1,438 results match your criteria concerns kinetic

Insight into the bioabsorption of Fe-based materials & their current developments in bone applications.

Biotechnol J 2021 Sep 14:e2100255. Epub 2021 Sep 14.

Center for Sustainable Nanomaterials, Ibnu Sina Institute for Scientific & Industrial Research, Universiti Teknologi Malaysia, Johor, Malaysia.

Iron (Fe) & Fe-based materials have been vigorously explored in orthopedic applications in the past decade mainly owing to their promising mechanical properties including high yield strength, elastic modulus & ductility. Nevertheless, their corrosion products & low corrosion kinetics are the major concerns that need to be improved further despite their appealing mechanical strengths. The current studies on porous Fe-based scaffolds show an improved corrosion rate but the in vitro biocompatibility is still problematic in general. Read More

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September 2021

Biodegradation of phorate by bacterial strains in the presence of humic acid and metal ions.

J Basic Microbiol 2021 Sep 14. Epub 2021 Sep 14.

Department of Microbiology, Lovely Professional University, Jalandhar, Punjab, India.

Phorate is a systemic insecticide used to eradicate mites, insects, and nematodes. Extensive use of this organophosphate has engendered severe environmental concerns. The current research aimed to explore the kinetic pathways of phorate biodegradation in aqueous solutions. Read More

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September 2021

An Overlooked Natural Hydrogen Evolution Pathway: Ni2+ Boosting H2O Reduction by Fe(OH)2 Oxidation during Low-temperature Serpentinization.

Angew Chem Int Ed Engl 2021 Sep 14. Epub 2021 Sep 14.

Central South University, School of Metallurgy and Environment, CHINA.

Natural hydrogen (H 2 ) has gained considerable attentions as a renewable energy resource to mitigate the globally increasing environmental concerns. Low-temperature serpentinization (< 200 ° C) as a typical water-rock reaction is a major source of the natural H 2 . However, the reaction mechanism and the controlling step to product H 2 remained unclear, which hinders the further utilization of natural H 2 . Read More

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September 2021

Biomarker-Based Management of AKI: Fact or Fantasy?

Nephron 2021 Aug 26:1-7. Epub 2021 Aug 26.

Department of Critical Care, King's College London, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom.

New biomarkers for acute kidney injury (AKI) have improved our understanding of the etiology and pathogenesis of AKI. Depending on their origin, function, and kinetic profile, biomarkers have a role in screening, diagnosis, prognostication, and monitoring of AKI. This offers opportunities to improve the management of AKI, but concerns and limitations remain. Read More

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Waste Wood Particles from Primary Wood Processing as a Filler of Insulation PUR Foams.

Materials (Basel) 2021 Aug 24;14(17). Epub 2021 Aug 24.

Department of Wood Based Materials, Faculty of Forestry and Wood Technology, Poznań University of Life Sciences, Wojska Polskiego 38/42, 60-627 Poznań, Poland.

A significant part of the work carried out so far in the field of production of biocomposite polyurethane foams (PUR) with the use of various types of lignocellulosic fillers mainly concerns rigid PUR foams with a closed-cell structure. In this work, the possibility of using waste wood particles (WP) from primary wood processing as a filler for PUR foams with open-cell structure was investigated. For this purpose, a wood particle fraction of 0. Read More

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Enhancing Fenton-like process at neutral pH by Fe(III)-GLDA complexation for the oxidation removal of organic pollutants.

J Hazard Mater 2021 08 11;416:126077. Epub 2021 May 11.

Key Laboratory of Groundwater Resources and Environment of the Ministry of Education, Jilin Provincial Key Laboratory of Water Resource and Environment, College of New Energy and Environment, Jilin University, 2519 Jiefang Road, Changchun 130021, PR China. Electronic address:

N,N-bis(carboxymethyl)glutamic acid (GLDA) was utilized in this study to significantly enhance the Fe(III) mediated Fenton-like oxidation removal of organic pollutants at neutral pH, in which ciprofloxacin (CIP) was used as the model pollutant. The CIP degradation rate in the GLDA/Fe(III)/HO system reached 96.5% within 180 min and was nearly 14 times higher than that in the Fe(III)/HO system. Read More

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Impact of heat on biological concentrations of toluene and acetone resulting from exposure by inhalation: A pilot study.

Environ Toxicol Pharmacol 2021 Sep 1;88:103737. Epub 2021 Sep 1.

Centre for Public Health Research (CReSP), 7101 Parc Avenue, Montreal, Quebec, H3N 1X9, Canada; Department of Environmental and Occupational Health, ESPUM, Université de Montréal, P.O. Box 6128, Downtown Branch, Montreal, Quebec, H3C 3J7, Canada. Electronic address:

Climatic conditions raise new concerns about the potential impact of heat on the absorption and kinetics of certain chemicals. The impact of 3 temperatures (21, 25 and 30 °C WBGT) on the toxicokinetics of toluene and acetone was therefore evaluated in five human subjects during controlled exposures in an inhalation chamber. Biological samples were collected and analyzed by GC-MS/MS. Read More

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September 2021

π-π stacking derived from graphene-like biochar/g-CN with tunable band structure for photocatalytic antibiotics degradation via peroxymonosulfate activation.

J Hazard Mater 2021 Aug 19;423(Pt A):126944. Epub 2021 Aug 19.

College of Resources & Environment, Hunan Agricultural University, Changsha 410128, China.

The severe pollution caused by antibiotics has raised serious concerns in recent decades. In this study, graphene-like Enteromorpha biochar modified g-CN (BC/CN) was synthesized and applied to degrade tetracycline by activating PMS under visible light, obtaining around 90% removal rate within 1 h. The Enteromorpha biochar can provide electron-withdrawing groups to adjust the electronic structure of g-CN, and induces more π-π interaction to decline the recombination of photocarriers. Read More

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Novel plantain peel activated carbon-supported zinc oxide nanocomposites (PPAC-ZnO-NC) for adsorption of chloroquine synthetic pharmaceutical used for COVID-19 treatment.

Biomass Convers Biorefin 2021 Aug 21:1-13. Epub 2021 Aug 21.

Landmark University SDG 6, Omu-Aran, Nigeria.

Chloroquine has been reported as an effective drug for the treatment of COVID-19 and with the rise in its administration and continued use, metabolites of chloroquine invariably find their way into the environment. There are many concerns recently on the presence of pharmaceuticals in the aquatic environment, hence the need for environmental remediation via effective adsorbent. Plantain peel activated carbon-supported zinc oxide (PPAC-ZnO) nanocomposite was prepared and characterized using physicochemical and spectroscopic techniques. Read More

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Thermal Stability and Decomposition Mechanism of PLA Nanocomposites with Kraft Lignin and Tannin.

Polymers (Basel) 2021 Aug 22;13(16). Epub 2021 Aug 22.

Laboratory of Chemistry and Technology of Polymers and Dyes, Department of Chemistry, Aristotle University of Thessaloniki, GR54124 Thessaloniki, Greece.

Packaging applications cover approximately 40% of the total plastics production, whereas food packaging possesses a high proportion within this context. Due to several environmental concerns, petroleum-based polymers have been shifted to their biobased counterparts. Poly(lactic acid) (PLA) has been proved the most dynamic biobased candidate as a substitute of the conventional polymers. Read More

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Cardiotoxicity Hazard and Risk Characterization of ToxCast Chemicals Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes from Multiple Donors.

Chem Res Toxicol 2021 Sep 27;34(9):2110-2124. Epub 2021 Aug 27.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas 77843-4458, United States.

Heart disease remains a significant human health burden worldwide with a significant fraction of morbidity attributable to environmental exposures. However, the extent to which the thousands of chemicals in commerce and the environment may contribute to heart disease morbidity is largely unknown, because in contrast to pharmaceuticals, environmental chemicals are seldom tested for potential cardiotoxicity. Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes have become an informative model for cardiotoxicity testing of drugs with the availability of cells from multiple individuals allowing testing of population variability. Read More

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September 2021

The Mare: A Pertinent Model for Human Assisted Reproductive Technologies?

Animals (Basel) 2021 Aug 4;11(8). Epub 2021 Aug 4.

Université Paris-Saclay, UVSQ, INRAE, BREED, 78350 Jouy-en-Josas, France.

Although there are large differences between horses and humans for reproductive anatomy, follicular dynamics, mono-ovulation, and embryo development kinetics until the blastocyst stage are similar. In contrast to humans, however, horses are seasonal animals and do not have a menstrual cycle. Moreover, horse implantation takes place 30 days later than in humans. Read More

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Kinetic investigation of protein adsorption into polyelectrolyte brushes by quartz crystal microbalance with dissipation: The implication of the chromatographic mechanism.

J Chromatogr A 2021 Sep 12;1654:462460. Epub 2021 Aug 12.

Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China; Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin 300350, China. Electronic address:

With the growing concerns of polymer-grafted ion-exchange chromatography, the importance of protein adsorption on charged polymer-grafted surfaces cannot be stressed enough. However, a full understanding in adsorption in polymer brushes is still a great challenge due to the lack of in situ characterization technique. In this work, we use quartz crystal microbalance with dissipation to in situ investigate adsorption kinetics of γ-globulin and recombinant human lactoferrin on poly(3-sulfopropyl methacrylate) (pSPM) sensors prepared via atom transfer radical polymerization. Read More

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September 2021

Removal of Zn(II) and Ni(II) heavy metal ions by new alginic acid-ester derivatives materials.

Carbohydr Polym 2021 Nov 14;272:118439. Epub 2021 Jul 14.

Laboratoire de Chimie Physique Macromoléculaire, Département de Chimie, Université Oran1 Ahmed Ben Bella, B.P 1524, El-Menaouer 31000, Oran, Algeria. Electronic address:

The present work concerns the preparation of new materials based on alginic acid (AA) and diols in a facile and efficient process by improving the adsorption properties of Zn(II) and Ni(II) metal ions on the modified AA. The materials were analysed by zeta potential, thermogravimetric analysis (TGA), derivative thermogravimetry (DTG), in addition to the Fourier Transform InfraRed spectroscopy (FTIR), scanning electron microscope (SEM) and X-ray photoelectron spectroscopy (XPS) before and after the adsorption behaviour was conducted. The results show that the esterification of AA with diols of different lengths significantly improves its adsorption efficiency of Zn(II) and Ni(II) with Q up to 200 mg/g and 185. Read More

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November 2021

Ferritin: A Multifunctional Nanoplatform for Biological Detection, Imaging Diagnosis, and Drug Delivery.

Acc Chem Res 2021 09 20;54(17):3313-3325. Epub 2021 Aug 20.

Experimental Center of Advanced Materials, School of Materials Science & Engineering, Beijing Institute of Technology, Beijing 100081, China.

Ferritins are spherical iron storage proteins within cells that are composed of a combination of 24 subunits of two types, heavy-chain ferritin (HFn) and light-chain ferritin (LFn). They autoassemble naturally into a spherical hollow nanocage with an outer diameter of 12 nm and an interior cavity that is 8 nm in diameter. In recent years, with the constantly emerging safety issues and the concerns about unfavorable uniformity and indefinite behavior of traditional nanomedicines, the characteristics of native ferritin nanocages, such as the unique nanocage structure, excellent safety profile, and definite behavior, make ferritin-based formulations uniquely attractive for nanomedicine development. Read More

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September 2021

Polyphenylene carboxymethylene (PPCM) microbicide repurposed as antiviral against SARS-CoV-2. Proof of concept in primary human undifferentiated epithelial cells.

Antiviral Res 2021 10 9;194:105162. Epub 2021 Aug 9.

Department of Pathology, University of Texas Medical Branch, Galveston, TX, 77555, USA; Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX, 77555, USA; Institute for Human Infections & Immunity and Sealy & Smith Foundation, University of Texas Medical Branch, Galveston, TX, 77555, USA. Electronic address:

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has infected over 200 million people throughout the world as of August 2021. There are currently no approved treatments providing high chance of recovery from a severe case of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2, and the beneficial effect of Remdesivir and passive immunization therapies may only be seen when administered early on disease onset. The emergence of variants is also raising concerns regarding the efficacy of antibody therapies, antivirals, and vaccines. Read More

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October 2021

Correlates of Neutralizing/SARS-CoV-2-S1-binding Antibody Response with Adverse Effects and Immune Kinetics in BNT162b2-Vaccinated Individuals.

medRxiv 2021 Jul 30. Epub 2021 Jul 30.

Background: While mRNA vaccines against SARS-CoV-2 have been exceedingly effective in preventing symptomatic viral infection, the features of immune response remain to be clarified.

Methods: In the present prospective observational study, 225 healthy individuals in Kumamoto General Hospital, Japan, who received two BNT162b2 doses in February 2021, were enrolled. Correlates of BNT162b2-elicited SARS-CoV-2-neutralizing activity (50% neutralization titer: NT ; assessed using infectious virions and live target cells) with SARS-CoV-2-S1-binding-IgG and -IgM levels, adverse effects (AEs), ages, and genders were examined. Read More

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Residue kinetics of neonicotinoids and abamectin in pistachio nuts under field conditions: model selection, effects of multiple sprayings, and risk assessment.

Environ Sci Pollut Res Int 2021 Aug 9. Epub 2021 Aug 9.

Department of Plant Protection, Academic Center for Education, Culture, and Research (ACECR)-Khorasan Razavi, Kashmar Higher Education Institute, Kashmar, Iran.

Pistachio is an economically valuable crop, and Iran is among the biggest producers, exporters, and consumers of this product in the world. During the growing season, pistachios are subjected to multiple sprayings with various pesticides, which result in the accumulation of their residues in nuts. These residues have raised concerns regarding consumers' health. Read More

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The Use of Genotoxicity Endpoints as Biomarkers of Low Dose Radiation Exposure in Interventional Cardiology.

Front Public Health 2021 23;9:701878. Epub 2021 Jul 23.

Laboratory of Health Physics, Radiobiology & Cytogenetics, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety (INRASTES), National Centre for Scientific Research "Demokritos", Athens, Greece.

The effect of the reportedly low ionizing radiation doses, such as those very often delivered to patients in interventional cardiology, remains ambiguous. As interventional cardiac procedures may have a significant impact on total collective effective dose, there are radiation protection concerns for patients and physicians regarding potential late health effects. Given that very low doses (<100 mSv) are expected to be delivered during these procedures, the purpose of this study was to assess the potency and suitability of current genotoxicity biomarkers to detect and quantitate biological effects essential for risk estimation in interventional cardiology. Read More

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Protein Corona Hinders N-CQDs Oxidative Potential and Favors Their Application as Nanobiocatalytic System.

Int J Mol Sci 2021 Jul 29;22(15). Epub 2021 Jul 29.

Department of Biochemistry, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Toruń, 87-100 Toruń, Poland.

The oxidative properties of nanomaterials arouse legitimate concerns about oxidative damage in biological systems. On the other hand, the undisputable benefits of nanomaterials promote them for biomedical applications; thus, the strategies to reduce oxidative potential are urgently needed. We aimed at analysis of nitrogen-containing carbon quantum dots (N-CQDs) in terms of their biocompatibility and internalization by different cells. Read More

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Three-Dimensional Fast Na-Ion Transport in Sodium Titanate Nanoarchitectures via Engineering of Oxygen Vacancies and Bismuth Substitution.

ACS Nano 2021 Aug 6. Epub 2021 Aug 6.

Centre for Materials Science, Queensland University of Technology, 2 George Street, Brisbane, QLD 4000, Australia.

Layered sodium titanates (NTO), one of the most promising anode materials for advanced sodium-ion batteries (SIBs), feature high theoretical capacity and no serious safety concerns. The pristine NTO electrode, however, has unfavorable Na transport kinetics, due to the dominant two-dimensional (2D) Na-ion transport channels within the crystal along the low energy barrier octahedron layers, which impedes the practical application of this class of potential materials. Herein, an interesting concept of opening three-dimensional (3D) fast ion transport channels within the intrinsic NTO frameworks is proposed to enhance the electrochemical performance through a combination of oxygen vacancy generation and cation substitution strategies, by which the interlayer spacing of the NTO frameworks is expanded for fast 3D Na-ion transport. Read More

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Valorization of crude olive stone in the removing of polyphenols from crude olive mill wastewater: kinetic, isotherm and mechanism study.

Heliyon 2021 Jul 9;7(7):e07525. Epub 2021 Jul 9.

Molecular Biology and Biochemical Engineering Department, Chemical Engineering Area, University of Pablo de Olavide, ES-41013 Seville, Spain.

Removal of polyphenols from crude olive mill wastewaters (COMWW) is vital to the development of olive industries. In addition, the exploitation of the residue of the olive oil industry such as crude olive stone (COS) constitutes a valorization of this substance and makes a contribution to the fight against environmental pollution. For this purpose, this study concerns the utilization of COS as an adsorbent of polyphenols from COMWW. Read More

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Sunlight Photolysis of Extracellular and Intracellular Antibiotic Resistance Genes and in Photosensitizer-Free Water.

Environ Sci Technol 2021 Aug 4. Epub 2021 Aug 4.

Department of Civil and Urban Engineering, Tandon School of Engineering, New York University, Brooklyn, New York 11201, United States.

Antibiotic resistance genes (ARGs; the genetic material in bacteria that encode for resistance to antibiotics) have been found in the aquatic environment, raising concerns of an environmental transmission route. In an effort to contribute to models predicting the fate of ARGs in the environment-to design control measures, predict health risks, inform ARG surveillance activities, and prioritize policy interventions-and given the importance of sunlight in damaging DNA, we evaluated the sunlight photolysis kinetics of antibiotic-resistant bacteria (ARB) and ARGs under laboratory conditions, focusing on SMS-3-5 and its ARGs and . Experiments were conducted in the absence of photosensitizers, and ARG decay rates were quantified by quantitative polymerase chain reaction (qPCR) with short and long amplicon targets. Read More

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Previous exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques.

PLoS Negl Trop Dis 2021 Jul 30;15(7):e0009641. Epub 2021 Jul 30.

Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

Concerns have arisen that pre-existing immunity to dengue virus (DENV) could enhance Zika virus (ZIKV) disease, due to the homology between ZIKV and DENV and the observation of antibody-dependent enhancement (ADE) among DENV serotypes. To date, no study has examined the impact of pre-existing DENV immunity on ZIKV pathogenesis during pregnancy in a translational non-human primate model. Here we show that macaques with a prior DENV-2 exposure had a higher burden of ZIKV vRNA in maternal-fetal interface tissues as compared to DENV-naive macaques. Read More

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DNA-protein interaction studies: a historical and comparative analysis.

Plant Methods 2021 Jul 23;17(1):82. Epub 2021 Jul 23.

Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Porto, Portugal.

DNA-protein interactions are essential for several molecular and cellular mechanisms, such as transcription, transcriptional regulation, DNA modifications, among others. For many decades scientists tried to unravel how DNA links to proteins, forming complex and vital interactions. However, the high number of techniques developed for the study of these interactions made the choice of the appropriate technique a difficult task. Read More

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Dissolution kinetics of a sodium borosilicate glass in Tris buffer solutions: impact of Tris concentration and acid (HCl/HNO) identity.

Phys Chem Chem Phys 2021 Aug;23(30):16165-16179

Department of Materials Science and Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

Understanding the corrosion behavior of glasses in near-neutral environments is crucial for many technologies including glasses for regenerative medicine and nuclear waste immobilization. To maintain consistent pH values throughout experiments in the pH = 7 to 9 regime, buffer solutions containing tris(hydroxymethyl)aminomethane ("Tris", or sometimes called THAM) are recommended in ISO standards 10993-14 and 23317 for evaluating biomaterial degradation and utilized throughout glass dissolution behavior literature-a key advantage being the absence of dissolved alkali/alkaline earth cations (i.e. Read More

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Measuring Postprandial Metabolic Flexibility To Assess Metabolic Health and Disease.

J Nutr 2021 Jul 22. Epub 2021 Jul 22.

Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.

Metabolic abnormalities substantially increase the risk of noncommunicable diseases, which are among the leading causes of mortality globally. Mitigating and preventing these adverse consequences remains challenging due to a limited understanding of metabolic health. Metabolic flexibility, a key tenet of metabolic health, encompasses the responsiveness of interrelated pathways to maintain energy homeostasis throughout daily physiologic challenges, such as the response to meal challenges. Read More

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Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases.

J Med Chem 2021 08 21;64(15):11267-11287. Epub 2021 Jul 21.

Department of Biochemistry and Biophysics, Texas A&M University, 300 Olsen Blvd, College Station, Texas 77843, United States.

Cysteine proteases comprise an important class of drug targets, especially for infectious diseases such as Chagas disease (cruzain) and COVID-19 (3CL protease, cathepsin L). Peptide aldehydes have proven to be potent inhibitors for all of these proteases. However, the intrinsic, high electrophilicity of the aldehyde group is associated with safety concerns and metabolic instability, limiting the use of aldehyde inhibitors as drugs. Read More

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In vitro cellular and proteome assays identify Wnt pathway and CDKN2A-regulated senescence affected in mesenchymal stem cells from mice after a chronic LD gamma irradiation in utero.

Radiat Environ Biophys 2021 08 21;60(3):397-410. Epub 2021 Jul 21.

Institute of Radiation Biology, Helmholtz Zentrum München GmbH, German Research Center for Environmental Health GmbH (HMGU), Ingolstaedter Landstraße 1, 85764, Neuherberg, Germany.

Reliable data on the effects of chronic prenatal exposure to low dose (LD) of ionizing radiation in humans are missing. There are concerns about adverse long-term effects that may persist throughout postnatal life of the offspring. Due to their slow cell cycle kinetics and life-long residence time in the organism, mesenchymal stem cells (MSCs) are more susceptible to low level genotoxic stress caused by extrinsic multiple LD events. Read More

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Case Study 10: A Case to Investigate Acetyl Transferase Kinetics.

Methods Mol Biol 2021 ;2342:781-808

Translational Medicine, Novartis Institutes for BioMedical Research, Inc., Cambridge, MA, USA.

Major routes of metabolism for marketed drugs are predominately driven by enzyme families such as cytochromes P450 and UDP-glucuronosyltransferases. Less studied conjugative enzymes, like N-acetyltransferases (NATs), are commonly associated with detoxification pathways. However, in the clinic, the high occurrence of NAT polymorphism that leads to slow and fast acetylator phenotypes in patient populations has been linked to toxicity for a multitude of drugs. Read More

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