8,144 results match your criteria compounds assayed

Six New 3,5-Dimethylcoumarins from Chelonopsis praecox, Chelonopsis odontochila and Chelonopsis pseudobracteata.

Nat Prod Bioprospect 2021 Sep 16. Epub 2021 Sep 16.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.

Ten 3,5-dimethylcoumarins (1-6 and 8‒11) involving six new ones (1-6), together with a known 3-methylcoumarin (7), were isolated from the aerial parts of three Chelonopsis plants, C. praecox, C. odontochila, and C. Read More

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September 2021

Isolation and identification of microalgal strains with potential as carotenoids producers from a municipal solid waste landfill.

Sci Total Environ 2021 Aug 24;802:149755. Epub 2021 Aug 24.

Department of Organisms and Systems Biology, University of Oviedo, C/ Catedrático Valentín Andrés Álvarez s/n, 33006 Oviedo, Spain.

Derived from their great capacity of adaptation, microalgae have several industrial applications, including pigment production for nutraceutical sector. However, the scarcity of studies on the diversity and life histories from several environments, highlight the need for more research on new species and habitats. Based on this, the present study assessed the microalgal diversity in water bodies of a municipal solid waste (MSW) landfill in Asturias (Spain). Read More

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Exploration of the Potential Mechanism of Tao Hong Si Wu Decoction for the Treatment of Breast Cancer Based on Network Pharmacology and Experimental Verification.

Front Oncol 2021 26;11:731522. Epub 2021 Aug 26.

The First Affiliated Hospital of Anhui University of Chinese Medicinee, Hefei, China.

Background: Tao Hong Si Wu Decoction (THSWD) is a well-known traditional Chinese medicine used clinically alone or combined with drugs to treat breast cancer. However, there has been no study to date on the underlying mechanisms of its therapeutic effects.

Objectives: To explore the potential mechanism of THSWD for the treatment of breast cancer using network pharmacology and experimental research. Read More

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Hybrids of 4-hydroxy derivatives of goniothalamin and piplartine bearing a diester or a 1,2,3-triazole linker as antiproliferative agents.

Bioorg Chem 2021 Aug 25;116:105292. Epub 2021 Aug 25.

Department of Organic Chemistry, Institute of Chemistry, University of Campinas, UNICAMP, 13083-970 Campinas, Sao Paulo, Brazil. Electronic address:

A library of nine hybrids of 4-hydroxygoniothalamin (2), 4-hydroxypiplartine (4), monastrol (5) and oxo-monastrol (6) was prepared via a modular synthetic route with a diester or a 1,2,3-triazole as linkers. The compounds were assayed against a panel of human cancer cell lines, including MCF-7 (breast adenocarcinoma), HeLa (cervical adenocarcinoma), Caco-2 (colorectal adenocarcinoma) and PC3 (prostate adenocarcinoma), as well as against normal breast (MCF10A) and prostate (PNT2) cells. In general, hybrids with an ester linker containing 4-hydroxypiplartine (4) were more potent than the corresponding hybrids with 4-hydroxygoniothalamin (2). Read More

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Chemical composition, antioxidant and anticholinesterase activity of the essential oil of algerian L.

Nat Prod Res 2021 Sep 10:1-9. Epub 2021 Sep 10.

School of Pharmacy, University of Camerino, Camerino, Italy.

In this work, in order to explore a new Algerian medicinal plant used in traditional medicine, the essential oil of the leaves of L. (Apiaceae) collected from Algeria, obtained by hydrodistillation, was analyzed by GC/MS. Thirty-two compounds were identified accounting for 98. Read More

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September 2021

Multilevel Approach for the Treatment of Giardiasis by Targeting Arginine Deiminase.

Int J Mol Sci 2021 Aug 31;22(17). Epub 2021 Aug 31.

Laboratorio de Biomoléculas y Salud Infantil, Instituto Nacional de Pediatría, Ciudad de Mexico 04530, Mexico.

Giardiasis represents a latent problem in public health due to the exceptionally pathogenic strategies of the parasite for evading the human immune system. Strains resistant to first-line drugs are also a challenge. Therefore, new antigiardial therapies are urgently needed. Read More

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Light-Struck Taste in White Wine: Protective Role of Glutathione, Sulfur Dioxide and Hydrolysable Tannins.

Molecules 2021 Aug 31;26(17). Epub 2021 Aug 31.

Department of Food, Environmental and Nutritional Sciences, Università degli Studi di Milano, Via G. Celoria 2, 20133 Milan, Italy.

Light exposure of white wine can cause a light-struck taste (LST), a fault induced by riboflavin (RF) and methionine (Met) leading to the formation of volatile sulfur compounds (VSCs), including methanethiol (MeSH) and dimethyl disulfide (DMDS). The study aimed to investigate the impact of different antioxidants, i.e. Read More

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The Chemical Profiling of Essential Oils from Different Tissues of L. and Their Antimicrobial Activities.

Molecules 2021 Aug 24;26(17). Epub 2021 Aug 24.

Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT 84043, USA.

L. is grown as an ornamental plant, used as raw material for furniture, as a source of camphor, and its essential oil can be used as an important source for perfume as well as alternative medicine. A comparative investigation of essential oil compositions and antimicrobial activities of different tissues of was carried out. Read More

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Three novel quinolinone alkaloids from the leaves of .

Nat Prod Res 2021 Sep 9:1-7. Epub 2021 Sep 9.

Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.

Three previously unreported quinolinone alkaloids: melicodenines J-L (-) and six known compounds (-), were isolated from the leaves of (Seem) T.G. Hartley. Read More

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September 2021

Phytochemical profile of Cespedesia spathulata leaves (Ochnaceae) and its effect on tyrosinase enzyme.

An Acad Bras Cienc 2021 3;93(4):e20200443. Epub 2021 Sep 3.

Instituto de Química, Universidade Federal Rural do Rio de Janeiro, Departamento de Química Orgânica, BR 465, Km 07, 23890-000 Seropédica, RJ, Brazil.

Phytochemical studies of Cespedesia spathulata (Ochnaceae) leaves using 1H, 13C NMR, and GC-MS have led to the isolation of some metabolites identified for the first time in these species such as cathechin, epicatechin, vitexin, orientin, 6''-O-acetyl-vitexin, sitosterol, stigmasterol, phytol, 4,5-dihydrovomifoliol and a mixture of aliphatic methyl esters, together with ochnaflavone, which was previously isolated from this plant. The modulating activity of some fractions and compounds from Cespedesia spathulata towards tyrosinase enzyme was assayed by spectroscopic and theoretical means/experiments. The dichloromethane fraction (133 μg mL-1) and ochnaflavone (333 μM) inhibited tyrosinase activity by 20 % and 2. Read More

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September 2021

Mithramycin delivery systems to develop effective therapies in sarcomas.

J Nanobiotechnology 2021 Sep 6;19(1):267. Epub 2021 Sep 6.

Sarcomas and Experimental Therapeutics Laboratory, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, Avenida de Roma, s/n, 33011, Oviedo, Spain.

Background: Sarcomas comprise a group of aggressive malignancies with very little treatment options beyond standard chemotherapy. Reposition of approved drugs represents an attractive approach to identify effective therapeutic compounds. One example is mithramycin (MTM), a natural antibiotic which has demonstrated a strong antitumour activity in several tumour types, including sarcomas. Read More

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September 2021

Phytochemical Screening, Toxicity Activity and Antioxidant Capacity of Ethanolic Extract of Rhizome.

Pak J Biol Sci 2021 Jan;24(7):807-814

<b>Background and Objective:</b> <i>Etlingera alba </i>(Blume) A.D. Poulsen is one of the plants of the genus <i>Etlingera</i> which is commonly found in Southeast Sulawesi. Read More

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January 2021

2D Strategy for the Construction of an Enzyme-Activated NIR Fluorophore Suitable for the Visual Sensing and Profiling of Homologous Nitroreductases from Various Bacterial Species.

ACS Sens 2021 Sep 1. Epub 2021 Sep 1.

Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Pharmacy, Dalian Medical University, Dalian 116044, China.

Nitroreductases (NTRs) mediate the reduction of nitroaromatic compounds to the corresponding nitrite, hydroxylamine, or amino derivatives. The activity of NTRs in bacteria facilitates the metabolic activation and antibacterial activity of 5-nitroimidazoles. Therefore, NTR activity correlates with the drug susceptibility and resistance of pathogenic bacteria. Read More

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September 2021

Activity of Anthracenediones and Flavoring Phenols in Hydromethanolic Extracts of against Grapevine Phytopathogenic Fungi.

Plants (Basel) 2021 Jul 26;10(8). Epub 2021 Jul 26.

Instituto Universitario de Investigación en Ciencias Ambientales de Aragón (IUCA), EPS, Universidad de Zaragoza, Carretera de Cuarte, s/n, 22071 Huesca, Spain.

In this work, the chemical composition of root hydromethanolic extract was analyzed by GC-MS, and over 50 constituents were identified. The main phytochemicals were alizarin-related anthraquinones and flavoring phenol compounds. The antifungal activity of this extract, alone and in combination with chitosan oligomers (COS) or with stevioside, was evaluated against the pathogenic taxa and , responsible for the so-called Botryosphaeria dieback of grapevine. Read More

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Screening Anti-Inflammatory Effects of Flavanones Solutions.

Int J Mol Sci 2021 Aug 18;22(16). Epub 2021 Aug 18.

Center for Chemical Research, Institute for Research Basic and Applied Sciences, Autonomous University of the State of Morelos, Av. Universidad 1001, Cuernavaca 62209, Mexico.

There are a large number of remedies in traditional medicine focused on relieving pain and inflammation. Flavanones have been a potential source in the search for leading compounds and biologically active components, and they have been the focus of much research and development in recent years. is used in traditional medicine for the treatment of kidney diseases, bladder infections, and diabetes mellitus. Read More

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Modulation of the PGE-Mediated Pathway in the Eclosion Blocking Effect of Flumethrin and Terpenoid Subfraction Isolated from in .

Molecules 2021 Aug 13;26(16). Epub 2021 Aug 13.

Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Pookode, Kerala Veterinary and Animal Sciences University, Lakkidi, P. O., Wayanad 673576, Kerala, India.

Prostaglandins are a group of important cell-signaling molecules involved in the regulation of ovarian maturation, oocyte development, egg laying and associated behaviors in invertebrates. However, the presence of prostaglandin E (PGE), the key enzymes for PGE biosynthesis and its interference by drugs were not investigated previously in the ovary of ticks. The present study was undertaken to assess the modulation of the PGE-mediated pathway in the eclosion blocking effect of flumethrin and terpenoid subfraction isolated from in ticks. Read More

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[(C^C)Au(N^N)]+ complexes as a new family of anticancer candidates: synthesis, characterization and exploration of the antiproliferative properties.

Chemistry 2021 Aug 26. Epub 2021 Aug 26.

Sorbonne Universite UFR de Chimie, Institut Parisien de Chimie Moléculaire, 4 Place Jussieu, 75252, Paris Cedex 05, FRANCE.

A library of eleven cationic gold(III) complexes of the general formula [(C^C)Au(N^N)] + when C^C is either biphenyl or 4,4'-ditertbutyldiphenyl and N^N is a bipyridine, phenanthroline or dipyridylamine derivative have been synthesized and characterized. Contrasting effects on the viability of the triple negative breast cancer cells MDA-MB-231 was observed from a preliminary screening. The antiproliferative activity of the seven most active complexes were further assayed on a larger panel of human cancer cells as well as on non-cancerous cells for comparison. Read More

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Induction of amylase and protease as antibiofilm agents by starch, casein, and yeast extract in Arthrobacter sp. CW01.

BMC Microbiol 2021 Aug 23;21(1):232. Epub 2021 Aug 23.

Department of Biotechnology, Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, 12930, Jakarta, Indonesia.

Background: In unfavourable environment, such as nutrient limitation, some bacteria encased themselves into a three dimensional polymer matrix called biofilm. The majority of microbial infections in human are biofilm related, including chronic lung, wound, and ear infections. The matrix of biofilm which consists of extracellular polymeric substances (EPS) causes bacterial colonization on medical implanted device in patients, such as catheter and lead to patient's death. Read More

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Integrated ionomic and transcriptomic dissection reveals the core transporter genes responsive to varying cadmium abundances in allotetraploid rapeseed.

BMC Plant Biol 2021 Aug 13;21(1):372. Epub 2021 Aug 13.

School of Agricultural Sciences, Zhengzhou University, Zhengzhou, 450001, China.

Background: Oilseed rape (B. napus L.) has great potential for phytoremediation of cadmium (Cd)-polluted soils due to its large plant biomass production and strong metal accumulation. Read More

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Effect of supplementation of Rhodomyrtus tomentosa fruit juice in preventing hypercholesterolemia and atherosclerosis development in rats fed with high fat high cholesterol diet.

Biomed Pharmacother 2021 Aug 10;142:111996. Epub 2021 Aug 10.

Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta 12930, Indonesia. Electronic address:

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Nutraceuticals, mainly based on natural products, have been proven to control the risk factors of CVDs effectively. Rhodomyrtus tomentosa is an underutilized fruit that is rich in phenolic compounds and has antioxidant activities. Read More

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Identification of active small-molecule modulators targeting the novel immune checkpoint VISTA.

BMC Immunol 2021 Aug 11;22(1):55. Epub 2021 Aug 11.

Jiangsu Key Lab of Drug Screening, China Pharmaceutical University, Nanjing, 210009, China.

Background: Cancer immunotherapy has gained increasing popularity as a novel approach to treat cancer. A member of the B7 family, V-domain immunoglobulin suppressor of T-cell activation (VISTA) is a novel immune checkpoint that regulates a broad spectrum of immune responses. VISTA is an acidic pH-selective ligand for P-selectin glycoprotein ligand-1(PSGL-1). Read More

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Antifungal Activity against Fungi of the Hydro-Methanolic Extract of Capitula Conjugated with Stevioside.

Plants (Basel) 2021 Jul 3;10(7). Epub 2021 Jul 3.

Plant Protection Unit, Agrifood Research and Technology Centre of Aragón, Instituto Agroalimentario de Aragón-IA2 (CITA-Universidad de Zaragoza), Avda. Montañana 930, 50059 Zaragoza, Spain.

(L.) Gaertn, viz. milk thistle, has been the focus of research efforts in the past few years, albeit almost exclusively restricted to the medicinal properties of its fruits (achenes). Read More

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The Antioxidative Role of Natural Compounds from a Green Coconut Mesocarp Undeniably Contributes to Control Diabetic Complications as Evidenced by the Associated Genes and Biochemical Indexes.

Oxid Med Cell Longev 2021 27;2021:9711176. Epub 2021 Jul 27.

Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), Serdang, 43400 Selangor, Malaysia.

The purpose of this study was to look into the effects of green coconut mesocarp juice extract (CMJE) on diabetes-related problems in streptozotocin- (STZ-) induced type 2 diabetes, as well as the antioxidative functions of its natural compounds in regulating the associated genes and biochemical markers. CMJE's antioxidative properties were evaluated by the standard antioxidant assays of 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide radical, nitric oxide, and ferrous ions along with the total phenolic and flavonoids content. The -amylase inhibitory effect was measured by an established method. Read More

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Induced With Chitosan Triggers Defense Response of Table Grapes Against Post-harvest Blue Mold Disease.

Front Microbiol 2021 22;12:704519. Epub 2021 Jul 22.

School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China.

To study the mechanism by which induced with chitosan (1% w/v) controls blue mold disease in table grapes caused by , this study evaluated alterations in three yeast enzymatic activities. The changes in the five primary disease defense-related enzymes and two non-enzyme activities of table grapes were assayed. The results of the study showed that chitosan (1% w/v) significantly increased the yeast β-1,3-glucanase, catalase (CAT), and malondialdehyde (MDA) activities. Read More

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New titanocene derivative with improved stability and binding ability to albumin exhibits high anticancer activity.

J Inorg Biochem 2021 Oct 2;223:111562. Epub 2021 Aug 2.

Universidad de Castilla-La Mancha, Facultad de Ciencias Ambientales y Bioquímica, 45071 Toledo, Spain; Universidad de Castilla-La Mancha, Departamento de Química Orgánica, Inorgánica y Bioquímica, Spain.

Titanium-based therapies have emerged as a promising alternative for the treatment of cancer patients, particularly those with cisplatin resistant tumors. Unfortunately, some titanium compounds show stability and solubility problems that have hindered their use in clinical practice. Here, we designed and synthesized a new titanium complex containing a titanocene fragment, a tridentate ligand to improve its stability in water, and a long aliphatic chain, designed to facilitate a non-covalent interaction with albumin, the most abundant protein in human serum. Read More

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October 2021

Flower beverages of native medicinal plants from Argentina (Acacia caven, Geoffroea decorticans and Larrea divaricata) as antioxidant and anti-inflammatory.

J Ethnopharmacol 2021 Aug 5;281:114490. Epub 2021 Aug 5.

Laboratorio de Investigación de Productos Naturales (LIPRON), Instituto de Bioprospección y Fisiología Vegetal (INBIOFIV-CONICET), Facultad de Ciencias Naturales e IML, Universidad Nacional de Tucumán, San Lorenzo, 1469, San Miguel de Tucumán, Tucumán, Argentina. Electronic address:

Ethnopharmacological Relevance: Herbal beverages have been used as a natural part of the medicinal and food culture in northwestern Argentina. The flower beverages (infusion or decoction) of Acacia caven, Geoffroea decorticans and Larrea divaricata, three native species from arid and semiarid regions of Argentina are widely used as anti-inflammatory and anti-rheumatic by several local communities.

Aim Of The Study: The aim of this study was to analyze the phytochemical composition of some Argentine flower beverage and to validate its traditional use as an antioxidant and anti-inflammatory agent. Read More

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Variability of the Chemical Composition and Bioactivity between the Essential Oils Isolated from Male and Female Specimens of (Ruiz & Pav.) G. Don.

Molecules 2021 Jul 29;26(15). Epub 2021 Jul 29.

Departamento de Química, Universidad Técnica Particular de Loja, Loja 110150, Ecuador.

(Ruiz & Pav.) G. is a native species of Ecuador used in traditional medicine for treatment of rheumatism, bronchitis, cold, cough, asthma, bone pain, and stomach pain. Read More

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Chemical Constituents of the Essential Oil from Ecuadorian Endemic Species and Its Antimicrobial, Antioxidant and α-Glucosidase Inhibitory Activity.

Molecules 2021 Jul 29;26(15). Epub 2021 Jul 29.

Departamento de Química, Universidad Técnica Particular de Loja, Loja 110150, Ecuador.

Kunth is an endemic species of Ecuador used in traditional medicine both for wound healing and as an antiseptic. In this study, fresh leaves were collected and subjected to hydrodistillation for extraction of the essential oil. The chemical composition of the essential oil was determined by gas chromatography equipped with a flame ionization detector and gas chromatography coupled to a mass spectrometer using a non-polar and a polar chromatographic column. Read More

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Identification of Broad-Spectrum MMP Inhibitors by Virtual Screening.

Molecules 2021 Jul 28;26(15). Epub 2021 Jul 28.

Research Group in Cheminformatics & Nutrition, Departament de Bioquímica i Biotecnologia, Campus de Sescelades, Universitat Rovira i Virgili, 43007 Tarragona, Catalonia, Spain.

Matrix metalloproteinases (MMPs) are the family of proteases that are mainly responsible for degrading extracellular matrix (ECM) components. In the skin, the overexpression of MMPs as a result of ultraviolet radiation triggers an imbalance in the ECM turnover in a process called photoaging, which ultimately results in skin wrinkling and premature skin ageing. Therefore, the inhibition of different enzymes of the MMP family at a topical level could have positive implications for photoaging. Read More

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Concerning the Role of -Hole in Non-Covalent Interactions: Insights from the Study of the Complexes of ArBeO with Simple Ligands.

Molecules 2021 Jul 24;26(15). Epub 2021 Jul 24.

Dipartimento per la Innovazione nei Sistemi Biologici, Agroalimentari e Forestali (DIBAF), Università della Tuscia, L.go dell'Università, s.n.c., 01100 Viterbo, Italy.

The structure, stability, and bonding character of some exemplary Ar and -ArBeO ( = He, Ne, Ar, N, CO, F, Cl, ClF, HF, HCl, NH) were investigated by MP2 and coupled-cluster calculations, and by symmetry-adapted perturbation theory. The nature of the stabilizing interactions was also assayed by the method recently proposed by the authors to classify the chemical bonds in noble-gas compounds. The comparative analysis of the Ar and -ArBeO unraveled geometric and bonding effects peculiarly related to the -hole at the Ar atom of ArBeO, including the major stabilizing/destabilizing role of the electrostatic interactionensuing from the negative/positive molecular electrostatic potential of at the contact zone with ArBeO. Read More

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