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Identification of seven exonic variants in the SLC4A1, ATP6V1B1 and ATP6V0A4 gene that alter RNA splicing by minigene assay.

Hum Mutat 2021 Jun 22. Epub 2021 Jun 22.

Department of Nephrology, the Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, China.

Primary distal renal tubular acidosis(dRTA) is a rare tubular disease associated with variants in SLC4A1, ATP6V0A4, ATP6V1B1, FOXⅠ1 or WDR72 genes. Currently, there is growing evidence that all types of exonic variants can alter splicing regulatory elements, affecting the pre-mRNA splicing process. This study was to determine the consequences of variants associated with dRTA on pre-mRNA splicing combined with predictive bioinformatics tools and minigene assay. Read More

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Diabetic wound healing: The impact of diabetes on myofibroblast activity and its potential therapeutic treatments.

Wound Repair Regen 2021 Jun 22. Epub 2021 Jun 22.

Department of Surgery, Division of Plastic and Reconstructive Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Diabetes is a systemic disease in which the body cannot regulate the amount of sugar, namely glucose, in the blood. High glucose toxicity has been implicated in the dysfunction of diabetic wound healing, following insufficient production (Type 1) or inadequate usage (Type 2) of insulin. Chronic non-healing diabetic wounds are one of the major complications of both types of diabetes, which are serious concerns for public health and can impact the life quality of patients significantly. Read More

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Thrombosis and Dissection of the Abdominal Arteries Associated with Infarcts of Solid Organs in a Patient with COVID-19: A Novel Clinical Entity.

Hamostaseologie 2021 Jun 22. Epub 2021 Jun 22.

Clinic of Angiology, University Hospital Zurich, Zurich, Switzerland.

The clinical spectrum of patients with coronavirus disease 2019 (COVID-19) ranges from asymptomatic cases to severe pneumonia with acute respiratory distress syndrome. COVID-19 is associated with an increased risk of thromboembolic complications, notably pulmonary embolism and deep vein thrombosis. Arterial cardiovascular complications and myocarditis have also been described in association with COVID-19, but appear to be less prevalent. Read More

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Can Mozart Improve Weight Gain and Development of Feeding Skills in Premature Infants? A Randomized Trial.

Am J Perinatol 2021 Jun 22. Epub 2021 Jun 22.

Department of Pediatrics, Christiana Care Health System, Newark, Delaware.

Objective:  The study aimed to assess in a prospective randomized study the effect of Mozart's music on time to regain birth weight (BW) and development of oral feeding skills in babies born between 28 and 31 weeks of gestation.

Study Design:  Healthy premature infants born between 28 and 31 completed weeks of gestation were randomized within 3 days of birth to either music or no music exposure. Infants in the music group were exposed to Mozart's double piano sonata twice per day for 14 days. Read More

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Eye Banks: Future Perspectives.

Klin Monbl Augenheilkd 2021 Jun 22;238(6):674-678. Epub 2021 Jun 22.

Klinik für Augenheilkunde, Universitätsklinikum Düsseldorf, Deutschland.

Technological progress and societal change are transforming medicine, and cornea banks are no exception. New infectiological factors, statutory requirements, management concepts, globalisation and digitalisation are also influencing how such facilities will operate in the future. The goal of providing high quality material to patients with corneal disease remains unaltered. Read More

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[Reversible left ventricular hypertrophy and congestive heart failure due to suspected myocarditis in a cat in the course of FLUTD].

Sonja Sinzinger

Tierarztl Prax Ausg K Kleintiere Heimtiere 2021 Jun 22;49(3):220-227. Epub 2021 Jun 22.

Tierklinik Stuttgart Plieningen GbR.

A 2.5-year-old castrated male domestic shorthair cat with a past pertinent history of FLUTD treatment 8 days earlier was presented during the night due to apathy and anorexia. Radiographs, ECG, blood pressure measurement and echocardiography revealed left-sided congestive heart failure, left ventricular concentric hypertrophy, left atrial dilation, severe diastolic dysfunction, hypotension, and vagotonus-associated sinus bradycardia with a first degree AV-block as well as a right bundle brunch block. Read More

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[Granulomatous colitis in a French Bulldog puppy].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2021 Jun 22;49(3):212-218. Epub 2021 Jun 22.

Klinikum Veterinärmedizin, Klinik für Kleintiere, Innere Medizin, Justus-Liebig-Universität Gießen.

A 6-month-old French bulldog was presented due to chronic large intestinal diarrhea of 4 months duration. The diagnostic procedures initiated by the referring veterinarian had resulted in a tentative diagnosis of chronic enteropathy, however treatment consisting of elimination diet as well as antibiotic, anthelmintic, anti-inflammatory and immunosuppressive medication had been unsuccessful. By means of endoscopy and histological examination, pronounced erosions and ulcerations of the colonic mucosa were detected. Read More

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Maintenance treatment in relapsed canine lymphoma after a short L-CHOP protocol.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2021 Jun 22;49(3):185-194. Epub 2021 Jun 22.

Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Faculty of Veterinary Medicine, LMU Munich.

Objective: A number of different rescue protocols for relapsed canine multicentric large-cell lymphoma have been described. The aim of this pilot study was to evaluate the efficacy of a maintenance treatment in dogs that experienced a second complete remission after a short L-CHOP-rescue protocol.

Material And Methods: Included in the study were dogs experiencing the first lymphoma relapse during a treatment-free period which were treated with a short L-CHOP protocol, achieved a complete remission and were afterwards treated with a continuous maintenance phase (MP) protocol. Read More

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An individually adjusted endurance test reveals differences in physical fitness between young and old Beagles.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2021 Jun 22;49(3):165-172. Epub 2021 Jun 22.

Clinic for Small Animals, University of Veterinary Medicine, Foundation.

Objective: Aim was to establish an individually adapted endurance test for dogs on a treadmill, which takes the individual's physical condition into account. To check the applicability of the test, two age groups of clinically healthy beagles were examined.

Methods: A total of 10 clinically healthy Beagles were enrolled and divided in a younger (1-3 years, n = 5) and older group (> 8 years, n = 5). Read More

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Cannabis use of patients with inflammatory bowel disease in Germany: a cross-sectional survey.

Z Gastroenterol 2021 Jun 22. Epub 2021 Jun 22.

Department for Internal and Integrative Medicine, Sozialstiftung Bamberg, Bamberg, Germany.

Background And Aims:  Progressive legalization and increasing utilization of medical cannabis open up potential new applications, including for inflammatory bowel disease (IBD). This study aimed to collect current figures on the use of and experience with cannabis among IBD patients in Germany.

Methods:  A 71-item questionnaire was mailed to a randomly selected representative sample of 1000 IBD patients. Read More

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Prevalence and risk factors of undiagnosed diabetes mellitus among gastroenterological patients: a HbA1c-based single center experience.

Z Gastroenterol 2021 Jun 22. Epub 2021 Jun 22.

I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: Diabetes mellitus is a major risk factor for microvascular disease, leading to chronic kidney injury or cardiovascular disease, but there is a tremendous proportion of patients worldwide who suffer from undiagnosed diabetes. Until now, little is known about the prevalence of undiagnosed diabetes in gastroenterology inpatients.

Objective: To improve detection of undiagnosed diabetes, a routine screening procedure for gastroenterology inpatients, based on hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG) measurement, was established. Read More

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Medicinal Plants in the Treatment of Depression. II: Evidence from Clinical Trials.

Planta Med 2021 Jun 22. Epub 2021 Jun 22.

Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Valencia, Spain.

Depression is a syndrome characterized by deep sadness and the inhibition of psychic functions, sometimes accompanied by neurovegetative disorders, with symptoms of anxiety almost always present. The disease produces alterations in a variety of neural networks and neurotransmission systems, along with a dysfunction of the hypothalamic-pituitary-adrenal axis, which leads to concomitant alterations in the immunological response. Generally, there is a parallel increase in proinflammatory mediators as well as oxidative and nitrosative damage caused by a reduction of antioxidant defenses. Read More

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Exploring Nanoemulsions for Prostate Cancer Therapy.

Drug Res (Stuttg) 2021 Jun 22. Epub 2021 Jun 22.

Faculty of Pharmacy, Integral University, Lucknow, India.

Prostate carcinoma is typical cancer. It is the second most common cancer globally. The estimated new cases in 2020 was 191 930 and estimated deaths was 33 330. Read More

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[Surgery site healing disorder following laparotomy in cattle: a retrospective study].

Tierarztl Prax Ausg G Grosstiere Nutztiere 2021 Jun 22;49(3):157-166. Epub 2021 Jun 22.

Universitätsklinik für Wiederkäuer, Department für Nutztiere und öffentliches Gesundheitswesen in der Veterinärmedizin, Veterinärmedizinische Universität Wien.

Objectives: Wound healing processes in consequence to bovine abdominal surgery performed from 2007 to 2016 at the University of Veterinary Medicine in Vienna were retrospectively assessed. The aim of this study was to evaluate the occurrence of wound healing complications following abdominal surgery in cattle during this 10-year-period as well as to identify possible risk factors such as elevated temperatures.

Material And Methods: Surgical procedures finding inclusion comprised ileus, left and right abomasal displacement, caecal dilation or displacement (right flank laparotomies), foreign body syndrome (left flank laparotomy), and umbilical surgery. Read More

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Hyperbaric oxygen treatment for intrauterine limb ischaemia: a newborn in the chamber.

Diving Hyperb Med 2021 Jun;51(2):220-223

Istanbul Faculty of Medicine, Underwater and Hyperbaric Medicine Department, Istanbul, Turkey.

Intrauterine limb ischaemia is a rare condition that may have devastating results. Various treatments are reported in the literature; however, results are not always promising and amputations may be required for some patients. Post-natal hyperbaric oxygen treatment (HBOT) may be a useful treatment option for the salvage of affected limbs. Read More

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Hyperbaric oxygen treatment for toxic epidermal necrolysis: A case report.

Diving Hyperb Med 2021 Jun;51(2):216-219

University of Health Sciences, Kartal Dr Lütfi Kirdar City Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey.

Toxic epidermal necrolysis (TEN) is a potentially life-threatening muco-cutaneous disease, largely caused by an idiosyncratic reaction to medication or infectious disease, and is characterised by acute necrosis of the epidermis. No definitive consensus regarding the treatment of TEN has been agreed. A 60-year-old woman, diagnosed with multiple myeloma three months prior, was admitted with signs of TEN to the intensive care burns unit. Read More

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Sinus barotrauma in diving.

Diving Hyperb Med 2021 Jun;51(2):182-189

Department of Otorhinolaryngology - Head and Neck Surgery, Head and Neck Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Introduction: Sinus barotrauma is a common occurrence in diving and subaquatic medicine, potentially compromising dive safety. To gain a more thorough understanding of the condition, an in-depth investigation is justified.

Methods: This was a survey study. Read More

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The impact of different gas mixtures on inflammatory responses in advanced recreational divers.

Diving Hyperb Med 2021 Jun;51(2):140-146

Department of Surgical and Medical Science and Translation Medicine, Sapienza University, Rome, Italy.

Introduction: Decompression sickness (DCS) is considered a 'bubble disease'. Intravascular bubbles activate inflammatory responses associated with endothelial dysfunction. Breathing gas has been proposed as a potential risk factor but this is inadequately studied. Read More

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Validation of the Skåne University Hospital nomogram for the preoperative prediction of a disease-free axilla in patients with breast cancer.

BJS Open 2021 May;5(3)

Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Background: Axillary staging via sentinel lymph node biopsy (SLNB) is performed for clinically node-negative (N0) breast cancer patients. The Skåne University Hospital (SUS) nomogram was developed to assess the possibility of omitting SLNB for patients with a low risk of nodal metastasis. Area under the receiver operating characteristic curve (AUC) was 0. Read More

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Ordered multi-path propagation for vessel centerline extraction.

Phys Med Biol 2021 Jun 22. Epub 2021 Jun 22.

School of Optics and Photonics, Beijing Institute of Technology, NO.5 Zhongguancun south street, Beijing, 100081, CHINA.

Vessel centerline extraction from x-ray angiography (XRA) images is essential for vessel structure analysis in the diagnosis of coronary artery disease. However, complete and continuous centerline extraction remains a challenging task due to image noise, poor contrast, and complexity of vessel structure. Thus, an iterative multi-path search framework for automatic vessel centerline extraction is proposed. Read More

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Technical evaluation of a prototype ratio 29:1 grid for adult patient cardiovascular angiography imaging conditions.

Phys Med Biol 2021 Jun 22. Epub 2021 Jun 22.

Mayo Clinic Minnesota, Rochester, Minnesota, UNITED STATES.

The purpose of this work was to assess technical performance of a prototype high ratio (r29), 80 line cmgrid for imaging conditions which mimic those for adult cardiovascular angiography. The standard equipment r15, 80 line cmgrid was used as a reference. Plastic Water® LR phantoms with thickness in the range 20 to 44 cm were used to simulate adult patient attenuation and scatter. Read More

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Parkinson's disease and REM sleep behavior disorder with special reference to cognitive decline.

Tomoyuki Kawada

Eur Neuropsychopharmacol 2021 Jun 19;51:105. Epub 2021 Jun 19.

Department of Hygiene and Public Health, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-Ku, Tokyo 113-8602, Japan. Electronic address:

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The risk of depression and anxiety in patients with familial mediterranean fever - a cross-sectional study.

J Affect Disord 2021 Jun 6;292:695-699. Epub 2021 Jun 6.

Division of Psychiatry, Barzilai Medical Center, Ashkelon, Israel.

Background: Familial Mediterranean Fever (FMF) is an autosomal recessive autoinflammatory disease associated with various systemic comorbidities. Recent research regarding the association with depression and anxiety has yielded conflicting results. The current study aims were to examine whether such an association exists using big data analysis methodology. Read More

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Characteristics and oncologic outcomes of patients with Ewing Sarcoma of the scapula.

Surg Oncol 2021 Jun 16;38:101619. Epub 2021 Jun 16.

Department of Orthopaedics, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA. Electronic address:

Background And Objectives: Ewing sarcoma is the second most common bone sarcoma of childhood. Ewing sarcomas of the scapula are rare, with little known about their characteristics and outcomes. In this study, we describe the demographic characteristics, tumor characteristics, and oncologic outcomes of patients with Ewing sarcoma of the scapula. Read More

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Mammographic density and prognosis in primary breast cancer patients.

Breast 2021 Jun 17;59:51-57. Epub 2021 Jun 17.

Department of Gynecology and Obstetrics, Erlangen University Hospital, Comprehensive Cancer Center, European Metropolitan Area Erlangen-Nuremberg (CCC ER-EMN), Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.

Purpose: Mammographic density (MD) is one of the strongest risk factors for breast cancer (BC). However, the influence of MD on the BC prognosis is unclear. The objective of this study was therefore to investigate whether percentage MD (PMD) is associated with a difference in disease-free or overall survival in primary BC patients. Read More

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Identifying genetic risk variants associated with noise-induced hearing loss based on a novel strategy for evaluating individual susceptibility.

Hear Res 2021 Jun 6;407:108281. Epub 2021 Jun 6.

Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, China; Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai 200233, China; Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai 200233, China.

Background: The overall genetic profile for noise-induced hearing loss (NIHL) remains elusive. Herein we proposed a novel machine learning (ML) based strategy to evaluate individual susceptibility to NIHL and identify the underlying genetic risk variants based on a subsample of participants with extreme phenotypes.

Methods: Five features (age, sex, cumulative noise exposure [CNE], smoking, and alcohol drinking status) of 5,539 shipbuilding workers from large cross-sectional surveys were included in four ML classification models to predict their hearing levels. Read More

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