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Effectively Promoting Activity and Stability of a MnCoO-Based Cathode by Constructed Heterointerfaces for Solid Oxide Fuel Cells.

ACS Appl Mater Interfaces 2021 May 12. Epub 2021 May 12.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.

The development of multiphase composite electrocatalysts plays a key role in achieving the efficient and durable operation of intermediate-temperature solid oxide fuel cells (IT-SOFCs). Herein, a self-assembled nanocomposite is developed as the oxygen reduction reaction (ORR) catalyst for IT-SOFCs through a coprecipitation method. The nanocomposite is composed of a doped (MnMg)ScCoO (MMSCO) spinel oxide (84 wt %), an orthorhombic perovskite phase (11. Read More

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Robust prediction of mortality of COVID-19 patients based on quantitative, operator-independent, lung CT densitometry.

Phys Med 2021 Apr 30;85:63-71. Epub 2021 Apr 30.

Medical Physics, San Raffaele Scientific Institute, Milano, Italy. Electronic address:

Purpose: To train and validate a predictive model of mortality for hospitalized COVID-19 patients based on lung densitometry.

Methods: Two-hundred-fifty-one patients with respiratory symptoms underwent CT few days after hospitalization. "Aerated" (AV), "consolidated" (CV) and "intermediate" (IV) lung sub-volumes were quantified by an operator-independent method based on individual HU maximum gradient recognition. Read More

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Quantum walks on a programmable two-dimensional 62-qubit superconducting processor.

Science 2021 May 6. Epub 2021 May 6.

National Institute of Informatics, 2-1-2 Hitotsubashi, Chiyoda-ku, Tokyo 101-8430, Japan.

Quantum walks are the quantum mechanical analog of classical random walks and an extremely powerful tool in quantum simulations, quantum search algorithms, and even for universal quantum computing. In our work, we have designed and fabricated an 8x8 two-dimensional square superconducting qubit array composed of 62 functional qubits. We used this device to demonstrate high fidelity single and two particle quantum walks. Read More

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Highly Selective CO Electroreduction to CH Using a Metal-Organic Framework with Dual Active Sites.

J Am Chem Soc 2021 May 6. Epub 2021 May 6.

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China.

Conversion from CO to CH is important for the development of energy and the environment, but the high energy barrier of hydrogenation of the *CO intermediate and C-C coupling step tend to result in C compounds as the main product and thus restrict the generation of CH. Here, we report a metal-organic framework (denoted as ), composed of 2,3,9,10,16,17,23,24-octahydroxyphthalo-cyaninato)copper(II) (PcCu-(OH)) ligands and the square-planar CuO nodes, as the electrocatalyst for CO to CH. Compared with the discrete molecular copper-phthalocyanine (Faradaic efficiency (FE) of CH = 25%), exhibits much higher performance for electrocatalytic reduction of CO to CH with a FE of 50(1)% and a current density of 7. Read More

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Growth restricted placentas show severely reduced volume of villous components with perivascular myofibroblasts.

Placenta 2021 Apr 20;109:19-27. Epub 2021 Apr 20.

LMU Munich, Department of Anatomy II, Pettenkoferstr. 11, 80336 Munich, Germany. Electronic address:

Introduction: The restricted placental growth in IUGR is associated with a simultaneous weight and volume restriction for the placental villous tree. It is unknown whether the whole villous tree or only specific parts of it are growth restricted in IUGR. In the case of uniform growth restriction of the villous tree, IUGR placentas could be interpreted as symmetrically smaller versions of normal placentas. Read More

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A Deep Learning Based Framework for Diagnosing Multiple Skin Diseases in a Clinical Environment.

Front Med (Lausanne) 2021 16;8:626369. Epub 2021 Apr 16.

Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Numerous studies have attempted to apply artificial intelligence (AI) in the dermatological field, mainly on the classification and segmentation of various dermatoses. However, researches under real clinical settings are scarce. This study was aimed to construct a novel framework based on deep learning trained by a dataset that represented the real clinical environment in a tertiary class hospital in China, for better adaptation of the AI application in clinical practice among Asian patients. Read More

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Vibrational Spectral Analysis of Natisite (NaTiSiO) and its Structure Evolution in Water and Sulfuric Acid Solutions.

Materials (Basel) 2021 Apr 27;14(9). Epub 2021 Apr 27.

National Engineering Laboratory for Hydrometallurgical Cleaner Production Technology, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.

Natisite (NaTiSiO) is a layered sodium titanosilicate containing TiO square pyramids. The structure evolution of natisite in water and acid solutions is the basis for its potential applications. With NaSiO as the silicon source, natisite with the shape of the square sheet was selectively prepared from the hydrothermal method with 14. Read More

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Structures of the ß-Keratin Filaments and Keratin Intermediate Filaments in the Epidermal Appendages of Birds and Reptiles (Sauropsids).

Authors:
David A D Parry

Genes (Basel) 2021 Apr 17;12(4). Epub 2021 Apr 17.

School of Fundamental Sciences, Massey University, Private Bag 11-222, Palmerston North 4442, New Zealand.

The epidermal appendages of birds and reptiles (the sauropsids) include claws, scales, and feathers. Each has specialized physical properties that facilitate movement, thermal insulation, defence mechanisms, and/or the catching of prey. The mechanical attributes of each of these appendages originate from its fibril-matrix texture, where the two filamentous structures present, i. Read More

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Highly Efficient Synthesis of -Benzoquinones Catalyzed by Robust Two-Dimensional POM-Based Coordination Polymers.

ACS Appl Mater Interfaces 2021 May 28;13(18):21261-21271. Epub 2021 Apr 28.

School of Chemical Engineering, Dalian University of Technology, Dalian 116023, People's Republic of China.

Selective oxidation of alkyl-substituted phenols offers efficient access to -benzoquinones (BQs) that serve as key components for synthesizing biologically active compounds, but rational manufacture of efficient recyclable catalysts for such a reaction remains a severe challenge. Herein, two crystalline 2D polyoxometalate-based coordination polymers (POMCPs), formulated as H[Cu(L)][PMO]·HO (M = Mo, = 4 for ; M = W, = 6 for ; and HL = 4-(1-tetazol-5-yl)pyridine), are prepared by a mineralizer-assisted one-step synthesis strategy and explored as heterogeneous catalysts for -BQs synthesis. Both compounds have been characterized through elemental analysis, EDS analysis, infrared spectroscopy, UV-vis diffuse reflectance spectrum, EPR, XPS, BET, single-crystal, and powder X-ray diffraction. Read More

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Oculomotor nerve guidance and terminal branching requires interactions with differentiating extraocular muscles.

Dev Biol 2021 Apr 24;476:272-281. Epub 2021 Apr 24.

Department of Biology, University of Nevada, Reno, NV, 89557, USA. Electronic address:

Muscle function is dependent on innervation by the correct motor nerves. Motor nerves are composed of motor axons which extend through peripheral tissues as a compact bundle, then diverge to create terminal nerve branches to specific muscle targets. As motor nerves approach their targets, they undergo a transition where the fasciculated nerve halts further growth then after a pause, the nerve later initiates branching to muscles. Read More

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Fibroblast-Specific Proteo-Transcriptomes Reveal Distinct Fibrotic Signatures of Human Sinoatrial Node in Non-Failing and Failing Hearts.

Circulation 2021 Apr 20. Epub 2021 Apr 20.

Department of Physiology & Cell Biology; Bob and Corrine Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH.

Up to fifty percent of the adult human sinoatrial node (SAN), is composed of dense connective tissue. Cardiac diseases including heart failure (HF) may further increase fibrosis within the SAN pacemaker complex, leading to impaired automaticity and conduction of electrical activity to the atria. However, unlike the role of cardiac fibroblasts in pathological fibrotic remodeling and tissue repair, nothing is known about fibroblasts that maintain the inherently fibrotic SAN environment. Read More

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ALK Rearrangements Characterize 2 Distinct Types of Salivary Gland Carcinomas: Clinicopathologic and Molecular Analysis of 4 Cases and Literature Review.

Am J Surg Pathol 2021 Mar 22. Epub 2021 Mar 22.

*Institute of Pathology ¶Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Comprehensive Cancer Center (CCC) Erlangen-EMN, Erlangen §DERMPATH Muenchen ∥Institute of Pathology, Ludwig Maximilians University, Munich, Germany †Department of Pathology, Charles University, Faculty of Medicine in Plzen ‡Bioptic Laboratory Ltd, Plzen, Czech Republic #Department of Translational Research, University of Pisa, School of Medicine, Pisa, Italy.

The majority of salivary gland carcinomas are characterized by recurrent gene fusions that proved highly valuable diagnostically, but only rarely of therapeutic impact. Most of these fusion-positive carcinomas belong to the low-grade or intermediate-grade biological category. To date, only 5 cases of salivary gland carcinomas carrying an oncogenic ALK fusion have been reported in 4 recent studies, but their phenotypic spectrum and their nosological classification remain uncharacterized. Read More

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Swimming kinematics of cyprids of the barnacle Balanus glandula.

Integr Comp Biol 2021 Apr 19. Epub 2021 Apr 19.

Oregon Institute of Marine Biology, University of Oregon, PO Box 5389, Charleston, Oregon 97420.

Larvae of barnacles typically pass through naupliar and cyprid planktonic stages before settlement and metamorphosis. As the final larval stage, cyprids swim much faster than nauplii and in turbulent fluid environments with high shears as they seek habitat. Cyprids swim with six pairs of reciprocating thoracic appendages and use two anterior antennules during settlement. Read More

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MRI of the Achilles tendon-A comprehensive pictorial review. Part one.

Eur J Radiol Open 2021 26;8:100342. Epub 2021 Mar 26.

Department of Orthopedics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden.

The normal Achilles tendon is composed of twisted subtendons separated by thin high signal septae, which are a potential pitfall on MRI because they mimic a tendon tear. Tendinopathy and full thickness tears may be assessed effectively both on MRI and ultrasound. MRI is superior to ultrasound in detection of partial tears and for postoperative assessment. Read More

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Improvement of pathological staging system for neuroendocrine tumors of the lung.

Ann Transl Med 2021 Mar;9(6):447

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China.

Background: Currently, the tumor, node, and metastasis (TNM) staging system has a limited value in prognostic stratification for neuroendocrine tumors of the lung (NETL). A specific pathological staging system was therefore explored.

Methods: Two cohorts were assessed: the training cohort was composed of surgically treated patients from the Surveillance, Epidemiologic, and End Results (SEER) database [2004-2015]; the Shanghai cohort included Shanghai resident patients treated at Shanghai Pulmonary Hospital [2009-2018]. Read More

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Resolving the non-papilionaceous flower of Camoensia scandens, a papilionoid legume of the core genistoid clade: development, glands and insights into the pollination and systematics of the group.

J Plant Res 2021 Apr 13. Epub 2021 Apr 13.

Instituto de Pesquisa Jardim Botânico do Rio de Janeiro, DIPEQ, Rua Pacheco Leão, 915 Cidade Universitária, Rio de Janeiro, RJ, 22460-030, Brazil.

Camoensia scandens is a papilionoid legume inserted in the core genistoid clade. It has large, crepuscular, scented flowers but the corolla is non-papilionaceous, which deviates from the pattern found in the subfamily. The vexillum has a folded claw, forming a tube, which is opposed to the androecium opening; all petals have yellow-gold crinkled margins. Read More

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Challenges during the execution, results, and monitoring phases of ecological restoration: Learning from a country-wide assessment.

PLoS One 2021 6;16(4):e0249573. Epub 2021 Apr 6.

Centro Regional de Investigaciones Multidisciplinarias, Universidad Nacional Autónoma de México, Cuernavaca, México.

Outcomes from restoration projects are often difficult for policymakers and stakeholders to assess, but this information is fundamental for scaling up ecological restoration actions. We evaluated technical aspects of the interventions, results (ecological and socio-economic) and monitoring practices in 75 restoration projects in Mexico using a digital survey composed of 137 questions. We found that restoration projects in terrestrial ecosystems generally relied on actions included in minimal (97%) and maximal (86%) intervention, while in wetlands, the preferred restoration strategies were intermediate (75%) and minimal intervention (63%). Read More

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[CLAG Regimen Composed of Continuous Intravenous Infusion of Cladribine in the Treatment of Refractory/Relapsed Acute Myeloid Leukemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Apr;29(2):333-338

Henan Cancer Hospital/The Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450008, Henna Province, China,E-mail:

Objective: To study the efficacy and safety of continuous intravenous infusion of 2-Chlorodeoxyadenosine (2-CdA) combined with high-dose cytarabine (Ara-C) and granulocyte colony-stimulating factor (G-CSF) (CLAG regiem) in the treatment of relapsed/refractory acute myeloid leukemia (AML).

Methods: Fifteen patients with refractory/relapsed AML hospitalized in 5 medical units such as Department of Hematology, the Affiliated Tumor Hospital of Zhengzhou University and received one course of CLAG regimen from June 2014 to August 2019 were analyzed retrospectively (specifically: cladribine 5 mg/M, day 1 to day 5, continuous 24-hour intravenous infusion; Ara-C 2 g/M, 1 time/day, day 1 to day 5, intravenous infusion; G-CSF 300 mg, 1 time/day, day 0 to day 5, subcutaneous injection).

Results: Among the 15 patients with refractory/relapsed AML, 9 males and 6 females, the median age was 35 (13-63) years old. Read More

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Snapshot Imaging Spectrometer Based on Pixel-Level Filter Array (PFA).

Sensors (Basel) 2021 Mar 25;21(7). Epub 2021 Mar 25.

Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China.

Snapshot spectral imaging technology plays an important role in many fields. However, most existing snapshot imaging spectrometers have the shortcomings of a large volume or heavy computational burden. In this paper, we present a novel snapshot imaging spectrometer based on the pixel-level filter array (PFA), which can simultaneously obtain both spectral and spatial information. Read More

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Teenagers Tell Better Stories After Improvisational Theater Courses.

Front Psychol 2021 16;12:638932. Epub 2021 Mar 16.

CRP-CPO, UR UPJV 7273, Université de Picardie Jules Verne, Amiens, France.

Improvisational theater (improv) is a booming theatrical practice, applying in many fields (teaching, medicine or entrepreneurship). Its effects on cognitive and behavioral processes are beginning to be demonstrated, despite scientific publications that are still rare, particularly about language. This study aimed to evaluate the effects of improv on adolescent narrative skills. Read More

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Cosolute modulation of protein oligomerization reactions in the homeostatic timescale.

Biophys J 2021 Mar 29. Epub 2021 Mar 29.

Precision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, Parque Tecnológico de Bizkaia, Derio, Spain. Electronic address:

Protein oligomerization processes are widespread and of crucial importance to understand degenerative diseases and healthy regulatory pathways. One particular case is the homo-oligomerization of folded domains involving domain swapping, often found as a part of the protein homeostasis in the crowded cytosol, composed of a complex mixture of cosolutes. Here, we have investigated the effect of a plethora of cosolutes of very diverse nature on the kinetics of a protein dimerization by domain swapping. Read More

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Improving and Understanding the Hydrogen Evolving Activity of a Cobalt Dithiolene Metal-Organic Framework.

ACS Appl Mater Interfaces 2021 Apr 31;13(14):16384-16395. Epub 2021 Mar 31.

Department of Chemistry, University of Southern California, Los Angeles, California 90089, United States.

Despite the promising previous reports on the development of electrocatalytic dithiolene-based metal-organic frameworks (MOFs) for the hydrogen evolution reaction (HER), these materials often display poor reproducibility of the HER performance because of their poor bulk properties upon integration with electrode materials. We demonstrate here an in-depth investigation of the electrocatalytic HER activity of a cobalt 2,3,6,7,10,11-triphenylenehexathiolate (CoTHT) MOF. To enhance the durability and charge transport properties of the constructed CoTHT/electrode architecture, CoTHT is deposited as an ink composite () composed of Nafion and carbon black. Read More

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Testicular Myofibroma in Children: A Case Report and Review of the Literature.

Urology 2021 Mar 23. Epub 2021 Mar 23.

Division of Pediatric Urology, Texas Children's Hospital and Scott Department of Urology, Baylor College of Medicine, Houston, TX; Department of Urology, Kyung Hee University Hospital, Seoul, South Korea.

Testicular tumors are rare in the prepubertal population and often are germ cell tumors. Myofibroma is a rare spindle cell neoplasm composed of myofibroblasts, which are intermediate cells between fibroblasts and smooth muscle cells. Only two prepubertal testicular myofibromas have been previously reported. Read More

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McNamara analysis cephalometric parameters in White-Brazilians, Japanese and Japanese-Brazilians with normal occlusion.

Dental Press J Orthod 2021 22;26(1):e2119133. Epub 2021 Mar 22.

Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Ortodontia (Bauru/SP, Brazil).

Introduction: McNamara's Jr. cephalometric analysis is a tool to diagnose dental and skeletal discrepancies and is widely used, guiding diagnosis for surgical procedures to be performed or for the use of functional devices. Few studies have shown that different ethnic groups have different cephalometric patterns. Read More

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Dissipative Gated and Cascaded DNA Networks.

J Am Chem Soc 2021 Apr 23;143(13):5071-5079. Epub 2021 Mar 23.

The Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

Nucleic acid based, out-of-equilibrium, dissipative networks driven by nucleic acid fuels coupled to the nicking enzyme, Nt.BbvCI, are presented. One set of experiments includes a functional module consisting of a duplex and two fluorophore-labeled strands. Read More

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Rare presentation of inflammatory myofibroblastic tumor on a digit.

J Cutan Pathol 2021 Mar 23. Epub 2021 Mar 23.

ProPath, Dallas, Texas, USA.

Inflammatory myofibroblastic tumors (IMTs) are rare soft tissue neoplasms consisting of a mixture of spindle-shaped myofibroblasts or fibroblasts and a variable inflammatory infiltrate composed of eosinophils, plasma cells, and lymphocytes. Associations with trauma and infectious agents have been proposed, but the etiology is unknown. While IMT predominantly develops in the lungs of pediatric patients or young adults, extrapulmonary IMT is well documented and may occur anywhere. Read More

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The structure of the native cardiac thin filament at systolic Ca levels.

Proc Natl Acad Sci U S A 2021 Mar;118(13)

Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA 23507;

Every heartbeat relies on cyclical interactions between myosin thick and actin thin filaments orchestrated by rising and falling Ca levels. Thin filaments are comprised of two actin strands, each harboring equally separated troponin complexes, which bind Ca to move tropomyosin cables away from the myosin binding sites and, thus, activate systolic contraction. Recently, structures of thin filaments obtained at low (pCa ∼9) or high (pCa ∼3) Ca levels revealed the transition between the Ca-free and Ca-bound states. Read More

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Lacto--biose synthesis via a modular enzymatic cascade with ATP regeneration.

iScience 2021 Mar 25;24(3):102236. Epub 2021 Feb 25.

State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China.

Human milk oligosaccharides (HMOs), the third most abundant solid component of human milk, are reported to be beneficial to infant health. The biosynthesis of lacto--biose (LNB), the building block for HMOs, suffers from excessive addition of cofactors and intermediate inhibition. Here, we developed an multienzyme cascade composed of LNB module, ATP regeneration, and pyruvate oxidase-driven phosphate recycling to produce LNB. Read More

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Knowledge Models as Teaching Aid for Training Intensity Modulated Radiation Therapy Planning: A Lung Cancer Case Study.

Front Artif Intell 2020 28;3:66. Epub 2020 Aug 28.

Department of Radiation Oncology, Duke University Medical Center, Durham, NC, United States.

Artificial intelligence (AI) employs knowledge models that often behave as a black-box to the majority of users and are not designed to improve the skill level of users. In this study, we aim to demonstrate the feasibility that AI can serve as an effective teaching aid to train individuals to develop optimal intensity modulated radiation therapy (IMRT) plans. The training program is composed of a host of training cases and a tutoring system that consists of a front-end visualization module powered by knowledge models and a scoring system. Read More

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Coulomb drag in metal monochalcogenides double-layer structures with Mexican-hat band dispersions.

J Phys Condens Matter 2021 Apr 23;33(18). Epub 2021 Apr 23.

Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX 77204, United States of America.

We theoretically study the Coulomb drag resistivity and plasmon modes behavior for a system composed of two parallel-type doped GaS monolayers with Mexican-hat valence energy band using the Boltzmann transport theory formalism. We investigate the effect of temperature,, carrier density,, and layer separation,, on the plasmon modes and drag resistivity within the energy-independent scattering time approximation. Our results show that the density dependence of plasmon modes can be approximated by. Read More

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