119,721 results match your criteria compounds reported


Reprocessing of Covalent Adaptable Polyamide Networks through Internal Catalysis and Ring-Size Effects.

J Am Chem Soc 2021 Sep 15. Epub 2021 Sep 15.

Polymer Chemistry Research Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Faculty of Sciences, Ghent University, Krijgslaan 281-S4, Ghent 9000, Belgium.

Here, we report the introduction of internally catalyzed amide bonds to obtain covalent adaptable polyamide networks that rely on the dissociation equilibrium between dicarboxamides and imides. While amide bonds are usually considered to be robust and thermally stable, the present study shows that their dynamic character can be activated by a smart choice of available building blocks without the addition of any external catalyst or other additives. Hence, a range of polyamide-based dynamic networks with variable mechanical and viscoelastic properties have been obtained in a systematic study, using a straightforward curing process of dibasic ester and amine compounds. Read More

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September 2021

P nuclear spin singlet lifetimes in a system with switchable magnetic inequivalence: experiment and simulation.

Phys Chem Chem Phys 2021 Sep 15;23(35):19465-19471. Epub 2021 Sep 15.

Department of Chemistry, New York University, New York, NY, USA.

P NMR spectroscopy and the study of nuclear spin singlet relaxation phenomena are of interest in particular due to the importance of phosphorus-containing compounds in physiology. We report the generation and measurement of relaxation of P singlet order in a chemically equivalent but magnetically inequivalent case. Nuclear magnetic resonance singlet state lifetimes of P pairs have heretofore not been reported. Read More

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September 2021

Thiophosphonium-Alkyne Cycloaddition Reactions: A Heavy Congener of the Carbonyl-Alkyne Metathesis.

Inorg Chem 2021 Sep 15. Epub 2021 Sep 15.

Institut für Anorganische und Analytische Chemie, Westfälische Wilhelms-Universität Münster, Corrensstrasse 28-30, 48149 Münster, Germany.

While the metathesis reaction between alkynes and thiocarbonyl compounds has been thoroughly studied, the reactivity of alkynes with isoelectronic main group RE=S compounds is rarely reported and unknown for [RP=S] analogues. We show that thiophosphonium ions, which are the isoelectronic phosphorus congeners to thiocarbonyl compounds, undergo [2 + 2]-cycloaddition reactions with different alkynes to generate 1,2-thiaphosphete ions. The four-membered ring species are in an equilibrium state with the corresponding P=C-C=S heterodiene structure and thus undergo hetero-Diels-Alder reactions with acetonitrile. Read More

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September 2021

Fugitive Emissions of Volatile Organic Compounds from a Tailings Pond in the Oil Sands Region of Alberta.

Environ Sci Technol 2021 Sep 15. Epub 2021 Sep 15.

Air Quality Processes Research Section, Air Quality Research Division, Environment and Climate Change Canada, 4905 Dufferin Street, Toronto, Ontario M3H 5T4, Canada.

Tailings ponds in the oil sands (OS) region in Alberta, Canada, have been associated with fugitive emissions of volatile organic compounds (VOCs) and other pollutants to the atmosphere. However, the contribution of tailings ponds to the total fugitive emissions of VOCs from OS operations remains uncertain. To address this knowledge gap, a field study was conducted in the summer of 2017 at Suncor's Pond 2/3 to estimate emissions of a suite of pollutants including 68 VOCs using a combination of micrometeorological methods and measurements from a flux tower. Read More

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September 2021

Recent Advances on Bioactive Ingredients of Morchella esculenta.

Appl Biochem Biotechnol 2021 Sep 15. Epub 2021 Sep 15.

Engineering Research Center of Bio-Process, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, Anhui, China.

Morchella esculenta (M. esculenta) is a delicious edible mushroom prized for its special flavor and strong health promoting abilities. Several bioactive ingredients including polysaccharides, polyphenolic compounds, proteins, and protein hydrolysates all contribute to the biological activities of M. Read More

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September 2021

Phase transition and chemical reactivity of 1H-tetrazole under high pressure up to 100 GPa.

Phys Chem Chem Phys 2021 Sep 15;23(35):19503-19510. Epub 2021 Sep 15.

Center for High Pressure Science and Technology Advanced Research, Beijing 100094, P. R. China.

The pressure-induced phase transition and polymerization of nitrogen-rich molecules are widely focused on due to their extreme importance for the development of green high-energy-density materials. Here, we present a study of the phase-transition behaviour and chemical reaction of 1H-tetrazole up to 100 GPa using Raman, IR, X-ray diffraction, neutron diffraction techniques and theoretical calculations. A phase transition above 2. Read More

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September 2021

Induction of hemolysis and eryptosis by occupational pollutant nickel chloride is mediated through calcium influx and p38 MAP kinase signaling.

Int J Occup Med Environ Health 2021 Aug 30. Epub 2021 Aug 30.

King Saud University, Riyadh, Saudi Arabia (College of Applied Medical Sciences, Department of Clinical Laboratory Sciences).

Objectives: Nickel (Ni) is an abundant environmental hazard and an occupational pollutant. Exposure to Ni compounds is prevalent in electroplating workers and in the printing industry, among others. The toxicity of Ni manifests as dermatological, gastrointestinal, respiratory, allergic, and cardiovascular symptoms. Read More

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Phenotypic and Genetic Characterization of Flavobacterium psychrophilum Recovered from Diseased Salmonids in China.

Microbiol Spectr 2021 Sep 15:e0033021. Epub 2021 Sep 15.

Department of Fisheries and Wildlife, College of Agriculture and Natural Resources, Michigan State Universitygrid.17088.36, East Lansing, Michigan, USA.

Flavobacterium psychrophilum, the etiological agent of bacterial coldwater disease (BCWD) and rainbow trout fry syndrome, causes great economic losses in salmonid aquaculture worldwide. Recent molecular studies have uncovered important epidemiological and ecological aspects of this pathogen; however, such data are lacking for F. psychrophilum populations affecting aquaculture in China. Read More

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September 2021

Synthesis of -(Indol-3-yl)phenols from Indoles and Cyclohexenone via Palladium(II)-Catalyzed Oxidative Heck Reaction and Dehydrogenative Aromatization in a One-Step Sequence.

Org Lett 2021 Sep 15. Epub 2021 Sep 15.

College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.

Facile construction of a -(indol-3-yl)phenol framework with a wide substrate scope (a total of 25 compounds) via a palladium(II)-catalyzed oxidative Heck reaction and dehydrogenative aromatization in a one-step sequence is reported. This methodology affords a novel route for the privileged structures that are challenging to access via a direct link between indole and phenol, in a highly efficient and atom-economical manner. Read More

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September 2021

Protective mechanisms of Agrimonia pilosa Ledeb in dextran sodium sulfate-induced colitis as determined by a network pharmacology approach.

Acta Biochim Biophys Sin (Shanghai) 2021 Sep 15. Epub 2021 Sep 15.

Department of Gastroenterology, Shuguang Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Previous studies reported that Agrimonia pilosa (AP) Ledeb possessed diverse biological activities, including anti-inflammatory, antioxidant, and anti-tumor activities. However, the effect of AP on ulcerative colitis (UC) remains unclear. In this study, we investigated the therapeutic effect and mechanisms of AP on dextran sodium sulfate (DSS)-induced colitis. Read More

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September 2021

Sn2PO4I: An Excellent Birefringent Material with Giant Optical Anisotropy in Non π-Conjugated Phosphate.

Angew Chem Int Ed Engl 2021 Sep 15. Epub 2021 Sep 15.

Xinjiang Technical Institute of Physics and Chemistry, Xinjiang Key Laboratory of Electronic Information Materials and Devices, 40-1 South Beijing Road, 830011, Urumqi, CHINA.

Exploring non π-conjugated phosphate birefringent crystal with a large birefringence has been a great challenge. Herein, based on the unique two-dimensional layered structure in KBe2BO3F2 (KBBF), two new compounds, Sn2PO4I and Sn2BO3I, were designed and synthesized successfully, maintaining the layer structural feature and enhancing the optical anisotropy of crystals. Especially, the birefringence of Sn2PO4I is larger than or equal to 0. Read More

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September 2021

A multiple-method comparative study using GC-MS, AMDIS and in-house-built software for the detection and identification of "unknown" volatile organic compounds in breath.

J Mass Spectrom 2021 Oct;56(10):e4782

Department of Analytical Chemistry, Israel Institute for Biological Research (IIBR), Ness Ziona, Israel.

The human respiratory system is a highly complex matrix that exhales many volatile organic compounds (VOCs). Breath-exhaled VOCs are often "unknowns" and possess low concentrations, which make their analysis, peak digging and data processing challenging. We report a new methodology, applied in a proof-of-concept experiment, for the detection of VOCs in breath. Read More

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October 2021

Pungent and volatile constituents of dried Australian ginger.

Curr Res Food Sci 2021 4;4:612-618. Epub 2021 Sep 4.

School of Health, Medical & Applied Sciences, CQUniversity Australia, Bruce Hwy, North Rockhampton, Qld, 4701, Australia.

Ginger is well known for its pungent flavour and health-benefitting properties, both of which are imparted by various gingerol derivatives and other volatile constituents. Although there has been a considerable amount of research into the chemical constituents found in fresh ginger, there is little information available on the quality of Australian-grown dried ginger, particularly that intended for processing purposes. Here, we investigate differences in the chemical composition of three samples of processing-grade ginger, ranging from very poor to good quality. Read More

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September 2021

Traditionally used edible Solanaceae plants of Mizoram, India have high antioxidant and antimicrobial potential for effective phytopharmaceutical and nutraceutical formulations.

Heliyon 2021 Sep 1;7(9):e07907. Epub 2021 Sep 1.

Department of Botany, Mizoram University, Aizawl 796004, Mizoram, India.

Ethnopharmacological Relevance: Solanaceae plants have been used as traditional medicines in Mizoram, India. This warrants the presence of therapeutic compounds and various bioactive phytochemicals in these plants, and characterizing their structures could lead to a possible focus for drug development.

Aim Of The Study: Solanaceae plants are incredible sources of proteins and minerals; some even have high medicinal values which has been recognized traditionally. Read More

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September 2021

A case report: Use of FT-IR analysis to improve Colovesical fistula diagnosis.

Pract Lab Med 2021 Nov 1;27:e00255. Epub 2021 Sep 1.

General Laboratory, Careggi University Hospital, Florence, Italy.

Colovesical fistula (CVF) is an abnormal connection between the colon and the urinary bladder. Faecaluria, reported in 40-70% of cases, is virtually pathognomonic for CVF. During the 5th day of recovery in an 84 years old subject, the passage of cloudy, malodorous urine with visible debris was observed. Read More

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November 2021

Low-temperature thermal hydrolysis of sludge prior to anaerobic digestion: Principal component analysis (PCA) of experimental data.

Data Brief 2021 Oct 25;38:107323. Epub 2021 Aug 25.

Civil and Environmental Engineering, University of Alberta, 116 Street NW, Edmonton, AB T6G 1H9, Canada.

Here, we report data of the principal component analysis (PCA) assessment and clustering analysis related to low-temperature thermal hydrolysis process (THP) for enhancing the anaerobic digestion (AD) of sludge in wastewater treatment plants (WWTPs) with primary sludge fermentation (Azizi et al., 2021). The PCA was examined to pinpoint the influence of different THP schemes on the variations of macromolecular compounds solubilization after low-temperature THP and the relative performances in enhancing methane potential in AD. Read More

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October 2021

Data on effect of Tempeh Fermentation on patients with type II diabetes.

Data Brief 2021 Oct 4;38:107310. Epub 2021 Sep 4.

Emerging Compounds Research Center, Department of Environmental Science and Engineering, College of Engineering, National Pingtung University of Science and Technology, Pingtung County 912, Taiwan.

Type II diabetes (T2D) arises through insulin resistance and a progressive decrease in insulin secretion, which may be partly related to pancreatic beta-cell function decline, obesity, and eventual hyperglycemia [1]. The first line for managing hyperglycemia in patients with T2D includes lifestyle modifications and metformin monotherapy. However, many patients still showed poor glycemic control due to progressive deterioration during the course of T2D [2, 3]. Read More

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October 2021

L (amla) branch: A safe and effective ingredient against skin aging.

J Tradit Complement Med 2021 Sep 9;11(5):390-399. Epub 2021 Feb 9.

School of Cosmetic Science, Mae Fah Luang University, Chiang Rai, 57100, Thailand.

Background And Aim: Skin aging influences the changes in skin, including skin dryness, wrinkle, and irregular pigmentation. Amla ( L.) branch has shown several benefits, but not the anti-skin aging. Read More

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September 2021

Synthesis and cytotoxic evaluation of some novel 3-[2-(2-phenyl-thiazol-4-yl)-ethyl]-3H-pyrido[2,3-d]pyrimidin-4-one derivatives.

Res Pharm Sci 2021 Oct 19;16(5):455-463. Epub 2021 Aug 19.

Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.

Background And Purpose: Pyridopyrimidine and its derivatives have a variety of chemical and biological significances. Thiazole-containing compounds have also been reported to have a wide range of biological activities. Due to the valuable cytotoxic effects of both thiazole and pyridopyrimidinone derivatives, a series of pyridopyrimidinone-thiazole hybrids were synthesized in the present study. Read More

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October 2021

Essential oils as alternative promising anti-Candidal agents: progress and prospects.

Curr Pharm Des 2021 Sep 14. Epub 2021 Sep 14.

Amity Institute of Biotechnology, Amity University Haryana, Manesar, Gurugram- 122413. India.

Candida albicans is one of the main agents responsible for opportunistic pathogenic infections. The progressive emergence of fungal resistance to conventional antibiotics and its side effects as well as treatment costs are considered as major limitations for antifungal drugs. It has drawn scientists' attention to search for potential substitution and therapeutic reliable alternatives for the antifungal compounds from sources like medicinal plants, which contain numerous bioactive compounds such as essential oils. Read More

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September 2021

New insights into neuropeptides regulation of immune system and hemopoiesis: effects on hematologic malignancies.

Curr Med Chem 2021 Sep 14. Epub 2021 Sep 14.

Department of Chemical, Biological, Pharmaceutical and Environmental Chemistry, University of Messina. Italy.

Several neurotransmitters and neuropeptides were reported to join to or to cooperate with different cells of the immune system, bone marrow, and peripheral cells and numerous data support that neuroactive molecules might control immune system activity and hemopoiesis operating on lymphoid organs, and the primary hematopoietic unit, the hematopoietic niche. Furthermore, many compounds seem to be able to take part to the leukemogenesis and lymphomagenesis process, and in the onset of multiple myeloma. In this review, we will assess the possibility that neurotransmitters and neuropeptides may have a role in the onset of haematological neoplasms, may affect the response to treatment or may represent a useful starting point for a new therapeutic approach. Read More

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September 2021

Seven-day Oral Intake of Orthosiphon stamineus Leaves Infusion Exerts Antiadhesive Ex Vivo Activity Against Uropathogenic E. coli in Urine Samples.

Planta Med 2021 Sep 14. Epub 2021 Sep 14.

University of Münster, Institute of Pharmaceutical Biology and Phytochemistry, Münster, Germany.

leaves (Java tea) extract is traditionally used for the treatment of urinary tract infections. According to recent data, animal infection studies, and transcriptomic investigations, polymethoxylated flavones from Java tea exert antiadhesive activity against uropathogenic (UPEC). This antiadhesive activity has been shown to reduce bladder and kidney lesion in a mice infection model. Read More

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September 2021

6-Fluorophenylbenzohydrazides inhibit Mycobacterium tuberculosis growth through alteration of tryptophan biosynthesis.

Eur J Med Chem 2021 Sep 9;226:113843. Epub 2021 Sep 9.

Department of Chemistry and Technologies of Drug, Sapienza University of Rome, Piazzale A. Moro 5, 00185, Rome, Italy. Electronic address:

A major constraint in reducing tuberculosis epidemic is the emergence of strains resistant to one or more of clinically approved antibiotics, which emphasizes the need of novel drugs with novel targets. Genetic knockout strains of Mycobacterium tuberculosis (Mtb) have established that tryptophan (Trp) biosynthesis is essential for the bacterium to survive in vivo and cause disease in animal models. An anthranilate-like compound, 6-FABA, was previously shown to synergize with the host immune response to Mtb infection in vivo. Read More

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September 2021

Divergent synthesis and biological evaluation of 2-(trifluoromethyl)pyridines as virulence-attenuating inverse agonists targeting PqsR.

Eur J Med Chem 2021 Aug 28;226:113797. Epub 2021 Aug 28.

Department of Drug Design and Optimization (DDOP), Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123, Saarbrücken, Germany; Department of Pharmacy, Saarland University, Campus E8.1, 66123, Saarbrücken, Germany; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, 66123, Saarbrücken, Germany. Electronic address:

A short and divergent route towards new derivatives of 2-(trifluoromethyl)pyridines as potent inverse agonists of the bacterial target PqsR against Pseudomonas aeruginosa (PA) infections is described. This Gram-negative pathogen causes severe nosocomial infections and common antibiotic treatment options are rendered ineffective due to resistance issues. Based on an earlier identified optimized hit, we conducted derivatization and rigidification attempts employing two central building blocks. Read More

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Phthalate metabolites: Characterization, toxicities, global distribution, and exposure assessment.

Environ Pollut 2021 Sep 4;291:118106. Epub 2021 Sep 4.

Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou, 510632, China. Electronic address:

Phthalates are plasticizers in various products and regarded as endocrine disruptors due to their anti-androgen effects. Environmental occurrence and toxicities of parent phthalates have been widely reported, while the current state of knowledge on their metabolites is rarely summarized. Based on the available literature, the present review mainly aims to 1) characterize the potential metabolites of phthalates (mPAEs) using the pharmacokinetics evidences acquired via animal or human models; 2) examine the molecular and cellular mechanism involved in toxicity for mPAEs; 3) investigate the exposure levels of mPAEs in different human specimens (e. Read More

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September 2021

Wildfires can increase regulated nitrate, arsenic, and disinfection byproduct violations and concentrations in public drinking water supplies.

Sci Total Environ 2021 Aug 27;804:149890. Epub 2021 Aug 27.

U.S. EPA, Office of Research and Development, Center for Public Health and Environmental Assessment, Health & Environmental Effects Assessment Division, Research Triangle Park, NC, USA.

Wildfires are a concern for water quality in the United States, particularly in the wildland-urban interface of populous areas. Wildfires combust vegetation and surface soil organic matter, reduce plant nutrient uptake, and can alter the composition of runoff and receiving waters. At the wildland-urban interface, fires can also introduce contaminants from the combustion of man-made structures. Read More

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Research on the co-pyrolysis of coal gangue and coffee industry residue based on machine language: Interaction, kinetics, and thermodynamics.

Sci Total Environ 2021 Sep 9;804:150217. Epub 2021 Sep 9.

Department of Thermal Science and Energy Engineering, University of Science and Technology of China, Jinzhai Road, Hefei 230026, China. Electronic address:

Co-pyrolysis technology of urban solid waste and biomass has broad application prospects in alleviating energy crisis and environmental pollution. In this study, thermogravimetric-Fourier transform infrared spectroscopy (TG-FTIR) was used to study the co-pyrolysis characteristics of coal gangue (CG) and coffee industry residue (CIR). CG and CIR were uniformly mixed according to the mass ratios of 1: 0, 7:3, 5:5, 3:7, and 0:1. Read More

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September 2021

Synthesis and evaluation of fosfomycin group end-capped packing materials for hydrophilic interaction liquid chromatography.

J Chromatogr A 2021 Sep 4;1656:462529. Epub 2021 Sep 4.

CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Research Center for Coastal Environmental Engineering and Technology, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, PR China. Electronic address:

Hydrophilic interaction liquid chromatography (HILIC) plays an important role in the analysis of compounds having high polarity. In this study, fosfomycin (F) was chosen as a new end-capping reagent, owing to the facile hydrolysis reaction of its epoxy group. Zirconia coated silica (ZrO/SiO) materials having good chemical and physical stability were prepared. Read More

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September 2021

Optimization and validation of capillary electrophoresis- and gas chromatography-tandem mass spectrometry methods for the analysis of intermediate metabolites in glycolysis and pentose phosphate pathways within biological samples.

J Chromatogr A 2021 Sep 4;1656:462531. Epub 2021 Sep 4.

Integrated Metabolomics Research Group, Western Seoul Center, Korea Basic Science Institute, Seoul 03759, Republic of Korea; Department of Chenistry and Nano Science, Ewha Womans University, Seoul 03760, Republic of Korea. Electronic address:

Highly selective methods for the analysis of intermediate metabolites involved in glycolysis and phosphate pentose pathways are essential for metabolism and metabolic flux studies. However, the successful separation of phosphorylated compounds is difficult due to their high polarity, as well as their structural isomers. In this study, phosphorylated compounds in spiked serum samples were analyzed using capillary electrophoresis tandem mass spectrometry (CE-MS/MS) and gas chromatography (GC)-MS/MS. Read More

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September 2021

Dammarane triterpenes and phytosterols from Dysoxylum tpongense Pierre and their anti-inflammatory activity against liver X receptors and NF-κB activation.

Steroids 2021 Sep 11:108902. Epub 2021 Sep 11.

Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam; Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi. Electronic address:

Dysoxylum tpongense Pierre (local name 'Huynh Dan Bap') belonging to family Meliaceae, is a tree (3 - 10 m height), distributed in the mountainous areas (ca. 1000 m a.s. Read More

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September 2021