40 results match your criteria complicated coin

Exploring Pediatric Tele-Rheumatology Practices During COVID-19: A Survey of the PRCOIN Network.

Front Pediatr 2021 4;9:642460. Epub 2021 Mar 4.

Division of Rheumatology, Nationwide Children's Hospital, Columbus, OH, United States.

Healthcare providers were rapidly forced to modify the way they practiced medicine during the coronavirus disease 2019 (COVID-19) pandemic. Many providers transitioned from seeing their patients in person to virtually using telemedicine platforms with limited training and experience using this medium. In pediatric rheumatology, this was further complicated as musculoskeletal exams typically require hands-on assessment of patients. Read More

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Look at Both Sides of the Coin in Determining Risk of Complicated Crohn's Disease.

Clin Gastroenterol Hepatol 2020 Aug 14. Epub 2020 Aug 14.

Gastroenterology Department, Hospital Clínico Universitario de Santiago de Compostela, A Coruña, Spain.

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Insights into population structure of East African sweetpotato cultivars from hybrid assembly of chloroplast genomes.

Gates Open Res 2018 21;2:41. Epub 2020 Jul 21.

Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.

The chloroplast (cp) genome is an important resource for studying plant diversity and phylogeny. Assembly of the cp genomes from next-generation sequencing data is complicated by the presence of two large inverted repeats contained in the cp DNA. We constructed a complete circular cp genome assembly for the hexaploid sweetpotato using extremely low coverage (<1×) Oxford Nanopore whole-genome sequencing (WGS) data coupled with Illumina sequencing data for polishing. Read More

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Encrypted monument: The birth of crypto place on the blockchain.

Bo Zhao Xu Huang

Geoforum 2020 Nov 3;116:149-152. Epub 2020 Sep 3.

School of Geography, Nanjing Normal University, Nanjing 210046, China.

In this paper, we coin the term "crypto place" to describe an emerging type of virtual place on the blockchain. Using an encrypted monument that was built to memorialize Dr. Wenliang Li, one of the whistleblowers of China's coronavirus outbreak, we extensively investigate three definitive dimensions of crypto place in terms of decentralized location, immutable locales and transaction-based sense of place. Read More

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November 2020

Endocrinology and immunology of acne: Two sides of the same coin.

Exp Dermatol 2020 09;29(9):840-859

Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane and Faculty of Health Sciences Brandenburg, Dessau, Germany.

Current experimental research on acne pathophysiology has revealed a more complicated background than the classically reported four-factor aetiology. Cells of the pilosebaceous unit, which represent the template for the development of acne lesions, seem to be parallelly affected by endocrinological/metabolic factors as well as inflammatory/immunological ones that cooperate in sebocyte differentiation and lipogenesis. Indeed, the unique programme of sebocyte terminal differentiation and death, the so called holocrine secretion, is influenced by inflammatory and metabolic (lipid) signalling with common denominator the selective regulation of peroxisome proliferator-activated receptors. Read More

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September 2020

Obesity and COVID-19: The Two Sides of the Coin.

Obes Facts 2020 13;13(4):430-438. Epub 2020 Jul 13.

European Association for the Study of Obesity (EASO), Teddington, United Kingdom.

The World Health Organization declared COVID-19, the infectious disease caused by the coronavirus SARS-CoV-2, a pandemic on March 12, 2020. COVID-19 is causing massive health problems and economic suffering around the world. The European Association for the Study of Obesity (EASO) promptly recognised the impact that the outbreak could have on people with obesity. Read More

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October 2020

Renal Autocrine and Paracrine Signaling: A Story of Self-protection.

Physiol Rev 2020 07 30;100(3):1229-1289. Epub 2020 Jan 30.

Department of Biomedicine, Aarhus University, Aarhus, Denmark; and Aarhus Institute of Advanced Studies (AIAS), Aarhus University, Aarhus, Denmark.

Autocrine and paracrine signaling in the kidney adds an extra level of diversity and complexity to renal physiology. The extensive scientific production on the topic precludes easy understanding of the fundamental purpose of the vast number of molecules and systems that influence the renal function. This systematic review provides the broader pen strokes for a collected image of renal paracrine signaling. Read More

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Effusion and coin shadow: is there a relation? A case report.

Eur Heart J Case Rep 2019 Dec 4;3(4):1-6. Epub 2019 Oct 4.

Department of Cardiovascular Medicine, Cairo University, 31, 30 Street, Hadayek Helwan, Cairo, Egypt.

Background: Malignant pericardial effusion is a common consequence of various types of cancer. The diagnosis of cardiac tamponade in malignant effusion may be challenging, as the typical echocardiographic signs are not met. Patients with cancer can present with cardiac tamponade in form of tachycardia (rather that hypotension) that improves after pericardiocentesis. Read More

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December 2019

Prevalence and Variation of Clinically Recognized Inpatient Alcohol Withdrawal Syndrome in the Veterans Health Administration.

J Addict Med 2020 Jul/Aug;14(4):300-304

University of Washington, Division of Pulmonary, Critical Care, & Sleep Medicine, Seattle-Denver Center of Innovation (COIN), VA Puget Sound Health Care System, Seattle Division, Seattle, WA (TLS); Center of Excellence in Substance Addiction Treatment and Education, VA Puget Sound Health Care System, Seattle Division, Seattle, WA (CAM); Kaiser Permanente Washington Health Research Institute, Seattle, WA (KAB); University of Washington, Division of Pulmonary, Critical Care, & Sleep Medicine, Harborview Medical Center, Seattle, WA (SL, CLH); Center of Excellence in Substance Addiction Treatment and Education Seattle-Denver Center of Innovation (COIN), University of Washington, Department of Psychiatry and Behavioral Sciences, VA Puget Sound Health Care System, Seattle Division, Seattle, WA (EJH).

Objectives: No prior study has evaluated the prevalence or variability of alcohol withdrawal syndrome (AWS) in general hospitals in the United States.

Methods: This retrospective study used secondary data from the Veterans Health Administration (VHA) to estimate the documented prevalence of clinically recognized AWS among patients engaged in VHA care who were hospitalized during fiscal year 2013. We describe variation in documented inpatient AWS by geographic region, hospital, admitting specialty, and inpatient diagnoses using International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis and/or procedure codes recorded at hospital admission, transfer, or discharge. Read More

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Advanced Nanoclay-Based Nanocomposite Solid Polymer Electrolyte for Lithium Iron Phosphate Batteries.

ACS Appl Mater Interfaces 2019 Mar 20;11(9):8954-8960. Epub 2019 Feb 20.

Department of Metallurgical Engineering, College of Mines and Earth Sciences , University of Utah , 135 S 1460 E, Room 412 , Salt Lake City , Utah 84112-0114 , United States.

High-performance solid polymer electrolytes (SPEs) have long been desired for the next generation of lithium batteries. One of the most promising ways to improve the morphological and electrochemical properties of SPEs is the addition of fillers with specific nanostructures. However, the production of such fillers is generally expensive and requires complicated preparation procedures. Read More

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Hepatotoxicity and hepatoprotection of Polygonum multiflorum Thund. as two sides of the same biological coin.

J Ethnopharmacol 2019 Feb 27;230:81-94. Epub 2018 Oct 27.

Center for Molecular Metabolism, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Nanjing 210094, PR China. Electronic address:

Ethnopharmacological Relevance: Polygonum multiflorum Thund., a well-known and commonly-used TCM (Traditional Chinese Medicine) for treating hypertension, hyperlipidemia, premature graying of hair, and etc., has aroused wide concern for its reported potential liver toxicity. Read More

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February 2019

A male Korean who was diagnosed with chronic enteropathy associated with (CEAS): case report with literature review.

BMJ Open Gastroenterol 2018 23;5(1):e000223. Epub 2018 Oct 23.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.

Objective: To further disseminate the nomenclature of chronic enteropathy associated with SLCO2A1 (CEAS), especially for physicians in China and Korea where the genetic feature of gene mutations related hypertrophic osteoarthropathy and pachydermia had been extensively studied. gene mutations related hypertrophic osteoarthropathy and pachydermia had been extensively studied.

Design: A case report with literature review of gene mutations-related disorders. Read More

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October 2018

[Clinical features and prognosis of gastrointestinal injury due to foreign bodies in the upper gastrointestinal tract in children: a retrospective analysis of 217 cases].

Zhongguo Dang Dai Er Ke Za Zhi 2018 Jul;20(7):567-571

Department of Gastroenterology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China.

Objective: To study the clinical features and prognosis of gastrointestinal injury caused by foreign bodies in the upper gastrointestinal tract in children.

Methods: A retrospective analysis was performed for the clinical data of 217 children who were diagnosed with foreign bodies in the upper gastrointestinal tract complicated by gastrointestinal injury by gastroscopy from January 2011 to December 2016, including clinical features, gastroscopic findings, complications, and prognosis.

Results: Among the 217 children, 114 (52. Read More

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ZNF687 mutations are frequently found in pagetic patients from South Italy: implication in the pathogenesis of Paget's disease of bone.

Clin Genet 2018 06 11;93(6):1240-1244. Epub 2018 Apr 11.

Institute of Genetics and Biophysics "Adriano Buzzati-Traverso", National Research Council of Italy, Naples, Italy.

Paget's disease of bone (PDB) is a skeletal disorder whose molecular basis is not fully elucidated. However, 10% of patients show a familial PDB and 35% of them carry mutations in the SQSTM1 gene. We recently reported a founder mutation (p. Read More

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Dry-Processed, Binder-Free Holey Graphene Electrodes for Supercapacitors with Ultrahigh Areal Loadings.

ACS Appl Mater Interfaces 2016 Nov 19;8(43):29478-29485. Epub 2016 Oct 19.

National Institute of Aerospace , 100 Exploration Way, Hampton, Virginia 23666-6147, United States.

For commercial applications, the need for smaller footprint energy storage devices requires more energy to be stored per unit area. Carbon nanomaterials, especially graphene, have been studied as supercapacitor electrodes and can achieve high gravimetric capacities affording high gravimetric energy densities. However, most nanocarbon-based electrodes exhibit a significant decrease in their areal capacitances when scaled to the high mass loadings typically used in commercially available cells (∼10 mg/cm). Read More

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November 2016

Further evidence of POP1 mutations as the cause of anauxetic dysplasia.

Am J Med Genet A 2016 09 6;170(9):2462-5. Epub 2016 Jul 6.

Faculté de Médecine et de Pharmacie, Centre de Génomique Humaine, Université Mohammed V. Souissi, Rabat, Morocco.

Anauxetic dysplasia (AAD, OMIM 607095) is a rare skeletal dysplasia inherited as an autosomal recessive trait, which is caused by mutations in RMRP and allelic to a more common disorder, cartilage hair hypoplasia (CHH). CHH is a multi-system disorder with a variety of extraskeletal changes. Whereas AAD is a bone-restricted disorder with a more severe skeletal phenotype: affected individuals are extremely short and complicated by orthopedic morbidity, and the radiological changes include modification of the vertebral bodies and epiphyseal dysplasia of the hip, as well as generalized metaphyseal dysplasia and severe brachydactyly. Read More

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September 2016

Oxidative stress during erythropoietin hyporesponsiveness anemia at end stage renal disease: Molecular and biochemical studies.

J Adv Res 2016 May 23;7(3):348-58. Epub 2016 Feb 23.

Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Cairo University, 12211 Giza, Egypt.

Inflammation and oxidative stress are two faces of one coin in end stage renal disease patients (ESRD) on maintenance hemodialysis. Their interconnection induces anemia complicated with erythropoietin hyporesponsiveness. The biochemical bases behind the resistance to erythropoietin therapy with frequent hemoglobinemia, oxidative stress and iron status have not been fully understood. Read More

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Esophageal foreign bodies in children: Emphasis on complicated cases.

Asian J Surg 2017 Sep 24;40(5):362-366. Epub 2016 Feb 24.

Department of Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: Esophageal foreign bodies (EFBs) are a relatively common clinical problem in pediatric patients. The majority of EFBs pass harmlessly through the gastrointestinal tract; however, some EFBs can cause significant morbidities. This study was conducted to review our experience in managing esophageal foreign bodies in pediatric patients, with an emphasis on the management and outcomes of complicated cases. Read More

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September 2017

Prediction of short-term newborn infectious morbidity based on maternal characteristics in patients with PPROM and Ureaplasma species infection.

Ginekol Pol 2015 Sep;86(9):685-8

Objectives: Preterm premature rupture of membranes (PPROM) complicates about 5% of pregnancies. Ureaplasma species is the most common pathogen found in the amniotic fluid in pregnancieneonatal outcome. The aim of the following study was to evaluate the impact of colonization with the Ureaplasma spp. Read More

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September 2015

Two sides of the same coin--an interview study of Swedish obstetricians' experiences using ultrasound in pregnancy management.

BMC Pregnancy Childbirth 2015 Nov 20;15:304. Epub 2015 Nov 20.

Department of Clinical Sciences, Obstetrics and Gynecology, Umeå University, Umeå, Sweden.

Background: The extended use of ultrasound that is seen in maternity care in most Western countries has not only affected obstetric care but also impacted on the conception of the fetus in relation to the pregnant woman. This situation has also raised concerns regarding the pregnant woman's reproductive freedom. The purpose of this study was to explore Swedish obstetricians' experiences and views on the role of obstetric ultrasound particularly in relation to clinical management of complicated pregnancy, and in relation to situations where the interests of maternal and fetal health conflict. Read More

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November 2015

Spectrum of complicated migraine in children: A common profile in aid to clinical diagnosis.

World J Clin Pediatr 2015 Feb 8;4(1):1-12. Epub 2015 Feb 8.

Surya N Gupta, Dawn M Fields, Pediatric Neurology, CAMC, Charleston, WV 25301, United States.

Complicated migraine encompasses several individual clinical syndromes of migraine. Such a syndrome in children frequently presents with various neurological symptoms in the Emergency Department. An acute presentation in the absence of headache presents a diagnostic challenge. Read More

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February 2015

Stochastic and empirical models of the absolute asymmetric synthesis by the Soai-autocatalysis.

J Mol Model 2015 Feb 3;21(2):33. Epub 2015 Feb 3.

Institute of Mathematics, University of Technology and Economics of Budapest, 1111, Budapest, Műegyetem rkp. 3/H, Hungary.

Absolute asymmetric synthesis (AAS) is the preparation of pure (or excess of one) enantiomer of a chiral compound from achiral precursor(s) by a chemical reaction, without enantiopure chiral additive and/or without applied asymmetric physical field. Only one well-characterized example of AAS is known today: the Soai-autocatalysis. In an attempt at clarification of the mechanism of this particular reaction we have undertaken empirical and stochastic analysis of several parallel AAS experiments. Read More

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February 2015

Crucial Role of Viral Reactivation in the Development of Severe Drug Eruptions: a Comprehensive Review.

Clin Rev Allergy Immunol 2015 Oct;49(2):192-202

Division of Flow Cytometry, School of Medicine, Kyorin University, Mitaka, Tokyo, 181-8611, Japan.

A growing number of cells, mediators, and pathways have been implicated in severe drug eruptions. Fifteen years ago, we published landmark studies that sparked the current advances in our understanding of the role of viral reactivations in severe drug eruptions. Viral reactivations then became critically important as diagnostic tools, but how precisely they participated in the pathogenesis remained less well-defined. Read More

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October 2015

A surprise behind a case of winter vomiting virus.

BMJ Case Rep 2013 Jul 22;2013. Epub 2013 Jul 22.

Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, NHS Foundation Trust, Bath, UK.

A 79-year-old man was admitted through the medical take with norovirus gastritis. Routine plain chest radiography demonstrated a right coin lesion. CT and subsequent positron emission tomography showed a right upper lobe mass consistent with primary bronchial carcinoma. Read More

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HLA-B27-mediated protection in HIV and hepatitis C virus infection and pathogenesis in spondyloarthritis: two sides of the same coin?

Curr Opin Rheumatol 2013 Jul;25(4):426-33

Department of Medicine II, Freiburg University Medical Center, University of Freiburg, Freiburg, Germany.

Purpose Of Review: HLA-B27 is associated with low viral load and long-term nonprogression in HIV infection as well as spontaneous clearance of hepatitis C virus (HCV) infection. This review summarizes mechanisms that have been suggested to be involved in this protective effect of HLA-B27, and highlights possible lessons for the role of HLA-B27 in spondyloarthritis.

Recent Findings: Recent studies linked protection by HLA-B27 in HIV and HCV infection to virological mechanisms such as a complicated pathways of viral escape from immunodominant HLA-B27-restricted virus-specific CD8+ T-cell epitopes. Read More

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A primary pulmonary glomus tumor complicated with hyperpyrexia and anemia.

Ann Thorac Surg 2013 Feb;95(2):e29-31

Department of Thoracic Surgery, Peking University People's Hospital, Beijing, PR China.

Pulmonary glomus tumors are extremely rare, with only 19 cases having been reported worldwide. The glomus body is considered to be related to the regulation of body temperature, but the reported cases were not associated with hyperpyrexia. Here, we describe a 28-year-old man with hyperpyrexia and anemia complicated with a coin lesion of the right lung. Read More

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February 2013

An autopsy case of a decomposed body with keyhole gunshot wound and secondary skull fractures.

Leg Med (Tokyo) 2012 Sep 24;14(5):255-7. Epub 2012 May 24.

Department of Forensic Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

The decomposed body of a 53 or 57-year-old male was found with a gun in a locked car parked in a coin-operated parking lot. During autopsy, the entrance wound in the frontal bone showed a characteristic keyhole defect with internal and external beveling. There was no exit wound. Read More

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September 2012

Interplay between microRNAs and the epigenetic machinery: an intricate network.

Biochim Biophys Acta 2010 Oct-Dec;1799(10-12):694-701. Epub 2010 May 20.

Molecular Targeting Unit, Experimental Oncology Department, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

microRNAs take their place into the epigenetic world revealing a complicated network of reciprocal interconnections: not only they are able to control gene expression at a post-transcriptional level, thus representing a new important class of regulatory molecules, but they are also directly connected to the epigenetic machinery through a regulatory loop. Indeed, if epigenetic modifications, such as DNA methylation or histone acetylation, have been demonstrated to affect microRNA expression, and to be potentially responsible for the aberrant miRNA regulation observed in cancer, the other side of the coin is represented by the capacity of microRNAs to control the epigenetic machinery directly targeting its enzymatic components. This review will analyze and describe the regulatory loop interconnecting microRNAs and epigenetics, describing either how epigenetics can affect the miRNome, as well as how epi-miRNAs can control the epigenome, particularly focusing on the alterations observed in human cancer. Read More

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February 2011

Eu3Co2In15 and KM2In9 (M = Co, Ni): 3D frameworks based on transition metal centered In9 clusters.

Inorg Chem 2009 Mar;48(6):2526-33

State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, P. R. China.

The title three compounds have been synthesized by solid state reactions at high temperatures, with excess indium as flux, and structurally characterized by single-crystal X-ray diffraction studies. Eu(3)Co(2)In(15) forms a new structure type and crystallizes in the tetragonal space group P4/mbm (No. 127), whereas KM(2)In(9) (M = Co, Ni) in the BaFe(2)Al(9) type crystallizes in the hexagonal space group P6/mmm (No. Read More

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More than two sides of a coin? How to detect the multiple activities of type 2 transglutaminase.

Methods Enzymol 2008 ;442:201-12

Department of Biology, University of Rome Tor Vergata, Rome, Italy.

Programmed cell death (PCD) by apoptosis has been widely characterized as a process in which the expression and protein activation of a gene must be regulated in a very precise way in order to achieve the elimination of the dying cell without disturbing the neighborhoods. One of the first genes observed to be induced during the onset of PCD is the one coding for type 2 transglutaminase (TG2). Since the late 1990s, the unveiling of different new properties and enzymatic activities suggested the involvement of TG2 in a variety of cellular processes other than PCD and rendered the study of this protein more and more complicated. Read More

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January 2009