6,949 results match your criteria conception natural


The gene: An appraisal.

Authors:
Keith Baverstock

Prog Biophys Mol Biol 2021 May 9. Epub 2021 May 9.

Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio Campus, Kuopio, Finland. Electronic address:

The gene can be described as the foundational concept of modern biology. As such, it has spilled over into daily discourse, yet it is acknowledged among biologists to be ill-defined. Here, following a short history of the gene, I analyse critically its role in inheritance, evolution, development, and morphogenesis. Read More

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Cytogenetic Analysis of the Products of Conception After Spontaneous Abortion in the First Trimester.

Cytogenet Genome Res 2021 May 11:1-12. Epub 2021 May 11.

Department of Gynecologic Oncology, Central Clinical College of Gynecology and Obstetrics, Tianjin Medical University, Tianjin, China.

In the present study, we retrospectively recruited 340 patients who underwent spontaneous abortions to investigate chromosomal abnormalities of the conception products in the first trimester. We also performed a relevant analysis of clinical factors. Of these patients, 165 had conception products with chromosomal abnormalities, including 135 aneuploidies, 11 triploidies, 10 complex abnormalities, and 9 segmental aneuploidies. Read More

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Mass balance of nine trace elements in two karst catchments in southwest China.

Sci Total Environ 2021 May 4;786:147504. Epub 2021 May 4.

State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550081, China; CAS Centre for Excellence in Quaternary Science and Global Change, Xi'an 710061, China. Electronic address:

High geological background levels of trace elements (TEs) and high population density in the karst areas of southwest China have imposed environmental pressure on the fragile ecosystems in this region. Understanding the mass budget of TEs, especially the toxic ones, is of great importance to sustain future developments. This study investigates the mass balance and fate of nine TEs (cadmium, arsenic, lead, chromium, copper, nickel, zinc, thallium, and antimony) in two karst catchments (Huilong and Chenqi) in southwest China through estimation of their mass budgets in throughfall, open field precipitation, total suspended particulate matter (TSP), litterfall, fertilization, harvested crops, surface runoff, and underground runoff. Read More

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The influence of frozen-thawed and fresh embryo transfer on utero-placental (vascular) development: the Rotterdam Periconception cohort.

Hum Reprod 2021 May 11. Epub 2021 May 11.

Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

Study Question: Does frozen-thawed or fresh embryo transfer (ET) influence utero-placental (vascular) development, when studied using three-dimensional (3D) ultrasound and virtual reality imaging techniques?

Summary Answer: In the first trimester, placental developmental parameters, that is, placental volume (PV) and utero-placental vascular volume (uPVV), were comparable between pregnancies resulting from frozen-thawed ET, fresh ET and natural conception; and in the second and the third trimester, uterine artery Doppler indices were lower in pregnancies after frozen-thawed ET compared to pregnancies after fresh ET and natural conception.

What Is Known Already: Pregnancies after frozen-thawed ET are at risk of developing placenta-related pregnancy complications. There is strong evidence that impaired first-trimester spiral artery remodelling is involved in the pathophysiology of these complications. Read More

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Sperm Competition, Sexual Selection, and the Diverse Reproductive Biology of Osteoglossiformes.

J Fish Biol 2021 May 10. Epub 2021 May 10.

Department of Integrative Biology, Graduate Program in Ecology, Evolution, and Behavior, East Lansing, Michigan, USA.

Osteoglossiformes are an order of "bony tongue" fish considered the most primitive living order of teleosts. This review seeks to consolidate known hypotheses and identify gaps in the literature regarding the adaptive significance of diverse reproductive traits and behavior of osteoglossiforms within the context of sperm competition and the wider lens of sexual selection. Many of the unusual traits observed in osteoglossiforms indicate low levels of sperm competition; most species have unpaired gonads and mormyroids are the only known vertebrate species with aflagellate sperm. Read More

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Single-cell transcriptome profiling of buffelgrass (Cenchrus ciliaris) eggs unveils apomictic parthenogenesis signatures.

Sci Rep 2021 May 10;11(1):9880. Epub 2021 May 10.

Institute of Plant Breeding, Genetics and Genomics, University of Georgia, Tifton, GA, 31793, USA.

Apomixis, a type of asexual reproduction in angiosperms, results in progenies that are genetically identical to the mother plant. It is a highly desirable trait in agriculture due to its potential to preserve heterosis of F hybrids through subsequent generations. However, no major crops are apomictic. Read More

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Current and next-year cranberry yields predicted from local features and carryover effects.

PLoS One 2021 10;16(5):e0250575. Epub 2021 May 10.

Département des Sols et de Génie Agroalimentaire, Université Laval, Québec, Québec, Canada.

Wisconsin and Quebec are the world leading cranberry-producing regions. Cranberries are grown in acidic, naturally low-fertility sandy beds. Cranberry fertilization is guided by general soil and tissue nutrient tests in addition to yield target and vegetative biomass. Read More

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Comparison of the Method of Endometrial Preparation Prior to Frozen-Thawed Embryo Transfer: a Retrospective Cohort Study from 9733 Cycles.

Reprod Sci 2021 May 10. Epub 2021 May 10.

Department of Gynecology, The First Affiliated Hospital of Xi'an Medical College, Xi'an City, Shaanxi Province, China.

Our objective was to compare the effectiveness of natural cycles (NC), modified natural cycle (mNC), and artificial cycles (AC) in women undergoing frozen-thawed embryo transfer (FET) after in vitro fertilization (IVF). This is a retrospective cohort study analyzing 9733 women undergoing the first cycle of FET over a 3-year period (June 2014-December 2017) at Northwest Women's and Children's Hospital after IVF-ICSI cycles. The type of endometrial preparation was determined by the treating physician's preference, based on patients' characteristics. Read More

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An Actinobacterium Strain From Soil of Cerrado Promotes Phosphorus Solubilization and Plant Growth in Soybean Plants.

Front Bioeng Biotechnol 2021 22;9:579906. Epub 2021 Apr 22.

Laboratory of Environmental Microbiology, Embrapa Environment, Jaguariúna, Brazil.

The huge biological diversity of the Brazilian Cerrado is an important source of economically interesting microbial agents. The phylum Actinobacteria plays an important role in nutrient cycling, potentially improving their availability to plants. In this study, we isolated an actinobacteria (strain 3AS4) from wheat rhizospheres of crops cultivated in the Cerrado biome. Read More

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Involvement of Nrf2-HO-1/JNK-Erk Signaling Pathways in Aconitine-Induced Developmental Toxicity, Oxidative Stress, and ROS-Mitochondrial Apoptosis in Zebrafish Embryos.

Front Pharmacol 2021 21;12:642480. Epub 2021 Apr 21.

Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.

Aconitine (AC), one of the bioactive diterpenoid alkaloids extracted from plants, is widely used in traditional herbal medicine to treat various diseases. Emerging evidence indicates that AC has attracted great interest for its wide cardiotoxicity and neurotoxicity. However, the toxic effects of AC on embryonic development and its underlying mechanisms remain unclear. Read More

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Changes in anti-müllerian hormone after ultrasound guided aspiration and ethanol sclerotic therapy of ovarian cyst.

Taiwan J Obstet Gynecol 2021 May;60(3):509-512

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, No 199 Dunhua N Rd, Songshan District, Taipei, 105, Taiwan. Electronic address:

Objective: To evaluate the effect of transvaginal ultrasound-guided aspiration and ethanol sclerotherapy on anti-müllerian hormone (AMH) in patients with ovarian endometriomas.

Setting: Teaching hospital affiliated with Chang Gung University, Taipei.

Material And Methods: We retrospectively reviewed 124 patients, with ovarian endometriomas who underwent transvaginal aspiration and sclerotherapy of endometrioma(s) at a tertiary medical center, Chang Gung Memorial Hospital, Taipei, Taiwan. Read More

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Effects of nutrient addition on endophyte-associated grass invasion in a long-term, old-field community experiment.

Oecologia 2021 May 7. Epub 2021 May 7.

Department of Biology, Wilfrid Laurier University, Waterloo, ON, N2L 3C5, Canada.

Strictly vertically transmitted (hereditary) Epichloë spp. fungal endophytes are symbionts with cool-season pooid host grasses. Such endophytes may increase host invasiveness in the non-native, introduced ranges. Read More

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Non-target analysis of organic waste amended agricultural soils: Characterization of added organic pollution.

Chemosphere 2021 Apr 19;280:130582. Epub 2021 Apr 19.

Aarhus University, Department of Environmental Science, Environmental Metabolomics Lab, Roskilde, Denmark. Electronic address:

Amendment of soil with organic urban and animal wastes can keep arable soil fertile without the need for synthetic fertilizers. However, pollutants present in these types of waste might be carried into the soil with unintended consequences for the environment. We studied an experimental agricultural plot, which had been amended with either synthetic inorganic fertilizers, human urine, manure, or wastewater treatment sludge at very high rates. Read More

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Prediction of reproductive function recovery after microsurgical varicocelectomy in men from infertile couples: Clinical and laboratory predictors.

Andrologia 2021 May 7:e14101. Epub 2021 May 7.

Department of Urology and Andrology, Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russia.

The objective was to reveal predictors for fertility recovery after varicocelectomy in subfertile men. This retrospective study recruited 93 men with clinical varicocele and pathozoospermia who underwent microsurgical varicocelectomy. Stepwise discriminant analysis was performed to identify predictors of spontaneous pregnancy (SP) after surgery. Read More

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The effect of CRISPR constructs microinjection on the expression of developmental genes in Rag1 knocked-out mice embryo.

Vet Med Sci 2021 May 6. Epub 2021 May 6.

Department of Gametes and Cloning, Research Institute of Animal Embryo Technology, Shahrekord University, Shahrekord, Iran.

Despite all the advances in the production of transgenic mice, the production efficiency of these animal models is still low. Given that the expression of developmental genes has a critical role in growth and development of embryo, we determined the expression pattern of pluripotency, trophectoderm and imprinting genes in the Rag1 (recombination-activating gene 1) knocked-out blastocysts resulting from microinjection of CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) constructs into the zygote cytoplasm of C57bl6 mice. Following microinjection, the embryos were cultured and the gene expression of developed blastocysts and natural blastocysts (Sham and control groups) were evaluated using real-time PCR. Read More

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Selecting low-carbon technologies and measures for high agricultural carbon productivity in Taihu Lake Basin, China.

Environ Sci Pollut Res Int 2021 May 4. Epub 2021 May 4.

Key Laboratory of Watershed Geographic Sciences, Nanjing Institute of Geography & Limnology, Chinese Academy of Sciences, Nanjing, 210008, China.

In this paper, Delphi method was used to evaluate the low-carbon technologies and measures for high agricultural carbon productivity in Taihu Lake Basin. We established the selecting process and standards and obtained the final list of low-carbon technologies and management measures of high agricultural carbon productivity in Taihu Lake Basin: (1) the initial list of low-carbon technologies and measures of planting industry included 19 items, of which 10 items were included in the final list. The 10 technologies and measures included in the final list were reducing fertilizers, mixed use of organic fertilizer and chemical fertilizer, soil testing and formulated fertilization, application of controlled release fertilizer, deep application of fertilizers, cultivation of new variety, extension of conservation tillage, extension of midseason/alternate drainage, paddy-upland rotation (rice-rape/rice-wheat), and reducing pesticides. Read More

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The foundational framework of tumors: Gametogenesis, p53, and cancer.

Semin Cancer Biol 2021 Apr 30. Epub 2021 Apr 30.

Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA. Electronic address:

The completion-of-tumor hypothesis involved in the dynamic interplay between the initiating oncogenic event and progression is essential to better recognize the foundational framework of tumors. Here we review and extend the gametogenesis-related hypothesis of tumors, because high embryonic/germ cell traits are common in tumors. The century-old gametogenesis-related hypothesis of tumors postulated that tumors arise from displaced/activated trophoblasts, displaced (lost) germ cells, and the reprogramming/reactivation of gametogenic program in somatic cells. Read More

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Proteostasis in the Male and Female Germline: A New Outlook on the Maintenance of Reproductive Health.

Front Cell Dev Biol 2021 16;9:660626. Epub 2021 Apr 16.

Priority Research Centre for Reproductive Science, Faculty of Science, The University of Newcastle, Callaghan, NSW, Australia.

For fully differentiated, long lived cells the maintenance of protein homeostasis (proteostasis) becomes a crucial determinant of cellular function and viability. Neurons are the most well-known example of this phenomenon where the majority of these cells must survive the entire course of life. However, male and female germ cells are also uniquely dependent on the maintenance of proteostasis to achieve successful fertilization. Read More

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Persistent increase of β-hCG level after salpingectomy in tubal pregnancy: Good or bad news?

Clin Case Rep 2021 Apr 11;9(4):2369-2372. Epub 2021 Mar 11.

Department of Obstetrics and Gynecology LMU Munich Munich Germany.

Heterotopic pregnancy is a rare event in natural conception (1:30000). We describe a case of a 36-year-old nulliparous. She presented to our department in the 4 + 6 gestational week with two simultaneous pregnancies intrauterine and extrauterine. Read More

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Positive Effects of Crop Diversity on Productivity Driven by Changes in Soil Microbial Composition.

Front Microbiol 2021 15;12:660749. Epub 2021 Apr 15.

Institute of Agricultural Sciences, Department of Environmental Systems Science, ETH Zürich, Zurich, Switzerland.

Intensive agriculture has major negative impacts on ecosystem diversity and functioning, including that of soils. The associated reduction of soil biodiversity and essential soil functions, such as nutrient cycling, can restrict plant growth and crop yield. By increasing plant diversity in agricultural systems, intercropping could be a promising way to foster soil microbial diversity and functioning. Read More

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Ultra-acute exposure to cadmium does not impair whitefish sperm motility.

J Fish Biol 2021 May 2. Epub 2021 May 2.

Department of Biology, University of Eastern Finland, P.O. Box 111, FI-80101, Joensuu, Finland.

Cadmium (Cd) exposure can impair the traits of aquatic animals associated with reproduction. In natural lakes Cd is typically detected at concentrations below 0.001 mg L . Read More

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Combined transvaginal and transabdominal oocyte retrieval in a patient with an ectopic ovary and unicornuate uterus.

Fertil Steril 2021 May;115(5):1347-1349

Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York.

Objective: To report the utility of combined transvaginal and transabdominal oocyte retrieval in a patient with an ectopic ovary and unicornuate uterus.

Design: Video case report with demonstration of oocyte retrieval technique.

Setting(s): University-affiliated fertility center. Read More

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2,4-DCP compromises the fertilization capacity of mouse oocytes.

J Cell Physiol 2021 Apr 30. Epub 2021 Apr 30.

Department of Aquaculture, School of Fisheries, Zhejiang Ocean University, Zhoushan, Zhejiang, China.

2,4-DCP (2,4-dichlorophenol) is an environmental estrogen that is ubiquitously distributed in the environment and widely used to produce herbicides and pharmaceutical intermediates. Although 2,4-DCP is suspected to have endocrine disruption, the reproductive toxicity of 2,4-DCP in mammals has not been adequately assessed. In the present study, we examined the effect of 2,4-DCP on the fertility of mouse eggs. Read More

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Microvascularization and Expression of Fibroblast Growth Factor and Vascular Endothelial Growth Factor and Their Receptors in the Mare Oviduct.

Animals (Basel) 2021 Apr 12;11(4). Epub 2021 Apr 12.

CIISA-Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, 1300-477 Lisbon, Portugal.

The oviduct presents the ideal conditions for fertilization and early embryonic development. In this study, (i) vascularization pattern; (ii) microvascular density; (iii) transcripts of angiogenic factors (, , ) and their receptors-, , , respectively, and (iv) the relative protein abundance of those receptors were assessed in cyclic mares' oviducts. The oviductal artery, arterioles and their ramifications, viewed by means of vascular injection-corrosion, differed in the infundibulum, ampulla and isthmus. Read More

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Changes in Diversity Due to Long-Term Management in a High Natural Value Grassland.

Plants (Basel) 2021 Apr 9;10(4). Epub 2021 Apr 9.

Department of Microbiology, Faculty of Agriculture, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Calea Mănăştur 3-5, 400372 Cluj-Napoca, Romania.

High nature value (HNV) grassland systems are increasingly important for the ecosystem services they provide and for their socio-economic impact in the current constant-changing context. The aim of our paper is to evaluate the long-term effect of organic fertilizers on HNV systems in the Apuseni Mountains, Romania. As an objective we want to identify the optimal intensity of conservation management and its recognition based on indicator value plant species. Read More

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Vaginal Probiotics for Reproductive Health and Related Dysbiosis: Systematic Review and Meta-Analysis.

J Clin Med 2021 Apr 2;10(7). Epub 2021 Apr 2.

Department of Microbiology, Faculty of Pharmacy, Campus of Cartuja, University of Granada, 18071 Granada, Spain.

The use of probiotics in reproductive-related dysbiosis is an area of continuous progress due to the growing interest from clinicians and patients suffering from recurrent reproductive microbiota disorders. An imbalance in the natural colonization sites related to reproductive health-vaginal, cervicovaginal, endometrial, and pregnancy-related altered microbiota-could play a decisive role in reproductive outcomes. Oral and vaginal administrations are in continuous discussion regarding the clinical effects pursued, but the oral route is used and studied more often despite the need for further transference to the colonization site. Read More

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Metagenomics Assessment of Soil Fertilization on the Chemotaxis and Disease Suppressive Genes Abundance in the Maize Rhizosphere.

Genes (Basel) 2021 Apr 7;12(4). Epub 2021 Apr 7.

Food Security and Safety Niche Area, Faculty of Natural and Agricultural Sciences, North-West University, Private Bag X2046, Mmabatho 2735, South Africa.

Soil fertility is a function of the level of organic and inorganic substances present in the soil, and it influences the activities of soil-borne microbes, plant growth performance and a host of other beneficial ecological functions. In this metagenomics study, we evaluated the response of maize microbial functional gene diversity involved in chemotaxis, antibiotics, siderophores, and antifungals producing genes within the rhizosphere of maize plants under compost, inorganic fertilizer, and unfertilized conditions. The results show that fertilization treatments at higher compost manure and lower inorganic fertilizer doses as well as maize plants itself in the unfertilized soil through rhizosphere effects share similar influences on the abundance of chemotaxis, siderophores, antifungal, and antibiotics synthesizing genes present in the samples, while higher doses of inorganic fertilizer and lower compost manure treatments significantly repress these genes. Read More

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Pharmaceutical Assessment Suggests Locomotion Hyperactivity in Zebrafish Triggered by Arecoline Might Be Associated with Multiple Muscarinic Acetylcholine Receptors Activation.

Toxins (Basel) 2021 04 3;13(4). Epub 2021 Apr 3.

Department of Chemistry, Chung Yuan Christian University, Chung-Li, Taoyuan City 320314, Taiwan.

Arecoline is one of the nicotinic acid-based alkaloids, which is found in the betel nut. In addition to its function as a muscarinic agonist, arecoline exhibits several adverse effects, such as inducing growth retardation and causing developmental defects in animal embryos, including zebrafish, chicken, and mice. In this study, we aimed to study the potential adverse effects of waterborne arecoline exposure on zebrafish larvae locomotor activity and investigate the possible mechanism of the arecoline effects in zebrafish behavior. Read More

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Effect of urea feeding on transforming and migrating soil fluorine in a tea garden of hilly region.

Environ Geochem Health 2021 Apr 28. Epub 2021 Apr 28.

College of Chemistry and Materials Science, Sichuan Normal University, Chengdu, 610068, People's Republic of China.

The hilly region of western Sichuan is famous for producing Mengding-mountain tea in China. However, it is very easy to enrich fluorine (F) in tea, which recently raised people's concern on fluorosis. In this study, we simulated the local special climate conditions, especially the natural precipitation through column leaching experiment to investigate the effect of fertilization on F desorption from soil. Read More

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Association of maternal folate use and reduced folate carrier gene polymorphisms with the risk of congenital heart disease in offspring.

Eur J Pediatr 2021 Apr 29. Epub 2021 Apr 29.

Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Er Road, Guangzhou, 510100, Guangdong, China.

Although it is generally recognized that genetic and environmental factors are associated with the risk of congenital heart disease (CHD), the mechanism remains largely uncertain. This study aimed to investigate the association of maternal folate use, the time when folate use was started, and polymorphisms of the reduced folate carrier (RFC1) gene with the risk of CHD in offspring of Chinese descent, which can help provide new insight into the etiology of folate-related birth defects. A case-control study of 683 mothers of CHD patients and 740 mothers of healthy children was performed. Read More

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