60,549 results match your criteria conditions wide


Effects of long-term vegan diet on breath composition.

J Breath Res 2022 Jan 20. Epub 2022 Jan 20.

Department of Chemistry and Industrial Chemistry, Universita degli Studi di Pisa Dipartimento di Chimica e Chimica Industriale, Via G. Moruzzi, 13, Pisa, Tuscany, 56124, ITALY.

The composition of exhaled breath derives from an intricate combination of normal and abnormal physiological processes that are modified by the consumption of food and beverages, circadian rhythms, bacterial infections, and genetics as well as exposure to xenobiotics. This complexity, which results wide intra- and inter-individual variability and is further influenced by sampling conditions, hinders the identification of specific biomarkers and makes it difficult to differentiate between pathological and nominally healthy subjects. The identification of a "normal" breath composition and the relative influence of the aforementioned parameters would make breath analyses much faster for diagnostic applications. Read More

View Article and Full-Text PDF
January 2022

Monitoring tissue engineered constructs and protocols with laboratory-based x-ray phase contrast tomography.

Acta Biomater 2022 Jan 17. Epub 2022 Jan 17.

Department of Medical Physics and Biomedical Engineering, University College London, London, WC1E 6BT, UK. Electronic address:

Tissue engineering (TE) aims to generate bioengineered constructs which can offer a surgical treatment for many conditions involving tissue or organ loss. Construct generation must be guided by suitable assessment tools. However, most current tools (e. Read More

View Article and Full-Text PDF
January 2022

ChIP-seq assay revealed histone modification H3K9ac involved in heat shock response of the sea cucumber Apostichopus japonicus.

Sci Total Environ 2022 Jan 17:153168. Epub 2022 Jan 17.

School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, Shandong 266109, China. Electronic address:

Heat stress poses an increasing threat for the marine invertebrate Apostichopus japonicus. Histone lysine acetylation is a central chromatin modification for epigenetic regulation of gene expression during stress response. In this study, a genome-wide characterization for acetylated lysine 9 on histone H3 (H3K9ac) binding regions in normal temperature (18 °C) and heat-stress conditions (26 °C) via ChIP-seq were carried out. Read More

View Article and Full-Text PDF
January 2022

Effects of abiotic factors on the stability and infectivity of polyvalent coliphage.

Water Sci Technol 2022 Jan;85(1):141-151

College of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu, Sichuan 610500, PR China E-mail: Research Institute of Industrial Hazardous Waste Disposal and Resource Utilization, Southwest Petroleum University, Chengdu, Sichuan 610500, PR China.

Bacteriophage has attracted growing interest as a promising therapeutic agent for pathogenic bacteria, especially for antibiotic-resistant bacteria. However, the various abiotic conditions could impact the stability of phages and further threat host-virus interactions. Here, we investigated the stability and lytic activity of virulent polyvalent coliphage (named PE1) by double-layer plaque assay. Read More

View Article and Full-Text PDF
January 2022

Bioinspired Self-Powered Piezoresistive Sensors for Simultaneous Monitoring of Human Health and Outdoor UV Light Intensity.

ACS Appl Mater Interfaces 2022 Jan 20. Epub 2022 Jan 20.

Key Laboratory for Analytical Science of Food Safety and Biology (MOE & Fujian Province), Department of Chemistry, Fuzhou University, Fuzhou 350108, People's Republic of China.

The exact fabrication of precise three-dimensional structures for piezoresistive sensors necessitates superior manufacturing methods or tooling, which are accompanied by time-consuming processes and the potential for environmental harm. Herein, we demonstrated a method for synthesis of zinc oxide nanorod (ZnO NR) arrays on graphene-treated cotton and paper substrates and constructed highly sensitive, flexible, wearable, and chemically stable strain sensors. Based on the structure of pine trees and needles in nature, the hybrid sensing layer consisted of graphene-attached cotton or paper fibers and ZnO NRs, and the results showed a high sensitivity of 0. Read More

View Article and Full-Text PDF
January 2022

A multi-environment framework to evaluate the adaptation of wheat (Triticum aestivum) to heat stress.

Theor Appl Genet 2022 Jan 20. Epub 2022 Jan 20.

Australian Grain Technologies, 20 Leitch Road, Roseworthy, SA, 5371, Australia.

Key Message: Assessing adaptation to abiotic stresses such as high temperature conditions across multiple environments presents opportunities for breeders to target selection for broad adaptation and specific adaptation. Adaptation of wheat to heat stress is an important component of adaptation in variable climates such as the cereal producing areas of Australia. However, in variable climates stress conditions may not be present in every season or are present to varying degrees, at different times during the season. Read More

View Article and Full-Text PDF
January 2022

Strategies Shaping the Transcription of Carbohydrate-Active Enzyme Genes in .

J Fungi (Basel) 2022 Jan 14;8(1). Epub 2022 Jan 14.

Department of Molecular Biotechnology and Microbiology, Faculty of Sciences and Technology, University of Debrecen, Egyetem tér 1, 4032 Debrecen, Hungary.

Understanding the coordinated regulation of the hundreds of carbohydrate-active enzyme (CAZyme) genes occurring in the genomes of fungi has great practical importance. We recorded genome-wide transcriptional changes of cultivated on glucose, lactose, or arabinogalactan, as well as under carbon-starved conditions. We determined both carbon-stress-specific changes (weak or no carbon source vs. Read More

View Article and Full-Text PDF
January 2022

Biosynthesis Pathways, Transport Mechanisms and Biotechnological Applications of Fungal Siderophores.

J Fungi (Basel) 2021 Dec 28;8(1). Epub 2021 Dec 28.

School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Tianjin 300072, China.

Iron (Fe) is the fourth most abundant element on earth and represents an essential nutrient for life. As a fundamental mineral element for cell growth and development, iron is available for uptake as ferric ions, which are usually oxidized into complex oxyhydroxide polymers, insoluble under aerobic conditions. In these conditions, the bioavailability of iron is dramatically reduced. Read More

View Article and Full-Text PDF
December 2021

A Multi-Species Investigation of Sponges' Filtering Activity towards Marine Microalgae.

Mar Drugs 2021 Dec 24;20(1). Epub 2021 Dec 24.

Institute of Marine Biology, Biotechnology & Aquaculture, Hellenic Centre for Marine Research, 715 00 Heraklion, Greece.

Chronic discharge of surplus organic matter is a typical side effect of fish aquaculture, occasionally leading to coastal eutrophication and excessive phytoplankton growth. Owing to their innate filter-feeding capacity, marine sponges could mitigate environmental impact under integrated multitrophic aquaculture (IMTA) scenarios. Herein, we investigated the clearance capacity of four ubiquitous Mediterranean sponges (, , and ) against three microalgal substrates with different size/motility characteristics: the nanophytoplankton sp. Read More

View Article and Full-Text PDF
December 2021

Lipid profile, lipid ratios, apolipoproteins, and risk of cardiometabolic multimorbidity in men: The Kuopio Ischaemic Heart Disease Risk Factor Study.

Lipids 2022 Jan 20. Epub 2022 Jan 20.

Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.

The blood level of lipids, apolipoproteins, and lipid ratios are important predictors of some chronic diseases. However, their association with cardiometabolic multimorbidity (CMM) is less known. We evaluated a wide range of lipid profiles and lipid ratios, including low-density lipoprotein-cholesterol (LDL-C), very-low-density lipoprotein-cholesterol (VLDL-C), high-density lipoprotein-cholesterol (HDL-C), and apoA1 and B, as well triglyceride and total cholesterol with risk of incident CMM. Read More

View Article and Full-Text PDF
January 2022

Digital interventions in mental health: evidence syntheses and economic modelling.

Health Technol Assess 2022 Jan;26(1):1-182

Centre for Health Economics, University of York, York, UK.

Background: Economic evaluations provide evidence on whether or not digital interventions offer value for money, based on their costs and outcomes relative to the costs and outcomes of alternatives.

Objectives: (1) Evaluate and summarise published economic studies about digital interventions across different technologies, therapies, comparators and mental health conditions; (2) synthesise clinical evidence about digital interventions for an exemplar mental health condition; (3) construct an economic model for the same exemplar mental health condition using the previously synthesised clinical evidence; and (4) consult with stakeholders about how they understand and assess the value of digital interventions.

Methods: We completed four work packages: (1) a systematic review and quality assessment of economic studies about digital interventions; (2) a systematic review and network meta-analysis of randomised controlled trials on digital interventions for generalised anxiety disorder; (3) an economic model and value-of-information analysis on digital interventions for generalised anxiety disorder; and (4) a series of knowledge exchange face-to-face and digital seminars with stakeholders. Read More

View Article and Full-Text PDF
January 2022

Hydroxylation of Platinum Surface Oxides Induced by Water Vapor.

J Phys Chem Lett 2022 Jan 20:879-883. Epub 2022 Jan 20.

Fritz-Haber-Institut der Max-Plack-Gesellschaft, Faradayweg 4-6, 14195 Berlin, Germany.

With its high stability and well-tuned binding strength for adsorbates, platinum is an excellent catalyst for a wide range of reactions. In applications like car exhaust purification, the oxidation of hydrocarbons, and fuel cells, platinum is exposed to highly oxidizing conditions, which often leads to the formation of surface oxides. To reveal the structure of these surface oxides, the oxidation of Pt in O has been widely studied. Read More

View Article and Full-Text PDF
January 2022

State-wide increase in prenatal diagnosis of Klinefelter syndrome on amniocentesis and chorionic villus sampling: impact of non-invasive prenatal testing (NIPT) for sex chromosome conditions.

Prenat Diagn 2022 Jan 19. Epub 2022 Jan 19.

Reproductive Epidemiology group, Murdoch Children's Research Institute, Parkville, VIC, Australia.

Background: To analyse population-based trends in the prenatal diagnosis of sex chromosome aneuploidy (SCA) since the availability of non-invasive prenatal testing (NIPT).

Methods: Retrospective state-wide data for all prenatal diagnoses performed <25 weeks gestation from 2005-20 in Victoria, Australia. NIPT became locally available from 2012. Read More

View Article and Full-Text PDF
January 2022

Achieving Large-Scale Quality Improvement in Primary Care Annual Wellness Visits and Hierarchical Condition Coding.

J Gen Intern Med 2022 Jan 19. Epub 2022 Jan 19.

University Hospitals, Cleveland, OH, USA.

Background: Completion of Medicare Annual Wellness Visits (AWV) and documentation of Hierarchical Condition Categories (HCC) are important metrics in accountable care organizations (ACO) with quality and financial implications. To improve performance in large healthcare organizations, quality improvement (QI) efforts need to be scaled up in a way that is feasible within available system-wide resources.

Objective: We describe a 3-year effort using a multifaceted QI framework called the fractal management system for AWV and HCC performance. Read More

View Article and Full-Text PDF
January 2022

Genome-Wide Identification and Expression Profile Analysis of the SnRK2 Gene Family in Nicotiana tabacum.

Biochem Genet 2022 Jan 20. Epub 2022 Jan 20.

Chongqing Branch of China National Tobacco Corporation, Chongqing, 400715, China.

SnRK2 protein kinase family plays an important role in plant response to abiotic stress and has been identified in various plants. This study aimed to identify SnRK2 genes in tobacco and systematically analyze their expression under abscisic acid treatment and abiotic stress. We identified 22 NtSnRK2 members, which were divided into three groups and located on 13 chromosomes, mainly at both ends of the chromosomes; additionally, 11 duplicated NtSnRK2 gene pairs were observed. Read More

View Article and Full-Text PDF
January 2022

Photoredox catalyzed cascade CF addition/chemodivergent annulations of -alkenyl aryl ureas.

Chem Commun (Camb) 2022 Jan 20. Epub 2022 Jan 20.

Department of Chemistry, Indian Institute of Science Education and Research (IISER) Tirupati, Tirupati 517507, India.

Herein, we report a substrate-controlled cascade cyclization of -alkenyl aryl ureas, an ambident nucleophile for constructing functionalized heterocycles such as 2-amino-1,3-benzoxazines and dihydroquinazolinones in a chemodivergent fashion using photoredox catalysis under mild conditions. The versatility of the method has been successfully demonstrated by applying this strategy to a wide range of substrates and for the synthesis of functionalized etifoxine drug derivatives. Read More

View Article and Full-Text PDF
January 2022

Adaptive and powerful microbiome multivariate association analysis via feature selection.

NAR Genom Bioinform 2022 Mar 14;4(1):lqab120. Epub 2022 Jan 14.

The important role of human microbiome is being increasingly recognized in health and disease conditions. Since microbiome data is typically high dimensional, one popular mode of statistical association analysis for microbiome data is to pool individual microbial features into a group, and then conduct group-based multivariate association analysis. A corresponding challenge within this approach is to achieve adequate power to detect an association signal between a group of microbial features and the outcome of interest across a wide range of scenarios. Read More

View Article and Full-Text PDF

Co-expression networks uncover regulation of splicing and transcription markers of disease.

Proc Annu Int Conf BioInform Comput Biol 2020 11;70:119-128. Epub 2020 Mar 11.

Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, the U.S.

Gene co-expression networks based on gene expression data are usually used to capture biologically significant patterns, enabling the discovery of biomarkers and interpretation of regulatory relationships. However, the coordination of numerous splicing changes within and across genes can exert a substantial impact on the function of these genes. This is particularly impactful in studies of the properties of the nervous system, which can be masked in the networks that only assess the correlation between gene expression levels. Read More

View Article and Full-Text PDF

Dissecting the Genetics of Early Vigour to Design Drought-Adapted Wheat.

Front Plant Sci 2021 3;12:754439. Epub 2022 Jan 3.

Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Brisbane, QLD, Australia.

Due to the climate change and an increased frequency of drought, it is of enormous importance to identify and to develop traits that result in adaptation and in improvement of crop yield stability in drought-prone regions with low rainfall. Early vigour, defined as the rapid development of leaf area in early developmental stages, is reported to contribute to stronger plant vitality, which, in turn, can enhance resilience to erratic drought periods. Furthermore, early vigour improves weed competitiveness and nutrient uptake. Read More

View Article and Full-Text PDF
January 2022

Characteristics of Patient Encounters for Athletic Training Students during Clinical Education: A Report from the AATE Research Network.

J Athl Train 2022 Jan 19. Epub 2022 Jan 19.

Dean, College of Health Sciences, Old Dominion University.

Context: To enhance the quality of patient care, athletic training students (ATSs) should experience a wide variety of clinical practice settings, interact with diverse patient populations, and engage with patients that have a wide variety of conditions. It is unclear in what ways, if any, ATSs have diverse opportunities during clinical experiences.

Objective: To describe the characteristics of patient encounters (PEs) ATSs engage in during clinical experiences. Read More

View Article and Full-Text PDF
January 2022

Systematic Assessment of the Accuracy of Subunit Counting in Biomolecular Complexes Using Automated Single-Molecule Brightness Analysis.

J Phys Chem Lett 2022 Jan 19:822-829. Epub 2022 Jan 19.

Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen 72076, Germany.

Analysis of single-molecule brightness allows subunit counting of high-order oligomeric biomolecular complexes. Although the theory behind the method has been extensively assessed, systematic analysis of the experimental conditions required to accurately quantify the stoichiometry of biological complexes remains challenging. In this work, we develop a high-throughput, automated computational pipeline for single-molecule brightness analysis that requires minimal human input. Read More

View Article and Full-Text PDF
January 2022

Simulations to cover the waterfront for iron oxide catalysis.

Chemphyschem 2022 Jan 19. Epub 2022 Jan 19.

Technion - Israel Institute of Technology, Department of Materials Science and Engineering, Technion City, 3600003, Haifa, ISRAEL.

Hematite has been widely studied for catalytic water splitting, but the role of the interactions between catalytic sites is unknown. In this paper, we calculate the oxygen evolution reaction free energies and the surface adsorption distribution using a combination of density functional theory and Monte Carlo Simulations to "cover the waterfront," or cover a wide range of properties with a simulation of the hematite surface under working conditions. First, we show that modeling noninteracting catalytic sites provides a poor explanation of hematite's slow reaction kinetics. Read More

View Article and Full-Text PDF
January 2022

Presurgical Orthopedic Treatment of a 3-Year-Old Child with Unoperated Complete Bilateral Cleft Lip and Palate and Protruding Premaxilla.

Cleft Palate Craniofac J 2022 Jan 19:10556656221074190. Epub 2022 Jan 19.

University of Nis, Nis, Republic of Serbia.

Unoperated patients with bilateral complete cleft lip and palate (BCCLP), who do not receive orthopedic treatment in infancy and present with significant sagittal excess of the premaxilla, are among the most difficult patients to treat. Delay in primary reconstruction reduces the elastic characteristics of the tissues. The resulting rigidity of bony structures accompanied by the wide alveolar and palatal clefts associated with sagittal excess of the premaxilla pose a great challenge for both surgeon and orthodontist. Read More

View Article and Full-Text PDF
January 2022

Construction of Synthetic Microbial Ecosystems and the Regulation of Population Proportion.

ACS Synth Biol 2022 Jan 19. Epub 2022 Jan 19.

State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266000, China.

With the development of synthetic biology, the design and application of microbial consortia have received increasing attention. However, the construction of synthetic ecosystems is still hampered by our limited ability to rapidly develop microbial consortia with the required dynamics and functions. By using modular design, we constructed synthetic competitive and symbiotic ecosystems with . Read More

View Article and Full-Text PDF
January 2022

Sodium-ion Battery with a Wide Operation-Temperature Range from -70 to 100 °C.

Angew Chem Int Ed Engl 2022 Jan 19. Epub 2022 Jan 19.

Fudan University, Handan Road 220, 200433, Shanghai, CHINA.

Sodium-ion batteries (SIBs), as one of the potential candidates for grid-scale energy storage systems, are required to tackle extreme weather conditions. However, the all-weather SIBs with a wide operation-temperature range are rarely reported. Herein, we propose a wide-temperature SIB, which involves a carbon-coated Na 4 Fe 3 (PO 4 ) 2 P 2 O 7 ([email protected]) cathode, a Bismuth (Bi) anode, and a diglyme-based electrolyte. Read More

View Article and Full-Text PDF
January 2022

Surface-enhanced Raman spectroscopy detection of organic molecules and monitoring of organic reactions by ion-induced silver nanoparticle clusters.

Phys Chem Chem Phys 2022 Jan 19. Epub 2022 Jan 19.

Faculty of Medicine, Faculty of Biochemistry and Molecular Medicine, University of Oulu, 2125B, Aapistie 5A, 90220 Oulu, Finland.

Surface-enhanced Raman spectroscopy (SERS) finds wide applications in the field of organic molecule detection. However, reliable SERS detection of organic molecules and monitoring of organic reactions under natural conditions by metal colloids are still challenging due to the formation of unstable nanoparticle clusters in solution and the low solubility of the organic molecules. Here, we approach the problems by introducing calcium ions to aggregate silver nanoparticles to form stable hot spots and acetone to promote uniform distribution of organic molecules on the nanoparticle surface. Read More

View Article and Full-Text PDF
January 2022

Iodine-catalyzed oxidative annulation: facile synthesis of pyrazolooxepinopyrazolones methyl azaarene sp C-H functionalization.

Org Biomol Chem 2022 Jan 19. Epub 2022 Jan 19.

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Shandong, Yantai, 264005, P. R. China.

An iodine-catalyzed methyl azaarene sp C-H functionalization has been developed for the synthesis of a seven-membered -heterocyclic architecture containing three different heterocyclic aromatic hydrocarbons. This method can be applied to a wide range of substituted methyl azaarenes and diverse 2,4-dihydro-3-pyrazol-3-ones, and brings about the efficient preparation of 2,9-dihydrooxepino[2,3-:6,5-']dipyrazol-3(7)-ones in high yields with the merits of low catalyst loading, good functional group tolerance and metal-free conditions. Read More

View Article and Full-Text PDF
January 2022

In Vitro Cytotoxicity and Apoptosis Inducing Evaluation of Novel Halogenated Isatin Derivatives.

Anticancer Agents Med Chem 2022 Jan 19. Epub 2022 Jan 19.

Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Isatin (1H-indole-2,3-dione) and its derivatives have been shown their responsibility in a wide range of biological activities. Among the range of beneficial properties, anticancer compounds were the most extensively highlighted and explored.

Objective: Herein, we report the targeting effect of halogenated isatin derivatives on cancer cell mitochondria and their antiproliferative mechanism. Read More

View Article and Full-Text PDF
January 2022

Adaptive Metabolism of Revealed by Untargeted Metabolomics.

J Proteome Res 2022 Jan 19. Epub 2022 Jan 19.

Department of Human Sciences, The Ohio State University, Columbus, Ohio 43210, United States.

(SA) is an opportunistic pathogen that can cause a wide spectrum of infections, from superficial skin inflammation to severe and potentially fatal and invasive diseases. Due to the many potential routes of infection, host-derived environmental signals (oxygen availability, nutrients, etc.) are vital for host colonization and thus contribute to SA's pathogenesis. Read More

View Article and Full-Text PDF
January 2022