2,369 results match your criteria concentration eliciting

Machine Learning-Based Analysis of Encrypted Medical Data in the Cloud: Qualitative Study of Expert Stakeholders' Perspectives.

JMIR Hum Factors 2021 Sep 16;8(3):e21810. Epub 2021 Sep 16.

Computer Science, Karlstad University, Karlstad, Sweden.

Background: Third-party cloud-based data analysis applications are proliferating in electronic health (eHealth) because of the expertise offered and their monetary advantage. However, privacy and security are critical concerns when handling sensitive medical data in the cloud. Technical advances based on "crypto magic" in privacy-preserving machine learning (ML) enable data analysis in encrypted form for maintaining confidentiality. Read More

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September 2021

Imaging associations of self-injurious behaviours amongst patients with Borderline Personality Disorder: A mini-review.

J Affect Disord 2021 Aug 31;295:781-787. Epub 2021 Aug 31.

Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, 20122 Milan, Italy.

Background: Borderline Personality Disorder (BPD) is a severe and disabling psychiatric syndrome, frequently associated with self-injurious behaviours (SIB). In recent years, functional magnetic resonance imaging (fMRI) investigations have tried to identify alterations associated with SIB amongst BPD patients, in order to better delineate possible neurobiological underpinnings of these manifestations. In this mini-review, we aimed at summarizing fMRI studies exploring patterns of neural activation associated with SIB in BPD patients. Read More

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Double-Strand RNA (dsRNA) Delivery Methods in Insects: Diaphorina citri.

Methods Mol Biol 2022 ;2360:253-277

Cellular and Molecular Biology, The University of Southern Mississippi, Hattiesburg, MS, USA.

RNAi is a gene-silencing mechanism conserved in the vast majority of eukaryotes. It is widely used to study gene function in animals due to the ease of eliciting gene knockdown. Beyond research applications, RNAi technology based on exogenous dsRNA is a promising candidate for next generation insect pest control. Read More

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January 2022

Through DNA sensors and hidden mitochondrial effects of SARS-CoV-2.

J Venom Anim Toxins Incl Trop Dis 2021 23;27:e20200183. Epub 2021 Aug 23.

Department of Immunology, Institute of Biomedical Sciences (ICB), University of São Paulo (USP), São Paulo, SP, Brazil.

The COVID-19 pandemic brought attention to studies about viral infections and their impact on the cell machinery. SARS-CoV-2, for example, invades the host cells by ACE2 interaction and possibly hijacks the mitochondria. To better understand the disease and to propose novel treatments, crucial aspects of SARS-CoV-2 enrolment with host mitochondria must be studied. Read More

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Root Extract Induces the Anagen Phase in the Human Hair Follicle Dermal Papilla Cells.

Pharmaceutics 2021 Jul 27;13(8). Epub 2021 Jul 27.

School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Korea.

Restoring hair follicles by inducing the anagen phase is a promising approach to prevent hair loss. Hair follicle dermal papilla cells (HFDPCs) play a major role in hair growth via the telogen-to-anagen transition. The therapeutic effect of activates β-catenin in HFDPCs, thereby inducing the anagen phase. Read More

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Next-Generation Bioinformatics Approaches and Resources for Coronavirus Vaccine Discovery and Development-A Perspective Review.

Vaccines (Basel) 2021 Jul 22;9(8). Epub 2021 Jul 22.

Department of Animal Biotechnology, Faculty of Biotechnology, Jeju National University, Jeju 63243, Korea.

COVID-19 is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To fight this pandemic, which has caused a massive death toll around the globe, researchers are putting efforts into developing an effective vaccine against the pathogen. As genome sequencing projects for several coronavirus strains have been completed, a detailed investigation of the functions of the proteins and their 3D structures has gained increasing attention. Read More

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Cardiotoxicity Hazard and Risk Characterization of ToxCast Chemicals Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes from Multiple Donors.

Chem Res Toxicol 2021 Aug 27. Epub 2021 Aug 27.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas 77843-4458, United States.

Heart disease remains a significant human health burden worldwide with a significant fraction of morbidity attributable to environmental exposures. However, the extent to which the thousands of chemicals in commerce and the environment may contribute to heart disease morbidity is largely unknown, because in contrast to pharmaceuticals, environmental chemicals are seldom tested for potential cardiotoxicity. Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes have become an informative model for cardiotoxicity testing of drugs with the availability of cells from multiple individuals allowing testing of population variability. Read More

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Pathological and Therapeutic Approach to Endotoxin-Secreting Bacteria Involved in Periodontal Disease.

Toxins (Basel) 2021 Jul 29;13(8). Epub 2021 Jul 29.

Department of Cell Biology, Histology and Pharmacology, Faculty of Medicine and INCYL, University of Valladolid, 47005 Valladolid, Spain.

It is widely recognized that periodontal disease is an inflammatory entity of infectious origin, in which the immune activation of the host leads to the destruction of the supporting tissues of the tooth. Periodontal pathogenic bacteria like , that belongs to the complex net of oral microflora, exhibits a toxicogenic potential by releasing endotoxins, which are the lipopolysaccharide component (LPS) available in the outer cell wall of Gram-negative bacteria. Endotoxins are released into the tissues causing damage after the cell is lysed. Read More

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Hydrogel/nanoadjuvant-mediated combined cell vaccines for cancer immunotherapy.

Acta Biomater 2021 Aug 15. Epub 2021 Aug 15.

Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, PR China. Electronic address:

Combined cell vaccines of tumor whole cells and dendritic cells (DCs) provide an effective individualized immunotherapy for malignant tumors. We propose an innovative strategy termed "biomaterial-mediated combined cell vaccines for immunotherapy," which combines tumor cell and DC vaccines with a cyclodextrin-polyethylene glycol hydrogel and a cytosine-phosphate-guanine (CpG) nanoadjuvant. The nanoadjuvant promotes antigen presentation and amplifies immune-eliciting potency by co-delivery of antigens and adjuvants. Read More

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The Phytochemical Scoulerine Inhibits Aurora Kinase Activity to Induce Mitotic and Cytokinetic Defects.

J Nat Prod 2021 08 18;84(8):2312-2320. Epub 2021 Aug 18.

Chengdu Anticancer Bioscience, Ltd., and J. Michael Bishop Institute of Cancer Research, Chengdu 610000, China.

To identify novel bioactive compounds, an image-based, cell culture screening of natural product extracts was conducted. Specifically, our screen was designed to identify phytochemicals that might phenocopy inhibition of the chromosomal passenger protein complex in eliciting mitotic and cytokinetic defects. A known alkaloid, scoulerine, was identified from the rhizomes of the plant as being able to elicit a transient mitotic arrest followed by either apoptosis induction or polyploidy. Read More

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Sesame as an allergen in Lebanese food products: Occurrence, consumption and quantitative risk assessment.

Food Chem Toxicol 2021 Oct 13;156:112511. Epub 2021 Aug 13.

Food Risk Analysis and Regulatory Excellence Platform (PARERA), Department of Food Science and Institute of Nutrition and Functional Foods (INAF), Université Laval, Quebec, Canada.

Despite the intensive use of sesame in the Middle Eastern diet, studies on this allergen in this region are lacking. A survey on the occurrence of sesame in Lebanese food products that did not contain this allergen as an ingredient, a food consumption survey conducted in Beirut schools, and the most recent sesame eliciting dose estimates were used to build a probabilistic risk assessment model providing estimates of sesame-induced allergic reactions per eating occasion and per week in Lebanese children and adolescents. Of 1270 food samples analysed, 34% contained sesame proteins (0. Read More

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October 2021

Extract Acts as Biostimulant and Modulates Metabolites and Hormone Balance in Basil ( L.) and Parsley ( L.).

Plants (Basel) 2021 Jul 7;10(7). Epub 2021 Jul 7.

Department of Agriculture, Food and Environment, University of Pisa, 56124 Pisa, Italy.

Natural elicitors from macroalgae may affect plant secondary metabolites. Ulvan is a sulfated heteropolysaccharide extracted from green seaweed, acting as both a plant biotic protecting agent, and a plant elicitor, leading to the synthesis of signal molecules. In this work, the aqueous extract of L. Read More

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The Inquiline Ant Uses Both Chemical and Vibroacoustic Deception Mechanisms to Integrate into Its Host Colonies.

Biology (Basel) 2021 Jul 12;10(7). Epub 2021 Jul 12.

Museum and Institute of Zoology, Polish Academy of Sciences, ul. Wilcza 64, 00-679 Warsaw, Poland.

Social parasitism represents a particular type of agonistic interaction in which a parasite exploits an entire society instead of a single organism. One fascinating form of social parasitism in ants is the "inquilinism", in which a typically worker-less parasitic queen coexists with the resident queen in the host colony and produces sexual offspring. To bypass the recognition system of host colonies, inquilines have evolved a repertoire of deceiving strategies. Read More

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Spatiotemporal Dynamics of Covert Versus Overt Processing of Happy, Fearful and Sad Facial Expressions.

Brain Sci 2021 Jul 17;11(7). Epub 2021 Jul 17.

Department of Developmental and Social Psychology, University of Padova, Via Venezia 8, 35131 Padova, Italy.

Behavioral and electrophysiological correlates of the influence of task demands on the processing of happy, sad, and fearful expressions were investigated in a within-subjects study that compared a perceptual distraction condition with task-irrelevant faces (e.g., covert emotion task) to an emotion task-relevant categorization condition (e. Read More

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The clinical spectrum and immunopathological mechanisms underlying ZIKV-induced neurological manifestations.

PLoS Negl Trop Dis 2021 Aug 5;15(8):e0009575. Epub 2021 Aug 5.

Department of Clinical Research, Instituto Fernandes Figueira, Fiocruz, Rio de Janeiro, Brazil.

Since the 2015 to 2016 outbreak in America, Zika virus (ZIKV) infected almost 900,000 patients. This international public health emergency was mainly associated with a significant increase in the number of newborns with congenital microcephaly and abnormal neurologic development, known as congenital Zika syndrome (CZS). Furthermore, Guillain-Barré syndrome (GBS), a neuroimmune disorder of adults, has also been associated with ZIKV infection. Read More

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Pharmacological potential of JWH133, a cannabinoid type 2 receptor agonist in neurodegenerative, neurodevelopmental and neuropsychiatric diseases.

Eur J Pharmacol 2021 Oct 29;909:174398. Epub 2021 Jul 29.

Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, PO Box - 17666, United Arab Emirates University, Al Ain, United Arab Emirates. Electronic address:

The pharmacological activation of cannabinoid type 2 receptors (CB2R) gained attention due to its ability to mitigate neuroinflammatory events without eliciting psychotropic actions, a limiting factor for the drugs targeting cannabinoid type 1 receptors (CB1R). Therefore, ligands activating CB2R are receiving enormous importance for therapeutic targeting in numerous neurological diseases including neurodegenerative, neuropsychiatric and neurodevelopmental disorders as well as traumatic injuries and neuropathic pain where neuroinflammation is a common accompaniment. Since the characterization of CB2R, many CB2R selective synthetic ligands have been developed with high selectivity and functional activity. Read More

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October 2021

Brief and Indirect Exposure to Natural Environment Restores the Directed Attention for the Task.

Front Psychol 2021 7;12:619347. Epub 2021 Jul 7.

Graduate School of Human Sciences, Osaka University, Suita, Japan.

The mental fatigue elicited by working and studying consumed mental resources, thereby eliciting a declined performance and an increased mental stress. The long-term continuous work and study, which is typical for modern workers and students, can increase mental fatigue and health risks. Previous studies reported that the natural environment (i. Read More

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Fast Eccentric Movement Tempo Elicits Higher Physiological Responses than Medium Eccentric Tempo in Ice-Hockey Players.

Int J Environ Res Public Health 2021 07 20;18(14). Epub 2021 Jul 20.

Institute of Sport Sciences, Jerzy Kukuczka Academy of Physical Education in Katowice, 40-065 Katowice, Poland.

Background: Resistance training is a significant part of ice-hockey players' conditioning, where optimal loading should ensure strength development and proper recovery. Therefore, this study aimed to compare the acute physiological responses to fast and medium movement tempo resistance exercises in ice-hockey players.

Methods: Fourteen ice-hockey players (26. Read More

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A Ru-anthraquinone dyad with triple functions of PACT, photoredox catalysis and PDT upon red light irradiation.

Dalton Trans 2021 Aug 23;50(31):10845-10852. Epub 2021 Jul 23.

Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.

Phototherapy for cancer treatment has received much attention in recent years, and compounds with multiple anticancer mechanisms upon irradiation are particularly appealing. In this work, a nitro-anthraquinone group was attached to a biq (2,2'-biquinoline) ligand based Ru(ii) complex, endowing the resultant Ru1 compound with multiple anticancer mechanisms upon 600 nm light irradiation. Ru1 can undergo biq ligand photodissociation, showing its potential as a photoactivated chemotherapy (PACT) agent. Read More

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'If I hadn't seen this picture, I'd be smoking'-perceptions about innovations in health warnings for cigarette packages in Brazil: a focus group study.

Tob Control 2021 Jul 21. Epub 2021 Jul 21.

Coppead, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Objective: To investigate the perceptions of young people and adults, smokers and non-smokers about the current set of innovations introduced in 2018 into the Brazilian tobacco products' health warnings.

Methods: Twenty focus groups were conducted in five state capitals in Brazil. The participants (n=163) were segmented by smoking status, age (15-17 years, 18-55 years) and social grade (C, D-E classes) to examine cigarette packaging and explore the participants' perceptions of health warnings. Read More

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Ipsilateral somatic nerves mediate histamine-induced vasosensory reflex responses involving perivascular afferents in rat models.

Sci Rep 2021 Jul 19;11(1):14648. Epub 2021 Jul 19.

Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.

Reflex cardiorespiratory alterations elicited after instillation of nociceptive agents intra-arterially (i.a) are termed as 'vasosensory reflex responses'. The present study was designed to evaluate such responses produced after i. Read More

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Posterior scleritis and acute posterior multifocal placoid pigment epitheliopathy: A case of painful chorioretinitis and review of the current literature.

Am J Ophthalmol Case Rep 2021 Sep 30;23:101159. Epub 2021 Jun 30.

Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI, USA.

Purpose: To describe a patient who developed concurrent acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and posterior scleritis.

Observations: We describe a middle-aged woman that developed eye pain and photopsia. She was found to have a "T-sign" on ultrasound of the right eye and multiple, nearly confluent, ill-defined subretinal whitish lesions in both eyes. Read More

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September 2021

What treatment outcomes matter most? A Q-study of outcome priority profiles among youth with lived experience of depression.

Eur Child Adolesc Psychiatry 2021 Jul 17. Epub 2021 Jul 17.

Research Department of Clinical, Research Department of Clinical, University College London, Gower Street, London, WC1E 6BT, UK.

Interest in youth perspectives on what constitutes an important outcome in the treatment of depression has been growing, but limited attention has been given to heterogeneity in outcome priorities, and minority viewpoints. These are important to consider for person-centred outcome tracking in clinical practice, or when conducting clinical trials targeting specific populations. This study used Q-methodology to identify outcome priority profiles among youth with lived experience of service use for depression. Read More

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Synthetic bacterial vesicles combined with tumour extracellular vesicles as cancer immunotherapy.

J Extracell Vesicles 2021 Jul 3;10(9):e12120. Epub 2021 Jul 3.

Krefting Research Centre Institute of Medicine University of Gothenburg Gothenburg Sweden.

Bacterial outer membrane vesicles (OMV) have gained attention as a promising new cancer vaccine platform for efficiently provoking immune responses. However, OMV induce severe toxicity by activating the innate immune system. In this study, we applied a simple isolation approach to produce artificial OMV that we have named Synthetic Bacterial Vesicles (SyBV) that do not induce a severe toxic response. Read More

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Eliciting the public preferences for pharmaceutical subsidy in Iran: a discrete choice experiment study.

J Pharm Policy Pract 2021 Jul 13;14(1):59. Epub 2021 Jul 13.

Research Center for Environmental Determinants of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Deciding on pharmaceutical subsidy is regarded as a challenging issue for healthcare policymakers in Iran in most times. Public preferences, rarely attended in Iran, could be invaluable for including a particular drug in the list of subsidized medications.

Objectives: The current study aims to elicit the public preferences to develop an evidence-based decision-making framework for entering a drug into the list of subsidies in Iran. Read More

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Systemic toxicity eliciting metal ion levels from metallic implants and orthopedic devices - A mini review.

Toxicol Lett 2021 Oct 9;350:213-224. Epub 2021 Jul 9.

Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL, USA. Electronic address:

The metal/metal alloy-based implants and prostheses are in use for over a century, and the rejections, revisions, and metal particle-based toxicities were reported concurrently. Complications developed due to metal ions, metal debris, and organo-metallic particles in orthopedic patients have been a growing concern in recent years. It was reported that local and systemic toxicity caused by such released products from the implants is one of the major reasons for implant rejection and revision. Read More

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October 2021

A scoping review of stereotype threat for BIPOC: cognitive effects and intervention strategies for the field of neuropsychology.

Clin Neuropsychol 2021 Jul 7:1-20. Epub 2021 Jul 7.

Department of Psychology, Illinois Institute of Technology, Chicago, IL, USA.

Objective: Abundant evidence documents stereotype threat's (ST) detrimental effect on test performance across identities and contexts (i.e., eliciting underperformance). Read More

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The Specificities of Elite Female Athletes: A Multidisciplinary Approach.

Life (Basel) 2021 Jun 26;11(7). Epub 2021 Jun 26.

CIAMS, Université Paris-Saclay, 91405 Orsay, France.

Female athletes have garnered considerable attention in the last few years as more and more women participate in sports events. However, despite the well-known repercussions of female sex hormones, few studies have investigated the specificities of elite female athletes. In this review, we present the current but still limited data on how normal menstrual phases, altered menstrual phases, and hormonal contraception affect both physical and cognitive performances in these elite athletes. Read More

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A Hepatitis B Virus-Derived Peptide Can Inhibit Infection of Human Lung Cells with SARS-CoV-2 in a Type-1 Interferon-Dependent Manner.

Viruses 2021 06 25;13(7). Epub 2021 Jun 25.

Department of Microbiology and Immunology, College of Medicine, Seoul National University, Seoul 110799, Korea.

The current COVID-19 pandemic has highlighted the urgent need to develop effective therapeutic strategies. We evaluated the in vitro antiviral effect against SARS-CoV-2 of a hepatitis B virus (HBV) hexamer peptide, Poly6, which is capable of eliciting an antiviral effect against human immunodeficiency virus -1 (HIV-1), as a novel HIV-1 integrase inhibitor, and a strong anticancer immune response in an IFN-I-dependent manner, as a novel potential adjuvant in anticancer immunotherapy. Here, we report that Poly6 exerts an anti-SARS-CoV-2 effect, with an estimated 50% inhibitory concentration of 2. Read More

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Proinflammatory response caused by lead nanoparticles triggered by engulfed nanoparticles.

Environ Toxicol 2021 Oct 29;36(10):2040-2050. Epub 2021 Jun 29.

Graduate School of Life Sciences, Toyo University, Itakura, Gunma, Japan.

In this study, the cellular effects of lead (Pb) nanoparticles with a primary particle size of 80 nm were evaluated in two types of cell lines: human lung carcinoma A549 and macrophage-differentiated THP-1 cells (dTHP-1). The cellular responses induced by the Pb nanoparticles varied among the cell types. Exposure to Pb nanoparticles for 24 h at a concentration of 100 μg/ml induced interleukin-8 (IL-8) expression in dTHP-1 cells. Read More

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October 2021