1,316,466 results match your criteria conclusions studies


Non-steroidal anti-inflammatory drugs (NSAIDs) for trigger finger.

Cochrane Database Syst Rev 2021 Apr 14;4:CD012789. Epub 2021 Apr 14.

Cochrane Singapore, Singapore, Singapore.

Background: Trigger finger is a common hand condition that occurs when movement of a finger flexor tendon through the first annular (A1) pulley is impaired by degeneration, inflammation, and swelling. This causes pain and restricted movement of the affected finger. Non-surgical treatment options include activity modification, oral and topical non-steroidal anti-inflammatory drugs (NSAIDs), splinting, and local injections with anti-inflammatory drugs. Read More

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Caregiver experiences of paediatric inpatient cardiac services: A qualitative systematic review.

Eur J Cardiovasc Nurs 2021 Apr;20(2):147-159

Newcastle Upon Tyne Hospitals NHS Foundation Trust, UK.

Background: Advances in paediatric care have contributed to an increasing survival of children with complex heart disease. Yet, life-saving management demands prolonged inpatient admissions, which contribute to emotional and psychological distress for parents and other caregivers in a role of main custody.

Aim: The purpose of this study was to identify, appraise and synthesise qualitative studies exploring caregivers' experiences of paediatric inpatient cardiac services, generating an understanding of their needs in hospital and informing priorities for change in healthcare delivery. Read More

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Shift work disorder and related influential factors among shift workers in China.

Sleep Med 2021 Mar 13;81:451-456. Epub 2021 Mar 13.

Center for Public Health Initiatives, University of Pennsylvania, Philadelphia, PA, USA.

Background: Shift work may cause insomnia and sleepiness in individuals. The present study aimed to exam shift work disorder (SWD), and to investigate their associations with individual characteristics.

Methods: A total of 1833 shift workers were assessed using the Pittsburg Sleep Quality Index, Epworth Sleepiness Scale (ESS), Composite Scale of Morningness (CSM), Circadian Type Inventory (CTI), Center for Epidemiologic Studies-Depression Scale (CES-D), Beck Anxiety Inventory (BAI) and other self-compiled socio-demographic questionnaires. Read More

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Sense of effort is distorted in people with chronic low back pain.

Musculoskelet Sci Pract 2021 Apr 2;53:102376. Epub 2021 Apr 2.

School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia.

Background: Proprioceptive deficits in people with low back pain (LBP) have traditionally been attributed to altered paraspinal muscle spindle afference and its central processing. Studies conducted in the upper limb demonstrated that sense of effort is also an important source of kinaesthetic information.

Objectives: To better understand proprioceptive deficits in people with chronic LBP (cLBP), this study aimed to test whether sense of effort is affected in people with cLBP. Read More

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Trauma mechanism and patient reported outcome in tibial plateau fractures with posterior involvement.

Knee 2021 Apr 10;30:41-50. Epub 2021 Apr 10.

Dept. Trauma Surgery, University Hospital Leuven, KU Leuven - University of Leuven, Leuven, Belgium. Electronic address:

Introduction: Posterior tibial plateau fractures (PTPF) have a high impact on functional outcome and the optimal treatment strategy is not well established. The goal of this study was to assess the relationship between trauma mechanism, fracture morphology and functional outcome in a large multicenter cohort and define possible strategies to improve the outcome.

Methods: An international retrospective cohort study was conducted in five level-1 trauma centers. Read More

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The estimations of the COVID-19 incubation period: A scoping reviews of the literature.

J Infect Public Health 2021 Feb 8;14(5):638-646. Epub 2021 Feb 8.

College of Engineering and Information Technology, Ajman University.

Background: A novel coronavirus (COVID-19) has taken the world by storm. The disease has spread very swiftly worldwide. A timely clue which includes the estimation of the incubation period among COVID-19 patients can allow governments and healthcare authorities to act accordingly. Read More

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February 2021

Antibiotics in treatment of COVID-19 complications: a review of frequency, indications, and efficacy.

J Infect Public Health 2021 Feb 9;14(5):570-576. Epub 2021 Feb 9.

Department of Infectious Diseases, Hotel Dieu de France, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.

Objectives: To report available information in the literature regarding frequency, indications, types of antibiotic usage, duration, and their efficacy in Covid-19 infected patients.

Methods: The search was conducted on April 30 and May 7, 2020, using Ovid database and Google search. Patients' characteristics, clinical outcomes, as well as selected characteristics regarding antibiotic use (indication, class used, rates and types of bacterial secondary and co-infection, and duration of treatment) were analyzed. Read More

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February 2021

Early prediction keys for COVID-19 cases progression: A meta-analysis.

J Infect Public Health 2021 Mar 5;14(5):561-569. Epub 2021 Mar 5.

Department of Pathology, College of Medicine, Qassim University, Buraidah, Qassim, Saudi Arabia.

BACKGROUNDː: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), within few months of being declared as a global pandemic by WHO, the number of confirmed cases has been over 75 million and over 1.6 million deaths since the start of the Pandemic and still counting, there is no consensus on factors that predict COVID-19 case progression despite the diversity of studies that reported sporadic laboratory predictive values predicting severe progression. We review different biomarkers to systematically analyzed these values to evaluate whether are they are correlated with the severity of COVID-19 disease and so their ability to be a predictor for progression. Read More

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Outcomes of Laparoscopic Versus Open Resection of Meckel's Diverticulum.

J Surg Res 2021 Apr 10;264:362-367. Epub 2021 Apr 10.

Division of Pediatric Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

Background: Meckel's Diverticulum (MD) is a common congenital anomaly accounting for half of pediatric gastrointestinal bleeds. No large-scale studies exist comparing open and laparoscopic surgery and conversion rates remain high. We sought to compare postoperative outcomes associated with each approach and to determine risk factors for conversion. Read More

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Machine Learning and Surgical Outcomes Prediction: A Systematic Review.

J Surg Res 2021 Apr 10;264:346-361. Epub 2021 Apr 10.

Division of Plastic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.

Background: Machine learning (ML) has garnered increasing attention as a means to quantitatively analyze the growing and complex medical data to improve individualized patient care. We herein aim to critically examine the current state of ML in predicting surgical outcomes, evaluate the quality of currently available research, and propose areas of improvement for future uses of ML in surgery.

Methods: A systematic review was conducted in accordance with the Preferred Reporting Items for a Systematic Review and Meta-Analysis (PRISMA) checklist. Read More

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Effectiveness of patient-targeted interventions to inform decision making and improve uptake of colorectal cancer genetic evaluation for at-risk individuals: A systematic review.

Int J Nurs Stud 2021 Mar 20;118:103928. Epub 2021 Mar 20.

Basic Nursing Department, School of Nursing, Jilin University, 965 Xinjiang Street, Changchun, Jilin 130021, China. Electronic address:

Background: Inherited colorectal cancer syndromes increase the risk of contracting colorectal and other cancers. International guidelines recommend the identification of individuals with hereditary colorectal cancer and the supervision of asymptomatic individuals with a family history. However, detection of hereditary colorectal cancer is suboptimal. Read More

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Parental perceptions of COVID-19-like illness in their children.

Public Health 2021 Mar 2;194:29-32. Epub 2021 Mar 2.

King's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, Weston Education Centre, Cutcombe Road, London, SE5 9RJ, UK.

Objectives: The objective of the study is to explore parents' perceptions of COVID-19-like symptoms in their child and attitudes towards isolating from others in the household when unwell.

Study Design: The study used qualitative, semistructured interviews.

Methods: The study involved thirty semistructured telephone interviews with parents of children between 4 and 18 years. Read More

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Dietary intake of B vitamins and their association with depression, anxiety, and stress symptoms: A cross-sectional, population-based survey.

J Affect Disord 2021 Mar 26;288:92-98. Epub 2021 Mar 26.

Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: B vitamins have vital roles in the development, maintenance, and functioning of the brain, while severe deficiencies have been linked to increased psychological disorders. However, no published studies have examined the association between dietary intake of vitamin B and depression, anxiety, and stress symptoms in a general population.

Methods: This cross-sectional study was done on 7387 Iranian adults aged 20-70 years within the population-based cohort study framework. Read More

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Executive Functions in panic disorder: A mini-review.

J Affect Disord 2021 Apr 3;288:107-113. Epub 2021 Apr 3.

Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.

Background: Panic disorder (PD) is an anxiety disorder characterized by recurrent panic attacks whose aetiology might be associated with alterations of the prefrontal-amygdala circuitry. The prefrontal cortex is a key region involved in executive functioning (EF) whose disturbance may imply harsh consequences over personal, social, and working aspects of PD patients. Indeed, defining the real involvement of EF in PD could lead to early assessment, better treatment, and rehabilitation options. Read More

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Criteria for failure and worsening after surgery for lumbar spinal stenosis. A prospective national spine registry observational study.

Spine J 2021 Apr 10. Epub 2021 Apr 10.

Innlandet Hospital Trust, The Research Center for Age-Related Functional Decline and Disease, PO Box 68, N-2313, Ottestad, Norway.

Background Context: Criteria for success after surgical treatment of lumbar spinal stenosis (LSS) have been defined previously; however, there are no clear criteria for failure and worsening after surgery as assessed by patient-reported outcome measures (PROMs).

Purpose: We aimed to quantify changes in standard PROMs that most accurately identified failure and worsening after surgery for LSS.

Study Design /setting: Retrospective analysis of prospective national spine registry data with 12-months follow-up. Read More

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Retrospective analysis of the incidence and predictive factors of parametrial involvement in FIGO IB1 cervical cancer.

J Gynecol Obstet Hum Reprod 2021 Apr 10:102145. Epub 2021 Apr 10.

Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:

Background And Objectives: Radical surgery is the standard primary treatment for patients with stage IB1 (FIGO 2009 staging) cervical cancer due to latent parametrial involvement. Recent studies suggested that less radical surgery was applicable for patients with no or low risk of parametrial involvement. In this study, we aimed to determine the incidence and possible predictive factors of parametrial involvement in patients with stage IB1 cervical cancer so as to evaluate whether less radical surgery was suitable for selected patients. Read More

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Herba Siegesbeckiae: A review on its traditional uses, chemical constituents, pharmacological activities and clinical studies.

J Ethnopharmacol 2021 Apr 10:114117. Epub 2021 Apr 10.

College of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji'nan, 250355, China. Electronic address:

Ethnopharmacological Relevance: Herba Siegesbeckiae, mainly includes Sigesbeckia orientalis L, Sigesbeckiae pubescens Makino and Sigesbeckiae glabrescens Makino. Herba Siegesbeckiae, also known as 'Xi-Xian Cao' (Chinese: ), has been regarded as an important traditional Chinese medicine since Tang dynasty. The dried aerial parts of Herba Siegesbeckiae are also being used as a herbal medicine in many countries such as Japan, Korea and Vietnam. Read More

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Genetic Factors associated with Pain Severity, Daily Opioid Dose Requirement, and Pain Response among Advanced Cancer Patients receiving Supportive Care.

J Pain Symptom Manage 2021 Apr 10. Epub 2021 Apr 10.

Department of Palliative care, Rehabilitation Medicine, and Integrative Medicine UT MD Anderson Cancer Center, Houston, United States.

Background: Current understanding of genetic factors associated with pain severity, and improvement of pain with opioids in advanced cancer patients (AC) is inadequate for delivery of personalized pain therapy(PPT). Therefore, the aim of this study was to determine the genetic factors associated with pain severity, daily opioid dose, and pain response in AC patients receiving supportive care.

Methods: In this prospective study, AC patients were eligible if they had cancer pain ≥4/10 on Edmonton Symptom Assessment Scale (ESAS) - Pain Item and needed opioid rotation for pain control by specialist at the outpatient supportive care center. Read More

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Evaluation of spin in the abstracts of systematic reviews and meta-analyses of studies on opioid use disorder.

Subst Abus 2021 Apr 13:1-9. Epub 2021 Apr 13.

Office of Medical Student Research, Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma, USA.

Background: Spin, or the inappropriate formatting of information to emphasize certain outcomes, should not be present in research. This study focuses on identifying and characterizing the presence of spin in systematic review and meta-analysis abstracts that focus on the treatment of opioid use disorder. Search strategies were developed to identify studies pertaining to the treatment of opioid use disorder. Read More

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Psychosocial interventions for siblings of children with cancer: A mixed methods systematic review.

Psychooncology 2021 Apr 2. Epub 2021 Apr 2.

School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Objective: This review systematically (1) describes the characteristics of psychosocial interventions for siblings of children with cancer (SCC); (2) assesses the effect of the psychosocial interventions on SCCs' outcomes, and (3) describes SCCs' experiences and perceptions of these interventions.

Methods: Seven databases were systematically searched for relevant literature. We included both quantitative and qualitative studies of psychological interventions designed to improve the adjustment of SCCs. Read More

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Furosemide clearance in very preterm neonates early in life: a pilot study using scavenged samples.

Pediatr Int 2021 Apr 13. Epub 2021 Apr 13.

Department of Pediatrics, Kagawa University, Kagawa, Japan.

Background: Furosemide is an off-label drug frequently used as a diuretic in neonates with oliguria and/or edema. Its clearance in preterm neonates is lower than in term neonates or children. We aimed herein to clarify furosemide clearance (CL) in very preterm (VP) neonates (< 28 weeks gestation) within the first two weeks of life and identify the factors predictive of the PK parameters, such as CL. Read More

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Junior and Collegiate Tennis Players Display Similar Bilateral Asymmetries of Humeral Retroversion.

J Athl Train 2021 Apr 13. Epub 2021 Apr 13.

dAssistant Professor, Palumbo Donahue School of Business, Duquesne University, Pittsburgh, PA, USA

Context: Overhead throwing athletes consistently display significant bilateral differences in humeral retroversion (HRV). However, there is limited evidence regarding HRV asymmetries in tennis players despite similarities between the overhead throw and tennis serve.

Objective: To determine if junior and collegiate tennis players demonstrate bilateral differences in HRV, and whether the magnitude of the side-to-side difference (HRVΔ) was similar across different age groups. Read More

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Racial and Ethnic Diversity of Athletic Trainers of the National Collegiate Athletic Association: A Retrospective Study.

J Athl Train 2021 Apr 13. Epub 2021 Apr 13.

5-University of Rochester Medical Center, Rochester, NY.

Context: Athletic trainers (ATs) are the most visible members of the sports medicine team and are responsible for the health and well-being of student-athletes (SAs).

Objective: Quantifying the representation from Black, Indigenous, and People of Color (BIPOC) ATs in National Collegiate Athletic Association (NCAA) member institutions has not been previously studied.

Design: Retrospective study Setting: National Collegiate Athletic Association's (NCAA) Demographic Database Participants: NCAA teams' athletic personnel at NCAA member institutions. Read More

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Telerehabilitation During the Covid-19 Pandemic in Outpatient Rehabilitation Settings: A Descriptive Study.

Phys Ther 2021 Apr 13. Epub 2021 Apr 13.

Net Health Systems, Inc., Pittsburgh PA, USA.

Objective: COVID-19 has widely affected delivery of health care. In response, telerehabilitation (TR) has emerged as alternative care model. Aims were: (1) describe baseline patient characteristics and available unadjusted outcomes for episodes of care administered during COVID-19 using TR vs. Read More

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US Public's Perceptions of Online Before and After Transformation Photos.

Aesthet Surg J 2021 Apr 13. Epub 2021 Apr 13.

chief of the division of plastic surgery, West Virginia University, Morgantown, WV.

Background: While many plastic surgeons seek to optimize their online presence and reach a broader patient base, no studies have evaluated the general public's perceptions of one of the most valued informational tools: transformation photos.

Objectives: The aim of this study was to evaluate the general public's preferences for viewing transformation photos online.

Methods: Respondents representative of the US public, crowdsourced through Amazon Mechanical Turk, answered a survey assessing perceptions of the posting of before-and-after photos. Read More

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The role of radiotherapy in neuroendocrine cervical cancer: SEER-based study.

Sci Prog 2021 Apr-Jun;104(2):368504211009336

Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Background: There are few randomised prospective data or guidelines for the treatment of neuroendocrine cervical cancer (NECC). In addition, the role of radiotherapy (RT) in NECC remains controversial. We used the Surveillance Epidemiology and End Results (SEER) database to investigate the role of RT for the treatment of NECC. Read More

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Patients' Perceived Satisfaction Through Telephone-Assisted Tele-Consultation During the SARS-CoV-2 Pandemic Period: Observational Single-Centre Study at a Tertiary-Referral Colorectal Surgery Department.

Surg Innov 2021 Apr 13:15533506211008053. Epub 2021 Apr 13.

Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), 16517Universidad Autónoma de Madrid (UAM), Madrid, España.

The pandemic produced by SARS-CoV-2 has obliged us to set up the tele-assistance to offer a continuity of care. This implies an innovation, being the degree of satisfaction of patients unknown. A telephonic survey was conducted with the validated in the Spanish tool (Telehealth Usability Questionnaire; rating from 1-7) of all candidate patients assisted consecutively in the Coloproctology Unit. Read More

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Mapping an Agenda for Psychedelic-Assisted Therapy Research in Patients with Serious Illness.

J Palliat Med 2021 Apr 13. Epub 2021 Apr 13.

Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

With support from the Radcliffe Institute for Advanced Study at Harvard University, we convened researchers representing palliative care, psychosocial oncology, spiritual care, oncology, and psychedelic-assisted therapies. We aimed to define priorities and envision an agenda for future research on psychedelic-assisted therapies in patients with serious illness. Over two days in January 2020, participants engaged in an iterative series of reflective exercises that elicited their attitude and perspectives on scientific opportunities for this research. Read More

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A Pilot Study of a Collaborative Palliative and Oncology Care Intervention for Patients with Head and Neck Cancer.

J Palliat Med 2021 Apr 13. Epub 2021 Apr 13.

Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.

Palliative care improves symptoms and coping in patients with advanced cancers, but has not been evaluated for patients with curable solid malignancies. Because of the tremendous symptom burden and high rates of psychological distress in head and neck cancer (HNC), we evaluated feasibility and acceptability of a palliative care intervention in patients with HNC receiving curative-intent chemoradiation therapy (CRT). This was a prospective single-arm study in HNC patients receiving CRT at a single center in the United States. Read More

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Pediatric Thoracolumbar Spinal Injuries in United States Trauma Centers.

Pediatr Emerg Care 2021 Apr 9. Epub 2021 Apr 9.

From the *Division of Pediatric Emergency Medicine, Rainbow Babies & Children's Hospital †Division of Pediatric Hospital Medicine, Rainbow Babies & Children's Hospital, University Hospitals Cleveland Medical Center ‡Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH.

Objectives: Injuries are the leading cause of morbidity and mortality in children ages 1 to 18 years. There are limited studies about pediatric thoracolumbar (TL) spinal injuries; the purpose of this study was to characterize TL spinal injuries among pediatric patients evaluated in US trauma centers.

Methods: This was a retrospective cohort study of the National Trauma Data Bank. Read More

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