314 results match your criteria concentrations pdr


[Bradykinin and angiotensin-converting enzyme in serum of patients with diabetic retinopathy and the prognosis of diabetic macular edema development (pilot study)].

Probl Endokrinol (Mosk) 2021 Aug 19;67(4):13-19. Epub 2021 Aug 19.

Helmholtz National Medical center of Eye Diseases.

Background: Diabetic macular edema (DME) is a microvascular complication of diabetic retinopathy. One of the key roles in the pathogenesis of DME may belong to the components of rennin-angiotensin and kallikrein-kinin systems: bradykinin (Bk) and angiotensin-converting enzyme (ACE).

Purpose: To determine the Bk and ACE concentration and ACE activity in serum of patients with proliferative diabetic retinopathy (PDR) and to estimate the significance of these parameters for the early diagnostic and prognosis of DMO. Read More

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Pro-inflammatory cytokine profile is present in the serum of Mexican patients with different stages of diabetic retinopathy secondary to type 2 diabetes.

BMJ Open Ophthalmol 2021 30;6(1):e000717. Epub 2021 Jun 30.

Research Unit, Microbiology and Ocular Proteomics Department, Instituto de Oftalmologia Fundacion Conde de Valenciana IAP, Mexico City, Mexico.

Aim: It's been reported that pro-inflammatory cytokines are elevated in patients with diabetic retinopathy (DR); this may contribute to the pathophysiology of the disease. The aim of this study is to measure the concentration of various inflammatory cytokines from the main CD4+ T helper inflammatory responses in blood serum from Mexican patients with DR in different stages using cytometric bead array (CBA) technology and correlate them with the presence and severity of DR in order to find possible DR biomarkers that serve as diagnostic or therapeutic predictors.

Methods: 64 subjects were included in the study, 16 in the control group, 16 in the type 2 diabetes mellitus no DR (NDR) group, 16 in the non-proliferative DR (NPDR) group and 16 in the proliferative DR (PDR) group. Read More

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Ocular TGF-, Matrix Metalloproteinases, and TIMP-1 Increase with the Development and Progression of Diabetic Retinopathy in Type 2 Diabetes Mellitus.

Mediators Inflamm 2021 25;2021:9811361. Epub 2021 Jun 25.

Swiss Eye Institute, Rotkreuz and Retina Clinic, Berner Augenklinik am Lindenhofspital, 3012, Switzerland.

Diabetic retinopathy (DR) is a sight-threatening late complication of diabetes mellitus (DM). Even though its pathophysiology has not been fully elucidated, several studies suggested a role for transforming growth factor- (TGF-) , matrix metalloproteinases (MMPs), and tissue inhibitors of matrix metalloproteinase (TIMP) in the onset and progression of the disease. Consequently, the aim of this study was to analyze the concentrations of TGF-1, TGF-2, TGF-3, MMP-3, MMP-9, and TIMP-1 in patients with different stages of DR in order to identify stage-specific changes in their concentrations during the progression of the disease. Read More

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Fine particulate matter exposure in four transport modes of Greater Cairo.

Sci Total Environ 2021 Oct 29;791:148104. Epub 2021 May 29.

Department of Construction Engineering, School of Sciences and Engineering, The American University in Cairo, New Cairo 11835, Egypt.

The number of daily commuters in Greater Cairo has exceeded 15 million nevertheless personal exposure studies in transport microenvironments are limited. The aim of this study is to quantify PM exposure during peak hours in four transport modes of Greater Cairo - car (windows-open, windows-closed with recirculation and AC-on), microbus (windows-open), cycling and walking - and understand its underlying drivers. Data was collected using a pDR-1500 monitor and analysed to capture concentration variations, spatial variability, exposure doses, commuting costs versus inhaled doses, health burden and economic losses. Read More

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October 2021

Detection of significantly high vitreous concentrations of fatty acid-binding protein 4 in patients with proliferative diabetic retinopathy.

Sci Rep 2021 Jun 11;11(1):12382. Epub 2021 Jun 11.

Department of Ophthalmology, Sapporo Medical University School of Medicine, Sapporo, Japan.

The fatty acid-binding protein4 (FABP4) and vascular endothelial growth factor A (VEGFA) play key roles in the metabolic and cardiovascular diseases, and proliferative diabetic retinopathy (PDR), respectively. To identify FABP4 in vitreous fluid in PDR, vitreous concentrations of FABP4 (V-FABP4) and VEGFA (V-VEGFA) from PDR (n = 20) and non-PDR (n = 20) patients were determined by Enzyme-Linked ImmunoSorbent Assays. The data, which included height and weight, systemic blood pressures, several blood biochemical parameters and blood flow at the optic nerve head (ONH) by laser speckle flowgraphy (LSFG) were collected. Read More

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Cytogenetic, Serum Liver Enzymes and Liver Cell Pathology of the Hampala Barb Fish ) Affected by Toxic Elements in the Contaminated Nam Kok River Near the Sepon Gold-Copper Mine, Lao PDR.

Int J Environ Res Public Health 2021 05 29;18(11). Epub 2021 May 29.

Division of Environmental Science, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.

This study aimed to determine toxic element concentrations in aquatic environments, including water and sediment, and in the fish, and to evaluate chromosome abnormalities, serum liver enzyme changes and liver histopathological alterations in from the Nam Kok River near the Sepon gold-copper mine, Lao People's Democratic Republic, as compared with a control area without mining activity. The results revealed significant differences ( < 0.05) in As, Ba, Cu, Fe, Mn, Ni, Se and Zn in water, in all of the studied potentially toxic elements in sediment, and in As, Ba, Cd, Cr, Cu, Mn, Ni, Se, and Zn in the fish between the study and control areas. Read More

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Increased serum concentration of netrin-1 after intravitreal bevacizumab injection: is it a compensatory mechanism to counteract drug side effects?

BMC Ophthalmol 2021 May 31;21(1):243. Epub 2021 May 31.

Recep Tayyip Erdoğan University, Zihni Derin Yerleşkesi - Fener Mahallesi, 53100, Merkez/Rize, Turkey.

Background: To evaluate alterations in the serum concentrations of vascular endothelial growth factor (VEGF) and netrin-1 after intravitreal bevacizumab (BCZ) injection for the treatment of diabetic macular edema (DME).

Methods: This prospective case-control study included a total of 50 participants assigned to one of three groups, including 10 individuals with DME and non-proliferative diabetic retinopathy (NPDR), 13 with DME, and proliferative diabetic retinopathy (PDR), and 27 healthy individuals as a control group. Serum VEGF and netrin-1 concentrations were measured by enzyme-linked immunosorbent assays (ELISAs) immediately before, as well as 1 week and 1 month after, intravitreal BCZ injection. Read More

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Sex-Based Analysis of Potential Inflammation-Related Protein Biomarkers in the Aqueous Humor of Patients With Diabetes Mellitus.

Transl Vis Sci Technol 2021 03;10(3):12

University of California, San Francisco, Department of Ophthalmology, San Francisco, CA, USA.

Purpose: To investigate whether men have higher inflammatory protein biomarker concentrations in their aqueous humor (AH) compared with women in groups of patients with varying levels of diabetic disease.

Methods: This cross-sectional study included AH specimens from 59 adult patients comprised of three groups: no diabetes mellitus (DM), DM without diabetic retinopathy (DR), and DM with proliferative diabetic retinopathy (PDR). Protein biomarker concentration values were quantified using a commercial proximity extension assay-based technique. Read More

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Determination of Cd, Pb, and Cu in the Atmospheric Aerosol of Central East Antarctica at Dome C (Concordia Station).

Molecules 2021 Apr 1;26(7). Epub 2021 Apr 1.

Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy.

Trace heavy metals Cd, Pb, and Cu were determined (by square wave anodic stripping voltammetry) in aerosol samples collected at Dome C (the Italo-French Station Concordia), a remote site of the Central East Antarctic plateau, for which no data are available until now. During the Austral Summer 2005-2006, three PM10 high-volume impactors were installed in two locations nearby of Concordia station: the first one very close and downwind of the station (about 50 m north), the other two (very close to each other) in a 'distant' site, upwind of the station and close to the astrophysics tent (not used in that expedition) at ~800 m south of Station Concordia. For each sample, the availability of the mass of the aerosol collected (obtained by differential weighing carried out on site), in addition to the volume of the filtered air, allowed us to express results both in terms of metal mass fractions in the aerosol and in the usual way of metal atmospheric concentrations. Read More

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Does the Phytochemical Diversity of Wild Plants Like the Correlate with Geographical Origin?

Molecules 2021 Mar 17;26(6). Epub 2021 Mar 17.

Département de Pharmacochimie Moléculaire (DPM), Univiversité Grenoble Alpes, CNRS, 38000 Grenoble, France.

Secondary metabolites are essential for plant survival and reproduction. Wild undomesticated and tropical plants are expected to harbor highly diverse metabolomes. We investigated the metabolomic diversity of two morphologically similar trees of tropical Africa, and , known for particular secondary metabolites named the cassaine-type diterpenoids. Read More

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Association of serum and aqueous humor myonectin concentrations with diabetic retinopathy.

Sci Rep 2021 Mar 30;11(1):7215. Epub 2021 Mar 30.

Department of Endocrinology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Shibei District, Qingdao, 266035, Shandong, China.

Myonectin, a newly discovered myokine, enhances fatty acid uptake in cultured adipocytes and hepatocytes and suppresses circulating levels of free fatty acids in mice. This study is performed to evaluate the association between serum and aqueous humor myonectin concentrations with diabetic retinopathy (DR). This study was performed in a population of 228 patients with type 2 diabetes (T2DM) and 72 control subjects. Read More

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Decreased expression of TIPE2 in the eye under high-glucose conditions tested in vivo and in vitro.

Int Immunopharmacol 2021 Jun 13;95:107517. Epub 2021 Mar 13.

Department of Ophthalmology, Qilu Hospital of Shandong University, China. Electronic address:

Aims: Inflammation is important in the development of angiogenesis diabetic retinopathy (DR). Anti-inflammation is promising strategy in early DR management. This study aimed to evaluate the level of tumour necrosis factor (TNF)-α-induced protein-8 like-2 (TIPE2), a formerly anti-inflammatory factor, under high-glucose conditions. Read More

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Anti-inflammatory Effect of Curcumin, Homotaurine, and Vitamin D3 on Human Vitreous in Patients With Diabetic Retinopathy.

Front Neurol 2020 5;11:592274. Epub 2021 Feb 5.

Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy.

To determine the levels of pro-inflammatory cytokines and soluble mediators (TNF-α, IL6, IL2, and PDGF-AB) in 28 vitreous biopsies taken from patients with proliferative diabetic retinopathy (PDR) and treated with increasing doses of curcumin (0. 5 and 1 μM), with or without homotaurine (100 μM) and vitamin D3 (50 nM). ELISA tests were performed on the supernatants from 28 vitreous biopsies that were incubated with bioactive molecules at 37°C for 20 h. Read More

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February 2021

Effects of hydrological regime and land use on in-stream Escherichia coli concentration in the Mekong basin, Lao PDR.

Sci Rep 2021 Feb 10;11(1):3460. Epub 2021 Feb 10.

Institut de Recherche Pour le Développement (IRD), iEES-Paris, UMR 242 (IRD, SU-UPMC, CNRS, INRA, Univ. de Paris, UPEC), PO Box 5992, Vientiane, Lao PDR.

In the basin of Mekong, over 70 million people rely on unimproved surface water for their domestic requirements. Surface water is often contaminated with fecal matter and yet little information exists on the underlying mechanisms of fecal contamination in tropical conditions at large watershed scales. Our objectives were to (1) investigate the seasonality of fecal contamination using Escherichia coli as fecal indicator bacteria (FIB), and (2) establish links between the fecal contamination in stream water and its controlling factors (hydrology and land use). Read More

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February 2021

Effect of Rice Grain ( L.) Enrichment with Selenium on Foliar Leaf Gas Exchanges and Accumulation of Nutrients.

Plants (Basel) 2021 Feb 3;10(2). Epub 2021 Feb 3.

Earth Sciences Department, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal.

An agronomic itinerary for Se biofortification of two rice cultivars (Ariete and Ceres) through foliar fertilization with sodium selenate and sodium selenite with different concentrations (25, 50, 75 and 100 g Se.ha), was implemented in experimental fields. The selenium toxicity threshold was not exceeded, as shown by the eco-physiological data obtained through leaf gas exchanges. Read More

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February 2021

Mortality of Pandrug-Resistant Bloodstream Infections in Critically Ill Patients: A Retrospective Cohort of 115 Episodes.

Antibiotics (Basel) 2021 Jan 15;10(1). Epub 2021 Jan 15.

Division of Infectious Diseases, School of Medicine, University of Patras, 26504 Patras, Greece.

Background: The increased frequency of bacteraemias caused by pandrug-resistant (PDR-Kp) has significant implications. The aim of the present study was to identify predictors associated with mortality of PDR-Kp bacteraemias.

Methods: Patients with monomicrobial bacteraemia due to PDR-Kp were included. Read More

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January 2021

Pharmaceutical disposal facilitates the mobilization of resistance determinants among microbiota of polluted environment.

Saudi Pharm J 2020 Dec 28;28(12):1626-1634. Epub 2020 Oct 28.

Department of Biosciences, Jamia Millia Islamia, New Delhi, India.

The emergence of resistance on exposure to pharmaceuticals among microorganisms has raised serious concern in the therapeutic approach against infectious diseases. Effluents discharge from hospitals, industries, and urban settlements containing pharmaceuticals and other toxic compounds into the aquatic ecosystem selects bacterial population against them; thereby promotes acquisition and dissemination of resistant traits among the inhabitant microbiota. The present study was aimed to determine the prevalence and multidrug resistance pattern of Extended Spectrum β-lactamase (ESBL) producing and non-producing bacterial isolates from the heavily polluted Delhi stretch of river Yamuna, India. Read More

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December 2020

Immunological biomarkers of the vitreous responsible for proliferative alteration in the different forms of retinal detachment.

BMC Ophthalmol 2020 Dec 28;20(1):491. Epub 2020 Dec 28.

Department of Ophthalmology, Semmelweis University, Mária u 39, Budapest, 1085, Hungary.

Background: The purpose of the study was to explore the immunological components that are responsible for the proliferative alterations in the different forms of retinal detachment (RD).

Methods: Vitreous fluids were collected during 23G pars plana vitrectomy from 54 eyes of 54 patients with different RD types, such as rhegmatogenous RD (RRD) without proliferative vitreoretinopathy (PVR) (n = 30), PVR (n = 16) and proliferative diabetic retinopathy (PDR) with tractional RD (n = 8). Vitreous fluids were obtained from 19 eyes with epiretinal membrane (ERM), which were used as control samples. Read More

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December 2020

Effects of Contamination by Heavy Metals and Metalloids on Chromosomes, Serum Biochemistry and Histopathology of the Bonylip Barb Fish Near Sepon Gold-Copper Mine, Lao PDR.

Int J Environ Res Public Health 2020 12 18;17(24). Epub 2020 Dec 18.

Ecotoxicology, Natural Resources and Environment Project, Khon Kaen University, Khon Kaen 40002, Thailand.

The objectives of the present study were to determine the concentrations of heavy metals and metalloids in water, sediment and fish, and to assess chromosome aberrations, serum biochemical changes and histopathological alterations in from the Nam Kok river near the Sepon gold-copper mine, Lao People's Democratic Republic compared with the reference area. The results showed that Fe, Mn and Ni in water, As and Cd in sediment as well as As, Cd, Cr, Mn and Ni in muscle samples near the gold-copper mine exceeded standard values. Furthermore, the chromosome assessment in revealed seven types of chromosome aberrations, and the highest total number of chromosome aberrations was a centromere gap. Read More

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December 2020

Associations of serum uric acid and urinary albumin with the severity of diabetic retinopathy in individuals with type 2 diabetes.

BMC Ophthalmol 2020 Nov 30;20(1):467. Epub 2020 Nov 30.

Department of Endocrinology, Daqing People's Hospital, the Fifth Affiliated Hospital of Harbin Medical University, No.213, Jianshe Road, Development zone, Daqing, 163000, China.

Background: Diabetic retinopathy (DR) is a serious microvascular complication of type 2 diabetes mellitus (T2DM). The aim of this retrospective study was to reveal the risk factors for the severity of DR in individuals with T2DM. Demographic data and biochemical parameters were collected and analyzed. Read More

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November 2020

Inflammation and diabetic retinopathy.

Mol Vis 2020 15;26:718-721. Epub 2020 Oct 15.

Ankara Public Health Laboratory, Associate Professor of Biochemistry, Ankara, Turkey.

Purpose: To investigate the relationship between inflammation in the vitreous and diabetic retinopathy.

Methods: Vitreous samples from 21 patients with proliferative diabetic retinopathy (PDR), 21 patients with nonproliferative diabetic retinopathy (NPDR), and 21 nondiabetic patients with idiopathic epiretinal membranes (control) were studied. The interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), matrix metalloproteinase (MMP)-2, MMP-9, and adiponectin levels in the vitreous were detected in all samples with enzyme-linked immunosorbent assay (ELISA). Read More

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Modeling the photoinactivation and transport of somatic and F-specific coliphages at a Great Lakes beach.

J Environ Qual 2020 Nov 5;49(6):1612-1623. Epub 2020 Nov 5.

Dep. of Civil & Environmental Engineering, Michigan State Univ., East Lansing, MI, 48824, USA.

Fecal indicator organisms (FIOs), such as Escherichia coli and enterococci, are often used as surrogates of contamination in the context of beach management; however, bacteriophages may be more reliable indicators than FIO due to their similarity to viral pathogens in terms of size and persistence in the environment. In the past, mechanistic modeling of environmental contamination has focused on FIOs, with virus and bacteriophage modeling efforts remaining limited. In this paper, we describe the development and application of a fate and transport model of somatic and F-specific coliphages for the Washington Park beach in Lake Michigan, which is affected by riverine outputs from the nearby Trail Creek. Read More

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November 2020

Metabolomics profiles associated with diabetic retinopathy in type 2 diabetes patients.

PLoS One 2020 29;15(10):e0241365. Epub 2020 Oct 29.

Division of Genome Research, Center for Genome Science, Korea National Institute of Health, Cheongju, Chungbuk, Republic of Korea.

Diabetic retinopathy (DR) is a common complication of diabetes, and it is the consequence of microvascular retinal changes due to high glucose levels over a long time. Metabolomics profiling is a rapidly evolving method used to identify the metabolites in biological fluids and investigate disease progression. In this study, we used a targeted metabolomics approach to quantify the serum metabolites in type 2 diabetes (T2D) patients. Read More

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December 2020

The role of IL-6-174 G/C polymorphism and intraocular IL-6 levels in the pathogenesis of ocular diseases: a systematic review and meta-analysis.

Sci Rep 2020 10 15;10(1):17453. Epub 2020 Oct 15.

Department of Ophthalmology, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia.

Interleukin-6 (IL-6) is one of the key regulators behind the inflammatory and pathological process associated with ophthalmic diseases. The role of IL-6-174 G/C polymorphism as well as intraocular IL-6 levels among various eye disease patients differ across studies and has not been systematically reviewed. Thus, this study aims to provide a summary to understand the relationship between IL-6 and ophthalmic disease. Read More

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October 2020

Microbial contamination in the communal-use Lao tobacco waterpipe.

Int Health 2021 07;13(4):344-349

Loma Linda University School of Public Health, 24951 N. Circle Drive, Nichol Hall 2014, Loma Linda, CA 92350, USA.

Background: The use of the Asian tobacco waterpipe (TWP) in the Lao People's Democratic Republic represents a potential communal source of infectious disease. This practice of smoking can lead to weakened defences of a smoker's respiratory epithelium, making the smoker vulnerable to respiratory diseases such as coronavirus disease 2019, tuberculosis and others.

Methods: This study evaluated the water quality and hygiene factors among 43 smokers of five villages in rural Luang Namtha Province. Read More

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Plume analysis from field evaluations of a portable air quality monitoring system.

J Air Waste Manag Assoc 2021 01 7;71(1):70-80. Epub 2020 Dec 7.

Atmospheric Science Research Center, University at Albany, State University of New York , Albany, NY, USA.

Near-road measurements in Rochester, NY with a Portable Air Quality Monitoring System indicate a significant plume control of PM black carbon (BC) concentrations. This study evaluates the performance of two portable air quality enclosures deployed at collocated research sites to determine their accuracy and usefulness in field deployments, and specifically in pollution plume analysis. One system deployed collocated sensors for measurement of particulate matter mass concentration (Thermo pDR 1500 against Tapered Element Oscillating Microbalance (TEOM) measurement) and the second system deployed sensors for measurement of black carbon (Magee AE33 aethalometer and Brechtel Tricolor Absorption Photometer) in ambient and near-road locations in Rochester, New York, respectively. Read More

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January 2021

In vitro intestinal transport and anti-inflammatory properties of ideain across Caco-2 transwell model.

Fitoterapia 2020 Oct 17;146:104723. Epub 2020 Sep 17.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Via Giovanni Palatucci, 98168 Messina, Italy. Electronic address:

The aim of the study was to investigate the absorption and transport mechanisms as well as the anti-inflammatory properties of ideain on Caco-2 transwell model. A concentration and time-dependent bidirectional transport was highlighted; despite this, a clear saturation of the transepithelial absorption in the A-B direction was observed at ideain concentration > 10 μM, suggesting an involvement of membrane transporters. Comparing Papp and PDR values of ideain (10 μM) to reference drugs with a low to a high apparent permeability, it is possible to predict a low in vivo absorption, with a transport efficiency of 1. Read More

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October 2020

Evidence of metabolic activity during low-temperature ovarian tissue preservation in different media.

J Assist Reprod Genet 2020 Oct 4;37(10):2477-2486. Epub 2020 Sep 4.

Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Avenue Mounier 52, bte B1.52.02, 1200, Brussels, Belgium.

Purpose: Although ovarian tissue transportation has been validated for up to 24 h, there is no standard protocol to date. We aimed to elucidate how existing media currently used for ovarian tissue transportation affect ovarian tissue metabolism and cell viability.

Methods: Cow ovarian fragments were immersed in 0. Read More

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October 2020

Carcinogenic effects of indoor black carbon and particulate matters (PM and PM) in rural households of India.

Environ Sci Pollut Res Int 2021 Jan 31;28(2):2082-2096. Epub 2020 Aug 31.

Department of Biotechnology, Kumaun University, Nainital, India.

Biomass is one of the prime domestic energy sources in the kitchens and about 60% of households are still using biomass and kerosene for cooking in India. These traditional cooking practices are incompetent as the use of biomass in traditional cookstove produces an enormous amount of carbonaceous aerosols that lead to indoor and outdoor air pollution. Emissions of various pollutants like black carbon (BC), PM and PM from burning of biomass cause serious health impacts like respiratory illness, lung cancer, watering of eyes, coughing, asthma and heart problems especially in women due to higher rate of inhalation of these fine particulate matters during the cooking period. Read More

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January 2021

Propranolol, chlorpromazine and diclofenac restore susceptibility of extensively drug-resistant (XDR)-Acinetobacter baumannii to fluoroquinolones.

PLoS One 2020 26;15(8):e0238195. Epub 2020 Aug 26.

Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Nosocomial infections caused by extensively drug-resistant (XDR) or Pan-Drug resistant (PDR) Acinetobacter (A.) baumannii have recently increased dramatically creating a medical challenge as therapeutic options became very limited. The aim of our study was to investigate the antibiotic-resistance profiles and evaluate the various combinations of ciprofloxacin (CIP) or levofloxacin (LEV) with antimicrobial agents and non-antimicrobial agents to combat antimicrobial resistance of XDR A. Read More

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October 2020