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Clinical profile of malaria at a tertiary care teaching hospital in North India.

Trop Parasitol 2021 Jan-Jun;11(1):25-30. Epub 2021 May 14.

Department of Medicine, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Introduction: Despite recent reductions in the overall malaria case incidence, malaria remains an important public health issue. There has been a change in clinical and epidemiological profile of malaria in our country and vivax malaria known to be benign has been reported to cause severe complications. Therefore, the present study was conducted to delineate the clinical profile of malaria, proportion of severity, spectrum of complications, and presence of comorbidities among adult patients admitted at a tertiary health-care center in North India. Read More

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Acute pulmonary edema due to severe preeclampsia in advanced maternal age women.

Pregnancy Hypertens 2021 Jun 2;25:150-155. Epub 2021 Jun 2.

Lis Hospital for Women, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objective: Acute pulmonary edema is a rare complication in women with preeclampsia especially at advanced maternal age. We aimed to determine the cardiovascular hemodynamics in advanced maternal age women who developed acute pulmonary edema and preeclampsia.

Study Design: Retrospective cohort study of women aged over 45 years giving birth at single university affiliated tertiary medical center which developed acute pulmonary edema due to severe preeclampsia. Read More

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Near-Infrared Reflectance Imaging to Detect an Incipient Retinal Arterial Macroaneurysm.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):150-153. Epub 2021 Apr 12.

Retina Division, Centro Oftalmológico Dr. Charles, Ciudad Autónoma de Buenos Aires, Argentina.

Retinal arterial macroaneurysms (RAM) are characterized by a saccular or fusiform dilation of the retinal artery wall. An 84-year-old Caucasian woman with a medical history of poorly controlled hypertension was diagnosed with RAM in the left eye. Previous macular spectral-domain optical coherence tomography images from the patient were available for comparison. Read More

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Analysis of Heart rate Variability and Implication of Different Factors on Heart Rate Variability.

Curr Cardiol Rev 2020 Dec 31. Epub 2020 Dec 31.

Department of Clinical Immunology, Allergology and Microbiology, Karaganda Medical University, Karaganda,. Kazakhstan.

Background: The heart is the central organ of the circulatory system which maintains the flow of blood along with the transport of nutrients to different cells and tissues. A well-functioning cardiac state is a complicated mode of changeability. A healthy heart is not only about oscillation as the rhythmometer is not the same in every circumstance. Read More

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December 2020

A triple-component deep inferior epigastric artery perforator chimeric free flap for three-dimensional reconstruction of a complex knee defect complicated with patella osteomyelitis.

Microsurgery 2021 May 25;41(4):370-375. Epub 2020 Dec 25.

Department of Plastic and Reconstructive Surgery, Center Hospital of National Center for Global Health and Medicine, Tokyo, Japan.

Reconstruction of a complex knee defect is challenging, especially when complicated with osteomyelitis. Complex knee defect requires multi-component three-dimensional reconstruction using a chimeric flap. Although anterolateral thigh (ALT) flap is the most workhorse chimeric flap, another chimeric flap is required when ALT flap is not available. Read More

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An Unusual Case of a Pediatric Nasal Septal Abscess with Life-Threatening Complications in COVID-19 Pandemic.

Indian J Otolaryngol Head Neck Surg 2020 Nov 11:1-4. Epub 2020 Nov 11.

Department of Otorhinolaryngology and Head and Neck Department, Ram Lal Eye and ENT Hospital, Government Medical College, Majitha Road, Amritsar, Punjab 143001 India.

In this modern era, when access to healthcare services is improved, and awareness among the general population is enhanced, the presentation of mere septal abscess of the nose as a fatal complication is less common. Due to various lockdown restrictions in the COVID-19 scenario and fear to contract an infection, patients are presenting late to the health care setting for proper management. We treated an 11-year old child of complicated nasal septal abscess who responded well to aspiration of pus and medical treatment. Read More

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November 2020

HIV-2 Drug Resistance Genotyping from Dried Blood Spots.

J Clin Microbiol 2020 12 17;59(1). Epub 2020 Dec 17.

Center for Emerging and Re-Emerging Infectious Diseases, Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.

The treatment of HIV-2 in resource-limited settings (RLS) is complicated by the limited availability of HIV-2-active antiretroviral drugs and inadequate access to HIV-2 viral load and drug resistance testing. Dried blood spots (DBS)-based drug resistance testing, widely studied for HIV-1, has not been reported for HIV-2 and could present an opportunity to improve care for HIV-2-infected individuals. We selected 150 DBS specimens from ongoing studies of antiretroviral therapy (ART) for HIV-2 infection in Senegal and subjected them to genotypic drug resistance testing. Read More

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December 2020

Deficiency of Adenosine Deaminase 2 in Adults and Children: Experience From India.

Arthritis Rheumatol 2021 02 26;73(2):276-285. Epub 2020 Dec 26.

Centro Malattie Autoinfiammatorie e Immunodeficienze, IRCCS, Istituto Giannina Gaslini, Genoa, Italy.

Objective: Deficiency of adenosine deaminase 2 (DADA2) is a potentially fatal monogenic syndrome characterized by variable manifestations of systemic vasculitis, bone marrow failure, and immunodeficiency. Most cases are diagnosed by pediatric care providers, given the typical early age of disease onset. This study was undertaken to describe the clinical phenotypes and treatment response both in adults and in children with DADA2 in India. Read More

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February 2021

In vivo quantitative imaging biomarkers of bone quality and mineral density using multi-band-SWIFT magnetic resonance imaging.

Bone 2021 02 24;143:115615. Epub 2020 Aug 24.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Bone is a composite biomaterial of mineral crystals, organic matrix, and water. Each contributes to bone quality and strength and may change independently, or together, with disease progression and treatment. Even so, there is a near ubiquitous reliance on ionizing x-ray-based approaches to measure bone mineral density (BMD) which is unable to fully characterize bone strength and may not adequately predict fracture risk. Read More

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February 2021

Double trouble: Airway management in a patient with a massive anterior mediastinal tumor complicated by a thyroid mass.

Ann Card Anaesth 2020 Jul-Sep;23(3):377-379

Department of Anaesthesiology and Critical Care Medicine, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.

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Guidance for post-discharge care following acute kidney injury: an appropriateness ratings evaluation.

BJGP Open 2020 Aug 25;4(3). Epub 2020 Aug 25.

National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care (NIHR CLAHRC) Greater Manchester, Centre for Primary Care and Health Services Research, Institute of Population Health, University of Manchester, Manchester, UK.

Background: Acute kidney injury (AKI) is associated with poor health outcomes, including increased mortality and rehospitalisation. National policy and patient safety drivers have targeted AKI as an example to ensure safer transitions of care.

Aim: To establish guidance to promote high-quality transitions of care for adults following episodes of illness complicated by AKI. Read More

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Removal vs. retention of cervical cerclage in pregnancies complicated by preterm premature rupture of membranes: a retrospective study.

Arch Gynecol Obstet 2020 09 12;302(3):603-609. Epub 2020 Jun 12.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

Purpose: To compare pregnancy outcomes in women with pPROM and a cervical cerclage in whom the cerclage was removed within 24 h and those in whom the cerclage was retained in situ.

Methods: A two-center retrospective cohort study of women with a singleton gestation with pPROM at < 34 weeks of gestation in the presence of cervical cerclage (January 1, 2012-July 30, 2016). Maternal and perinatal outcomes were compared between women in whom cerclage was removed within 24 h from pPROM and those in whom cerclage was retained until the onset of delivery. Read More

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September 2020

Cultural evolution of conformity and anticonformity.

Proc Natl Acad Sci U S A 2020 06 27;117(24):13603-13614. Epub 2020 May 27.

Department of Biology, Stanford University, Stanford, CA 94305;

Conformist bias occurs when the probability of adopting a more common cultural variant in a population exceeds its frequency, and anticonformist bias occurs when the reverse is true. Conformist and anticonformist bias have been widely documented in humans, and conformist bias has also been observed in many nonhuman animals. Boyd and Richerson used models of conformist and anticonformist bias to explain the evolution of large-scale cooperation, and subsequent research has extended these models. Read More

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Congenital tracheal stenosis & associated cardiac anomalies: operative management & techniques.

J Thorac Dis 2020 Mar;12(3):1184-1193

Department of Cardiovascular Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Congenital tracheal stenosis can lead to symptomatic airway obstruction in children and often mandates surgical correction. Over the past half-century, numerous tracheal reconstruction techniques have been developed, including tracheal resection with end-to-end anastomosis (for short-segment complete tracheal stenosis), patch tracheoplasty, slide tracheoplasty, and homograft and autograft augmentation repairs. However, operative management of congenital tracheal stenosis is often complicated by the presence of congenital heart disease, the most common of which is pulmonary artery sling. Read More

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Pregnancy outcomes in association with placental histopathology in pregnancies complicated by macrosomia in diabetic vs. non-diabetic women.

Eur J Obstet Gynecol Reprod Biol 2020 May 7;248:24-29. Epub 2020 Mar 7.

Departments of Obstetrics & Gynecology, The Edith Wolfson Medical Center, Holon, Israel(1).

Objective: We aimed to compare pregnancy outcomes in association with placental pathology in pregnancies complicated by macrosomia in diabetic vs. non-diabetic women.

Study Design: Pregnancies complicated by macrosomia (≥4000gr) were included. Read More

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To treat or not to treat: a clinical series of retinal arterial macroaneurysms: A single-center retrospective study.

Medicine (Baltimore) 2020 Jan;99(5):e19077

Retinal arterial macroaneurysms (RAMs) develop as outpouchings of the arterial wall that is weakened by arteriosclerosis. The traditional treatment of RAMs comprises observation, focal laser photocoagulation, or surgery. Recently, intravitreal injection of anti-vascular endothelial growth factor (VEGF) drugs has been announced as an effective therapy for fovea-threatening RAMs and quickly improve visual acuity and central retinal thickness (CRT). Read More

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January 2020

NV center based nano-NMR enhanced by deep learning.

Sci Rep 2019 Nov 28;9(1):17802. Epub 2019 Nov 28.

Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem, 91904, Givat Ram, Israel.

The growing field of nano nuclear magnetic resonance (nano-NMR) seeks to estimate spectra or discriminate between spectra of minuscule amounts of complex molecules. While this field holds great promise, nano-NMR experiments suffer from detrimental inherent noise. This strong noise masks to the weak signal and results in a very low signal-to-noise ratio. Read More

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November 2019

Successful Ventilation of Acute Respiratory Distress Syndrome Complicated by Pneumothorax Using Airway Pressure Release Ventilation: A Case Report.

Indian J Crit Care Med 2019 Sep;23(9):437-438

Division of Pediatric Critical Care, Department of Pediatrics, ABVIMS and Dr Ram Manohar Lohia Hospital, New Delhi, India.

Pneumothorax can develop in children being mechanically ventilated for 'severe acute respiratory distress syndrome' making the situation worse and challenging for the treating intensivist. There is no evidence on use of 'airway pressure release ventilation' mode in children with acute respiratory distress syndrome complicated by pneumothorax. We present a case of a girl who had severe acute respiratory distress syndrome and developed pneumothorax on pressure control ventilation mode. Read More

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September 2019

Does peritoneal lavage influence the rate of complications following pediatric Laparoscopic Appendicectomy in Children with Complicated Appendicitis? A Prospective Randomized Clinical Trial.

J Pediatr Surg 2019 Dec 30;54(12):2524-2527. Epub 2019 Aug 30.

Department of Paediatric Surgery, Urology & Surgical Simulation, Monash Children's Hospital, Melbourne, Australia.

Background: There is ongoing debate concerning the use of peritoneal irrigation in the setting of complicated appendicitis (CA) in children. Our aim was to conduct a prospective randomized controlled trial for the treatment of CA during a laparoscopic appendicectomy in children.

Methods: Following ethical approval (REC10138B), pediatric patients (≤16 years old) were recruited from a single institution over a 3-year time period (2015-2018). Read More

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December 2019

A composite consisting of sulfo-functionalized magnetic graphene and mesoporous silica for extraction of metformin and glimepiride prior to their determination by liquid chromatography tandem mass spectrometry.

Mikrochim Acta 2019 07 31;186(8):590. Epub 2019 Jul 31.

Fudan University Affiliated Pudong Medical Center & Pharmaceutical Analysis Department, School of Pharmacy, Fudan University, Shanghai, 201203, China.

A new sorbent was synthesized for restricted-access matrix solid phase extraction (RAM-SPE) of the diabetes drugs metformin (MET) and glimepiride (Glim). Mesoporous silica layers were placed on FeO-magnetized graphene modified with sulfo-functionalized pore walls (denoted as [email protected] composites). The composites have a large specific surface (173 m·g), appropriate pore sizes (typically 3. Read More

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Medical therapy versus TEVAR for uncomplicated type B aortic dissection.

Indian J Thorac Cardiovasc Surg 2019 Jun 30;35(Suppl 2):174-178. Epub 2019 May 30.

Institute of Vascular & Endovascular Sciences, Sir Ganga Ram Hospital, New Delhi, Delhi 110060 India.

The standard of care in uncomplicated acute type B aortic dissection (uTBAD) has been optimal medical management. Surgical repair and endovascular interventions are adjuncts in managing complicated type B dissection. Increasing safety and confidence in the thoracic endovascular aortic repair (TEVAR) and recent data indicating long-term complications in medical management of uTBAD has brought a shift in treatment approach. Read More

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: software for high-resolution hierarchical modeling of solution X-ray scattering from complex structures.

J Appl Crystallogr 2019 Feb 1;52(Pt 1):219-242. Epub 2019 Feb 1.

Institute of Chemistry, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, 9190401, Jerusalem, Israel.

This paper presents the computer program (https://scholars.huji.ac. Read More

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February 2019

Appropriateness of deep vein thrombosis (DVT) prophylaxis use among medical inpatients: a DVT risk alert tool (DRAT) study.

Med J Malaysia 2019 02;74(1):45-50

Hospital Sultanah Nora Ismail, Department of Medicine, Batu Pahat, Johor, Malaysia.

Introduction: Increasing incidence of Venous Thromboembolism (VTE) has complicated treatment courses for hospitalised patients. Despite recommendation to support deep vein thrombosis (DVT) risk assessment and appropriate use of prophylaxis in medical inpatients, it is either neglected or prescribed unnecessarily by the clinicians. This study aimed to assess and compare the appropriateness of DVT prophylaxis prescribing between usual care versus a pharmacist-driven DVT Risk Alert Tool (DRAT) intervention among hospitalised medical patients. Read More

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February 2019

Noninvasive diagnosis of recurrent autoimmune type 1 diabetes after islet cell transplantation.

Am J Transplant 2019 06 18;19(6):1852-1858. Epub 2019 Mar 18.

Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

Islet cell transplantation is curative therapy for patients with complicated autoimmune type 1 diabetes (T1D). We report the diagnostic potential of circulating transplant islet-specific exosomes to noninvasively distinguish pancreatic β cell injury secondary to recurrent autoimmunity vs immunologic rejection. A T1D patient with hypoglycemic unawareness underwent islet transplantation and maintained normoglycemia until posttransplant day 1098 before requiring exogenous insulin. Read More

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3D Cell Culture Models of Epithelial Tissues.

Methods Mol Biol 2019 ;1926:77-84

Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland.

Cells in tissues in vivo face a very different microenvironment than typical cultured cells plated on a plastic dish. Already several decades ago, cell biologists observed that cell lines show dramatically different morphology and growth characteristics when embedded into three-dimensional (3D) substrates or standard tissue culture plates (Montesano R, Schaller G, Orci L, Cell. 66:697-711, 1991; Barcellos-Hoff MH, Aggeler J, Ram TG, Bissell MJ, Development. Read More

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New Job, New Challenges: Life After Radiology Training.

AJR Am J Roentgenol 2019 03 30;212(3):483-489. Epub 2019 Jan 30.

1 Department of Radiology, Wake Forest University and Baptist Health, 1 Medical Center Blvd, Winston-Salem, NC 27157.

Objective: Beginning a new job after radiology training is exciting but can also be nerve-racking. The key challenge remains making the strange familiar and assimilating with the new practice as soon as possible. This process is complicated and may require learning new policies, getting to know new colleagues, adapting to new surroundings, and learning new skills. Read More

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Monolithic silicon-photonic platforms in state-of-the-art CMOS SOI processes [Invited].

Opt Express 2018 May;26(10):13106-13121

Integrating photonics with advanced electronics leverages transistor performance, process fidelity and package integration, to enable a new class of systems-on-a-chip for a variety of applications ranging from computing and communications to sensing and imaging. Monolithic silicon photonics is a promising solution to meet the energy efficiency, sensitivity, and cost requirements of these applications. In this review paper, we take a comprehensive view of the performance of the silicon-photonic technologies developed to date for photonic interconnect applications. Read More

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Is Smaller Better? A Proposal to Use Bacteria For Neuroscientific Modeling.

Front Comput Neurosci 2018 23;12. Epub 2018 Feb 23.

Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States.

Bacteria are easily characterizable model organisms with an impressively complicated set of abilities. Among them is quorum sensing, a cell-cell signaling system that may have a common evolutionary origin with eukaryotic cell-cell signaling. The two systems are behaviorally similar, but quorum sensing in bacteria is more easily studied in depth than cell-cell signaling in eukaryotes. Read More

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February 2018

Depression and its associated factors among people living with HIV/AIDS: Can it affect their quality of life?

J Family Med Prim Care 2017 Jul-Sep;6(3):549-553

Associate Professor, Department of Community Medicine, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India.

Introduction: Depression, being the most common neuropsychiatric complication of HIV, is also associated with increased health-care utilization, decreased quality of life (QOL), and poor adherence to antiretroviral therapy (ART). Depression is a multidimensional disorder affected by a variety of biological, psychological, and social determinants and this relation becomes more complicated in HIV patients. The current study therefore aimed to investigate the sociodemographic and clinical determinants of depression and assess difference in the QOL of HIV patients not having depression and those suffering from depression. Read More

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February 2018

Case Report: Migrainous Infarct without Aura.

Case Rep Neurol 2017 Sep-Dec;9(3):241-251. Epub 2017 Oct 24.

Department of Medicine, Saral Diagnostics, Delhi, India.

Background: Stroke in a migraine with aura has been documented in several cases, even deserving the merit of a classification as complicated migraine. Herein, we present a rare case of migrainous infarct without aura. The diagnosis was challenging due to lack of risk factors. Read More

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October 2017