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Dynamic Bifunctional Metasurfaces for Holography and Color Display.

Adv Mater 2021 Jul 26:e2101258. Epub 2021 Jul 26.

State Key Laboratory on Tunable laser Technology, Ministry of Industry and Information Technology Key Lab of Micro-Nano Optoelectronic Information System, Shenzhen Graduate School, Harbin Institute of Technology, Shenzhen, 518055, China.

Metasurfaces have shown their unprecedented ability in wavefront shaping and triggered various applications with state-of-the-art performances, e.g., color nanoprinting and metaholograms. Read More

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Multi-dimensional frailty and its risk factors among older residents in long-term care facilities in Shanghai, China.

Int J Nurs Sci 2021 Jul 5;8(3):298-303. Epub 2021 Jun 5.

School of Nursing, Fudan University, Shanghai, China.

Objectives: The integrated model of frailty shifted the physiologically-dominated view to an integrated and multidisciplinary view of frailty and adopted an integrated and holistic approach to the complex challenges facing frail older adults and their caregivers. There is an urgent need for researchers to identify multi-faceted frailty among older adults and to explore contributors to it. We assessed the level of frailty among older residents in long-term care (LTC) facilities in Shanghai, China and explored risk factors of multiple dimensions of frailty among older residents. Read More

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Cell-Permeable Nanobodies Allow Dual-Color Super-Resolution Microscopy in Untransfected Living Cells.

Angew Chem Int Ed Engl 2021 Jul 21. Epub 2021 Jul 21.

FMP Berlin: Leibniz-Forschungsinstitut fur Molekulare Pharmakologie, Chemical Biology, GERMANY.

Super-resolution microscopy in living cells can be restricted by the availability of small molecule probes, which only exist against few targets and genetically encoded tags. Here, we expand the applicability of live-cell STED by engineering cell-permeable and highly fluorescent nanobodies as intracellular targeting agents. To ensure bright fluorescent signals at low concentrations we used the concept of intramolecular photostabilization by ligating a fluorophore along with the photostabilizer trolox to the nanobody using expressed protein ligation (EPL). Read More

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Electrically Tunable Optical Metasurfaces for Dynamic Polarization Conversion.

Nano Lett 2021 Jul 21. Epub 2021 Jul 21.

Max Planck Institute for Solid State Research, Heisenbergstrasse 1, 70569 Stuttgart, Germany.

Dynamic control over the polarization of light is highly desirable in many optical applications, including optical communications, laser science, three-dimensional displays, among others. Conventional methods for polarization control are often based on bulky optical elements. To achieve highly integrated optical devices, metasurfaces, which have been intensively studied in recent years, hold great promises to replace conventional optical elements for a variety of optical functions. Read More

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Contending with Our Racial Past in Medical Education: A Foucauldian Perspective.

Teach Learn Med 2021 Jul 11:1-10. Epub 2021 Jul 11.

Department of Medicine, Uniformed Services University, Bethesda, Maryland, USA.

Issue: Practices of systemic and structural racism that advantage some groups over others are embedded in American society. Institutions of higher learning are increasingly being pressured to develop strategies that effectively address these inequities. This article examines medical education's diversity reforms and inclusion practices, arguing that many reify preexisting social hierarchies that privilege white individuals over those who are minoritized because of their race/ethnicity. Read More

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Children should be seen and also heard: an explorative qualitative study into the influences on children's choice of footwear, their perception of comfort and the language they use to describe footwear experiences.

J Foot Ankle Res 2021 Jul 16;14(1):49. Epub 2021 Jul 16.

University of Salford School of Health and Society, Brian Blatchford Building, Frederick Road Campus, Greater Manchester, M6 6PU, Salford, England.

Background: Footwear has an essential role including protection of the feet, overall performance, foot health and potentially, supporting normal development of the foot. In addition to these physical aspects which may influence choice of footwear design, there are psychological influences on what a person chooses to wear. The concept of footwear 'comfort' spans physical and psychological perceptions of comfort in adults. Read More

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Multi-enzyme co-immobilized nano-assemblies: Bringing enzymes together for expanding bio-catalysis scope to meet biotechnological challenges.

Int J Biol Macromol 2021 Jul 14;186:735-749. Epub 2021 Jul 14.

Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey 64849, Mexico. Electronic address:

Co-immobilization of multi-enzymes has emerged as a promising concept to design and signify bio-catalysis engineering. Undoubtedly, the existence and importance of basic immobilization methods such as encapsulation, covalent binding, cross-linking, or even simple adsorption cannot be ignored as they are the core of advanced co-immobilization strategies. Different strategies have been developed and deployed to green the twenty-first century bio-catalysis. Read More

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Teledentistry-based Program to Improve Oral Hygiene Indicators in Rural Pakistan-A Protocol.

J Contemp Dent Pract 2021 Apr 1;22(4):406-411. Epub 2021 Apr 1.

Centre of Clinical Research, Telemedicine and Telepharmacy, School of Medicinal and Health Products Sciences, University of Camerino, Macerta, Italy.

Aim: The primary aim of this research protocol is to secure funding to initiate a teledentistry pilot project in order to improve the oral hygiene conditions of the most vulnerable population of rural Sindh in Pakistan, through hands-on training of 1,000 lady health workers by dentists and community dentistry specialists of other colleges led by Jinnah Medical and Dental College.

Materials And Methods: Training courses on digital health consultation would be given to participating healthcare workers. The trainees would be trained on all aspects of dental hygiene including precautions, tooth brushing techniques, and oral care. Read More

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Challenges and next steps in the advancement of immunotherapy: summary of the 2018 and 2020 National Cancer Institute workshops on cell-based immunotherapy for solid tumors.

J Immunother Cancer 2021 Jul;9(7)

ImmunoOncology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, Maryland, USA

Cell-based immunotherapies have had remarkable success in the clinic, specifically in the treatment of hematologic malignancies. However, these strategies have had limited efficacy in patients with solid tumors. To better understand the challenges involved, the National Cancer Institute (NCI) convened an initial workshop with immuno-oncology thought leaders in December 2018 and a follow-up workshop in December 2020. Read More

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Field-effect silicon-plasmonic photodetector for coherent T-wave reception.

Opt Express 2021 Jul;29(14):21586-21602

Plasmonic internal photoemission detectors (PIPED) have recently been shown to combine compact footprint and high bandwidth with monolithic co-integration into silicon photonic circuits, thereby opening an attractive route towards optoelectronic generation and detection of waveforms in the sub-THz and THz frequency range, so-called T-waves. In this paper, we further expand the PIPED concept by introducing a metal-oxide-semiconductor (MOS) interface with an additional gate electrode that allows to control the carrier dynamics in the device and the degree of internal photoemission at the metal-semiconductor interfaces. We experimentally study the behavior of dedicated field-effect (FE-)PIPED test structures and develop a physical understanding of the underlying principles. Read More

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On the space-time statistics of motion pictures.

J Opt Soc Am A Opt Image Sci Vis 2021 Jul;38(7):908-923

It is well known that natural images possess statistical regularities that can be captured by bandpass decomposition and divisive normalization processes that approximate early neural processing in the human visual system. We expand on these studies and present new findings on the properties of space-time natural statistics that are inherent in motion pictures. Our model relies on the concept of temporal bandpass (e. Read More

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The Communicative Participation Item Bank: Evaluating, and Reevaluating, Its Use across Communication Disorders in Adults.

Semin Speech Lang 2021 Jun 14;42(3):225-239. Epub 2021 Jul 14.

Department of Rehabilitation Medicine, University of Washington, Seattle, Washington.

Patient-reported outcomes (PROs) are essential in patient-centered, evidence-based practice in speech-language pathology. PROs respect individuals who live with communication disorders as key stakeholders providing a critically unique perspective on consequences of communication disorders, and whether interventions bring about meaningful changes. Some PROs focus on specific communication symptoms such as voice or language symptom severity, while others focus on broader constructs such as quality of life. Read More

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Fluorescent protein expression as a proxy of bacterial fitness in a high throughput assay.

Appl Environ Microbiol 2021 Jul 14:AEM0098221. Epub 2021 Jul 14.

School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.

Bacterial growth is classically assessed by measuring the increase in optical density of pure cultures in shaken liquid media. Measuring growth using optical density has severe limitations when studying multistrain interactions as it is not possible to measure the growth of individual strains within mixed cultures. Here we demonstrated that constitutively expressed fluorescent proteins can be used to track the growth of individual strains in different liquid media. Read More

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Human monocytes respond to lipopolysaccharide (LPS) stimulation in a sex-dependent manner.

J Cell Physiol 2021 Jul 12. Epub 2021 Jul 12.

Laboratorio Nazionale di Medicina e Farmacologia di Genere, Istituto Nazionale Biostrutture Biosistemi, Sassari, Italy.

Monocytes play a critical role in inflammation and immune response, their activity being sex-dependent. However, the basis of sex differences is not well understood. Therefore, we investigated the lipopolysaccharide (LPS) effects on tumor necrosis factor-α (TNF-α) release, autophagy, and chemotaxis in freshly isolated monocytes from healthy young men and women. Read More

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Telemedicine at the Joint Readiness Training Center: Expanding Forward Medical Capability.

Med J (Ft Sam Houst Tex) 2021 Apr-Jun(PB 8-21-04/05/06):9-13

Joint Readiness Training Center, Ft. Polk, LA.

Introduction: The US Army's transition from counterinsurgency operations to preparation for large-scale combat operations is likely to bring unique access to care challenges on the battlefield. Ruggedized computer systems exist that allow forward medical personnel to establish telehealth connections with rear-based specialists. We describe our use of one such device during simulated force on force operations at the Joint Readiness Training Center (JRTC). Read More

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Molecular Engineering on MoS2 Enables Large Interlayers and Unlocked Basal Planes for High-Performance Aqueous Zn-Ion Storage.

Angew Chem Int Ed Engl 2021 Jul 9. Epub 2021 Jul 9.

Nankai University, Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Weijin Road No.94, Nankai District, 300071, Tianjin, CHINA.

The aqueous Zn-storage behaviors of MoS2-based cathodes mainly rely on the ion-(de)intercalation at edge sites but are limited by the inactive basal plane. Herein, an in-situ molecular engineering strategy in terms of structure defects manufacturing and O-doping is proposed for MoS2  ( designated as D-MoS2-O) to unlock the inert basal plane, expand the interlayer spacing (from 6.2 to 9. Read More

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ZeroExpander: Metal-free automatic palatal expansion for special-needs patients.

Eur J Paediatr Dent 2021 Jun;22(2):151-154

DDS, MS Ortho, Phd, Private Practice in Bari, Italy.

Aim: The aim of this paper is to illustrate a new concept for approaching maxillary expansion in paediatric orthodontics with a metal-free fixed automatic appliance in special-needs patients.

Case Reports: The ZeroExpander is a complete CAD-CAT full digital and automatic metal-free fixed device. It is designed to expand the maxilla in a pre-programmed automatic way using deciduous teeth as anchorage. Read More

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Impact of repeated remote ischemic conditioning on diabetic foot ulcers: A proof-of-concept study.

Wound Repair Regen 2021 Jul 8. Epub 2021 Jul 8.

LifeCuff Technologies, Inc., Philadelphia, Pennsylvania, USA.

Patients with a diabetic foot ulcer (DFU) suffer disabilities and are at increased risk for lower extremity amputation. Current standard of care includes debridement, topical antibiotics, and weight off-loading-still resulting in low rates of healing. Previous small-scale research has indicated that repeated remote ischemic conditioning (rRIC) is a novel modality that delivers significantly higher DFU healing rates. Read More

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Simulation-Based Peer-Assisted Learning: Perceptions of Health Science Students.

Adv Med Educ Pract 2021 30;12:731-737. Epub 2021 Jun 30.

Faculty of Nursing, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.

Objective: Since 2010, simulation-based learning has become increasingly popular as a well-recognized method of learning used by medical undergraduates in clinical settings. However, the relatively new concept of simulation-based peer-assisted learning has not yet been widely accepted, so it has not been well documented. Therefore, this study evaluated the perceived advantages of simulation-based peer-assisted learning among health professions students and interns and their acceptance of this new concept of learning from a student-instructor. Read More

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Therapeutic Peptides as Emerging Options to Restore Misguided Host Defence and Homeostasis: From Teaching to Concept to Clinic.

Chimia (Aarau) 2021 Jun;75(6):495-499

University of Basel, Department of Pharmaceutical Sciences, Klingelbergstrasse 50, CH-4056 Basel, Switzerland;, Email:

Among the many molecular entities suitable for therapeutic use, peptides have emerged as a particularly attractive option for academic drug discovery and development. Their modular structure and extendibility, the availability of powerful and affordable screening platforms, and the relative ease-of-synthesis render therapeutic peptides highly approachable for teaching and research alike. With a strong focus on the therapeutic modulation of host defence pathways, including the complement and renin-angiotensin systems, the Molecular Pharmacy group at the University of Basel strongly relies on peptides to introduce students to practical aspects of modern drug design, to discover novel therapeutics for immune and inflammatory diseases, and to expand on options for the preclinical development of a promising drug class. Read More

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Conception and Feasibility of a Digital Tele-Guided Abdomen, Thorax, and Thyroid Gland Ultrasound Course for Medical Students (TELUS study).

Ultraschall Med 2021 Jul 5. Epub 2021 Jul 5.

Clinic of Internal Medicine III, Oncology, Hematology, Rheumatology and Clinical Immunology, University Hospital Bonn, Germany.

Purpose:  Medical education has been transformed during the COVID-19 pandemic, creating challenges regarding adequate training in ultrasound (US). Due to the discontinuation of traditional classroom teaching, the need to expand digital learning opportunities is undeniable. The aim of our study is to develop a tele-guided US course for undergraduate medical students and test the feasibility and efficacy of this digital US teaching method. Read More

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Pharmacoepidemiology for nephrologists (part 1): concept, applications and considerations for study design.

Clin Kidney J 2021 May 14;14(5):1307-1316. Epub 2020 Dec 14.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden.

Randomized controlled trials on drug safety and effectiveness are the foundation of medical evidence, but they may have limited generalizability and be unpowered to detect rare and long-term kidney outcomes. Observational studies in routine care data can complement and expand trial evidence on the use, safety and effectiveness of medications and aid with clinical decisions in areas where evidence is lacking. Access to routinely collected large healthcare data has resulted in the proliferation of studies addressing the effect of medications in patients with kidney diseases and this review provides an introduction to the science of pharmacoepidemiology to critically appraise them. Read More

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Plasma Cell-Free DNA Genotyping: From an Emerging Concept to a Standard-of-Care Tool in Metastatic Non-Small Cell Lung Cancer.

Oncologist 2021 Jul 3. Epub 2021 Jul 3.

Division of Hematology/Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Plasma cell-free DNA (cfDNA) genotyping is an alternative to tissue genotyping, particularly when tissue specimens are insufficient or unavailable, and provides critical information that can be used to guide treatment decisions in managing patients with non-small cell lung cancer (NSCLC). In this article, we review the evolution of plasma cfDNA genotyping from an emerging concept, through development of analytical methods, to its clinical applications as a standard-of-care tool in NSCLC. The number of driver or resistance mutations recommended for testing in NSCLC continues to increase. Read More

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Simultaneous separation and electroanalysis in a single polydimethylsiloxane-based platform.

Talanta 2021 Oct 19;233:122514. Epub 2021 May 19.

Faculdade de Ciências Exatas e Tecnologia, Universidade Federal da Grande Dourados, Rodovia Dourados-Itahum, km 12, CEP 79804-970, Dourados, MS, Brazil; Unesp, National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM), Institute of Chemistry, CEP 14800-900, Araraquara, SP, Brazil. Electronic address:

Channel-based microfluidic devices integrating the separation step and detection system are key factors to expand microanalysis application. However, these devices still depend on macroscale external equipment for pre-treatment of the sample, separation, or detection. The integration of all steps in only one stage is critical to improving feasibility. Read More

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October 2021

Modulation of striatal functional connectivity differences in adults with and without autism spectrum disorder in a single-dose randomized trial of cannabidivarin.

Mol Autism 2021 Jul 1;12(1):49. Epub 2021 Jul 1.

Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AF, UK.

Background: Autism spectrum disorder (ASD) has a high cost to affected individuals and society, but treatments for core symptoms are lacking. To expand intervention options, it is crucial to gain a better understanding of potential treatment targets, and their engagement, in the brain. For instance, the striatum (caudate, putamen, and nucleus accumbens) plays a central role during development and its (atypical) functional connectivity (FC) may contribute to multiple ASD symptoms. Read More

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Coherence between Decomposed Components of Wrist and Finger PPG Signals by Imputing Missing Features and Resolving Ambiguous Features.

Sensors (Basel) 2021 Jun 24;21(13). Epub 2021 Jun 24.

Cardiovascular Center, Department of Internal Medicine, Division of Cardiology, National Taiwan University Hospital, Taipei 100225, Taiwan.

Background: Feature extraction from photoplethysmography (PPG) signals is an essential step to analyze vascular and hemodynamic information. Different morphologies of PPG waveforms from different measurement sites appear. Various phenomena of missing or ambiguous features exist, which limit subsequent signal processing. Read More

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Development of EndoScreen Chip, a Microfluidic Pre-Endoscopy Triage Test for Esophageal Adenocarcinoma.

Cancers (Basel) 2021 Jun 8;13(12). Epub 2021 Jun 8.

QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.

The current endoscopy and biopsy diagnosis of esophageal adenocarcinoma (EAC) and its premalignant condition Barrett's esophagus (BE) is not cost-effective. To enable EAC screening and patient triaging for endoscopy, we developed a microfluidic lectin immunoassay, the EndoScreen Chip, which allows sensitive multiplex serum biomarker measurements. Here, we report the proof-of-concept deployment for the EAC biomarker Jacalin lectin binding complement C9 (JAC-C9), which we previously discovered and validated by mass spectrometry. Read More

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Contributions of Affective Temperament Traits to Professional Choice: Evidence from the Study of Firefighters, Musicians, Athletes, Bank Managers, Nurses and Paramedics.

Psychol Res Behav Manag 2021 22;14:827-834. Epub 2021 Jun 22.

Department of Clinical Neuropsychology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, Poland.

Purpose: The purpose of this study was to expand knowledge about the relationship between temperament and choice of profession by comparing temperaments among representatives of various professional groups.

Subjects And Methods: A total of 759 subjects aged 18-71, representatives of six professional groups: firefighters, musicians, athletes, bank managers, nurses and paramedics, were included in the study. Temperament was assessed using the TEMPS-A autoquestionnaire. Read More

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Targeted radionuclide therapy: an emerging field in solid tumours.

Curr Opin Oncol 2021 Jun 28. Epub 2021 Jun 28.

Department of Nuclear Medicine, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium.

Purpose Of Review: Targeted radionuclide therapy (TRNT) is characterized by systemic administration of radiolabelled drugs, targeting specific molecular alterations expressed on the tumour cells. Small molecules, labelled with β- or α- emitting radioisotopes, are used to deliver radiation directly to the tumour sites. Pretreatment imaging to visualize whole body biodistribution of the target, using the same drugs labelled with positron or γ-emitting radionuclides, completes the concept of theranostic. Read More

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Responsible Leadership and the Reflective CEO: Resolving Stakeholder Conflict by Imagining What be done.

J Bus Ethics 2021 Jun 23:1-25. Epub 2021 Jun 23.

Professor of Leadership, Director Centre for Workplace Leadership, University of Melbourne, 198 Berkeley Street, Melbourne, VIC 3010 Australia.

In light of grand societal challenges, most recently the global Covid-19 pandemic, there is a call for research on responsible leadership. While significant advances have been made in recent years towards a better understanding of the concept, a gap exists in the understanding of responsible leadership in emerging countries, specifically how leaders resolve prevalent moral dilemmas. Following Werhane (1999), we use moral imagination as an analytical approach to analyze a dilemmatic stakeholder conflict (between indigenous communities in rural India and an emerging market multinational enterprise headquartered in the same country) through the lense of different responsible leadership mindsets and in light of different ethical principles and moral background theories. Read More

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