521 results match your criteria concentration fpg


Insulin secretion is a strong predictor for need of insulin therapy in patients with new-onset diabetes and HbA1c of more than 10%: A post hoc analysis of the EDICT study.

Diabetes Obes Metab 2021 Apr 14. Epub 2021 Apr 14.

Division of Diabetes, University of Texas Health Science Center and Texas Diabetes Institute, San Antonio, Texas, USA.

Aim: To identify predictors of response to glucose-lowering therapy in patients with new-onset diabetes and very high HbA1c (>10%).

Methods: The study included EDICT participants with an initial HbA1c of more than 10% (N = 104). All subjects received a 75-g oral glucose tolerance test (OGTT) before initiation of therapy, and then were randomized to receive: (a) initial triple therapy with metformin, pioglitazone and exenatide versus (b) stepwise conventional therapy with metformin followed by glipizide and then glargine insulin to reduce HbA1c to less than 6. Read More

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Value of simple clinical parameters to predict insulin resistance among newly diagnosed patients with type 2 diabetes in limited resource settings.

PLoS One 2021 31;16(3):e0248469. Epub 2021 Mar 31.

Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.

Background: Insulin resistance (IR) has been considered as a therapeutic target in the management of type 2 diabetes mellitus (T2DM). Readily available, simple and low cost measures to identify individuals with IR is of utmost importance for clinicians to plan optimal management strategies. Research on the associations between surrogate markers of IR and routine clinical and lipid parameters have not been carried out in Sri Lanka, a developing country with rising burden of T2DM with inadequate resources. Read More

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Hemoglobin concentration is associated with the incidence of metabolic syndrome.

BMC Endocr Disord 2021 Mar 19;21(1):53. Epub 2021 Mar 19.

Department of Endocrinology, Xinhua Hospital Chongming Branch, School of Medicine, Shanghai Jiaotong University, 25 Nanmen Road, Shanghai, 202150, China.

Background: An association between hemoglobin and metabolic syndrome (MetS) has been reported. However, the relationships between hemoglobin and individual MetS components remain unclear. Therefore, we investigated these associations at baseline and at the 3-year follow-up. Read More

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1,2-Diarylethanols-A New Class of Compounds That Are Toxic to K12, R2-R4 Strains.

Materials (Basel) 2021 Feb 22;14(4). Epub 2021 Feb 22.

Institute of Organic Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw, Poland.

An initial study of 1,2-diarylethanols derivatives as new potential antibacterial drugs candidates was conducted. Particular emphasis was placed on the selection of the structure of 1,2-diarylethanols with the highest biological activity of lipopolysaccharides (LPS) in the model strains of Escherichia coli K12 (without LPS in its structure) and R2-R4 (with different lengths of LPS in its structure). In the presented studies, based on the conducted minimum inhibitory concentration (MIC) and MBC tests, it was demonstrated that the antibacterial (toxic) effect of 1,2-diarylethanols depends on their structure and the length of LPS bacteria in the membrane of specific strains. Read More

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February 2021

One-hour plasma glucose concentration can identify elderly Chinese male subjects at high risk for future type 2 diabetes mellitus: A 20-year retrospective and prospective study.

Diabetes Res Clin Pract 2021 Mar 17;173:108683. Epub 2021 Feb 17.

Department of Endocrinology, the Second Medical Center, the People's Liberation Army General Hospital, Beijing, China; National Clinical Research Center for Geriatric Disease, the People's Liberation Army General Hospital, Beijing, China. Electronic address:

Aim: There have been few reports regarding the association between 1 h-PG concentration and type 2 diabetes mellitus (T2DM) in the elderly. This study was performed to assess the efficacy of 1 h-PG and 2 h-PG values in predicting future risk of T2DM in elderly.

Methods: The study population consisted of 928 male volunteers ≥ 55 years old without diabetes who were involved in a retrospective-prospective cohort study over 20 years with a baseline fasting plasma glucose (FPG) and OGTT that included measurement of 1 h-PG and 2 h-PG. Read More

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Systemic Stressors and Retinal Microvascular Alterations in People Without Diabetes: The Kailuan Eye Study.

Invest Ophthalmol Vis Sci 2021 Feb;62(2):20

Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Capital Medical University, Beijing, China.

Purpose: The purpose of this study was to determine systemic stressors, including fasting plasma glucose (FPG), and other major atherosclerotic cardiovascular disease (ASCVD) risk factors of the retinal microvasculature in people without diabetes.

Methods: The Kailuan Eye Study enrolled applicants from the community-based longitudinal Kailuan Study. Applicants underwent optical coherence tomographic angiography (OCTA) and systemic examinations. Read More

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February 2021

Fluorosilicic acid induces DNA damage and oxidative stress in bone marrow mesenchymal stem cells.

Mutat Res 2021 Jan-Feb;861-862:503297. Epub 2020 Nov 21.

Lutheran University of Brazil (ULBRA), Laboratory of Genetic Toxicology, PPGBioSaúde (Postgraduate Program in Cellular and Molecular Biology Applied to Health), 92425-900, Canoas, RS, Brazil; Laboratory of Genetic Toxicology, La Salle University (UniLaSalle), Canoas, RS, Brazil. Electronic address:

Excess fluoride in water can produce changes in tooth enamel mineralization and lead to diseases such as dental or skeletal fluorosis. The present study aimed to assess the genotoxic effects, oxidative stress, and osteoblastic mineralization induced by fluorosilicic acid (FA) in murine bone marrow-derived mesenchymal stem cells (BM-MSCs). BM-MSCs were isolated from the femurs and tibias of rats and cultured under standard conditions. Read More

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Plasma Alarin Level and Its Influencing Factors in Obese Newly Diagnosed Type 2 Diabetes Patients.

Diabetes Metab Syndr Obes 2021 27;14:379-385. Epub 2021 Jan 27.

Department of Endocrinology, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400000, People's Republic of China.

Objective: To investigate the plasma alarin level in newly diagnosed obese type 2 diabetes mellitus (T2DM) and its correlation with glucose and lipid metabolism and insulin resistance.

Methods: From October 2018 to June 2020, 239 newly diagnosed T2DM patients were collected. According to obesity, patients were divided into T2DM obese group (n=135) and T2DM non-obese group (n =104). Read More

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January 2021

Evaluation of MASP1, CMPF and U.A serum levels in pre-diabetic subjects in comparison to Normal individuals for early diagnosis of subjects with pre-diabetes, a case-control study.

J Diabetes Metab Disord 2020 Dec 21;19(2):1593-1598. Epub 2020 Nov 21.

Department of Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

Background: The present study designed to evaluate the Serum levels of CMPF, MASP1 and UA in pre-diabetic subjects was compared to normal subjects

Methods: This research is a case-control study. We studied 44 pre-diabetics with 44 normal subjects and were evaluated serum concentration of CMPF, Masp1 and U.Ain both groups andfurthermore serum concentration FPG, BUN, Cr, Cho, TG, HDLc, LDLc, AST, ALT, ALP, HbA1c was examined and correlation between of CMPF, Masp1 and U. Read More

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December 2020

Predictive Model of Type 2 Diabetes Remission after Metabolic Surgery in Chinese Patients.

Int J Endocrinol 2020 31;2020:2965175. Epub 2020 Oct 31.

Department of Endocrinology, Third Xiangya Hospital of Central South University & Diabetic Foot Research Center of Central South University, Changsha, Hunan Province 410013, China.

Introduction: Metabolic surgery is an effective treatment for type 2 diabetes (T2D). At present, there is no authoritative standard for predicting postoperative T2D remission in clinical use. In general, East Asian patients with T2D have a lower body mass index and worse islet function than westerners. Read More

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October 2020

The Correlation Between Metabolic Disorders And Tpoab/Tgab: A Cross-Sectional Population-Based Study.

Endocr Pract 2020 Aug;26(8):869-882

Department of Endocrinology and Metabolism, Affiliated Hospital of Guiyang Medical University, Guiyang, Guizhou, P.R. China.

Objective: Studies have shown that metabolic abnormalities influence the immune system. Because the prevalence of metabolic and autoimmune thyroid diseases has increased synchronously, the correlation between them was worth exploring. The study objective was to investigate the relationship between metabolic disorders and thyroid auto-antibodies in euthyroid subjects. Read More

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Evaluation of the cytotoxic and genotoxic effects of Cav extract using human neuroblastoma cell line SH-SY5Y.

J Toxicol Environ Health A 2021 Apr 12;84(8):345-355. Epub 2021 Jan 12.

Laboratory of Genetic Toxicology, PPGBioSaúde (Postgraduate Program in Cellular and Molecular Biology Applied to Health), Lutheran University of Brazil (ULBRA), Canoas, RS, Brazil.

is a weed thought to have originated in Brazil, where it is present in abundant quantities, but also this plant is also found in south-central Florida, Indian Ocean Islands, and the Pacific Islands. produces neurotoxicity that adversely affects livestock breeding with heavy animal losses and consequent negative impact on Brazil's economy. The aim of this study was to determine the chemical profile, cytotoxic and genotoxic effects of ethanolic extracts of collected in winter (leaf extract) and summer (leaf extract and leaf + flower extract) using an model of human neuroblastoma cell line SH-SY5Y. Read More

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The effects of vitamin D supplementation on glycemic control and maternal-neonatal outcomes in women with established gestational diabetes mellitus: A systematic review and meta-analysis.

Clin Nutr 2020 Dec 21. Epub 2020 Dec 21.

Department of Preventive Medicine, Hangzhou Normal University School of Medicine, Hangzhou, 311121, China. Electronic address:

Background & Aims: Gestational Diabetes Mellitus (GDM) is associated with a well-documented range of adverse pregnancy outcomes. The present meta-analysis was conducted to evaluate the effects of vitamin D supplementation on glycemic control and maternal-neonatal outcomes in women with established GDM.

Methods: Published literature was retrieved and screened from PubMed, Embase, Web of Science, CNKI (China National Knowledge Infrastructure), Wanfang, and Cochrane Center Register of Controlled Trails up to May 2020. Read More

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December 2020

Efficacy and safety of a herbal drug of Coccinia grandis (Linn.) Voigt in patients with type 2 diabetes mellitus: A double blind randomized placebo controlled clinical trial.

Phytomedicine 2021 Jan 3;81:153431. Epub 2020 Dec 3.

Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka. Electronic address:

Background: Several lines of preclinical studies have shown promising antidiabetic effects of the aqueous leaves extract of Coccinia grandis (Linn.) Voigt (Cucurbitaceae) in vivo and in vitro.

Purpose: The present study was conducted to evaluate the efficacy and safety of a newly developed herbal formulation of C. Read More

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January 2021

[Effects of occupational nickel exposure on glycemic parameters in workers].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020 Nov;38(11):843-845

Changshu Municipal Center for Disease Control and Prevention, Changshu 215500, China.

To explore the effect of occupational nickel exposure on blood glucose related indicators of workers. In March 2019, five electroplating enterprises and one plastic hardware enterprise were selected by cluster sampling method. 159 nickel plating workers were selected as the contact group, and 66 administrative personnel of the same enterprise were selected as the control group. Read More

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November 2020

Associations of urinary carbon disulfide metabolite with oxidative stress, plasma glucose and risk of diabetes among urban adults in China.

Environ Pollut 2021 Mar 29;272:115959. Epub 2020 Oct 29.

Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, And State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. Electronic address:

Carbon disulfide (CS) has been reported to induce disorder of glucose metabolism. However, the associations of CS exposure with plasma glucose levels and risk of diabetes have not been explored in general population, and the underlying mechanisms remain unclear. We aim to examine the relationships between CS exposure and fasting plasma glucose (FPG) levels, as well as diabetes, and assess the potential role of oxidative stress among the abovementioned relationships in Chinese general adults. Read More

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Safety, Pharmacokinetics, and Pharmacodynamics of Globalagliatin, a Glucokinase Activator, in Chinese Patients with Type 2 Diabetes Mellitus: A Randomized, Phase Ib, 28-day Ascending Dose Study.

Clin Drug Investig 2020 Dec 30;40(12):1155-1166. Epub 2020 Oct 30.

Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, #300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.

Background And Objectives: Globalagliatin, a glucokinase activator, plays a vital role in glucose homeostasis. The aim of this study was to assess the safety, pharmacokinetics, and pharmacodynamics of globalagliatin in Chinese patients with type 2 diabetes.

Methods: In this dose-titration study, 24 patients were randomized (3:1 ratio) to receive globalagliatin or placebo. Read More

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December 2020

The Usefulness of Diagnostic Panels Based on Circulating Adipocytokines/Regulatory Peptides, Renal Function Tests, Insulin Resistance Indicators and Lipid-Carbohydrate Metabolism Parameters in Diagnosis and Prognosis of Type 2 Diabetes Mellitus with Obesity.

Biomolecules 2020 09 9;10(9). Epub 2020 Sep 9.

Department of Community Pharmacy, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland.

The quantitative analysis of selected regulatory molecules, i.e., adropin, irisin, and vaspin in the plasma of obese patients with newly diagnosed, untreated type 2 diabetes mellitus, and in the same patients after six months of using metformin, in relation to adropinemia, irisinemia and vaspinemia in obese individuals, was performed. Read More

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September 2020

Total Bilirubin Predicts Severe Progression of Diabetic Retinopathy and the Possible Causal Mechanism.

J Diabetes Res 2020 31;2020:7219852. Epub 2020 Jul 31.

Department of Ophthalmology, Hefei Binhu Hospital, The Third Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230001, China.

Early detection and treatment are key to delaying the progression of diabetic retinopathy (DR), avoiding loss of vision, and reducing the burden of advanced disease. Our study is aimed at determining if total bilirubin has a predictive value for DR progression and exploring the potential mechanism involved in this pathogenesis. A total of 540 patients with nonproliferative diabetic retinopathy (NPDR) were enrolled between July 2014 and September 2016 and assigned into a progression group ( = 67) or a stable group ( = 473) based on the occurrence of diabetic macular edema (DME), vitreous hemorrhage, retinal detachment, or other conditions that may cause severe loss of vision following a telephonic interview in August 2019. Read More

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Giant Enhancement of Fluorescence Emission by Fluorination of Porous Graphene with High Defect Density and Subsequent Application as Fe Ion Sensors.

ACS Appl Mater Interfaces 2020 Sep 25;12(36):40662-40672. Epub 2020 Aug 25.

College of Polymer Science and Engineering, State Key Laboratory of Polymer Material and Engineering, Sichuan University, Chengdu 610065, P.R. China.

Defect-mediated nonradiative recombination in traditional semiconductors, such as porous graphene, tremendously lowers the fluorescence emission, thus greatly restricting their applications in more extensive fields. Here, we report that the fluorescence emission of porous graphene with a high defect density has a giant enhancement (about two orders of magnitude) by a direct and simple fluorination strategy, showing a fine defect-tolerance characteristic. Meanwhile, the corresponding fluorocarbon bonds with excellent thermostability (over 500 °C in N even air) also bring about good stability. Read More

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September 2020

A Meta-analysis of Randomized Controlled Trials of the Effect of Probiotic Food or Supplement on Glycemic Response and Body Mass Index in Patients with Type 2 Diabetes, Updating the Evidence.

Curr Diabetes Rev 2021 ;17(3):356-364

Department of Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: To investigate the effects of probiotics on glucose metabolism and body mass index (BMI), and compare the efficacy of probiotic food with the probiotic supplement in patients with type 2 diabetes mellitus using a meta-analysis of randomized, controlled trials.

Methods: Online databases Embase, Web of Science, and PubMed were searched until November 2019 to identify eligible articles. Fourteen trials were included. Read More

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Morphological transformation enhances Tumor Retention by Regulating the Self-assembly of Doxorubicin-peptide Conjugates.

Theranostics 2020 9;10(18):8162-8178. Epub 2020 Jul 9.

College of pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.

Both spatial accuracy and temporal persistence are crucial in drug delivery, especially for anti-tumor intravenous nanomedicines, which have limited persistence due to their small particle sizes and easy removal from tumors. The present study takes advantage of morphological transformation strategy to regulate intravenous nanomedicines to display different sizes in different areas, achieving high efficient enrichment and long retention in lesions. We designed and synthesized functional doxorubicin-peptide conjugate nanoparticles (FDPC-NPs) consisting of self-assembled doxorubicin-peptide conjugates (DPCs) and an acidic-responsive shielding layer named the functional polylysine graft (FPG), which can regulate the assembly morphology of the DPCs from spherical DPC nanoparticles (DPC-NPs) to DPC-nanofibers (DPC-NFs) by preventing the assembly force from π-π stacking and hydrogen bond between the DPC-NPs. Read More

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Combined cytotoxic and genotoxic effects of ochratoxin A and fumonisin B in human kidney and liver cell models.

Toxicol In Vitro 2020 Oct 24;68:104949. Epub 2020 Jul 24.

Department of Human Genetics, National Institute of Health Doutor Ricardo Jorge, I.P. (INSA), Av. Padre Cruz, 1649-016 Lisbon, Portugal; ToxOmics - Centre for Toxicogenomics and Human Health, NOVA Medical School/FCM, Universidade NOVA de Lisboa, Portugal. Electronic address:

Food products can be contaminated by several fungi species and each species may produce different mycotoxins, leading to human combined exposure. Although predictions about the joint toxic effects of mycotoxins can be made from their individual toxicities, experimental data is still limited to allow a reliable hazard assessment. Thus, this study aimed to characterize the combined cytotoxic and genotoxic effects of ochratoxin A (OTA) and fumonisin B1 (FB) in cell lines representative of their target organs, kidney and liver. Read More

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October 2020

Association between ambient particulate matter (PM) and incidence of diabetes in northwest of China: A prospective cohort study.

Ecotoxicol Environ Saf 2020 Oct 23;202:110880. Epub 2020 Jun 23.

Department of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, 730000, China. Electronic address:

Objectives: We aimed to assess the association between long-term exposure to ambient PM and risk of diabetes incidence, based on the "Jinchang Cohort" platform in the Northwest of China.

Methods: We selected 19884 subjects who had not yet developed diabetes in the baseline and had completed survey information from "Jinchang Cohort". The residential address was used to match the nearest pollution monitoring station for each subject, and the average concentration of PM from baseline to follow-up were used as an estimate of individual exposure level. Read More

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October 2020

DNA damage and DNA protection from digested raw and griddled green pepper (poly)phenols in human colorectal adenocarcinoma cells (HT-29).

Eur J Nutr 2021 Mar 19;60(2):677-689. Epub 2020 May 19.

Departamento de Ciencias de la Alimentación y Fisiología, Facultad de Farmacia y Nutrición, Universidad de Navarra, C/Irunlarrea 1, 31008, Pamplona, Spain.

Purpose: To determine whether (poly)phenols from gastrointestinal-digested green pepper possess genoprotective properties in human colon cells and whether the application of a culinary treatment (griddling) on the vegetable influences the potential genoprotective activity.

Methods: (Poly)phenols of raw and griddled green pepper (Capsicum annuum L.) submitted to in vitro-simulated gastrointestinal digestion were characterized by LC-MS/MS. Read More

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Decreased Plasma Maresin 1 Concentration Is Associated with Diabetic Foot Ulcer.

Mediators Inflamm 2020 16;2020:4539035. Epub 2020 Apr 16.

Department of Endocrinology, Translational Research of Diabetes Key Laboratory of Chongqing Education Commission of China, The Second Affiliated Hospital of Army Medical University, Chongqing, China.

Aims: To assess the maresin 1 (MaR1) contents in type 2 diabetic patients with or without diabetic foot ulcer and to analyze the association of MaR1 concentrations with several metabolism-related parameters.

Methods: Plasma MaR1 concentrations were analyzed in 96 subjects with normal glucose tolerant (NC, = 43), type 2 diabetes (T2DM, = 40), or diabetic foot ulcer (DFU, = 13). The intravenous glucose tolerance test (IVGTT) and biochemical parameters were measured in all participants. Read More

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Development of a co-culture model of mouse primary hepatocytes and splenocytes to evaluate xenobiotic genotoxicity using the medium-throughput Comet assay.

Toxicol In Vitro 2020 Aug 25;66:104874. Epub 2020 Apr 25.

National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

To date, only a limited number of toxicological studies have focused on the establishment and validation of in vitro genotoxicity screening systems using primary hepatocytes, and the results of these studies have been inconsistent. Therefore, the aim of this study was to develop an effective co-culture model of mouse-derived primary hepatocytes and splenocytes for screening chemicals for genotoxicity using the medium-throughput Comet assay. This cocultured model was constructed and verified using known genotoxic and non-genotoxic compounds as positive and negative controls, respectively. Read More

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Demographic Associations of Diabetes Status by Both Fasting Plasma Glucose Concentration and Glycated Hemoglobin in a Community Survey in Galle District, Sri Lanka.

J Nutr Metab 2020 6;2020:6127432. Epub 2020 Apr 6.

Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.

Diagnostic tools used in detecting individuals with diabetes mellitus (DM) include fasting plasma glucose (FPG), glycated hemoglobin (HbA), and oral glucose tolerance test (OGTT). The present study was aimed to determine the demographic associations of diabetes status by both tests (FPG and HbA) in Galle district, Sri Lanka. 147 adults (30-60 years) who are having FPG ≥ 126 mg/dL underwent demographic evaluations and testing for HbA. Read More

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Potassium bromate as positive assay control for the Fpg-modified comet assay.

Mutagenesis 2020 09;35(4):341-348

Department of Nutrition, University of Oslo, Sognsvannsveien 9, 0372, Oslo, Norway.

The comet assay is a popular assay in biomonitoring studies. DNA strand breaks (or unspecific DNA lesions) are measured using the standard comet assay. Oxidative stress-generated DNA lesions can be measured by employing DNA repair enzymes to recognise oxidatively damaged DNA. Read More

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September 2020

Leisure-time physical activity and milk intake synergistically reduce the risk of pathoglycemia: A cross-sectional study in adults in Beijing, China.

Asia Pac J Clin Nutr 2020 ;29(1):183-191

Department of Social Medicine and Health Education, School of Public Health, Peking University Health Science Center, Beijing, China. Email:

Background And Objectives: To evaluate the synergistic and individual associations of leisure-time physical activity (LTPA) intensity and the frequency of milk intake in adulthood with newly diagnosed pathoglycemia. Pathoglycemia comprised impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM).

Methods And Study Design: This cross-sectional study of 3977 adults was conducted in Mentougou District, Beijing, China. Read More

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January 2021