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Early Versus Delayed Feeding After Therapeutic Endoscopic Procedures: A Meta-Analysis of Randomized Controlled Trials.

Dig Endosc 2021 Sep 18. Epub 2021 Sep 18.

Division of Emergency Medicine, Department of Emergency and Critical Care, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan.

Introduction: Early feeding was previously considered to increase the risk of postprocedural bleeding. However, many trials have demonstrated the benefits of early feeding after therapeutic endoscopic procedures. We conducted a meta-analysis of randomized controlled trials to evaluate the safety and outcomes between early feeding and delayed feeding after therapeutic endoscopic procedures. Read More

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September 2021

Recent improvement in survival outcomes and reappraisal of prognostic factors in pediatric living donor liver transplantation.

Liver Transpl 2021 Sep 18. Epub 2021 Sep 18.

Department of Pediatrics, Asan Medical Center Children's Hospital, University Ulsan College of Medicine, Seoul, Korea.

Background: Living donor liver transplantation (LDLT) is a significant advancement for the treatment of children with end-stage liver disease given the shortage of deceased donors. The ultimate goal of pediatric LT is to achieve complete donor safety and zero recipient mortality.

Methods: We conducted a retrospective, single center assessment of the outcomes as well as the clinical factors that may influence graft and patient survival after primary LDLTs conducted between 1994 and 2020. Read More

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September 2021

Efficacy and safety of immune checkpoint inhibitors in elderly patients (≥70 years) with squamous cell carcinoma of the head and neck.

Eur J Cancer 2021 Sep 15;157:190-197. Epub 2021 Sep 15.

Department of Head and Neck Oncology, Gustave Roussy Cancer Campus, Villejuif, France.

Background: Recent meta-analysis showed that immune checkpoint inhibitors (ICIs) have comparable activity between younger and older patients. However, little is known about efficacy and safety of ICI in elderly patients with relapsed/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). The aim of this study is to compare the efficacy of ICI for patients aged ≥70 y to that for younger patients, while taking into account potential confounding factors. Read More

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September 2021

Virtual reality surgical planning for endoscopic endonasal approaches to the craniovertebral junction.

Am J Otolaryngol 2021 Sep 11;43(1):103219. Epub 2021 Sep 11.

Department of Otolaryngology Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Otolaryngology Head and Neck Surgery, New York Eye and Ear Infirmary of Mount Sinai, New York, NY 10003, USA.

Purpose: To demonstrate the utility of virtual reality (VR) for preoperative surgical planning of endoscopic endonasal craniovertebral junction (CVJ) surgery.

Materials And Methods: Five patients who had undergone endoscopic endonasal surgery of the craniovertebral junction with preoperative virtual reality surgical planning were identified and described.

Results: The anterior approach to the CVJ has been traditionally accomplished transorally. Read More

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September 2021

F-FDG-PET/CT interpretation pitfalls in patients with head and neck cancer.

Am J Otolaryngol 2021 Sep 10;43(1):103209. Epub 2021 Sep 10.

Department of Otorhinolaryngology-Head and Neck Surgery, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.

Aim: The aim of the present study is to raise awareness of ENT Surgeons on the limitations of F-FDG PET/CT in head and neck cancer by presenting illustrative cases from our department archives.

Materials And Methods: A retrospective chart review was conducted for all patients with head and neck cancer treated in our ENT department from 2015 to 2020. Cases with various interpretation pitfalls due to false-positive and false-negative PET/CT results that lead to diagnostic dilemmas and treatment delays either in their pre-therapeutic work-up or in their post-therapeutic monitoring were included. Read More

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September 2021

Functional correlates of response inhibition in impulse control disorders in Parkinson's disease.

Neuroimage Clin 2021 Sep 11;32:102822. Epub 2021 Sep 11.

Neuroscience Area, CIMA, University of Navarra, Av. de Pío XII 55, 31008 Pamplona, Spain; Department of Neurology, Clínica Universidad de Navarra, Universidad de Navarra, Av. de Pío XII 36, 31008 Pamplona, Spain. Electronic address:

Impulse control disorder is a prevalent side-effect of Parkinson's disease (PD) medication, with a strong negative impact on the quality of life of those affected. Although impulsivity has classically been associated with response inhibition deficits, previous evidence from PD patients with impulse control disorder (ICD) has not revealed behavioral dysfunction in response inhibition. In this study, 18 PD patients with ICD, 17 PD patients without this complication, and 15 healthy controls performed a version of the conditional Stop Signal Task during functional magnetic resonance imaging. Read More

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September 2021

Utility and usability of an automated COVID-19 symptom monitoring system (CoSMoS) in primary care during COVID-19 pandemic: A qualitative feasibility study.

Int J Med Inform 2021 Sep 6;155:104567. Epub 2021 Sep 6.

University of Malaya eHealth Unit, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; Department of Artificial Intelligence, Faculty of Computer Science & Information Technology, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Background: COVID-19 telemonitoring applications have been developed and used in primary care to monitor patients quarantined at home. There is a lack of evidence on the utility and usability of telemonitoring applications from end-users' perspective.

Objectives: This study aimed to evaluate the feasibility of a COVID-19 symptom monitoring system (CoSMoS) by exploring its utility and usability with end-users. Read More

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September 2021

Systemic lupus erythematosus and autoimmune features in chronic hospitalized patients with schizophrenia.

Schizophr Res 2021 Sep 15;237:166-173. Epub 2021 Sep 15.

Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Public Health, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung, Taiwan. Electronic address:

Objectives: Recent studies highlighted the link of schizophrenia risk with genetic variations in complement, which share the same pathogenesis with systemic lupus erythematosus (SLE). However, the coexistence of SLE and schizophrenia were rarely reported. We aimed to explore the autoantibody profiles, complement levels and prevalence of SLE in chronic schizophrenia patients. Read More

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September 2021

Identification of a novel immune-related prognostic signature associated with tumor microenvironment for breast cancer.

Int Immunopharmacol 2021 Sep 15;100:108122. Epub 2021 Sep 15.

Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address:

Background: In the view that immune-related genes play a crucial role in breast cancer progression and long-term patient outcomes, we aimed to identify a novel gene signature based on immune-related genes to improve the prognostic prediction of breast cancer.

Methods: RNA sequencing data and clinical information were obtained from The Cancer Genome Atlas (TCGA). Univariate and multivariate Cox regression analyses were conducted to establish the immune-related prognostic signature (IRPS). Read More

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September 2021

Modified Valsalva maneuver for treatment of supraventricular tachycardias: A Meta-analysis.

Am J Emerg Med 2021 Aug 31;50:507-512. Epub 2021 Aug 31.

Department of Heart Center, The First Hospital of Lanzhou University, Medical College of Lanzhou University, Chengguan District, Lanzhou 730000, Gansu, China; Key Laboratory of Cardiovascular Diseases of Gansu Province, Medical College of Lanzhou University, Chengguan District, Lanzhou 730000, Gansu, China. Electronic address:

Backgroud: Valsalva maneuver (VM) is a simple and easy method for acute termination of supraventricular tachycardia (SVT), while a postural modification to the VM has been suggested to be superior to the standard VM (SVM). The objective of this meta-analysis is to explore the efficacy and safety of the modified VM (MVM) to terminate SVT compared with the SVM.

Methods: Extensive literature was conducted using the database such as PubMed, Embase, Web of Science, Cochrane library and included randomized controlled trials (RCTs) assessing the efficacy and safety of the MVM and SVM for SVT. Read More

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Converting scores between the PANSS and SAPS/SANS beyond the positive/negative dichotomy.

Psychiatry Res 2021 Sep 1;305:114199. Epub 2021 Sep 1.

Research Center of the Montreal Mental Health University Institute, Montreal, Quebec, Canada; Department of Psychiatry and Addictology, University of Montreal, Montreal, Quebec, Canada. Electronic address:

Previous work provided conversion equations for overall indices of positive and negative symptomatology between the Positive and Negative Syndrome Scale (PANSS) and the Scales for the Assessment of Positive/Negative Symptoms (SAPS/SANS). Our objective was to provide such conversion equations for subdomains of positive and negative symptomatology in order to better account for the diversity of symptom profiles in schizophrenia. Symptoms severity was assessed using both the PANSS and SAPS/SANS in 205 patients with schizophrenia. Read More

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September 2021

Direct anterior approach vs. SuperPATH vs. conventional approaches in total hip replacement: a network meta-analysis of randomized controlled trials.

Orthop Traumatol Surg Res 2021 Sep 15:103058. Epub 2021 Sep 15.

Department of Trauma, Hand and Reconstructive Surgery, University Hospital Jena, Friedrich Schiller University, Am Klinikum 1, 07747 Jena, Germany.

Background: Two minimally invasive approaches showed some advantages in outcomes compared to conventional approaches (CAs) - the direct anterior approach (DAA) and the supercapsular percutaneously assisted approach in THA (SuperPATH). To the best of our knowledge, DAA and SuperPATH have never been compared in clinical studies before. Therefore, we conducted a systematic review and network meta-analysis of randomized controlled trials comparing short-term outcomes of DAA, SuperPATH and CAs in total hip joint arthroplasty (THA), using CAs as common comparator. Read More

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September 2021

The effect of immunosuppression therapy on activities of daily living and comfort level after liver transplantation.

Transpl Immunol 2021 Sep 15:101468. Epub 2021 Sep 15.

Surgical Nursing Department, Health Sciences Faculty, Gaziosmanpasa University, Erbaa Campus, Tokat, Turkey. Electronic address:

Objectives: This study was carried out to investigate the effect of immunosuppression therapy on activities of daily living and comfort level after liver transplantation.

Materials And Methods: This study was conducted in a descriptive and correlational type with the participation of 148 liver transplant patients hospitalized in the liver transplant center of a university hospital. Personal Information Form, Katz Activities of Daily Living Scale and General Comfort Questionnaire were used in data collection. Read More

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September 2021

Case-control study evaluating risk factors for SARS-CoV-2 outbreak amongst healthcare personnel at a tertiary care center.

Am J Infect Control 2021 Sep 15. Epub 2021 Sep 15.

Stanford University School of Medicine, Stanford, California, USA; Stanford Health Care, Stanford.

Background: Despite several outbreaks of SARS-CoV-2 amongst healthcare personnel (HCP) exposed to COVID-19 patients globally, risk factors for transmission remain poorly understood.

Methods: We conducted an outbreak investigation and case-control study to evaluate SARS-CoV-2 transmission risk in an outbreak among HCP at an academic medical center in California that was confirmed by whole genome sequencing.

Results: A total of 7/9 cases and 93/182 controls completed a voluntary survey about risk factors. Read More

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September 2021

Transcriptomic Repositioning Analysis Identifies mTOR Inhibitor as Potential Therapy for Epidermolysis Bullosa Simplex.

J Invest Dermatol 2021 Sep 15. Epub 2021 Sep 15.

Department of Dermatology, Stanford University Medical Center, Redwood City, CA, USA.

Expression-based systematic drug repositioning has been explored to predict novel treatments for a number of skin disorders. Here, we utilize this approach to identify, to our knowledge, previously unreported therapies for epidermolysis bullosa simplex (EBS). RNA sequencing analysis was performed on skin biopsies of acute blisters (<1 week) (n=9) and non-blistered epidermis (n=11) obtained from 11 EBS patients. Read More

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September 2021

Guideline Recommended Lung Cancer Screening Adherence is Superior with Centralized Approach.

Chest 2021 Sep 15. Epub 2021 Sep 15.

Medical University of South Carolina, Thoracic Oncology Research Group, Division of Pulmonary and Critical Care; Ralph H. Johnson Veteran Affairs Hospital, Health Equity and Rural Outreach Innovation Center (HEROIC). Electronic address:

Background: In order to fully recognize the benefit of lung cancer screening annual adherence must approach the high levels seen in the National Lung Screening Trial. Emerging data suggests annual adherence is poor and that a centralized approach to screening improves adherence.

Research Question: Is there a difference in adherence between a centralized and decentralized approach to lung cancer screening within a hybrid program and what are predictors of adherence?

Study Design: A retrospective evaluation of a single center hybrid lung cancer screening program was conducted to compare outcomes including patient eligibility and adherence between the centralized and decentralized approach. Read More

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September 2021

Central neuroinflammation in Covid-19: a systematic review of 182 cases with encephalitis, acute disseminated encephalomyelitis, and necrotizing encephalopathies.

Rev Neurosci 2021 Sep 17. Epub 2021 Sep 17.

Research Center for Immunodeficiencies, Tehran University of Medical Sciences (TUMS), Children's Medical Center Hospital, Dr. Qarib St., Keshavarz Blvd, Tehran, 14194, Iran.

Growing evidence demonstrates the association of encephalitis, meningoencephalitis or encephalomyelitis, with SARS-CoV-2 infection. This study aims to determine the profile and possible mechanisms behind CNS inflammatory diseases in the context of Covid-19. We conducted a systematic review of case reports on Covid-19-related encephalitis, meningoencephalitis, acute necrotizing encephalitis, and acute disseminated encephalomyelitis in adults, published before January 2021. Read More

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September 2021

Patterns of communicating care and caring in the intensive care unit.

Nurs Open 2021 Sep 18. Epub 2021 Sep 18.

Aim: To explore the perceptions and experiences of nurses in communicating the care and caring in the intensive care unit (ICU).

Design: A focused ethnography.

Methods: This study was conducted in an Australian metropolitan hospital, in which data were gathered from multiple sources: participant observations, document reviews, interviews, and participant's additional written information - over six months (April-September, 2014). Read More

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September 2021

Informed Consent Challenges and Strategies: A Qualitative Study of the Orthodontists' Perspective.

Orthod Craniofac Res 2021 Sep 18. Epub 2021 Sep 18.

Faculty of Medicine & Dentistry, University of Alberta, Alberta, Canada.

Objective: To identify the barriers and strategies perceived by orthodontists when obtaining consent from their adult patients concerning patients' comprehension or recollection of treatment information. Settings and Sample Population The sample comprised 12 orthodontists working in 8 different cities in Alberta, Canada.

Methods: An exploratory investigation using qualitative inquiry was conducted. Read More

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September 2021

An Echocardiography-derived Calcium Score as a Predictor of Major Adverse Cardiovascular Events in Peritoneal Dialysis Patients - A Prospective Cohort Study.

Nephrology (Carlton) 2021 Sep 18. Epub 2021 Sep 18.

Kwong Wah Hospital, Hong Kong.

Background: An echocardiography-derived calcium score (ECS) has been shown to predict CV mortality in the general population but has not been utilized in the dialysis population.

Methods: We conducted a prospective cohort study including 125 prevalent PD patients. Two blinded and independent echocardiographers determined the ECS for each subject at baseline. Read More

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September 2021

Demographic and clinical characteristics of a population-based paediatric cohort of type 1 and type 2 diabetes in Western Australia (1999-2019).

Pediatr Diabetes 2021 Sep 18. Epub 2021 Sep 18.

Children's Diabetes Centre, Telethon Kids Institute, The University of Western Australia, Perth, Western Australia.

Objectives: To determine demographic and clinical characteristics of youth diagnosed with type 1 (T1D) or type 2 (T2D) diabetes aged ≤15 years from 1999-2019 in Western Australia, and examine time to first diagnosis of diabetes complications.

Methods: A retrospective cohort study was conducted of patients identified from the population-based, prospective Western Australian Children's Diabetes Database and longitudinal data extracted for available demographic and clinical variables. Patients were followed from diagnosis to transition to adult services, death or 31 December 2019. Read More

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September 2021

Lesser Known Uses of γ-Aminobutyric Acid Analogue Medications in Otolaryngology.

Laryngoscope 2021 Sep 18. Epub 2021 Sep 18.

Department of Otolaryngology-Head and Neck Surgery, Walter Reed National Military Medical Center, Bethesda, Maryland, U.S.A.

Objectives/hypothesis: In otolaryngology, γ-aminobutyric acid (GABA) analogues have been previously analyzed for their roles in neuropathic pain, chronic cough, tinnitus, and perioperative analgesia. The primary aim of this study is to comprehensively summarize and synthesize the existing evidence for lesser known uses of gabapentin and pregabalin in otolaryngology.

Study Design: A scoping review conducted of the available English-language literature was performed by two authors through April 1, 2021. Read More

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September 2021

Pre-transplant morphometry by computed tomography scan and post-transplant dialysis risk in overweight or obese kidney transplant recipients.

Int Urol Nephrol 2021 Sep 18. Epub 2021 Sep 18.

Department of Urology and Transplantation Surgery, Hôpital de Bicêtre, AP-HP. Université Paris Saclay, 78 rue du général Leclerc, Le Kremlin-Bicêtre, 94270, Paris, France.

Purpose: Adipose distribution and sarcopenia could better assess kidney transplantation outcomes than body mass index (BMI) and have been poorly evaluated among obese and overweight recipients. We aimed to evaluate morphometric radiologic markers to predict post-operative dialysis within this population.

Methods: We conducted a retrospective study including patients with a BMI > 25 kg/m undergoing kidney transplantation during 5 years. Read More

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September 2021

Clinical features of autosomal recessive polycystic kidney disease in the Japanese population and analysis of splicing in PKHD1 gene for determination of phenotypes.

Clin Exp Nephrol 2021 Sep 18. Epub 2021 Sep 18.

Department of Pediatrics, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.

Background: Autosomal recessive polycystic kidney disease (ARPKD) is caused by mutations in the PKHD1 gene. The clinical spectrum is often more variable than previously considered. We aimed to analyze the clinical features of genetically diagnosed ARPKD in the Japanese population. Read More

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September 2021

The COVID-19 pandemic: a new epoch and fresh challenges for cancer patients and caregivers-a descriptive cross-sectional study.

Support Care Cancer 2021 Sep 18. Epub 2021 Sep 18.

Department of Onco-Anesthesia and Palliative Medicine, Dr B.R.A. Institute Rotary Cancer Hospital, AIIMS, New Delhi, 110029, India.

Purpose: Cancer patients and their caregivers are overwhelmed with features of uncertainty, fear, shock, worry, anxiety, sadness, and grief. To add on to their misery, the COVID-19 pandemic has severely afflicted the cancer care delivery. The study was conducted to observe the challenges faced by cancer patients and their caregivers and to formulate strategies for oncological setups to overcome those challenges. Read More

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September 2021

Failure rates of common grafts used in ACL reconstructions: a systematic review of studies published in the last decade.

Arch Orthop Trauma Surg 2021 Sep 18. Epub 2021 Sep 18.

PRIVATKLINIK HOCHRUM, Sanatorium der Kreuzschwestern, Lärchenstraße 41, 6063, Rum, Austria.

Introduction: In this review paper, graft failure rates of different graft types (hamstring tendon autografts, bone-patellar tendon-bone autografts, quadriceps tendon autografts and diverse allografts) that are used for surgical reconstruction of the anterior cruciate ligament are compared and statistically analysed.

Methods: Literature search was conducted in PubMed according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) criteria. A total of 194 studies, which reported graft failure rates of at least one of the anterior cruciate ligament reconstruction methods mentioned above, were included in this systematic review. Read More

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September 2021

Shared medical appointments for weight loss: a systematic review.

Fam Pract 2021 Sep 18. Epub 2021 Sep 18.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Australia.

Purpose: Shared medical appointments (SMAs) may help mitigate some of the barriers for managing obesity in primary care. The primary aim of this systematic review was to measure the effect of weight loss SMAs.

Methods: Systematic searches using keywords and Medical Subject Headings for overweight, obesity, and SMAs were conducted in the CENTRAL, Medline Complete, PsycINFO, Scopus, CINAHL, EMBASE, and Web of Science databases with no date limits. Read More

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September 2021

Continuity of care for patients with chronic disease: a registry-based observational study from Norway.

Fam Pract 2021 Sep 18. Epub 2021 Sep 18.

Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.

Background: Continuity of care (CoC) is accepted as a core value of primary care and is especially appreciated by patients with chronic conditions. Nevertheless, there are few studies investigating CoC for these patients across levels of healthcare.

Objective: This study aims to investigate CoC for patients with somatic chronic diseases, both with regular general practitioners (RGPs) and across care levels. Read More

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September 2021

Use of Complementary and Alternative Therapy for Knee Osteoarthritis: Race and Gender Variations.

ACR Open Rheumatol 2021 Sep 19;3(9):660-667. Epub 2021 Jul 19.

Veterans Affairs Pittsburgh Healthcare System and University of Pittsburgh, Pittsburgh, Pennsylvania.

Objective: To evaluate race and gender variations in complementary and alternative medicine (CAM) use for knee osteoarthritis (OA) (unadjusted and adjusted for demographic and clinical factors).

Methods: A secondary analysis of cross-sectional data was conducted. The sample included Veterans Affairs patients 50 years of age or older with symptomatic knee OA. Read More

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September 2021

Post-burn scar malignancy: 5-year management review and experience.

Int Wound J 2021 Sep 18. Epub 2021 Sep 18.

Surgical Oncology, Medical School of Bany-Swif University, Bany-Swif, Egypt.

The study spotlights a severe uncommon post-burn complication, Marjolin's ulcer, in upper Egypt plastic and wound care centres. This problem is mainly related to inadequate medical care and awareness. No community or race is immune. Read More

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September 2021