risk of atrial fibrillation: A meta-analysis and systematic review.

Int J Cardiol 2022 May 23. Epub 2022 May 23.

Department of Cardiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China. Electronic address:

Background: Multiple studies have shown that mental disorders are common risk factors for cardiovascular diseases (CVD). However, the relationship between psychological factors and atrial fibrillation (AF) incidence remains unclear. Therefore, we performed a systematic review and meta-analysis to assess the risk of AF due to psychological factors. Read More

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Use of renin angiotensin aldosterone system inhibitors in children with lupus and time to glucocorticoid discontinuation.

Kidney Int 2022 May 23. Epub 2022 May 23.

Pediatric Nephrology, Baylor College of Medicine, Texas Children's Hospital, Houston TX.

There is little data to inform use of renin angiotensin aldosterone system (RAAS) inhibitors in pediatric patients with systemic lupus erythematosus (SLE). Here, we sought to characterize RAAS inhibitor use in pediatric SLE, and determine whether early RAAS inhibitor initiation among children with incident lupus nephritis is associated with decreased duration of chronic glucocorticoid exposure. A retrospective cohort study was performed of children (ages 5-18) with SLE and/or lupus nephritis in the Truven MarketScan Medicaid and Commercial databases (2013-2018) and estimated RAAS inhibitor use. Read More

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Correlation of Orexin-A and brain-derived neurotrophic factor levels in metabolic syndrome and cognitive impairment in schizophrenia treated with clozapine.

Neurosci Lett 2022 May 23:136695. Epub 2022 May 23.

Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Orexin-A and brain-derived neurotrophic factor (BDNF) are implicated in regulating metabolic syndrome (MetS) and cognitive impairment of schizophrenia. However, the associations among them remains unclear. Here, we aimed to investigate the relationship between Orexin-A levels, BDNF, MetS, clinical symptom profile, and cognitive function in schizophrenia patients following long-term clozapine treatment. Read More

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Deep sternal wound infection and mortality in cardiac surgery: A meta-analysis.

Ann Thorac Surg 2022 May 23. Epub 2022 May 23.

Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York City, NY, USA.

Background: Deep sternal wound infection (DSWI) is a rare but severe complication after cardiac surgery and has been associated with increased early morbidity and mortality. Studies reporting long-term outcomes in patients with DSWI have shown contradictory results. We performed a study-level meta-analysis evaluating the impact of DSWI on short- and long-term clinical outcomes. Read More

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Association between sub-daily exposure to ambient air pollution and risk of asthma exacerbations in Australian children.

Environ Res 2022 May 23:113556. Epub 2022 May 23.

School of Public Health, Faculty of Medicine, University of Queensland, 288 Herston Road, Herston, QLD, 4006, Australia. Electronic address:

Short-term exposure to ambient air pollution is associated with risk of asthma attacks. We investigated the association between ultra-short-term exposure to air pollution and risk of childhood asthma exacerbations. Hourly data on emergency department visits (EDVs) for asthma in children during 2013-2015 in Brisbane, Australia, were obtained. Read More

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Impact of a Deep Learning Model for Predicting Mammographic Breast Density in Routine Clinical Practice.

J Am Coll Radiol 2022 May 23. Epub 2022 May 23.

Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Division Chief of the Division of Breast Imaging.

Objective: Legislation in 38 states requires patient notification of dense mammographic breast tissue because increased density is a marker of breast cancer risk and can limit mammographic sensitivity. Since radiologist density assessments vary widely, our objective was to implement and measure the impact of a deep learning (DL) model on mammographic breast density assessments in clinical practice.

Methods: This institutional review board-approved prospective study identified consecutive screening mammograms performed across three clinical sites over two periods: 2017 period (January 1, 2017, through September 30, 2017) and 2019 period (January 1, 2019, through September 30, 2019). Read More

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Joint effect of multiple prothrombotic genotypes and mean platelet volume on the risk of incident venous thromboembolism.

Thromb Haemost 2022 May 26. Epub 2022 May 26.

Thrombosis Research Center, Department of Clinical Medicine, UiT - The Arctic University of Norway, Tromsø, Norway.

Background: A high mean platelet volume (MPV), a marker of increased platelet reactivity, is a risk factor for venous thromboembolism (VTE). Whether established prothrombotic single nucleotide polymorphisms (SNPs) further increase the VTE risk in subjects with high MPV because of biological interaction remains unknown.

Aim: To investigate the joint effect of high MPV and prothrombotic genotypes, comprising a 5-SNP genetic risk score (GRS), on the risk of VTE in a population-based case-cohort. Read More

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Infarct location and cognitive change in patients after acute ischemic stroke: The ICONS study.

J Neurol Sci 2022 May 11;438:120276. Epub 2022 May 11.

National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China. Electronic address:

Background And Purpose: Post stroke cognitive impairment is closely related to the quality of life. We aimed to evaluate the association between infarct location and cognitive change over time after acute ischemic stroke (AIS).

Methods: Patients were selected from the Impairment of Cognition and Sleep after AIS or transient ischemic attack in Chinese patients (ICONS) study. Read More

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The impact of childhood epilepsy on academic performance: A population-based matched cohort study.

Seizure 2022 May 18;99:91-98. Epub 2022 May 18.

Australian Institute of Health Innovation, Macquarie University, Sydney, Australia.

Objectives: To compare academic performance and high school completion of young people admitted to hospital with epilepsy and matched peers from the general population not admitted to hospital with epilepsy during the study period.

Methods: A population-based matched case-comparison cohort study of young people aged ≤18 years hospitalised with epilepsy during 2005-2018 in New South Wales, Australia, using linked birth, health, education, and mortality records. The comparison cohort was matched on age, sex, and residential postcode. Read More

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Increased risk of death immediately after discharge from compulsory care for substance abuse.

Drug Alcohol Depend 2022 May 10;236:109492. Epub 2022 May 10.

Department of Public Health Sciences, Stockholm University, SE-106 91 Stockholm, Sweden.

Background: In Sweden, approximately 1000 persons per year are committed to compulsory care for substance abuse for a maximum duration of six months. People admitted to compulsory care are known to suffer high mortality risks, but whether the risk of dying is further heightened immediately after discharge is not known.

Methods: Individual data from Swedish national registers were used to follow all persons discharged from a six months compulsory care episode in the period 2000-2017 (N = 7, 929). Read More

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Association between cognitive social capital and all-cause mortality in Great East Japan Earthquake survivors: a prospective cohort study.

Public Health 2022 May 23;207:108-112. Epub 2022 May 23.

Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University School of Public Health, Graduate School of Medicine, Sendai, Japan.

Objectives: Cognitive social capital (SC), such as attitude, trust, or norms, may help improve resilience among survivors, thus improving their health. However, the association between cognitive SC and the risk of all-cause mortality among survivors after the natural disaster has never been investigated. The purpose of the present study is to investigate the association between cognitive SC and the risk of all-cause mortality among survivors of the Great East Japan Earthquake (GEJE). Read More

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Hyperdontia across sub-Saharan Africa: Prevalence, patterning, and implications.

Joel D Irish

Arch Oral Biol 2022 May 18;140:105463. Epub 2022 May 18.

Research Centre in Evolutionary Anthropology and Palaeoecology, School of Biological and Environmental Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK. Electronic address:

Objective: Hyperdontia data in modern and premodern sub-Saharan Africans are presented by region-West, Central, East, and South, and sex. Beyond describing the anomaly, comparisons are made with other world populations and future work is promoted. These findings may be useful to both dental clinicians and anthropologists. Read More

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Development and validation of dietary atherogenic index using common carotid artery-intima-media thickness: A food frequency questionnaire-based longitudinal study in Korean adults.

Nutr Res 2022 Apr 29;104:55-65. Epub 2022 Apr 29.

Department of Preventive Medicine, College of Medicine, Hanyang University, Seoul, Korea; Institute for Health and Society, Hanyang University, Seoul, Korea. Electronic address:

Dietary patterns based on pathways of diseases such as subclinical atherosclerosis can predict diet-disease associations better than dietary quality indices or data-driven indices. We aimed to develop and validate a novel dietary atherogenic index (DAI) in adults using the common carotid artery-intima media thickness (c-IMT) in Korean adults. Participants aged ≥40 years from the Yangpyeong cohort were enrolled in the development set (n = 1373). Read More

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Predictive Factors for Conversion from Laparoscopic Adrenalectomy to Open Surgery: A 9-Year Review of 911 Cases.

J Laparoendosc Adv Surg Tech A 2022 May 26. Epub 2022 May 26.

Department of Urology, The Second Hospital of Lanzhou University, Lanzhou, China.

With the development of minimally invasive techniques, laparoscopic adrenalectomy (LA) has become the standard for the treatment of adrenal surgical diseases, but conversion to open adrenalectomy (OA) is also necessary in some cases. The purpose of this study was to investigate the risk factors for conversion from LA to OA. A retrospective study was performed on 911 patients who were diagnosed with adrenal tumors and underwent LA in the Department of Urology, Second Hospital of Lanzhou University from January 2013 to December 2021. Read More

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Prevalence of Psychological Distress Among Working-Age Adults in the United States, 1999-2018.

Michael Daly

Am J Public Health 2022 May 26:e1-e5. Epub 2022 May 26.

Michael Daly is with the Department of Psychology, Maynooth University, Maynooth, Ireland.

To test whether the prevalence of reported psychological distress increased among working-age adults in the United States between 1999 and 2018. I examined psychological distress in the past 30 days using the Kessler-6 Distress Scale, completed by 403 223 participants aged 25 to 64 years across 20 annual waves of the National Health Interview Study conducted from 1999 to 2018. I examined overall and demographic-specific trends. Read More

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Robust Hepatitis A Vaccination Response Within the United States Veterans Health Administration in the Wake of State Outbreaks.

Am J Public Health 2022 May 26:e1-e5. Epub 2022 May 26.

Andrew M. Moon is with the Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill. Joleen A. Borgerding and Elliott Lowy are with Health Services Research & Development, Veterans Affairs Puget Sound Healthcare System, Seattle, WA. Ronald G. Hauser is with the Pathology and Laboratory Medicine Department, Veterans Affairs Connecticut Healthcare, New Haven. Maggie Chartier is with the Office of Specialty Care Services, VA HIV, Hepatitis, and Related Conditions Program, Washington, DC. Marissa M. Maier is with the Division of Infectious Diseases, Department of Medicine at Oregon Health and Sciences University, Portland. Timothy Morgan is with the Gastroenterology Section, VA Long Beach Healthcare System, Long Beach, CA. Adam Ruege is with Community Solutions, New York, NY. Jillian Weber is with the Homeless Program Office, US Department of Veterans Affairs, Veterans Health Administration, Washington, DC. Lauren A. Beste is with the Division of General Internal Medicine, Veterans Affairs Puget Sound Healthcare System.

We assessed hepatitis A (HepA) vaccine receipt among susceptible individuals in outbreak and matched nonoutbreak states. Difference-in-differences models and multivariable logistic regression were used to compare HepA vaccination rates in these states. In the postoutbreak year, there was a 112% increase in HepA vaccinations in outbreak states versus a 6% decrease in nonoutbreak states. Read More

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Gaps in naloxone ownership among people who inject drugs during the fentanyl wave of the opioid overdose epidemic in New York City, 2018.

Subst Abus 2022 ;43(1):1172-1179

New York City Department of Health and Mental Hygiene, Bureau of Hepatitis, HIV, and STIs, Long Island City, New York, USA.

Community distribution of naloxone, a medication that reverses opioid overdose, is an effective public health strategy to prevent overdose deaths. However, data are limited on who has naloxone during the current fentanyl wave of the opioid overdose epidemic in the United States. We aim to determine correlates of naloxone ownership among a community sample of people who inject drugs (PWID) from New York City (NYC). Read More

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January 2022

Is a High Medication Risk Score Associated With Increased Risk of 30-Day Readmission? A Population-Based Cohort Study From CROSS-TRACKS.

J Patient Saf 2022 Jun 17;18(4):e714-e721. Epub 2021 Dec 17.

From the Research Center for Emergency Medicine.

Objectives: The primary aim of this study was to evaluate whether a high Medication Risk Score (MERIS) upon admission to an emergency department is associated with increased risk of 30-day readmission in patients discharged directly home. Mortality, visit to general practitioner, and drug changes within 30 days were included as secondary outcomes.

Methods: This is a historical cohort study with data from the Danish population-based open-cohort CROSS-TRACKS. Read More

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Eight-Year Trends in Direct-Acting Oral Anticoagulant Dosing, Based on Age and Kidney Function, in Patients With Atrial Fibrillation.

J Patient Saf 2022 Jun 15;18(4):337-341. Epub 2021 Oct 15.

From the School of Pharmacy and Pharmacology, University of Tasmania, Hobart, Tasmania, Australia.

Objective: Concerns have been raised over the appropriateness of dosing of direct-acting oral anticoagulants (DOACs) in clinical practice. We investigated this issue in patients who were initiated on a DOAC in Australian general practices.

Methods: This was a retrospective study among patients newly diagnosed with atrial fibrillation (AF) who were prescribed DOACs, using data obtained from 417 general practice sites across Australia over 8 years (2011-2019). Read More

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Phase I Trial of a Novel Anti-HER2 Antibody-drug Conjugate, ARX788, for the Treatment of HER2-positive Metastatic Breast Cancer.

Clin Cancer Res 2022 May 26. Epub 2022 May 26.

Fudan University Shanghai Cancer Center, Shanghai, China.

Purpose: ARX788 is a novel antibody-drug conjugate (ADC) comprised of an anti-HER2 monoclonal antibody and a potent tubulin inhibitor payload AS269 that is site-specifically conjugated to the antibody via a non-natural amino acid incorporated into the antibody. Herein, we present the results of a phase I study of the safety, pharmacokinetics, and antitumor activity of ARX788 in HER2-positive metastatic breast cancer (MBC) patients.

Experimental Design: Patients with HER2-positive MBC received ARX788 at doses of 0. Read More

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Nivolumab retreatment in non-small cell lung cancer patients who responded to prior immune-checkpoint inhibitors and had ICI-free intervals (WJOG9616L).

Clin Cancer Res 2022 May 26. Epub 2022 May 26.

Kindai University Hospital, Osakasayama, Osaka, Japan.

Purpose: To explore the efficacy of retreatment with immune checkpoint inhibitors (ICIs) in advanced non-small cell lung cancer (NSCLC) patients who responded to prior ICI and had adequate ICI-free interval.

Patients And Methods: Advanced NSCLC patients who had achieved complete response (CR), partial response (PR), or stable disease for {greater than or equal to}6 months with prior ICI therapy preceding progression were prospectively enrolled. All patients should have had ICI-free interval {greater than or equal to} 60 days before registration. Read More

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Osimertinib plus selumetinib in EGFR-mutated, non-small cell lung cancer after progression on EGFR-TKIs: A Phase 1b, open-label, multicenter trial (TATTON Part B).

Clin Cancer Res 2022 May 26. Epub 2022 May 26.

Sungkyunkwan University School of Medicine, Seoul, Korea (South), Republic of.

Background: MEK/ERK inhibition can overcome acquired resistance to osimertinib in preclinical models. Osimertinib (epidermal growth factor receptor [EGFR]-tyrosine kinase inhibitor [TKI]) plus selumetinib (mitogen-activated protein kinase [MEK]1/2 inhibitor) was assessed in the global TATTON study.

Methods: This multicenter, open-label, Phase 1b study expansion cohort enrolled patients (aged {greater than or equal to}18 years) with advanced MET-negative, EGFRm NSCLC who had progressed on EGFR-TKIs. Read More

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