17,925 results match your criteria complication diabetes

ENDOCRINOLOGY IN THE TIME OF COVID-19 - 2021 updates: The Management of Diabetes insipidus and Hyponatraemia.

Eur J Endocrinol 2021 Jul 1. Epub 2021 Jul 1.

M Sherlock, Endocrinology, The Adelaide and Meath Hospital, Incorporating the National Children's Hospital, Tallaght, Dublin 24 , Dublin, Ireland.

COVID-19 has changed the nature of medical consultations, emphasizing virtual patient counseling, with relevance for patients with diabetes insipidus (DI) or hyponatremia. The main complication of desmopressin treatment in DI is dilutional hyponatraemia. Since plasma sodium monitoring is not always possible in times of COVID-19, we recommend to delay the desmopressin dose once a week until aquaresis occurs allowing excess retained water to be excreted. Read More

View Article and Full-Text PDF

Diabetes Mellitus Is Not a Negative Prognostic Factor for Patients Undergoing Hip Arthroscopy.

Orthopedics 2021 Jul-Aug;44(4):241-248. Epub 2021 Jul 1.

Diabetes mellitus (DM) has been associated with inferior clinical outcomes and comorbidities in general. The authors sought to compare the outcomes of hip arthroscopy at minimum 2-year follow-up for patients with DM with those of patients without DM. Data were prospectively collected and retrospectively reviewed for patients who underwent hip arthroscopy between February 2008 and December 2014. Read More

View Article and Full-Text PDF

Effective Treatment Recommendations for Type 2 Diabetes Management Using Reinforcement Learning: Treatment Recommendation Model Development and Validation.

J Med Internet Res 2021 Jul 22;23(7):e27858. Epub 2021 Jul 22.

Ping An Healthcare Technology, Beijing, China.

Background: Type 2 diabetes mellitus (T2DM) and its related complications represent a growing economic burden for many countries and health systems. Diabetes complications can be prevented through better disease control, but there is a large gap between the recommended treatment and the treatment that patients actually receive. The treatment of T2DM can be challenging because of different comprehensive therapeutic targets and individual variability of the patients, leading to the need for precise, personalized treatment. Read More

View Article and Full-Text PDF

The Association of Coagulation Indicators and Coagulant Agents With 30-Day Mortality of Critical Diabetics.

Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211026385

Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.

Diabetes, regarded as a global health concerned disease, was focused by the World Health Organization (WHO). Patients with diabetes may have a hypercoagulable and hypo-fibrinolysis state. There is lots of research about cardiovascular effects on diabetes patients, but less about the coagulation system. Read More

View Article and Full-Text PDF

Acute Kidney Injury and Associated Factors in Intensive Care Units at a Tertiary Hospital in Northern Tanzania.

Can J Kidney Health Dis 2021 8;8:20543581211027971. Epub 2021 Jul 8.

Kilimanjaro Christian Medical University College, Moshi, Tanzania.

Background: Acute kidney injury (AKI) is a recognized complication in critically ill patients. The epidemiology of AKI varies worldwide, depending on the diagnostic criteria used and the setting. The International Society of Nephrology has called for a reduction in preventable deaths from AKI to zero by the year 2025. Read More

View Article and Full-Text PDF

Diabetic Retinopathy in the Aging Population: A Perspective of Pathogenesis and Treatment.

Clin Interv Aging 2021 15;16:1367-1378. Epub 2021 Jul 15.

Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana University, Indianapolis, IN, USA.

The elderly population in the United States is projected to almost double by the year 2050. In addition, the numbers of diabetics are rising, along with its most common complication, diabetic retinopathy (DR). To effectively treat DR within the elderly population, it is essential first to consider the retinal changes that occur due to aging, such as decreased blood flow, retinal thinning, and microglial changes, and understand that these changes can render the retina more vulnerable to oxidative and ischemic damage. Read More

View Article and Full-Text PDF

Is Mucormycosis an inevitable complication of Covid-19 in India?

Braz J Infect Dis 2021 Jul 5:101597. Epub 2021 Jul 5.

Junior Research Fellow, Central Council for Research in Siddha (Ministry of AYUSH), Siddha Central Research Institute, Department of Pharmacology, Arumbakkam, Chennai, amilnadu, India.

Mucormycosis or black fungus infection is a less common disease but highly fatal infection, infecting the immunocompromised individuals. The site of predilection of the fungus is found to be lungs and brain in addition to its sequestration in sinusoidal spaces. Presently with the ongoing COVID 19 pandemic, the prevalence of this infection is found to be high in the Indian population. Read More

View Article and Full-Text PDF

The Impact of Peripheral Artery Disease (PAD) on Lower Limb Kinematics in Type 2 Diabetes Mellitus.

Rev Diabet Stud 2021 10;17(1):11-16. Epub 2021 May 10.

Faculty of Health Sciences, University of Malta.

Background: Peripheral artery disease (PAD) and diabetes mellitus are factors known to influence gait characteristics. However, there is a lack of knowledge on the extent to which type 2 diabetes mellitus (T2D) and PAD as comorbidities cause limb and gait complications.

Aim: The purpose of this study was to investigate the impact of PAD as a complication of T2D on ankle joint dorsiflexion and knee joint flexion angles using an optoelectronic motion analysis system and to find out whether these alterations are complications secondary to neuropathy or reduced blood perfusion. Read More

View Article and Full-Text PDF

Predicting critical state after COVID-19 diagnosis: model development using a large US electronic health record dataset.

NPJ Digit Med 2021 Jul 20;4(1):113. Epub 2021 Jul 20.

IBM Switzerland Ltd, Zurich, Switzerland.

As the COVID-19 pandemic is challenging healthcare systems worldwide, early identification of patients with a high risk of complication is crucial. We present a prognostic model predicting critical state within 28 days following COVID-19 diagnosis trained on data from US electronic health records (IBM Explorys), including demographics, comorbidities, symptoms, and hospitalization. Out of 15753 COVID-19 patients, 2050 went into critical state or deceased. Read More

View Article and Full-Text PDF

US Database Study of Clinical Burden and Unmet Need in Recurrent Pericarditis.

J Am Heart Assoc 2021 Jul 21:e018950. Epub 2021 Jul 21.

Kiniksa Pharmaceuticals Lexington MA.

Background Patients with recurrent pericarditis (RP) may develop complications, multiple recurrences, or inadequate treatment response. This study aimed to characterize disease burden and unmet needs in RP. Methods and Results This retrospective US database analysis included newly diagnosed patients with RP with ≥24 months of continuous history following their first pericarditis episode. Read More

View Article and Full-Text PDF

Psychiatric illness, emotional distress, glycemic control and chronic complications in type 1 diabetes subjects.

Arch Endocrinol Metab 2021 Jul 16. Epub 2021 Jul 16.

Divisão de Endocrinologia, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brasil.

Objective: To assess the prevalence of psychiatric disorders in patients with type 1 diabetes mellitus (T1D) and to compare patients with and without psychiatric disorder.

Methods: We made a cross-sectional study including patients with T1D assisted in the outpatient clinics of the Brazilian National Health System. To assess depression and anxiety, we used the PHQ-9 questionnaire and the DSM-5th edition criteria, respectively. Read More

View Article and Full-Text PDF

Predictive factors of postoperative diabetes insipidus in 333 patients undergoing transsphenoidal surgery for non-functioning pituitary adenoma.

Pituitary 2021 Jul 20. Epub 2021 Jul 20.

Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

Purpose: Diabetes insipidus (DI) following transsphenoidal surgery (TSS) is a common complication. Although postoperative DI often occurs in patients with craniopharyngioma and Rathke's cleft cyst, postoperative DI in patients with non-functioning pituitary adenoma (NFPA) has not been fully examined. We clarified the clinical characteristics and magnetic resonance imaging (MRI) findings predicting postoperative DI in NFPAs. Read More

View Article and Full-Text PDF

Incidence and factors influencing tourniquet pain.

Chin J Traumatol 2021 May 21. Epub 2021 May 21.

Department of Orthopaedics, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India.

Purpose: The use of tourniquet in orthopedic surgeries facilitates operations by establishing a bloodless surgical field. However, many complications following the use of tourniquets have been reported. Tourniquet pain is the most common complication. Read More

View Article and Full-Text PDF

Investigation on the expression regulation of RIPK1/RIPK3 in the retinal ganglion cells (RGCs) cultured in high glucose.

Bioengineered 2021 Dec;12(1):3947-3956

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.

Diabetic retinopathy (DR) represents the most typical complication of type 2 diabetes mellitus and one of the most primary oculopathy causing blindness. However, the mechanism of DR remains unknown. RIPK1/RIPK3, as homologous serine/threonine kinases, are key elements in mediating necroptosis and may have functions in DR development. Read More

View Article and Full-Text PDF
December 2021

Fibroblast Growth Factor Type 1 Ameliorates High-Glucose-Induced Oxidative Stress and Neuroinflammation in Retinal Pigment Epithelial Cells and a Streptozotocin-Induced Diabetic Rat Model.

Int J Mol Sci 2021 Jul 5;22(13). Epub 2021 Jul 5.

Department of Ophthalmology, National Taiwan University Hospital, No. 7, Zhongshan South Road, Taipei 100, Taiwan.

Diabetic retinopathy (DR) is a common complication of diabetes that causes severe visual impairment globally. The pathogenesis of DR is related to oxidative stress and chronic inflammation. The fibroblast growth factor type 1 (FGF-1) mitogen plays crucial roles in cell function, development, and metabolism. Read More

View Article and Full-Text PDF

Exploring the Relationship of Health Beliefs and Self-Care Behaviors Related to Diabetic Foot Ulcers of Type II Diabetes Mellitus Patients: A Cross-Sectional Study.

Int J Environ Res Public Health 2021 Jul 5;18(13). Epub 2021 Jul 5.

School of Nursing, Chung Shan Medical University, Taichung 40201, Taiwan.

Objective: Diabetic foot ulcers are an invasive complication of diabetes and are increasing. This study investigates the relationship between health beliefs and foot self-care behaviors, among people with type II diabetes.

Methods: A cross-sectional design was adopted, and 98 patients were recruited from outpatient clinics of the endocrine department. Read More

View Article and Full-Text PDF

PPP1CA/YAP/GS/Gln/mTORC1 pathway activates retinal Müller cells during diabetic retinopathy.

Exp Eye Res 2021 Jul 17;210:108703. Epub 2021 Jul 17.

Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, Jiangsu, China. Electronic address:

Diabetic retinopathy (DR) is a vision-loss complication caused by diabetes with high prevalence. During DR, the retinal microvascular injury and neurodegeneration derived from chronic hyperglycemia have attracted global attention to retinal Müller cells (RMCs), the major macroglia in the retina contributes to neuroprotection. Protein Phosphatase 1 Catalytic Subunit Alpha (PPP1CA) dephosphorylates the transcriptional coactivator Yes-associated protein (YAP) to promote the transcription of glutamine synthetase (GS). Read More

View Article and Full-Text PDF

Tryptophan, kynurenine pathway, and diabetic ketoacidosis in type 1 diabetes.

PLoS One 2021 19;16(7):e0254116. Epub 2021 Jul 19.

Department of Chemistry, Chemical Instrumentation Center (CIC), Boston University, Boston Massachusetts, United States of America.

Diabetic ketoacidosis (DKA) is a serious complication of complete insulin deficiency and insulin resistance in Type 1 diabetes (T1D). This results in the body producing high levels of serum ketones in an attempt to compensate for the insulin deficiency and decreased glucose utilization. DKA's metabolic and immunologic dysregulation results in gradual increase of systemic and cerebral oxidative stress, along with low grade systemic and cerebral inflammation and the development of pretreatment subclinical BE. Read More

View Article and Full-Text PDF

Indicators of Obesity and Cardio-Metabolic Risks: Important Consideration in Adults and Children.

Curr Diabetes Rev 2021 Jul 16. Epub 2021 Jul 16.

Department of Pediatric Endocrinology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR , Iran.

The prevalence of obesity was dramatically increased all over the world. Body mass index [BMI] has been used as the most common available measure to determining obesity status. In contrast, excessive fat mass accumulation is a more vital determinant of cardio-metabolic complication than systemic and generalized obesity, which lonely confined through BMI. Read More

View Article and Full-Text PDF

Assessment of Serum and Urine Neurophil Gelatinase- Associated Lipocalin (s-NGAL and u-NGAL) Level as a Predictive Factor of Disease Progression in Diabetic Nephropathy in Type 2 DM.

Iran J Kidney Dis 2021 Jul;15(4):270-278

Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran.

Introduction: Diabetic nephropathy (DN) is a major complication of diabetes Mellitus. Early detection and intervention of DN can slow its progression and improve patients' outcomes. Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of tubular damage might become a useful biomarker for the evaluation of renal involvement in diabetic patients. Read More

View Article and Full-Text PDF

Cross-sectional analysis of emergency hypoglycaemia and outcome predictors among people with diabetes in an urban population.

Diabet Med 2021 Jul 19:e14654. Epub 2021 Jul 19.

Clinical Audit and Research Unit, London Ambulance Service NHS Trust, London, U.K.

Aims/hypothesis: Out of hospital hypoglycaemia is a common complication for individuals with diabetes mellitus and represents a significant burden to emergency medical services (EMS). We aim to identify factors associated with receiving parenteral treatment and hospital conveyance.

Methods: We retrospectively analysed a six-month dataset of all London EMS hypoglycaemia. Read More

View Article and Full-Text PDF

Tacrolimus inhibits insulin release and promotes apoptosis of Min6 cells through the inhibition of the PI3K/Akt/mTOR pathway.

Mol Med Rep 2021 Sep 19;24(3). Epub 2021 Jul 19.

Department of Clinical Pharmacy, General Hospital of Central Theater Command, Wuhan, Hubei 430000, P.R. China.

As a calcineurin inhibitor, tacrolimus is commonly used as a first‑line immunosuppressant in organ transplant recipients. Post‑transplantation diabetes mellitus (PTDM) is a common complication following kidney transplantation and is associated with immunosuppressant drugs, such as tacrolimus. PTDM caused by tacrolimus may be related to its influence on insulin secretion and insulin resistance. Read More

View Article and Full-Text PDF
September 2021

Women's perspectives on motivational factors for lifestyle changes after gestational diabetes and implications for diabetes prevention interventions.

Endocrinol Diabetes Metab 2021 Jul 19;4(3):e00248. Epub 2021 Mar 19.

DEFACTUM - Public Health and Rehabilitation Research Central Denmark Region Aarhus Denmark.

Introduction: Gestational diabetes mellitus (GDM) is a common complication in pregnancy and constitutes a public health problem due to the risk of developing diabetes and other diseases. Most women face barriers in complying with preventive programs. This study aimed to explore motivational factors for lifestyle changes among women with a history of GDM and their suggestions for preventive programs. Read More

View Article and Full-Text PDF

Hypogonadism induced by surgical stress and brain trauma is reversed by human chorionic gonadotropin in male rats: A potential therapy for surgical and TBI-induced hypogonadism?

Endocrinol Diabetes Metab 2021 Jul 18;4(3):e00239. Epub 2021 Mar 18.

Division of Geriatrics and Gerontology Department of Medicine University of Wisconsin-Madison School of Medicine and Public Health Madison WI USA.

Introduction: Hypogonadotropic hypogonadism (HH) is an almost universal, yet underappreciated, endocrinological complication of traumatic brain injury (TBI). The goal of this study was to determine whether the developmental hormone human chorionic gonadotropin (hCG) treatment could reverse HH induced by a TBI.

Methods: Plasma samples were collected at post-surgery/post-injury (PSD/PID) days -10, 1, 11, 19 and 29 from male Sprague-Dawley rats (5- to 6-month-old) that had undergone a Sham surgery (craniectomy alone) or CCI injury (craniectomy + bilateral moderate-to-severe CCI injury) and treatment with saline or hCG (400 IU/kg; i. Read More

View Article and Full-Text PDF

Baseline characteristics of participants in the LANDMARC trial: A 3-year, -india, prospective, longitudinal study to assess management and real-world outcomes of diabetes mellitus.

Endocrinol Diabetes Metab 2021 Jul 8;4(3):e00231. Epub 2021 Feb 8.

Center for Diabetes & Endocrine Care Srinagar India.

Introduction: Longitudinal data on progression, complications, and management of type 2 diabetes mellitus (T2DM) across India are scarce. LANDMARC (CTRI/2017/05/008452), the first -India, longitudinal, prospective, observational study, aims to understand the management and real-world outcomes of T2DM over 3 years.

Methods: Adults (≥25 to ≤60 years old at T2DM diagnosis; diabetes duration ≥2 years at enrollment; controlled/uncontrolled on ≥2 anti-diabetic agents) were enrolled. Read More

View Article and Full-Text PDF

Failure to Medically Optimize Before Total Hip Arthroplasty: Which Modifiable Risk Factor Is the Most Dangerous?

Arthroplast Today 2021 Aug 5;10:18-23. Epub 2021 Jul 5.

OrthoCarolina Research Institute, Charlotte, NC, USA.

Background: There is mounting evidence that smoking, abnormal body mass index (BMI), uncontrolled diabetes, and poor nutritional status are associated with complications after total hip arthroplasty (THA). The goal of the present study was to evaluate the consequences of failure to medically optimize Medicare-eligible patients with respect to these key modifiable health targets by assessing complications in the early postoperative period after THA.

Methods: The National Surgical Quality Improvement Program database was queried for all primary THAs performed in 2018. Read More

View Article and Full-Text PDF

Prostaglandin F2α protects against pericyte apoptosis by inhibiting the PI3K/Akt/GSK3β/β-catenin signaling pathway.

Ann Transl Med 2021 Jun;9(12):1021

NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.

Background: Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and the main cause of non-traumatic blindness in adults. Pericyte loss is known to be an early pathological change of DR. Our group's previous research indicated that prostaglandin F2α (PGF2α) acts as an eicosanoidal protector against non-proliferative DR that can regulate the mobility of pericytes in a RhoA-mediated manner. Read More

View Article and Full-Text PDF

Robust Angiogenesis and Arteriogenesis in the Skin of Diabetic Mice by Transient Delivery of Engineered VEGF and PDGF-BB Proteins in Fibrin Hydrogels.

Front Bioeng Biotechnol 2021 1;9:688467. Epub 2021 Jul 1.

Cell and Gene Therapy, Department of Biomedicine, University Hospital of Basel, University of Basel, Basel, Switzerland.

Non-healing ulcers are a serious complication of diabetes mellitus and a major unmet medical need. A major cause for the lack of healing is the impairment of spontaneous vascularization in the skin, despite mostly normal blood flow in deeper large vessels. Therefore, pro-angiogenic treatments are needed to increase therapeutic perfusion by recruiting new arterial connections (therapeutic arteriogenesis). Read More

View Article and Full-Text PDF

Association Between Diabetic Retinopathy and Carotid Intima-Media Thickness.

Cureus 2021 Jun 10;13(6):e15575. Epub 2021 Jun 10.

Internal Medicine, Kabul University of Medical Sciences, Kabul, AFG.

Introduction Patients with diabetes having advanced stage of diabetic retinopathy (DR) may predict future risk of coronary artery disease. To predict cardiovascular outcomes carotid intima-media thickness (CIMT) is utilized in diabetic patients. The aim of our study was the evaluation of the relationship between retinopathy and CIMT as two valuable non-invasive methods for early detection of micro- and macrovascular complication of diabetes. Read More

View Article and Full-Text PDF