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Isolated and anxious: A qualitative exploration of the impact of the COVID-19 pandemic on individuals living with spinal cord injury in the UK.

J Spinal Cord Med 2021 Jul 22:1-9. Epub 2021 Jul 22.

The Department of Rehabilitation Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

People living with spinal cord injury (SCI) are often immunocompromised, and at increased risk of respiratory infection. Given the restrictions in response to the COVID-19 pandemic, those with SCI may be at increased risk of health deterioration, though how this is experienced is poorly understood. This study explored the experiences of people living with SCI during the COVID-19 pandemic. Read More

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Using Best-Worst Choice Methodology in a Survey of Pharmacists Regarding Pharmacy Practice Skills Teaching.

Am J Pharm Educ 2020 Dec 2;84(12):848015. Epub 2020 Oct 2.

University of Otago, Dunedin School of Medicine, Dunedin, New Zealand.

To conduct a survey of practicing pharmacists in which best-worst choice methodology was used to prioritize pharmacy practice skills for inclusion in a pharmacy curriculum in New Zealand. A literature search and review of pharmacy curricula were conducted, and the findings were used to develop a best-worst choice survey instrument regarding inclusion of pharmacy practice skills in the pharmacy curriculum. The survey was sent to registered pharmacists and intern pharmacists in New Zealand. Read More

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December 2020

Sterile Compounding Knowledge, Skills, and Confidence Among Graduating Doctor of Pharmacy Students.

Am J Pharm Educ 2021 Mar 23;85(3):8345. Epub 2020 Dec 23.

Southeast Louisiana Veterans Healthcare System, New Orleans, Louisiana.

To determine whether the exposure to sterile compounding in the pharmacy curriculum produces Doctor of Pharmacy graduates who are both competent and confident in the area of sterile compounding, and to identify additional variables that may predict student performance. Participants were recruited from the fourth-year pharmacy class of 2018 at one university. The students were asked to complete a questionnaire assessing the following domains: demographics, confidence in compounding performance, prior experience, and theoretical knowledge. Read More

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Antibiotic prophylaxis of postoperative endophthalmitis following cataract surgery: Results of the 2021 ASCRS member survey.

J Cataract Refract Surg 2021 Jul 19. Epub 2021 Jul 19.

From University of California, San Francisco (Chang), San Francisco, California and the Case Western Reserve University (Rhee), Cleveland OH.

In an online survey of > 1200 global cataract surgeons, 66% were using intracameral (IC) antibiotic prophylaxis. This compares with 50% and 30% in the 2014 and 2007 surveys. Irrigation bottle infusion and intravitreal injection was each used by only 5% of respondents. Read More

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Simultaneous quantitation of inorganic ions in oligonucleotides using mixed-mode liquid chromatography coupled with a charged aerosol detector.

J Pharm Biomed Anal 2021 Jul 8;204:114244. Epub 2021 Jul 8.

Department of Analytical Development, Biogen, 225 Binney St, Cambridge, MA 02142, USA.

The amounts of inorganic ions (e.g. sodium, potassium, magnesium, calcium, chloride, and phosphate) in intrathecally administered oligonucleotide drug products need to be controlled in order to meet the final target formulation composition. Read More

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Lowering barriers to active learning: a novel approach for online instructional environments.

Authors:
Ashley Rhodes

Adv Physiol Educ 2021 Sep;45(3):547-553

Division of Biology, Kansas State University, Manhattan, Kansas.

The value of active learning for increasing student comprehension and retention of science, technology, e,ngineering, and mathematics (STEM) concepts within undergraduate courses has proven to be beneficial many times over; however, barriers still exist for both instructors and students. For example, instructors are often left to decide what type of active learning activities to incorporate and how to implement them yet receive little to no formal training about how to do this effectively. Additionally, student resistance to active learning persists, which adds to the pressure faced by some instructors. Read More

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September 2021

COVID-19 pandemic preparedness: A practical guide from an operational pharmacy perspective.

Am J Health Syst Pharm 2020 09;77(19):1598-1605

Department of Pharmacy, NYU Langone Health, New York, NY.

Purpose: To describe our medical center's pharmacy services preparedness process and offer guidance to assist other institutions in preparing for surges of critically ill patients such as those experienced during the coronavirus disease 2019 (COVID-19) pandemic.

Summary: The leadership of a department of pharmacy at an urban medical center in the US epicenter of the COVID-19 pandemic proactively created a pharmacy action plan in anticipation of a surge in admissions of critically ill patients with COVID-19. It was essential to create guidance documents outlining workflow, provide comprehensive staff education, and repurpose non-intensive care unit (ICU)-trained clinical pharmacotherapy specialists to work in ICUs. Read More

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September 2020

The Influence of Adverse Childhood Experiences (ACEs), Including the COVID-19 Pandemic, and Toxic Stress on Development and Health Outcomes of Latinx Children in the USA: a Review of the Literature.

Int J Child Maltreat 2021 Jul 11:1-22. Epub 2021 Jul 11.

Department of Languages, Clemson University, 504 Strode Tower, Clemson, SC 29634 USA.

The purpose of this review is to synthesize existing literature to analyze the influence of the Adverse Childhood Experiences (ACEs), including the COVID-19 pandemic, and toxic stress on child development and lifelong health outcomes of Latinx children in the USA, utilizing the ACE framework. Without adequate protective factors, children's early experiences with adversity and toxic stress have implications for their physiological, psychological, and social health. The COVID-19 pandemic has shown to exacerbate childhood adversity and toxic stress and has disproportionately harmed Latinx communities. Read More

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A Survey of Community Dermatologists Reveals the Unnecessary Impact of Trial-and-Error Behavior on the Psoriasis Biologic Treatment Paradigm.

Dermatol Ther (Heidelb) 2021 Jul 18. Epub 2021 Jul 18.

Baylor University Medical Center, Dallas, TX, USA.

Introduction: In the USA, psoriasis affects approximately 3% of the population and costs more than $110 billion annually. The development of targeted biologics has revolutionized psoriasis management, but at an increasing cost. According to Joint AAD/NPF guidelines, an important need exists to identify biomarkers that can predict the appropriate biologic agent for patients. Read More

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Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in postmenopausal osteoporosis.

J Orthop Surg Res 2021 Jul 16;16(1):459. Epub 2021 Jul 16.

Department of Orthopedics, The First Affiliated Hospital of Zhejiang University, Qingchun Road No. 79, Hangzhou, 310001, Zhejiang Province, China.

Background: Circular RNAs (circRNAs) are emerging as crucial regulators in various human diseases. So far, the expression profile and regulatory mechanism of circRNAs in postmenopausal osteoporosis (PMOP) are less studied and should be deciphered urgently. Herein, we aimed to reveal key circRNAs affecting PMOP and clarify their compounding regulatory actions. Read More

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Multilevel Associations with Cancer Screening Among Women in Rural, Segregated Communities Within the Northeastern USA: a Mixed-Methods Study.

J Cancer Educ 2021 Jul 15. Epub 2021 Jul 15.

Department of Family and Community Medicine, Department of Public Health Sciences, Penn State College of Medicine, The Pennsylvania State University, 134 Sipe Ave., #205, MC HS72, P.O. Box 850, Hershey, PA, 17033, USA.

We recruited women (primarily non-Hispanic White) from 14 rural, segregated counties in a Northeastern US state for an explanatory sequential study: 100 women (ages 50-65 years) completed a survey, and 16 women participated in focus groups. We sought to identify personal (e.g. Read More

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Contribution of Schistosoma mansoni to systemic inflammation and microbial translocation among people with HIV in Zambia.

Trans R Soc Trop Med Hyg 2021 Jul 14. Epub 2021 Jul 14.

Tropical Gastroenterology & Nutrition Group, University of Zambia School of Medicine, Nationalist Road, Lusaka, Zambia.

Background: Schistosoma mansoni is hyperendemic in many rural areas of Zambia where up to 77% of people are positive for infection via serologic evaluation. Zambia also has a high prevalence of HIV infection. Individually, S. Read More

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Error Bounds of Imitating Policies and Environments for Reinforcement Learning.

IEEE Trans Pattern Anal Mach Intell 2021 Jul 14;PP. Epub 2021 Jul 14.

In sequential decision-making, imitation learning (IL) trains a policy efficiently by mimicking expert demonstrations. Various imitation methods were proposed and empirically evaluated, meanwhile, their theoretical understandings need further studies, among which the compounding error in long-horizon decisions is a major issue. In this paper, we firstly analyze the value gap between the expert policy and imitated policies by two imitation methods, behavioral cloning (BC) and generative adversarial imitation. Read More

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Pharmacy Distribution, Clinical, and Management Services: A Survey of Small Hospitals in Canada Supported by Telepharmacy Services.

Can J Hosp Pharm 2021 1;74(3):256-268. Epub 2021 Jul 1.

, BScPhm, ACPR, is with Northwest Telepharmacy Solutions, Deep River, Ontario.

Background: The Canadian Society of Hospital Pharmacists' Hospital Pharmacy in Canada Report presents data from pharmacy departments that service hospitals with at least 50 acute care beds. This report provides valuable data on pharmacy distribution, clinical, and management services in relation to hospital size, type, and geographic region. Pharmacy and hospital leadership use these extensive data in identifying baseline, benchmarking current, and planning enhanced pharmacy services. Read More

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Integrating solutions to adapt cities for climate change.

Lancet Planet Health 2021 Jul;5(7):e479-e486

National University of Singapore, Singapore.

Record climate extremes are reducing urban liveability, compounding inequality, and threatening infrastructure. Adaptation measures that integrate technological, nature-based, and social solutions can provide multiple co-benefits to address complex socioecological issues in cities while increasing resilience to potential impacts. However, there remain many challenges to developing and implementing integrated solutions. Read More

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A pediatrician's guide to climate change-informed primary care.

Curr Probl Pediatr Adolesc Health Care 2021 Jul 7:101027. Epub 2021 Jul 7.

Division of General Pediatrics, Boston Children's Hospital, Center for Climate, Health and the Global Environment, Harvard T.H. Chan School of Public Health, Boston, MA and Harvard Global Health Institute, Cambridge, MA, United States. Electronic address:

Despite the urgency of the climate crisis and mounting evidence linking climate change to child health harms, pediatricians do not routinely engage with climate change in the office. Each primary care visit offers opportunities to screen for and support children burdened with risks to health that are increasingly intense due to climate change. Routine promotion of healthy behaviors also aligns with some needed-and powerful-solutions to the climate crisis. Read More

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Curing or causing? HIV/AIDS in health care system of Punjab, Pakistan.

PLoS One 2021 9;16(7):e0254476. Epub 2021 Jul 9.

Shifa International Hospital, Islamabad, Pakistan.

Background: Pakistan's National AIDS Control Program has registered 44,000 HIV/AIDS patients to date, but the actual number of cases have been estimated to be as high as 150,000-170,000. The health care system has a very important role to play in this equation and must be reformed to improve the health care services in Pakistan, with regards to HIV/AIDS.

Methods: It was a qualitative research employing a phenomenological approach. Read More

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Availability of essential medicines in Pakistan-A comprehensive document analysis.

PLoS One 2021 9;16(7):e0253880. Epub 2021 Jul 9.

Centre for Pharmaceutical Policy and Practice Research, University of Huddersfield, Huddersfield, United Kingdom.

Introduction: Access to essential medicines (EMs) is a basic human right. Non-availability and shortages of EMs are reported for Pakistan but there is insufficient data to define the nature and magnitude of this problem. The current study is designed to systematically analyze the medicines included in the National Essential Medicines List (NEML) for their availability through comprehensive document analysis. Read More

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Further development of the content of the national part of the Czech Pharmacopoeia 2017 in its supplements from the point of view of drug preparation in pharmacies.

Ceska Slov Farm 2021 ;70(1):3-6

The paper deals with developing the national part of the Czech Pharmacopoeia 2017 (CL 2017) in its supplements from 2018, 2019, and 2020. It focuses on the preparation of medicinal products in pharmacies. The possibilities of further developing the national part of the CL 2017 to accelerate the necessary changes in its content are also discussed. Read More

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Psychological distance and the pandemic: Insights from Construal Level Theory and relationship science.

Authors:
Jeffrey D Bowen

Soc Personal Psychol Compass 2021 May 29;15(5):e12594. Epub 2021 Mar 29.

Johns Hopkins University Baltimore Maryland USA.

The coronavirus disease 2019 pandemic has brought about unprecedented challenges to public health. Compounding these hardships is the fact that typical social functions such as maintaining valued relationships cannot proceed as usual. Social cognitive perspectives like that presented by Construal Level Theory (CLT) can provide a valuable framework for understanding our unique interpersonal experiences during this difficult time, and potentially offer avenues for adaptation and healthier coping. Read More

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Osteotomy in lateral position for correcting severe thoracolumbar kyphosis combined with hip flexion contracture in ankylosing spondylitis: a case report and literature review.

Eur Spine J 2021 Jul 6. Epub 2021 Jul 6.

Department of Chemistry, Bacha Khan University, Charsadda, 24461, Pakistan.

Purpose: The purpose of this case study and literature review is to describe the successful spinal osteotomy in the lateral position performed on ankylosing spondylitis (AS) patients with thoracolumbar kyphotic deformity combined with severe hip flexion contracture. The case study and literature review aim to determine alternative surgical methods for patients who are inoperable in the prone position.

Methods: A 33-year-old female AS patient with a prior total hip replacement (THR) is later diagnosed with severe thoracolumbar kyphosis and hip flexion ankylosis. Read More

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A hollow CoS rod-acidified CNT-NiCoLDH composite providing excellent electrochemical performance in asymmetric supercapacitors.

Dalton Trans 2021 Jul;50(26):9283-9292

Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, Beijing, 100083, PR China.

Co9S8 and transition metal hydroxides are both potential pseudo-capacitance electrode materials for supercapacitors. Co9S8 has a large specific capacitance and electrochemical activity, and transition metal hydroxides have the advantages of high capacitance and redox activity due to their multiple valence metals and open layered structure. In this study, Co9S8 and NiCoLDH are used to form a Co9S8-aCNT-NiCoLDH composite electrode material by twining acidified carbon nanotubes (aCNTs) around hollow Co9S8 rods and then compounding nickel cobalt hydroxide (NiCoLDH) on the outside. Read More

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Stability-indicating HPLC method to determine the stability of extemporaneously prepared vancomycin oral solution cups.

Am J Health Syst Pharm 2021 Jul 6. Epub 2021 Jul 6.

Department of Pharmaceutical Sciences, Jefferson College of Pharmacy, Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: To determine the stability of compounded sweetened vancomycin oral formulations in plastic unit dose cups stored up to 180 days under 2 temperature conditions: refrigeration (2°C-6°C) and room temperature (25°C with 60% relative humidity).

Methodology: A stability-indicating high-performance liquid chromatography (HPLC) method was developed to analyze vancomycin in the presence of degradation peaks. The stability of extemporaneously compounded vancomycin solution stored in oral unit dose cups was investigated using this method. Read More

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Time to review how injectable medicines are prepared and administered in European hospitals.

Farm Hosp 2021 05 13;45(4):204-209. Epub 2021 May 13.

Prescrire Programme Éviter l'Évitable, Paris. France..

It has been known, for decades, that the use of injectable medicines in European hospitals has been associated with frequent medication errors, some of which cause preventable severe harms and deaths. There  have been national and European inquiries and reports concerning  improving patient safety by recommending greater use of pharmacy  aseptic preparation services and provision of ready-to administer  injectables, which have not been widely implemented.In England experience of treating patients with COVID-19 infections has  brought into focus other benefits of significantly extending pharmacy aseptic preparation services. Read More

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Centralized drug compounding units: an essential driver of patient safety.

Farm Hosp 2021 06 30;45(4):163-164. Epub 2021 Jun 30.

Department of Pharmacy, Hospital General Universitario Gregorio Marañón, Madrid. Spain..

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How stereochemistry of lipid components can affect lipid organization and the route of liposome internalization into cells.

Nanoscale 2021 Jul;13(27):11976-11993

Dipartimento per la Innovazione nei sistemi Biologici, Agroalimentari e Forestali (DIBAF), Università degli Studi della Tuscia, L.go dell'Università, s.n.c., 01100 Viterbo, Italy.

Though liposome-based drugs are in clinical use, the mechanism of cell internalization of liposomes is yet an object of controversy. The present experimental investigation, carried out on human glioblastoma cells, indicated different internalization routes for two diastereomeric liposomes. Molecular dynamics simulations of the lipid bilayers of the two formulations indicated that the different stereochemistry of a lipid component controls some parameters such as area per lipid molecule and fluidity of lipid membranes, surface potential and water organization at the lipid/water interface, all of which affect the interaction with biomolecules and cell components. Read More

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Nanocomposites Materials of PLA Reinforced with Nanoclays Using a Masterbatch Technology: A Study of the Mechanical Performance and Its Sustainability.

Polymers (Basel) 2021 Jun 29;13(13). Epub 2021 Jun 29.

Group LEPAMAP-PRODIS, Department of Chemical Engineering, University of Girona, C/M. Aurèlia Capmany, 61, 17003 Girona, Spain.

Packaging consumes around 40% of the total plastic production. One of the most important fields with high requirements is food packaging. Food packaging products have been commonly produced with petrol polymers, but due to environmental concerns, the market is being moved to biopolymers. Read More

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In-Line Rheo-Optical Investigation of the Dispersion of Organoclay in a Polymer Matrix during Twin-Screw Compounding.

Polymers (Basel) 2021 Jun 29;13(13). Epub 2021 Jun 29.

Institute for Polymers and Composites, University of Minho, 4800-058 Guimarães, Portugal.

The dispersion mechanisms in a clay-based polymer nanocomposite (CPNC) during twin-screw extrusion are studied by in-situ rheo-optical techniques, which relate the CPNC morphology with its viscosity. This methodology avoids the problems associated with post extrusion structural rearrangement. The polydimethylsiloxane (PDMS) matrix, which can be processed at ambient and low temperatures, is used to bypass any issues associated with thermal degradation. Read More

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Emulsion-Based Multicompartment Vaginal Drug Carriers: From Nanoemulsions to Nanoemulgels.

Int J Mol Sci 2021 Jun 16;22(12). Epub 2021 Jun 16.

Department of Drug Form Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland.

In order to overcome the limitations associated with vaginal administration of drugs, e.g., the short contact time of the drug form with the mucosa or continuous carrier wash-out, the development of new carriers for gynecological use is necessary. Read More

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Cryptosporidiosis Modulates the Gut Microbiome and Metabolism in a Murine Infection Model.

Metabolites 2021 Jun 11;11(6). Epub 2021 Jun 11.

Land and Water, Commonwealth Scientific and Industrial Research Organization, Ecosciences Precinct, Dutton Park, QLD 4102, Australia.

Cryptosporidiosis is a major human health concern globally. Despite well-established methods, misdiagnosis remains common. Our understanding of the cryptosporidiosis biochemical mechanism remains limited, compounding the difficulty of clinical diagnosis. Read More

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