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Fetoscopic laser ablation therapy in monochorionic diamniotic twin pregnancies with twin-to-twin transfusion syndrome treated at a single centre over 10 years: a retrospective study.

J Perinat Med 2021 Sep 15. Epub 2021 Sep 15.

Department of Obstetrics and Gynecology, Spedali Civili, Brescia, Italy.

Objectives: To review experience with fetoscopic laser ablation of placental anastomoses to treat monochorionic diamniotic (MCDA) twin pregnancies complicated by twin-to-twin transfusion syndrome (TTTS) in a single centre over a ten-year period.

Methods: A retrospective study on 142 MCDA twin pregnancies complicates by TTTS treated with equatorial laser ablation of placental anastomoses (2008-2018). Solomon technique was also applied after 2013. Read More

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September 2021

Neonatal respiratory distress due to a third or fourth branchial pouch sinus: A systematic review.

Int J Pediatr Otorhinolaryngol 2021 Sep 9;151:110922. Epub 2021 Sep 9.

Department of Otorhinolaryngology, Amsterdam UMC Location AMC, University of Amsterdam, Amsterdam, the Netherlands.

Objectives: Third and fourth branchial pouch sinuses can be rare causes of respiratory distress in neonates. An overview of this distinct clinical entity is missing in literature. To aid clinicians in recognizing and adequately treating this unique entity, we conducted a systematic review to discuss patient characteristics, diagnostic considerations and treatment strategy. Read More

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September 2021

A Comparison of Clinical Outcomes Between Two Different Models of Surgical Robots in Roux-en-Y Gastric Bypass.

J Laparoendosc Adv Surg Tech A 2021 Sep 17;31(9):969-977. Epub 2021 Aug 17.

General Surgery Department, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain.

For the past 20 years, robotic surgical systems have been used for the Roux-en-Y gastric bypass (RYGB). The da Vinci Surgical System (Intuitive Surgical, Inc.) has been one of the most used robotic platforms. Read More

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September 2021

Long-term outcomes in severe aplastic anemia patients treated with immunosuppression and eltrombopag: a phase 2 study.

Blood 2021 Sep 15. Epub 2021 Sep 15.

NHLBI, NIH, Bethesda, Maryland, United States.

Patients with severe aplastic anemia (SAA) are either treated with bone marrow transplant (BMT) or immunosuppression (IST) depending on their age, comorbidities, and available donors. In 2017, our phase 2 trial reported improved hematologic responses with the addition of eltrombopag (EPAG) to standard IST for SAA when compared to a historical cohort treated with IST alone. However, the rates and characteristics of long-term complications, relapse, and clonal evolution, previously described in patients treated with IST alone are not yet known with this new regimen, IST and EPAG. Read More

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September 2021

Risk Factors and Outcomes for Gastroparesis After Lung Transplantation.

Dig Dis Sci 2021 Sep 15. Epub 2021 Sep 15.

Division of Digestive and Liver Diseases, Department of Medicine, New York Presbyterian Columbia University Medical Center, 622 West 168th Street, New York, NY, USA.

Background: Gastroparesis is common after lung transplantation and is associated with worse transplant outcomes, including the development of chronic lung allograft dysfunction (CLAD). This study sought to identify the prevalence, risk factors, and outcomes associated with a new diagnosis of gastroparesis after lung transplantation.

Methods: This was a single-center retrospective study of patients who underwent lung transplantation in 2008-2018. Read More

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September 2021

Australian experience with robot-assisted Roux-en-Y gastric bypass with comparison to a conventional laparoscopic series.

Surg Endosc 2021 Sep 15. Epub 2021 Sep 15.

Department of General Surgery, Epworth Richmond, 89 Bridge Road, Richmond, VA, 3121, USA.

Background: Robotic surgery is a novel approach to abdominal surgery. In Australia, the uptake of robotic assistance for bariatric surgery has been relatively slow compared to many other countries. The aim of this study is to report the first high volume experience of robotic-assisted Roux-en-Y gastric bypass surgery in Australia (RRYGB) and compare outcomes with a similar laparoscopic group (LRYGB). Read More

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September 2021

Clinical application of a three-dimensional reconstruction technique for complex liver cancer resection.

Surg Endosc 2021 Sep 15. Epub 2021 Sep 15.

Department of General Surgery, Second Affiliated Hospital of Nanchang University, No. 1, Minde Road, Nanchangm, 330006, China.

Objective: To explore the utility of three-dimensional (3D) visualization technology in liver resection for patients with complex liver cancer.

Methods: In this retrospective cohort study, we collected and analyzed clinic pathological data from 105 patients who underwent complicated liver cancer resection at the authors' unit between January 2014 and June 2019. Observation indicators included general demographic information, operative time, intraoperative blood loss, blood transfusion volume, postoperative liver function, complication rate, hospital stay, and in-hospital mortality. Read More

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September 2021

A cooperative approach for treatment of Zenker's diverticulum.

Surg Endosc 2021 Sep 15. Epub 2021 Sep 15.

Digestive Disease Institute, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, 2nd Floor, Weston, FL, 33331, USA.

Background: Symptomatic Zenker's diverticulum management has evolved from an open intervention to an endoscopic management. At our center, both an otolaryngologist and a gastroenterologist are present in the operating room when treating these lesions. An intra-procedural consensus is reached to undergo either rigid endoscopy or flexible endoscopic diverticulotomy with ENT guidance. Read More

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September 2021

Comparison of interventions and outcomes of enhanced recovery after surgery: a systematic review and meta-analysis of 2456 adolescent idiopathic scoliosis cases.

Eur Spine J 2021 Sep 15. Epub 2021 Sep 15.

Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Purpose: The objective of this meta-analysis and systematic review is to compare the methodology and evaluate the efficacy of Enhanced recovery after Spine Surgery (ERAS) for adolescent idiopathic scoliosis (AIS) and to compare the outcomes with traditional discharge (TD) pathways.

Methods: Using major databases, a systematic search was performed. Studies comparing the implementation of ERAS or ERAS-like and TD pathways in patients with AIS were identified. Read More

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September 2021

Osteochondral allograft transplantation for complex distal humeral fractures assisted by 3D computer planning and printing technology: technical note.

Eur J Orthop Surg Traumatol 2021 Sep 15. Epub 2021 Sep 15.

IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

Purpose: The surgical treatment of comminuted distal humeral articular fractures (DHF) is challenging and is jeopardized by the high rate of complications. The study aims to describe the application of osteochondral allograft (OCA) transplantation for the treatment of complex DHF assisted with a 3D printed specific instrumentation.

Methods: Retrospective study. Read More

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September 2021

Comparison of Patent Ductus Arteriosus Stent and Blalock-Taussig Shunt as Palliation for Neonates with Sole Source Ductal-Dependent Pulmonary Blood Flow: Results from the Congenital Catheterization Research Collaborative.

Pediatr Cardiol 2021 Sep 15. Epub 2021 Sep 15.

Children's Heart Center, Children's Healthcare of Atlanta, Emory University School of Medicine, 1405 Clifton Road, Atlanta, GA, 30322, USA.

Patent ductus arteriosus (PDA) stenting is an accepted method for securing pulmonary blood flow in cyanotic neonates. In neonates with pulmonary atresia and single source ductal-dependent pulmonary blood flow (SSPBF), PDA stenting remains controversial. We sought to evaluate outcomes in neonates with SSPBF, comparing PDA stenting and surgical Blalock-Taussig shunt (BTS). Read More

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September 2021

Maternal education and cognitive development in 15 European very-preterm birth cohorts from the RECAP Preterm platform.

Int J Epidemiol 2021 Sep 15. Epub 2021 Sep 15.

Department of Pediatrics and Adolescent Medicine, Turku University Hospital Turku, Turku, Finland.

Background: Studies are sparse and inconclusive about the association between maternal education and cognitive development among children born very preterm (VPT). Although this association is well established in the general population, questions remain about its magnitude among children born VPT whose risks of medical and developmental complications are high. We investigated the association of maternal education with cognitive outcomes in European VPT birth cohorts. Read More

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September 2021

Are functional outcomes and reoperation rates really better than those of cementless stems in displaced femoral neck fractures? An updated systematic review and meta-analysis of randomised controlled trials in current-generation stem designs.

J Chin Med Assoc 2021 Sep 9. Epub 2021 Sep 9.

Department of Orthopedic Surgery, Mackay Memorial Hospital, Taipei, Taiwan, ROC Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC Department of Surgery, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Department of exercise and health science, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan, ROC.

Background: The study aim was to conduct a systematic review and meta-analysis to compare the functional outcomes and reoperation rates of cemented and cementless hip arthroplasty for treating displaced femoral neck fractures in elderly patients.

Methods: Systematic searches were conducted of literature up to December 2018 on PubMed, Embase, Cochrane, and Web of Science for randomised controlled trials (RCTs) concerning current-generation stem designs only. Two reviewers independently determined eligibility, extracted the outcome data and assessed the risk of bias of eligible studies. Read More

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September 2021

A randomised double-blind comparison of phenylephrine and norepinephrine for the management of postspinal hypotension in pre-eclamptic patients undergoing caesarean section.

Eur J Anaesthesiol 2021 Oct;38(10):1077-1084

From the Department of Anaesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital (MM, LR, GTC), Department of Obstetrics and Gynaecology, University College of Medical Sciences and Guru Teg Bahadur Hospital (RA), Delhi Cancer Registry, Dr BRA IRCH, All India Institute of Medical Sciences, Delhi, India (RKM).

Background: Studies comparing phenylephrine and norepinephrine for the treatment of postspinal hypotension in pre-eclamptic patients are limited.

Objective: To compare bolus doses of phenylephrine and norepinephrine for treating hypotension in pre-eclamptic mothers undergoing caesarean section under spinal anaesthesia. It was hypothesised that norepinephrine and phenylephrine use would be associated with similar neonatal outcome. Read More

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October 2021

The effect of transverse fascia inversion on postoperative seroma in direct hernias treated with laparoscopic TAPP procedure.

Ann Ital Chir 2021 ;92:384-389

Aim: This study aims to reveal the results of the transverse fascia inversion technique applied in laparoscopic transabdominal preperitoneal (TAPP) procedure to reduce the risk of seroma in direct hernias.

Marial And Methods: Patients who underwent elective inguinal hernia repair with the laparoscopic TAPP procedure were retrospectively evaluated. Indirect inguinal or femoral hernias and emergency operations were excluded, and only patients with direct or indirect + direct inguinal hernia were included in the study. Read More

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January 2021

Apatinib Combined with Paclitaxel and Cisplatin Neoadjuvant Chemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma.

Cancer Biother Radiopharm 2021 Sep 15. Epub 2021 Sep 15.

Department of Internal Medicine, First Hospital of Xingtai City, Xingtai, China.

We conducted a trial to evaluate the efficacy and safety of apatinib, a tyrosine inhibitor against vascular endothelial growth factor receptor 2, combined with neoadjuvant chemotherapy in patients with locally advanced esophageal squamous cell carcinoma (ESCC). One hundred twenty six patients were randomized into two cycles of paclitaxel and cisplatin (TP) ( = 61) or combined with apatinib (Apa+TP) ( = 65), followed by surgery. The primary endpoint was objective response rate (ORR). Read More

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September 2021

Reproductive outcome after early miscarriage: comparing vaginal misoprostol treatment with expectant management in planned secondary analysis of randomized controlled trial.

Ultrasound Obstet Gynecol 2021 Sep 15. Epub 2021 Sep 15.

Department of Obstetrics and Gynecology, Skåne University Hospital, Malmö, Sweden.

Objective: To compare the reproductive outcome after early miscarriage between women managed expectantly or treated with vaginal misoprostol.

Methods: This study is a planned secondary analysis of prospectively collected data in a published randomized controlled trial comparing expectant management with vaginal single dose 800 μg misoprostol treatment of early embryonic or anembryonic miscarriage. The outcome measure is the number of women with a clinical pregnancy conceived within 14 months after complete miscarriage and the outcome of these pregnancies in terms of live birth, miscarriage, ectopic pregnancy and legal termination of pregnancy. Read More

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September 2021

[Lithium use in women with bipolar disorder during peripartum].

Tijdschr Psychiatr 2021 ;63(7):557-564

Background: Lithium use during peripartum requires careful consideration due to a risk of teratogenic effects, adverse side effects and risk of neonatal complications. However, given the effectiveness of lithium, use during the peripartum period may be indicated.

Aim: To provide an overview of the current evidence regarding the clinical use of lithium during peripartum, including risk of relapse in case of (dis)continuation and evolution of lithium levels. Read More

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January 2021

Characteristics of a large-scale cohort with accessory pathway(s): A cross-sectional retrospective study highlighting over a twenty-year experience.

Turk Kardiyol Dern Ars 2021 Sep;49(6):456-462

Department of Cardiology, Liv Hospital, Ankara, Turkey.

Objective: Catheter ablation following electrophysiologic study (EPS) is the mainstay of diagnosis and treatment for patients with atrioventricular reentrant tachycardia (AVRT), demonstrating excellent long-term outcome and a low rate of complications. In this study, our aim was to assess our experience in patients with accessory pathway (AP) and to compare our data with the literature.

Methods: We included 1,437 patients who were diagnosed and treated for AP in our hospital between 1998 and 2020. Read More

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September 2021

Giant pulmonary hydatid cyst in children.

Monaldi Arch Chest Dis 2021 Sep 14. Epub 2021 Sep 14.

Pulmonology B Department, Abderrahmen Mami Hospital, Ariana; Faculty of Medicine, El Manar University, Tunis.

Hydatid disease is still endemic in Tunisia. It is mostly seen in young people less than 40 years and children are affected in one third of cases. The lungs are the predominant location in children. Read More

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September 2021

Reverse circadian glucocorticoid treatment in prepubertal children with congenital adrenal hyperplasia.

J Pediatr Endocrinol Metab 2021 Sep 15. Epub 2021 Sep 15.

Division for Pediatric Endocrinology, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany.

Objectives: Children with salt-wasting congenital adrenal hyperplasia (CAH) have an impaired function of steroid synthesis pathways. They require therapy with glucocorticoid (GC) and mineralocorticoid hormones to avoid salt-wasting crisis and other complications. Most commonly, children receive hydrocortisone thrice daily with the highest dose in the morning, mimicking the regular physiology. Read More

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September 2021

[Clinical application of split three-dimensional printing patient-specific instrumentation in medial open-wedge high tibial osteotomy].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Sep;35(9):1119-1124

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha Hunan, 410008, P.R.China.

Objective: To investigate the accuracy of split three-dimensional (3D) printing patient-specific instrumentation (PSI) in medial open-wedge high tibial osteotomy (MOWHTO) and its effectiveness in treating medial knee osteoarthritis.

Methods: Clinical data of 14 patients with medial knee osteoarthritis and treated with split 3D printing PSI-assisted MOWHTO between August 2019 and August 2020 were retrospectively analyzed. There were 5 males and 9 females with an average age of 61 years (range, 43-68 years). Read More

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September 2021

Management of Single Subsegmental Pulmonary Embolism - a Prospective Observational Study at North Shore and Waitakere Hospitals, Auckland.

Intern Med J 2021 Sep 15. Epub 2021 Sep 15.

Consultant Haematologist at Waitemata District Health Board.

Background: Single subsegment pulmonary embolism is increasingly diagnosed but the benefit to anticoagulate in the absence of concurrent deep vein thrombosis is not consistently established.

Aims: To investigate the safety of an observational approach in patients with isolated subsegmental pulmonary embolism and the utility of the second lower limb ultrasound after seven days.

Methods: Prospective observational study of patients diagnosed with isolated subsegmental pulmonary embolism between July 2016 and July 2020 at North Shore and Waitakere Hospitals, Auckland. Read More

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September 2021

Long-Term (> 6 Years) Outcomes of Duodenal Switch (DS) Versus Single-Anastomosis Duodeno-Ileostomy with Sleeve Gastrectomy (SADI-S): a Matched Cohort Study.

Obes Surg 2021 Sep 14. Epub 2021 Sep 14.

Bariatric Medicine Institute, 1046 East 100 South, Salt Lake City, UT, 84102, USA.

Background: There are no comparative studies on the long-term outcomes after the primary traditional duodenal switch (DS) and single-anastomosis duodeno-ileostomy with sleeve gastrectomy (SADI-S).

Purpose: This study aims to compare the long-term outcomes in a matched cohort.

Setting: This study took place in a single private institute, in the USA. Read More

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September 2021

Robotic Surgery in Pediatric Oncology: Lessons Learned from the First 100 Tumors-A Nationwide Experience.

Ann Surg Oncol 2021 Sep 14. Epub 2021 Sep 14.

Department of Pediatric Surgery and Urology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.

Background: While robotics has become commonplace in adult oncology, it remains rare in pediatric oncology due to the rarity of childhood cancers. We present the results of a large nationwide experience with robotic oncology, with the aim of providing practical and feasible guidelines for child selection.

Methods: This was a prospective analysis performed over a period of 4 years. Read More

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September 2021

Artificial Learning and Machine Learning Decision Guidance Applications in Total Hip and Knee Arthroplasty: A Systematic Review.

Arthroplast Today 2021 Oct 3;11:103-112. Epub 2021 Sep 3.

New York-Presbyterian/Columbia University Irving Medical Center, New York, NY.

Background: Artificial intelligence (AI) and machine learning (ML) modeling in hip and knee arthroplasty (total joint arthroplasty [TJA]) is becoming more commonplace. This systematic review aims to quantify the accuracy of current AI- and ML-based application for cognitive support and decision-making in TJA.

Methods: A comprehensive search of publications was conducted through the EMBASE, Medline, and PubMed databases using relevant keywords to maximize the sensitivity of the search. Read More

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October 2021

Phenotypic characterization of patients with activated PI3Kδ syndrome 1 presenting with features of systemic lupus erythematosus.

Genes Dis 2021 Nov 30;8(6):907-917. Epub 2020 Apr 30.

National Clinical Research Center for Child Health and Disorders (Chongqing), Children's Hospital ofChongqing Medical University, Chongqing, 400014, PR China.

Activated phosphoinositide 3-kinase δ syndrome 1 (APDS1) is a primary immunodeficiency disease caused by gain-of-function mutations in . Clinical features of autoimmune disease have been reported in patients with APDS1. In this study, we reported three patients with APDS1 presenting with systemic lupus erythematosus (SLE) phenotype. Read More

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November 2021

Surgical Dilemmas in Multiple Facial Fractures - Coronal Flap Versus Minimally Invasive: Case Report and Literature Review.

Ann Maxillofac Surg 2021 Jan-Jun;11(1):191-194. Epub 2021 Jul 24.

Department of Oral and Maxillofacial Surgery, Rambam Health Care Campus, Haifa, Israel.

The Rationale: Pan-facial fracture is a complex trauma that involves the upper, middle, and lower third of the facial bones. The surgical management of such complex cases is either by the posterior approach (coronal flap) or anterior approach through local incisions.

Patient Concerns: This report describes the case of severe pan-facial trauma in a 52-year-old male who sustained a severe pan-facial trauma. Read More

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Gummy Smile Management Using Diode Laser Gingivectomy Versus Botulinum Toxin Injection - A Prospective Study.

Ann Maxillofac Surg 2021 Jan-Jun;11(1):70-74. Epub 2021 Jul 24.

Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine for Girls, Al-Azhar University, and Taibah University, Cairo, Egypt.

Introduction: Gummy smile (GS) is a nonesthetic condition that affects the confidence of many young people. The present study aimed to compare the results of two approaches used in the management of GS in a group of Egyptian females.

Materials And Methods: This comparative cohort study included 24 female patients aged 25-35 years, divided into two groups. Read More

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Evaluation of Postoperative Sensory and Motor Deficit Following Craniomaxillofacial Reconstruction Using Bicoronal Flap: An Evaluative Study.

Ann Maxillofac Surg 2021 Jan-Jun;11(1):21-26. Epub 2021 Jul 24.

Department of Oral and Maxillofacial Surgery, PMNM Dental College and Hospital, Bagalkot, Karnataka, India.

Introduction: The ideal surgical approach to treat craniomaxillofacial skeleton should provide maximum exposure of the facial skeleton, ensure less potential for injury to facial structures and allow for good cosmetic result. Several designs have been described such as hemicoronal, preauricular, lateral eyebrow, and bicoronal approach. Although the bicoronal flap gives superior long-term cosmetic results, it has a few disadvantages. Read More

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