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Correlation between chemical composition and Sr concentrations in groundwater of the Chornobyl NPP industrial site.

J Environ Radioact 2021 Oct 11;240:106756. Epub 2021 Oct 11.

Radioecological Center, Natl. Acad. Sciences, Ukraine, 55-b, O. Gonchar Str, Kiev, 01054, Ukraine. Electronic address:

The volumetric activity of the divalent Sr ion in groundwater at the Chornobyl NPP industrial site ranges from 1 to 2 to 400-3800 Bq/l. The increase in groundwater radionuclides concentrations is associated with the reduced sorption properties of local sediments, which affect the migration capacity of radionuclides in the environment. The decrease of the Sr sorption properties of sediments is caused by changes in the chemical composition of groundwater. Read More

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October 2021

Point-of-care molecular diagnosis of Mycoplasma pneumoniae including macrolide sensitivity using quenching probe polymerase chain reaction.

PLoS One 2021 14;16(10):e0258694. Epub 2021 Oct 14.

Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.

Objectives: Macrolides are generally considered to be the drugs of choice for treatment of patients with Mycoplasma pneumoniae infection. However, macrolide-resistant M. pneumoniae has been emerging since about 2000. Read More

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October 2021

Risk of lead exposure, subcortical brain structure, and cognition in a large cohort of 9- to 10-year-old children.

PLoS One 2021 14;16(10):e0258469. Epub 2021 Oct 14.

Children's Hospital Los Angeles, and the Department of Pediatrics, University of Southern California, Los Angeles, California, United States of America.

Background: Lead, a toxic metal, affects cognitive development at the lowest measurable concentrations found in children, but little is known about its direct impact on brain development. Recently, we reported widespread decreases in cortical surface area and volume with increased risks of lead exposure, primarily in children of low-income families.

Methods And Findings: We examined associations of neighborhood-level risk of lead exposure with cognitive test performance and subcortical brain volumes. Read More

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October 2021

Altered production of reproductive neuropeptides in rats subjected to chronic intermittent hypoxia.

J Integr Neurosci 2021 Sep;20(3):651-657

Cátedra de Fisiología, Facultad de Odontología, Universidad de Buenos Aires, 1122 Buenos Aires, Argentina.

Hypobaric hypoxia is a stressful condition known to decrease fertility both in humans and animals. However, the mechanism by which the hypothalamus-pituitary-gonad axis is altered remains unknown. The aim of the present study was to analyze the effects of chronic intermittent and continuous exposure to hypoxia on hypothalamic-pituitary-gonadal axis regulation in male rats. Read More

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September 2021

[Forensic medical characteristics of metabolic myocardial lesions affecting cardiac contractile ability in cases of death from alcoholic cardiomyopathy].

Authors:
O V Sokolova

Sud Med Ekspert 2021 ;64(5):27-31

Academician I.P. Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia.

Objective - a morphological study of myocardial tissue was carried out in order to characterize the metabolic lesions that influence the heart contractility in cases of sudden cardiac death from alcoholic cardiomyopathy. The occurrence of metabolic damages in myocardial tissue in cases of alcoholic cardiomyopathy is a vivid reflection of the toxic effects on the cardiac muscle of ethanol and its metabolites. The toxic damage of the main structural components of the microcirculatory vessels contributes to the disruption of the transport of electrolytes and nutrients with the development of trophic disorders and the increasing phenomena of hypoxia that is the cause dystrophic and necrobiotic changes in myocardial tissue. Read More

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October 2021

Ultrahigh-Throughput Detection of Enzymatic Alcohol Dehydrogenase Activity in Microfluidic Droplets with a Direct Fluorogenic Assay.

Chembiochem 2021 Oct 13. Epub 2021 Oct 13.

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA, Cambridge, UK.

The exploration of large DNA libraries of metagenomic or synthetic origin is greatly facilitated by ultrahigh-throughput assays that use monodisperse water-in-oil emulsion droplets as sequestered reaction compartments. Millions of samples can be generated and analysed in microfluidic devices at kHz speeds, requiring only micrograms of reagents. The scope of this powerful platform for the discovery of new sequence space is, however, hampered by the limited availability of assay substrates, restricting the functions and reaction types that can be investigated. Read More

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October 2021

Ca2+-dependent modulation of voltage-gated myocyte sodium channels.

Biochem Soc Trans 2021 Oct 13. Epub 2021 Oct 13.

Department of Biochemistry, University of Cambridge, Cambridge, U.K.

Voltage-dependent Na+ channel activation underlies action potential generation fundamental to cellular excitability. In skeletal and cardiac muscle this triggers contraction via ryanodine-receptor (RyR)-mediated sarcoplasmic reticular (SR) Ca2+ release. We here review potential feedback actions of intracellular [Ca2+] ([Ca2+]i) on Na+ channel activity, surveying their structural, genetic and cellular and functional implications, translating these to their possible clinical importance. Read More

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October 2021

Chitosan-Based Accelerated Portland Cement Promotes Dentinogenic/Osteogenic Differentiation and Mineralization Activity of SHED.

Polymers (Basel) 2021 Sep 30;13(19). Epub 2021 Sep 30.

School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, KTN, Malaysia.

Calcium silicate-based cements (CSCs) are widely used in various endodontic treatments to promote wound healing and hard tissue formation. Chitosan-based accelerated Portland cement (APC-CT) is a promising and affordable material for endodontic use. This study investigated the effect of APC-CT on apoptosis, cell attachment, dentinogenic/osteogenic differentiation and mineralization activity of stem cells from human exfoliated deciduous teeth (SHED). Read More

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September 2021

Magnetoelectric Response of Laminated Cantilevers Comprising a Magnetoactive Elastomer and a Piezoelectric Polymer, in Pulsed Uniform Magnetic Fields.

Sensors (Basel) 2021 Sep 24;21(19). Epub 2021 Sep 24.

East Bavarian Centre for Intelligent Materials (EBACIM), Ostbayerische Technische Hochschule (OTH) Regensburg, Seybothstr. 2, D-93053 Regensburg, Germany.

The voltage response to pulsed uniform magnetic fields and the accompanying bending deformations of laminated cantilever structures are investigated experimentally in detail. The structures comprise a magnetoactive elastomer (MAE) slab and a commercially available piezoelectric polymer multilayer. The magnetic field is applied vertically and the laminated structures are customarily fixed in the horizontal plane or, alternatively, slightly tilted upwards or downwards. Read More

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September 2021

Characterization of Wet Olive Pomace Waste as Bio Based Resource for Leather Tanning.

Materials (Basel) 2021 Oct 3;14(19). Epub 2021 Oct 3.

A3 Leather Innovation Center, Escola Politècnica Superior, Departament d'Informàtica i Enginyeria Industrial, Universitat de Lleida (UdL), 25001 Lleida, Spain.

Olive mill wastes represent an important environmental problem. Their high phenol, lipid, and organic acid concentrations turn them into phytotoxic materials. Specifically, wet olive pomace (WOP) is the waste generated in the two-phase continuous extraction process. Read More

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October 2021

Impact of centrifugation time and pneumatic tube transport on plasma concentrations of direct oral anticoagulants.

Int J Lab Hematol 2021 Oct 12. Epub 2021 Oct 12.

Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.

Introduction: Rapid results are needed when plasma concentrations of direct oral anticoagulants (DOACs) are required in acute clinical settings. We evaluated the impact of centrifugation time and pneumatic tube transport on DOAC plasma concentrations with the overall aim of reducing turnaround time.

Methods: Blood samples were spiked with rivaroxaban, apixaban or dabigatran in a low and a high concentration prior to centrifugation for 25 minutes (3163 g) or 5 minutes (3000 g) (n = 20 for each DOAC). Read More

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October 2021

Internal loop sustains cyanobacterial blooms in eutrophic lakes: Evidence from organic nitrogen and ammonium regeneration.

Water Res 2021 Sep 30;206:117724. Epub 2021 Sep 30.

State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing 210008, China. Electronic address:

Algal bloom species can live upon internal regenerated ammonium (NH) for growth during the nitrogen-limited period. However, the linkages between NH regeneration and phytoplankton biomass and community composition dynamics remain largely unknown. To unravel the interactions between NH regeneration and phytoplankton community, we measured water column NH regeneration rates (REGs) during a continuous phytoplankton growing period and a contrast summer/winter turnover in eutrophic Lake Taihu. Read More

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September 2021

Bioequivalence and Food Effect Assessment of 2 Rivaroxaban Formulations in Healthy Chinese Volunteers: An Open, Randomized, Single-Dose, and 4-Period Crossover Study.

Clin Pharmacol Drug Dev 2021 Oct 12. Epub 2021 Oct 12.

Phase I Clinical Research Center, the Affiliated Hospital of Qingdao University, Qingdao, China.

Rivaroxaban is a direct factor Xa inhibitor used for the management of thromboembolic disorders. The aim of this study was to evaluate the safety, pharmacokinetic profile, and bioequivalence of a generic and a branded rivaroxaban formulation (Xarelto) under fasted and fed conditions in healthy Chinese volunteers. An open-label, randomized, single-dose, 4-period complete, and replicate crossover study in healthy Chinese volunteers was performed. Read More

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October 2021

Rapid Analysis of Trace Phthalates by Spray-Inlet Microwave Plasma Torch Ionization-Tandem Mass Spectrometry in Commercial Perfumes.

J AOAC Int 2021 Oct 12. Epub 2021 Oct 12.

Shanghai University of Medicine & Health Sciences, Collaborative Research Center, Shanghai, 200120 China.

Background: The less volatile fraction of perfumes can be easily contaminated by phthalates esters (PAEs) which are endocrine-disrupting chemicals during the production, bottling and transportation processes. It is necessary to establish an innovative and rapid method to determine the trace PAEs in commercial perfumes.

Objective: Hence, self-built spray-inlet microwave plasma torch ionization coupled with a quadrupole time-of-flight tandem mass spectrometer (QTOF-MS) was developed for direct analysis of PAEs in perfumes with no sample pretreatment. Read More

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October 2021

Insight into the Ozone-Assisted Low-Temperature Combustion of Dimethyl Ether by Means of Stabilized Cool Flames.

J Phys Chem A 2021 Oct 12. Epub 2021 Oct 12.

University of Lille, CNRS, UMR 8522-PC2A-Physicochimie des Processus de Combustion et de l'Atmosphère, F-59000 Lille, France.

The low-temperature combustion kinetics of dimethyl ether (DME) were studied by means of stabilized cool flames in a heated stagnation plate burner configuration using ozone-seeded premixed flows of DME/O. Direct imaging of CHO* chemiluminescence and laser-induced fluorescence of CHO were used to determine the flame front positions in a wide range of lean and ultra-lean equivalence ratios and ozone concentrations for two strain rates. The temperature and species mole fraction profiles along the flame were measured by coupling thermocouples, gas chromatography, micro-chromatography, and quadrupole mass spectrometry analysis. Read More

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October 2021

NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells.

J Cell Mol Med 2021 Oct 12. Epub 2021 Oct 12.

Department of Pediatrics, University of Yamanashi, Yamanashi, Japan.

In chemotherapy for childhood acute lymphoblastic leukaemia (ALL), maintenance therapy consisting of oral daily mercaptopurine and weekly methotrexate is important. NUDT15 variant genotype is reportedly highly associated with severe myelosuppression during maintenance therapy, particularly in Asian and Hispanic populations. It has also been demonstrated that acquired somatic mutations of the NT5C2 and PRPS1 genes, which are involved in thiopurine metabolism, are detectable in a portion of relapsed childhood ALL. Read More

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October 2021

Co-occurrence of severe PTSD, somatic symptoms and dissociation in a large sample of childhood trauma inpatients: a network analysis.

Eur Arch Psychiatry Clin Neurosci 2021 Oct 11. Epub 2021 Oct 11.

School of Health and Social Care, Edinburgh Napier University, Edinburgh, UK.

Co-occurrence of mental disorders including severe PTSD, somatic symptoms, and dissociation in the aftermath of trauma is common and sometimes associated with poor treatment outcomes. However, the interrelationships between these conditions at symptom level are not well understood. In the present study, we aimed to explore direct connections between PTSD, somatic symptoms, and dissociation to gain a deeper insight into the pathological processes underlying their comorbidity that can inform future treatment plans. Read More

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October 2021

Impact of Individualized Hemolysis Management Based on Biological Variation Cut-offs in a Clinical Laboratory.

Ann Lab Med 2022 Mar;42(2):169-177

Department of Clinical Biochemistry, University Hospital of Salamanca, Salamanca, Spain.

Background: Hemolysis is the most common type of preanalytical interference. Cut-offs based on the hemolysis index level can be established using different approaches. The Working Group for Preanalytical Phase of the European Federation of Laboratory Medicine has developed a protocol for hemolysis management based on cut-offs estimated from biological variation (BV) and the use of interpretative comments. Read More

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Rapid cloud removal of dimethyl sulfide oxidation products limits SO and cloud condensation nuclei production in the marine atmosphere.

Proc Natl Acad Sci U S A 2021 Oct;118(42)

Atmospheric Chemistry Observations and Modeling Laboratory, National Center for Atmospheric Research, Boulder, CO 80301.

Oceans emit large quantities of dimethyl sulfide (DMS) to the marine atmosphere. The oxidation of DMS leads to the formation and growth of cloud condensation nuclei (CCN) with consequent effects on Earth's radiation balance and climate. The quantitative assessment of the impact of DMS emissions on CCN concentrations necessitates a detailed description of the oxidation of DMS in the presence of existing aerosol particles and clouds. Read More

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October 2021

The dinoflagellate Alexandrium affine acutely induces significant modulations on innate immunity, hepatic function, and antioxidant defense system in the gill and liver tissues of red seabream.

Aquat Toxicol 2021 Oct 5;240:105985. Epub 2021 Oct 5.

Department of Marine Science, College of Natural Sciences, Incheon National University, Incheon 22012, Republic of Korea; Research Institute of Basic Sciences, Incheon National University, Incheon 22012, Republic of Korea; Yellow Sea Research Institute, Incheon 21999, Republic of Korea. Electronic address:

Alexandrium affine is a global harmful algal bloom (HAB)-forming dinoflagellate. In this study, the effect of non-toxin-producing A. affine on the gill and liver tissues of red seabream, Pagrus major, was analyzed over 24 h exposure and 2 h depuration phases. Read More

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October 2021

Study of rheological and tableting properties of lubricated mixtures of co-processed dry binders for orally disintegrating tablets.

Eur J Pharm Sci 2021 Oct 8:106035. Epub 2021 Oct 8.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Charles University, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.

Co-processed dry binders for ODTs are important multifunctional excipients for tablet manufacturing by direct compression. Testing their binary mixtures with lubricants is an important aspect of their use in combination with drugs. The aim of this study was to evaluate the rheological and compression properties of lubricated mixtures of co-processed dry binders Parteck® ODT, Prosolv® ODT G2 and Ludiflash®, and subsequently also the compactability and disintegration time of the tablets made thereof. Read More

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October 2021

Catecholamine-Induced Secondary Takotsubo Syndrome in Children With Severe Enterovirus 71 Infection and Acute Heart Failure: A 20-year Experience of a Single Institute.

Front Cardiovasc Med 2021 23;8:752232. Epub 2021 Sep 23.

Department of Pediatrics, Tungs' Taichung Metroharbor Hospital, Taichung, Taiwan.

Acute heart failure (AHF) is the major cause of death in children with severe enterovirus 71 (EV71) infection. This study aimed to report our clinical experience with EV71-related AHF, as well as to discuss its pathogenesis and relationship to Takotsubo syndrome (TTS). A total 27 children with EV71-related AHF between 1998 and 2018 were studied. Read More

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September 2021

Diacetyl and Other Ketones in e-Cigarette Aerosols: Some Important Sources and Contributing Factors.

Front Chem 2021 23;9:742538. Epub 2021 Sep 23.

Research and Development, British American Tobacco, Southampton, United Kingdom.

Concerns over the presence of the diketones 2,4 butanedione (DA) and 2,3 pentanedione (AP) in e-cigarettes arise from their potential to cause respiratory diseases. Their presence in e-liquids is a primary source, but they may potentially be generated by glycerol (VG) and propylene glycol (PG) when heated to produce aerosols. Factors leading to the presence of AP, DA and acetoin (AC) in e-cigarette aerosols were investigated. Read More

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September 2021

Analysis of organochlorine pesticides residues in fish from Edko Lake (North of Egypt) using eco-friendly method and their health implications for humans.

Toxicol Res 2021 Oct 8;37(4):495-503. Epub 2021 Mar 8.

Faculty of Agriculture, Plant Protection Department, Damanhour University, PO Box 59, Damnhour, Elbehera Egypt.

Levels of organochlorine pesticides (OCPs) residues in tilapia fish and their health risk associated with the consumption of fish from Edko lake, Egypt were determined. The quick, easy, cheap, effective, rugged, and safe method (QuEChERS) was used for extraction and clean-up of 18 OCPs residues from fish followed by GC-ECD and GC-ITD analytical tools were employed for identification of OPs. Out of the 18 OCPs, only heptachlorepoxide, p,p-DDE, dieldrin, p,p-DDD, and endrin ketone were detected in muscles of fish with concentrations of 0. Read More

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October 2021

Effect of on ruminal fermentation, feed intake and dry matter digestibility in cows fed forage-based diets.

Anim Biotechnol 2021 Oct 10:1-6. Epub 2021 Oct 10.

Departamento de Rumiantes, Instituto de Ciencia Animal, Mayabeque, Cuba.

The present study was conducted to investigate the effect of inclusion on ruminal fermentation, feed intake and dry matter (DM) apparent digestibility in cows fed forage and concentrate. Cows were randomly assigned in a replicated 4 × 4 Latin square design, into four treatments: control and three doses of culture (1, 2 and 3 g/d). Experimental periods had 21 days, in which 14 days were allowed for treatment adaptation and 7 days for sampling. Read More

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October 2021

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling.

Arch Toxicol 2021 Oct 10. Epub 2021 Oct 10.

In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, 78457, Konstanz, Germany.

Several neonicotinoids have recently been shown to activate the nicotinic acetylcholine receptor (nAChR) on human neurons. Moreover, imidacloprid (IMI) and other members of this pesticide family form a set of diverse metabolites within crops. Among these, desnitro-imidacloprid (DN-IMI) is of special toxicological interest, as there is evidence (i) for human dietary exposure to this metabolite, (ii) and that DN-IMI is a strong trigger of mammalian nicotinic responses. Read More

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October 2021

NEW ASPECTS OF THE INTERACTION OF COPPER (II) WITH SERUM ALBUMIN: VOLTAMMETRIC AND MICROCALORIMETRIC STUDIES.

Georgian Med News 2021 Sep(318):139-142

1Ivane Beritashvili Center of Experimental Biomedicine, Tbilisi; 3Ivane Javakhishvili Tbilisi State University, Department of Physics, Georgia.

Structural organization of serum albumins - the most abundant globular proteins in serum plasma - gives rise to their extraordinary binding and functional capacity. Various classes of ligands, including the metal ions can be captured and transported by albumins. Metal binding to human serum albumin, HSA, that is an essential multipurpose target for the modern biomedicine, to its bovine equivalent, BSA, and other mammalian analogs have been extensively explored in the context of metabolism of essential metal ions, like Cu2+. Read More

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September 2021

Trimellitic anhydride facilitates transepithelial permeability disrupting tight junctions in sinonasal epithelial cells.

Toxicol Lett 2021 Oct 7;353:27-33. Epub 2021 Oct 7.

Department of Surgery-Otolaryngology, Head and Neck Surgery, University of Adelaide, Adelaide, South Australia, Australia; Basil Hetzel Institute for Translational Health Research, Central Adelaide Local Health Network, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia. Electronic address:

Trimellitic anhydride (TMA) is a chemical agent classified as a low molecular weight (LMW) agent causing occupational rhinitis (OR) or asthma. Although TMA is recognized as a respiratory sensitizer, the direct and non-immunologic effects of TMA remain unclear. Air- liquid interface (ALI) cultured human nasal epithelial cells (HNECs) derived from control subjects were treated with TMA, followed by measurement of the transepithelial electrical resistance (TEER), paracellular permeability of fluorescein isothiocyanate (FITC)-dextran and immunofluorescence of tight junction proteins claudin-1 and zonula occludens-1 (ZO-1). Read More

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October 2021

Warming effects on the flux of CH from peatland mesocosms are regulated by plant species composition: Richness and functional types.

Sci Total Environ 2021 Oct 7:150831. Epub 2021 Oct 7.

Key Laboratory of Wetland Ecology and Environment, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun 130102, China.

Peatlands in northeast China are experiencing severe climate warming. Most studies on peatlands focus on the responses of CH dynamics to temperature. However, they rarely consider the synchronous changes in the composition of plant communities caused by the expansion of vascular plants. Read More

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October 2021

Prioritization of Pesticides for Assessment of Risk to Aquatic Ecosystems in Canada and Identification of Knowledge Gaps.

Rev Environ Contam Toxicol 2021 Oct 10. Epub 2021 Oct 10.

School of Environmental Sciences, University of Guelph, Guelph, ON, Canada.

Pesticides can enter aquatic environments via direct application, via overspray or drift during application, or by runoff or leaching from fields during rain events, where they can have unintended effects on non-target aquatic biota. As such, Fisheries and Oceans Canada identified a need to prioritize current-use pesticides based on potential risks towards fish, their prey species, and habitats in Canada. A literature review was conducted to: (1) Identify current-use pesticides of concern for Canadian marine and freshwater environments based on use and environmental presence in Canada, (2) Outline current knowledge on the biological effects of the pesticides of concern, and (3) Identify general data gaps specific to biological effects of pesticides on aquatic species. Read More

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October 2021