20,384 results match your criteria comprehensive strategy

Novel Two-Dimensional Janus MoSiGeN and WSiGeN as Highly Efficient Photocatalysts for Spontaneous Overall Water Splitting.

ACS Appl Mater Interfaces 2021 Jun 11. Epub 2021 Jun 11.

School of Materials Science and Engineering & Centre for Integrated Computational Materials Science, International Research Institute for Multidisciplinary Science, Beihang University, Beijing 100191, China.

Searching for highly efficient and eco-friendly photocatalysts for water splitting is essential for renewable conversion and storage of inexhaustible solar energy but remains a great challenge. Herein, based on the new emerging two-dimensional (2D) material of MoSiN, we report novel Janus MoSiGeN and WSiGeN structures with excellent stabilities and great potentials in photocatalytic applications through first-principles calculations. Comprehensive studies show that MoSiN, MoSiGeN, and WSiGeN exhibit semiconductor characteristics with an indirect gap, appropriate band gaps, and strong optical absorbance in the visible spectrum. Read More

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EXPRESS: Stroke in India: a systematic review of the incidence, prevalence and case fatality.

Int J Stroke 2021 Jun 11:17474930211027834. Epub 2021 Jun 11.

The George Institute for Global Health, Mental Health, The University of New South Wales, Newtown, New South Wales, Australia.

Background: The burden of stroke is increasing in India; stroke is now the fourth leading cause of death and the fifth leading cause of disability. Previous research suggests that the incidence of stroke in India ranges between 105 and 152/100,000 people per year. However, there is a paucity of available data and a lack of uniform methods across published studies. Read More

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A Novel Management Platform Based on Personalized Home Care Pathways for Medicine Management and Rehabilitation of Persons With Parkinson's Disease-Requirements and Implementation Plan of the Care-PD Program.

Front Neurol 2021 25;12:672208. Epub 2021 May 25.

School of Kinesiology, Shanghai University of Sport, Shanghai, China.

As the percentage of the aging population increases, the incidence of Parkinson's disease (PD) in China is increasing year by year. PD is both a public health and social problem facing the government and society as a whole. Persons with PD need reasonable medication management and rehabilitation strategies after a clear diagnosis. Read More

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Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy.

Nat Commun 2021 06 10;12(1):3530. Epub 2021 Jun 10.

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA, USA.

Targeting tumor-associated macrophages (TAMs) is a promising strategy to modify the immunosuppressive tumor microenvironment and improve cancer immunotherapy. Monoamine oxidase A (MAO-A) is an enzyme best known for its function in the brain; small molecule MAO inhibitors (MAOIs) are clinically used for treating neurological disorders. Here we observe MAO-A induction in mouse and human TAMs. Read More

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Evaluations of public health interventions produced by health technology assessment agencies: A mapping review and analysis by type and evidence content.

Health Policy 2021 May 25. Epub 2021 May 25.

Cluster for Global Health, Division for Health Services, Norwegian Institute of Public Health, PO Box 222 Skøyen, 0213 Oslo, Norway.

Objectives: Health technology assessments (HTAs) have been suggested as a strategy to bridge the evidence-to-policy gap in public health. It is unclear to what extent HTAs have been prepared to assist decisions to implement public health interventions (PHIs). We aimed to describe the experience of HTA agencies by mapping, classifying, and analyzing the evidence content of HTAs of PHIs. Read More

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Parallel, High-Quality Proteomic and Targeted Metabolomic Quantification Using Laser Capture Microdissected Tissues.

Anal Chem 2021 Jun 10. Epub 2021 Jun 10.

Department of Pharmaceutical Sciences, SUNY-Buffalo, Buffalo, New York 14214, United States.

Quantitative proteomics/metabolomics investigation of laser-capture-microdissection (LCM) cell populations from clinical cohorts affords precise insights into disease/therapeutic mechanisms, nonetheless high-quality quantification remains a prominent challenge. Here, we devised an LC/MS-based approach allowing parallel, robust global-proteomics and targeted-metabolomics quantification from the same LCM samples, using biopsies from prostate cancer (PCa) patients as the model system. The strategy features: (i) an optimized molecular weight cutoff (MWCO) filter-based separation of proteins and small-molecule fractions with high and consistent recoveries; (ii) microscale derivatization and charge-based enrichment for ultrasensitive quantification of key androgens (LOQ = 5 fg/1k cells) with excellent accuracy/precision; (iii) reproducible/precise proteomics quantification with low-missing-data using a detergent-cocktail-based sample preparation and an IonStar pipeline for reproducible and precise protein quantification with excellent data quality. Read More

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Tumor-Specific Multipath Nucleic Acid Damages Strategy by Symbiosed [email protected] with Synergistic Self-Cyclic Catalysis.

Small 2021 Jun 10:e2100766. Epub 2021 Jun 10.

State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan, 410082, China.

The high proliferation efficiency, redox imbalance, and elevated nucleic acid repair capabilities of tumor cells severely restrict the theranostic efficacy. Selectively interference chaotic tumors with devastating nucleic acid damages (NUDs) properties are expected to overcome theranostic barriers. Here, an exquisite catalytic-based strategy with comprehensive NUDs mechanisms is demonstrated. Read More

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An anchored chromosome-scale genome assembly of spinach improves annotation and reveals extensive gene rearrangements in euasterids.

Plant Genome 2021 Jun 10:e20101. Epub 2021 Jun 10.

Department of Plant Sciences, University of California, Davis, CA, USA.

Spinach (Spinacia oleracea L.) is a member of the Caryophyllales family, a basal eudicot asterid that consists of sugar beet (Beta vulgaris L. subsp. Read More

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Using Sankey diagrams to visualize drag and drop action sequences in technology-enhanced items.

Behav Res Methods 2021 Jun 9. Epub 2021 Jun 9.

Educational Testing Service, Princeton, NJ, USA.

We propose a Sankey diagram-based visualization method to illustrate test-takers' action sequences in technology-enhanced, drag-and-drop items. This method extends existing studies focusing only on initial or last attempt(s) of answer formulation, and extracts, at the item level, comprehensive information of test-takers' drag-and-drop actions. Using the process data from three mathematical items in the National Assessment of Educational Progress, we exemplify how to develop Sankey diagrams, discover frequent actions at each stage of problem solving, deduce test-takers' response strategies, and discuss the relationship among domain (i. Read More

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Molecular Identification and Genetic Characterization of Early-Stage Multiple Primary Lung Cancer by Large-Panel Next-Generation Sequencing Analysis.

Front Oncol 2021 24;11:653988. Epub 2021 May 24.

Department of Thoracic Surgery, Beijing Haidian Hospital, Beijing, China.

Objective: The incidence of early stage multiple primary lung cancer (MPLC) has been increasing in recent years, while the ideal strategy for its diagnosis and treatment remains controversial. The present study conducted genomic analysis to identify a new molecular classification method for accurately predicting the diagnosis and therapy for patients with early stage MPLC.

Methods: A total of 240 tissue samples from 203 patients with multiple-non-small-cell lung cancers (NSCLCs) (n = 30), early stage single-NSCLC (Group A, n = 94), and advanced-stage NSCLC (Group B, n = 79) were subjected to targeted multigene panel sequencing. Read More

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Multiomics analysis reveals CT83 is the most specific gene for triple negative breast cancer and its hypomethylation is oncogenic in breast cancer.

Sci Rep 2021 Jun 9;11(1):12172. Epub 2021 Jun 9.

Breast and Thyroid Center, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Fenghuang N Rd, Zunyi, 563000, Guizhou, China.

Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer (BrC) subtype lacking effective therapeutic targets currently. The development of multi-omics databases facilities the identification of core genes for TNBC. Using TCGA-BRCA and METABRIC datasets, we identified CT83 as the most TNBC-specific gene. Read More

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Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers and immune infiltration characteristics of vitiligo via comprehensive strategies.

Bioengineered 2021 Dec;12(1):2214-2227

Department of Dermatology, the First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.

This study aims to explore biomarkers associated with vitiligo and analyze the pathological role of immune cell infiltration in the disease. We used the robust rank aggregation (RRA) method to integrate three vitiligo data sets downloaded from gene expression omnibus database, identify the differentially expressed genes (DEGs) and analyze the functional correlation. Then, the comprehensive strategy of combined weighted gene coexpression network analysis (WGCNA) and logical regression of the selection operator (LASSO), support vector machine recursive feature elimination (SVM-RFE), and random forest (RF) machine learning algorithm are employed to screen and biomarkers associated with vitiligo. Read More

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December 2021

Systematic review and quality evaluation of published human ingestion-time trials of blood pressure-lowering medications and their combinations.

Chronobiol Int 2021 Jun 9:1-17. Epub 2021 Jun 9.

Bioengineering & Chronobiology Laboratories, Atlantic Research Center for Information and Communication Technologies (atlanTTic), Universidade de Vigo, Vigo, Spain.

The pharmacokinetics (PK) - absorption, distribution, metabolism, and elimination - and pharmacodynamics (PD) of hypertension medications can be significantly affected by circadian rhythms. As a consequence, the time when blood pressure (BP) lowering medications are ingested, with reference to the staging of all involved circadian rhythms modulating PK and PD, can affect their duration of action, magnitude of effect on features of the 24 h BP profile, and safety. We conducted a systematic and comprehensive review of published prospective human trials that investigated individual hypertension medications of all classes and their combinations for ingestion-time differences in BP-lowering, safety, patient adherence, and markers of hypertension-associated target organ pathology of the kidney and heart. Read More

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Tissue mechanics in stem cell fate, development, and cancer.

Dev Cell 2021 Jun 3. Epub 2021 Jun 3.

Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Bioengineering and Therapeutic Sciences and Department of Radiation Oncology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; The Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

Cells in tissues experience a plethora of forces that regulate their fate and modulate development and homeostasis. Cells sense mechanical cues through localized mechanoreceptors or by influencing cytoskeletal or plasma membrane organization. Cells translate force and modulate their behavior through a process termed mechanotransduction. Read More

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Adenosine AR/AR Antagonists Enabling Additional HR Antagonism for the Treatment of Parkinson's Disease.

J Med Chem 2021 Jun 9. Epub 2021 Jun 9.

Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Duesseldorf, Universitaets street 1, 40225 Duesseldorf, Germany.

Adenosine A/A receptors (AR/AR) represent targets in nondopaminergic treatment of motor disorders such as Parkinson's disease (PD). As an innovative strategy, multitargeting ligands (MTLs) were developed to achieve comprehensive PD therapies simultaneously addressing comorbid symptoms such as sleep disruption. Recognizing the wake-promoting capacity of histamine H receptor (HR) antagonists in combination with the "caffeine-like effects" of AR/AR antagonists, we designed AR/AR/HR MTLs, where a piperidino-/pyrrolidino(propyloxy)phenyl HR pharmacophore was introduced with overlap into an adenosine antagonist arylindenopyrimidine core. Read More

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Discovery of as a Potent and Orally Bioavailable Inhibitor of the WDR5-Mixed Lineage Leukemia 1 Protein-Protein Interaction for the Treatment of MLL Fusion Leukemia.

J Med Chem 2021 Jun 9. Epub 2021 Jun 9.

Jiangsu Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.

WD repeat-containing protein 5 (WDR5) is essential for the stability and methyltransferase activity of the mixed lineage leukemia 1 (MLL1) complex. Dysregulation of the gene is associated with human acute leukemias, and the direct disruption of the WDR5-MLL1 protein-protein interaction (PPI) is emerging as an alternative strategy for MLL-rearranged cancers. Here, we represent a new aniline pyrimidine scaffold for WDR5-MLL1 inhibitors. Read More

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Multi-scale hybrid modified coatings on titanium implants for non-cytotoxicity and antibacterial properties.

Nanoscale 2021 Jun 8. Epub 2021 Jun 8.

State Key Laboratory of Metal Matrix Composites, School of Material Science and Engineering, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai, 200240, China. and Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, China.

Titanium and its alloys are among the widely used materials in the biomedical field, but they have poor wear resistance and antibacterial properties. In the present study, anodization, photo-reduction, and spin-coating technologies were integrated to prepare a hybrid modified coating for bio-inert titanium implants, having excellent comprehensive performance. The surface roughness of Ti-35Nb-2Ta-3Zr was specifically optimized by surface modification leading to improved wear resistance. Read More

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Cardiovascular risk in menopausal women and our evolving understanding of menopausal hormone therapy: risks, benefits, and current guidelines for use.

Ther Adv Endocrinol Metab 2021 30;12:20420188211013917. Epub 2021 Apr 30.

Department of Medicine, Emory University, 137 Johnson Ferry Rd, Suite 1200, Marietta, GA 30068, USA.

Women are at increased risk for cardiovascular disease (CVD) compared with men. While traditional risk factors for CVD seem to disproportionately affect women and contribute to this disparity, increased prevalence of CVD at midlife calls into question the contribution of menopause. Given the potential role that declining hormone levels play in this transition, menopause hormone therapies (MHT) have been proposed as a strategy for risk factor reduction. Read More

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Experience with regorafenib in the treatment of hepatocellular carcinoma.

Therap Adv Gastroenterol 2021 28;14:17562848211016959. Epub 2021 May 28.

Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Regorafenib is a diphenylurea oral multikinase inhibitor, structurally comparable to sorafenib, which targets a variety of kinases implicated in angiogenic and tumor growth-promoting pathways. Regorafenib was the first agent to positively show significant survival advantage as a second-line therapy in patients with unresectable hepatocellular carcinoma (HCC) who had previously failed first-line treatment with sorafenib. Recent evidence has shown that its antitumor efficacy is due to a comprehensive spectrum of tumor neo-angiogenesis and proliferation inhibition and immunomodulatory effects on the tumor microenvironment, which plays a crucial role in tumor development. Read More

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High-Yield Preparation of Edge-Functionalized and Water Dispersible Few-Layers of Hexagonal Boron Nitride (hBN) by Direct Wet Chemical Exfoliation.

Nanotechnology 2021 Jun 8. Epub 2021 Jun 8.

University of Adelaide Faculty of Engineering Computer and Mathematical Sciences, Adelaide, South Australia, 5005, AUSTRALIA.

Owing to many fascinating properties including high thermal and chemical stability, excellent electrical insulation, fire-retardant and antibacterial properties, hexagonal boron nitride (hBN) has emerged as a prominent 2D material for broad applications. However, the production of high quality of hBN by chemical exfoliation from its precursor is still challenging. This paper presents a high-yield (+83 %), low cost and energy-efficient wet chemical exfoliation strategy, which produces few-layers (FL, 3-6 layers) of edge-functionalized (OH) hBN nanosheets with uniform size (486±51 nm). Read More

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Adjuvant Aromatase Inhibitors or Tamoxifen following Chemotherapy for Perimenopausal Breast Cancer Patients.

J Natl Cancer Inst 2021 Jun 8. Epub 2021 Jun 8.

Division of Molecular Pathology, Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.

Background: Benefit of adjuvant aromatase inhibitors (AI) versus tamoxifen has been investigated in randomized clinical trials for premenopausal and postmenopausal patients with early, estrogen receptor positive (ER+) breast cancer. The optimal endocrine treatment for chemotherapy-treated perimenopausal women, who generally develop chemotherapy-induced amenorrhea, is uncertain.

Methods: All Dutch women who received adjuvant chemotherapy and endocrine treatment for stage I-III, ER + (>10% positive cells), invasive breast cancer, diagnosed between 2004-2007, were identified through the Netherlands Cancer Registry. Read More

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The Paradox of Empathy and Data: Measuring Outcomes of Empathic Communication Education.

J Nurses Prof Dev 2021 Jun 8. Epub 2021 Jun 8.

Lori L. Arcand, PhD, MS, RN, NPD-BC, is Nursing Education Specialist, Mayo Clinic, and Assistant Professor of Nursing, Mayo Clinic College of Medicine and Science, Rochester, Minnesota. Holly L. Burkhartzmeyer, MAN, RN, is Nursing Education Specialist, Mayo Clinic, and Instructor in Nursing, Mayo Clinic College of Medicine and Science, Rochester, Minnesota. Jane E. Clobes, MSN, RN, CHSE, is Nursing Education Specialist, Mayo Clinic, and Assistant Professor of Nursing, Mayo Clinic College of Medicine and Science, Rochester, Minnesota. Shari L. Eversman, MS, RN, is Nursing Education Specialist, Mayo Clinic, and Instructor in Nursing, Mayo Clinic College of Medicine and Science, Rochester, Minnesota. Kelly M. Kiker, MSN, RN, is Nursing Education Specialist, Mayo Clinic, and Instructor in Nursing, Mayo Clinic College of Medicine and Science, Rochester, Minnesota. Maura M. McCabe, MSN, RN, NPD-BC, CPAN, is RN, Post-Anesthesia Care Unit, Mayo Clinic, and Instructor in Nursing, Mayo Clinic College of Medicine and Science, Rochester, Minnesota. Alicia J. Pfeilsticker, MSN, RN, is Nursing Education Manager, Mayo Clinic, and Instructor in Nursing, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.

This article addresses the nursing professional development practitioner's role in the design and management of the evaluation process used for a large-scale educational intervention developed to improve patient satisfaction with the use of empathic communication skills. The scope of this educational activity and the direct alignment with organizational priorities necessitated that a robust and comprehensive evaluation strategy be implemented to demonstrate the connection from the education to performance and, ultimately, organization-level results. Read More

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Combination chemotherapy versus temozolomide for patients with methylated MGMT (m-MGMT) glioblastoma: results of computational biological modeling to predict the magnitude of treatment benefit.

J Neurooncol 2021 Jun 8. Epub 2021 Jun 8.

Cellworks Group, Inc., S. San Francisco, CA, USA.

Background: A randomized trial in glioblastoma patients with methylated-MGMT (m-MGMT) found an improvement in median survival of 16.7 months for combination therapy with temozolomide (TMZ) and lomustine, however the approach remains controversial and relatively under-utilized. Therefore, we sought to determine whether comprehensive genomic analysis can predict which patients would derive large, intermediate, or negligible benefits from the combination compared to single agent chemotherapy. Read More

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Viral Metagenome-Based Precision Surveillance of Pig Population at Large Scale Reveals Viromic Signatures of Sample Types and Influence of Farming Management on Pig Virome.

mSystems 2021 Jun 8:e0042021. Epub 2021 Jun 8.

Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, Jilin Province, China.

Pigs are a major meat source worldwide and a pillar of Chinese animal husbandry; hence, their health and safety are a prioritized concern of the national economy. Although pig viruses have been continuously investigated, the full extent of the pig virome has remained unknown and emerging viruses are still a major threat to the pig industry. Here, we report a comprehensive study to delineate the pig virome of 1,841 healthy weaned pigs from 45 commercial farms collected from 25 major pig-producing regions across China. Read More

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Co-assembly and multicomponent hydrogel formation upon mixing nucleobase-containing peptides.

Nanoscale 2021 Jun 8. Epub 2021 Jun 8.

Université de Lorraine, CNRS, LCPM, F-54000 Nancy, France.

Peptide-based hydrogels are physical gels formed through specific supramolecular self-assembling processes, leading to ordered nanostructures which constitute the water entrapping scaffold of the soft material. Thanks to the inherent properties of peptides, these hydrogels are highly considered in the biomedical domain and open new horizons in terms of application in advanced therapies and biotechnologies. The use of one, and only one, native peptide to formulate a gel is by far the most reported approach to design such materials, but suffers from several limitations, including in terms of mechanical properties. Read More

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Associations between maternal urinary iodine assessment, dietary iodine intakes and neurodevelopmental outcomes in the child: a systematic review.

Thyroid Res 2021 Jun 7;14(1):14. Epub 2021 Jun 7.

Nutrition Innovation Centre for Food and Health, Ulster University, Coleraine, Northern Ireland.

Objective: Mild to moderate iodine deficiency during pregnancy has been associated with adverse neurodevelopmental outcomes in offspring. Few research studies to date combine assessment of urinary iodine (UIC and/or ICr), biomarkers that best reflect dietary intake, with reported dietary intake of iodine rich foods in their assessment of iodine deficiency. Thus, a systematic review was conducted to incorporate both these important measures. Read More

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The African Network for Improved Diagnostics, Epidemiology and Management of common infectious Agents.

BMC Infect Dis 2021 Jun 7;21(1):539. Epub 2021 Jun 7.

Centre Hospitalier Universitaire Bouaké, Bouaké, Côte d'Ivoire.

Background: In sub-Saharan Africa, acute respiratory infections (ARI), acute gastrointestinal infections (GI) and acute febrile disease of unknown cause (AFDUC) have a large disease burden, especially among children, while respective aetiologies often remain unresolved. The need for robust infectious disease surveillance to detect emerging pathogens along with common human pathogens has been highlighted by the ongoing novel coronavirus disease 2019 (COVID-19) pandemic. The African Network for Improved Diagnostics, Epidemiology and Management of Common Infectious Agents (ANDEMIA) is a sentinel surveillance study on the aetiology and clinical characteristics of ARI, GI and AFDUC in sub-Saharan Africa. Read More

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[Paying attention to the fundus complications and improving the prevention and treatment of pathological myopia].

W B Wei L Dong

Zhonghua Yan Ke Za Zhi 2021 Jun;57(6):401-405

Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology&Visual Sciences Key Laboratory, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

Pathological myopia, an important blinding eye disease worldwide, has caused a heavy social burden. The patients have become younger in recent years. In general, people have limited knowledge of pathological myopia. Read More

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Health policy and public health implications of obesity in China.

Lancet Diabetes Endocrinol 2021 Jun 4. Epub 2021 Jun 4.

Department of Health Administration and Policy, College of Health and Human Services, George Mason University, Fairfax, VA, USA.

China has experienced many drastic social and economic changes and shifts in people's lifestyles since the 1990s, in parallel with the fast rising prevalence of obesity. About half of adults and a fifth of children have overweight or obesity according to the Chinese criteria, making China the country with the highest number of people with overweight or obesity in the world. Assuming that observed time trends would continue in the future, we projected the prevalence of and the number of people affected by overweight and obesity by 2030, and the associated medical costs. Read More

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Doing Great With DOTATATE: Update on GA-68 DOTATATE Positron Emission Tomography/Computed Tomography and Magnetic Resonance Imaging for Evaluation of Sinonasal Tumors.

Top Magn Reson Imaging 2021 Jun;30(3):151-158

Department of Radiology, Northwell Health Lenox Hill Hospital, New York, NY.

Abstract: Sinonasal tumors are relatively rare and radiographically challenging to evaluate due to their wide variety of pathologies and imaging features. However, sinonasal tumors possessing somatostatin receptor overexpression have the benefit of utilizing a multimodality anatomic and functional imaging for a more comprehensive evaluation. This is particularly evident with esthesioneuroblastoma, with computed tomography and magnetic resonance imaging defining the anatomic extent of the tumor, whereas somatostatin receptor imaging, particularly with gallium-68 DOTATATE positron emission tomography/computed tomography, is used to assess the presence of metastatic disease for staging purposes as well as in the surveillance for tumor recurrence. Read More

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