18,999 results match your criteria complexes enhanced


Effects of individual or in-combination antioxidant supplementation during in vitro maturation culture on the developmental competence and quality of porcine embryos.

Reprod Domest Anim 2021 Dec 4. Epub 2021 Dec 4.

Faculty of Bioscience and Bioindustry, Tokushima University, Tokushima, Japan.

The oocyte maturation process requires a high supply of energy, which generates reactive oxygen species (ROS), adversely affecting oocyte and embryo development. Balancing ROS by antioxidant supplementation is essential for maintaining oocyte maturation and embryonic quality in vitro. This study aimed to evaluate the impact of four antioxidants: β-mercaptoethanol (β-ME), chlorogenic acid (CGA), curcumin, and sericin, when applied individually or in combinations, during oocyte maturation on development of porcine oocytes. Read More

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December 2021

Portrait of a Family of Highly Stabilizing and Selective Guanine Quadruplex Platinum(II)-Based Binders.

Chemistry 2021 Dec 3. Epub 2021 Dec 3.

École Polytechnique: Ecole Polytechnique, Laboratoire d'Optique et Biosciences, FRANCE.

The long-standing history of platinum coordination complexes in nucleic acid recognition attests to the unique suitability of such species for therapeutic applications. Here, we report the synthetic exploration and development of a family of di-imine ligands, and their platinum(II) complexes, elaborated on a 3-(2-pyridyl)-[1,2,4]triazolo[4,3- a ]pyridine platform which, in its unsubstituted form, has recently been shown to display exceptional capabilities for guanine quadruplex (G4) targeting. The identification of facile, high-yielding synthetic methods for the derivatization of this platform for the incorporation of additional sites of interactions with guanine quadruplex loops and grooves, along with the optimization of platinum(II) complexation methods, are discussed. Read More

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December 2021

A proteomic atlas of ligand-receptor interactions at the ovine maternal-fetal interface reveals the role of histone lactylation in uterine remodeling.

J Biol Chem 2021 Nov 30:101456. Epub 2021 Nov 30.

Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University. Electronic address:

Well-orchestrated maternal-fetal crosstalk occurs via secreted ligands, interacting receptors, and coupled intracellular pathways between the conceptus and endometrium, and is essential for successful embryo implantation. However, previous studies mostly focus on either the conceptus or the endometrium in isolation. The lack of integrated analysis impedes our understanding of early maternal-fetal crosstalk. Read More

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November 2021

Metal-Phenolic Network-Coated Dendrimer-Drug Conjugates for Tumor MR Imaging and Chemo/Chemodynamic Therapy via Amplification of Endoplasmic Reticulum Stress.

Adv Mater 2021 Dec 2:e2107009. Epub 2021 Dec 2.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China.

Amplification of endoplasmic reticulum stress (ERS) to realize enhanced cancer therapy has been considered to be unique in current cancer nanomedicine design. Herein, we report the design of metal-phenolic network-coated dendrimer-drug conjugates as a novel theranostic nanoplatform based on ERS amplification. In our design, acetylated generation 5 poly(amidoamine) dendrimers were conjugated with an ERS drug toyocamycin (Toy) through the attached phenylboronic acid moiety, and coated with iron (Fe)-tannic acid (TF) network. Read More

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December 2021

CD122-targeted interleukin-2 and αPD-L1 treat bladder cancer and melanoma via distinct mechanisms, including CD122-driven natural killer cell maturation.

Oncoimmunology 2021 22;10(1):2006529. Epub 2021 Nov 22.

Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, USA.

Bladder cancer (BC) and melanoma are amenable to immune checkpoint blockade (ICB) therapy, yet most patients with advanced/metastatic disease do not respond. CD122-targeted interleukin (IL)-2 can improve ICB efficacy, but mechanisms are unclear. We tested αPD-L1 and CD122-directed immunotherapy with IL-2/αIL-2 complexes (IL-2c) in primary and metastatic bladder and melanoma tumors. Read More

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November 2021

A comprehensive genome-wide scan detects genomic regions related to local adaptation and climate resilience in Mediterranean domestic sheep.

Genet Sel Evol 2021 Dec 2;53(1):90. Epub 2021 Dec 2.

Department of Animal and Veterinary Sciences, Scotland's Rural College, Roslin Institute Building, Easter Bush, Midlothian, EH25 9RG, UK.

Background: The management of farm animal genetic resources and the adaptation of animals to climate change will probably have major effects on the long-term sustainability of the livestock sector. Genomic data harbour useful relevant information that needs to be harnessed for effectively managing genetic resources. In this paper, we report the genome characterization of the highly productive Mediterranean Chios dairy sheep and focus on genetic diversity measures related with local adaptation and selection and the genetic architecture of animal resilience to weather fluctuations as a novel adaptative trait linked to climate change. Read More

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December 2021

FT-IR and synchronous fluorescence two-dimensional correlation spectroscopic analysis on the binding properties of mercury onto humic acids as influenced by pH modification and sulfide addition.

Sci Total Environ 2021 Nov 29:152047. Epub 2021 Nov 29.

Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address:

Mercuric Hg ion forms strong complexes with dissolved organic matter (DOM) in natural waters. The complexation of Hg by sulfhydryl groups of DOM was regarded as the main mechanism for Hg-DOM interactions, particularly in anoxic sulfur and DOM-rich environments. In the present study, the influences of pH and sulfide addition on the molecular structure of Hg-DOM complexes and the characteristics of Hg binding to DOM were investigated using FT-IR and synchronous fluorescence two-dimensional correlation spectroscopic analysis. Read More

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November 2021

A monomeric (trimethylsilyl)methyl lithium complex: synthesis, structure, decomposition and preliminary reactivity studies.

Dalton Trans 2021 Dec 2. Epub 2021 Dec 2.

Chemistry-School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.

Monomeric organolithium (LiR) complexes could provide enhanced Li-C bond reactivity and suggest mechanisms for a plethora of LiR-mediated reactions. They are highly sought-after but remain a synthetic challenge for organometallic chemists. In this work, we report the synthesis and characterisation of a monomeric (trimethylsilyl)methyl lithium complex, namely [Li(CHSiMe)(κ-,',''-MeTren)] (1), where MeTren is a tetradentate neutral amine ligand. Read More

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December 2021

Analysis of Proteins by Immunoblotting.

Cold Spring Harb Protoc 2021 Dec 1;2021(12):pdb.prot102251. Epub 2021 Dec 1.

In immunoblotting (western blotting), proteins are first separated by SDS-PAGE and then transferred electrophoretically from the gel onto a support membrane that binds proteins tightly. After the unreacted binding sites of the membrane are blocked to suppress nonspecific adsorption of antibodies, the immobilized proteins are reacted with a specific polyclonal or monoclonal antibody. Antigen-antibody complexes are visualized using chromogenic, fluorescent, or chemiluminescent reactions. Read More

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December 2021

Ketoprofen and Loxoprofen Platinum(IV) Complexes Displaying Antimetastatic Activities by Inducing DNA Damage, Inflammation Suppression, and Enhanced Immune Response.

J Med Chem 2021 Dec 1. Epub 2021 Dec 1.

Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, P. R. China.

Metastasis is a major contributor of death in cancer patients, and there is an urgent need for effective treatments of metastatic malignancies. Herein, ketoprofen (KP) and loxoprofen (LP) platinum(IV) complexes with antiproliferative and antimetastatic properties were designed and prepared by integrating chemotherapy and immunotherapy targeting cyclooxygenase-2 (COX-2), matrix metalloproteinase-9 (MMP-9), and programmed death ligand 1 (PD-L1), besides DNA. A mono-KP platinum(IV) complex with a cisplatin core is screened out as a candidate possessing potent anti-proliferative and anti-metastasis activities both in vitro and in vivo. Read More

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December 2021

Loss of PRC2 subunits primes lineage choice during exit of pluripotency.

Nat Commun 2021 Nov 30;12(1):6985. Epub 2021 Nov 30.

Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands.

Polycomb Repressive Complex 2 (PRC2) is crucial for the coordinated expression of genes during early embryonic development, catalyzing histone H3 lysine 27 trimethylation. Two distinct PRC2 complexes, PRC2.1 and PRC2. Read More

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November 2021

Reduction of plasmid vector backbone length enhances reporter gene expression.

Bioelectrochemistry 2021 Oct 29;144:107981. Epub 2021 Oct 29.

Department of Electrical and Computer Engineering, Old Dominion University, Norfolk, VA, United States.

Gene therapy has a wide range of applications for various types of pathologies. Viral methods of gene delivery provide high levels of gene expression but have various safety concerns. Non-viral methods are largely known to provide lower levels of expression. Read More

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October 2021

In-Depth Studies of Ground- and Excited-State Properties of Re(I) Carbonyl Complexes Bearing 2,2':6',2″-Terpyridine and 2,6-Bis(pyrazin-2-yl)pyridine Coupled with π-Conjugated Aryl Chromophores.

Inorg Chem 2021 Nov 30. Epub 2021 Nov 30.

Institute of Chemistry, University of Silesia, ninth Szkolna Str., 40-006 Katowice, Poland.

In the current work, comprehensive photophysical and electrochemical studies were performed for eight rhenium(I) complexes incorporating 2,2':6',2″-terpyridine (terpy) and 2,6-bis(pyrazin-2-yl)pyridine (dppy) with appended 1-naphthyl-, 2-naphthyl-, 9-phenanthrenyl, and 1-pyrenyl groups. Naphthyl and phenanthrenyl substituents marginally affected the energy of the MLCT absorption and emission bands, signaling a weak electronic coupling of the appended aryl group with the Re(I) center. The triplet MLCT state in these complexes is so low lying relative to the triplet IL that the thermal population of the triplet excited state delocalized on the organic chromophore is ineffective. Read More

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November 2021

Transition metal complexes with functionalized indenyl phosphine ligands: structures and catalytic properties.

Org Biomol Chem 2021 Nov 30. Epub 2021 Nov 30.

State Key Laboratory of Synthetic Chemistry and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.

Transition-metal indenyl complexes usually exhibit different reactivities compared with their cyclopentadienyl analogues. Up to now, at least 10 metal-indenyl bonding modes have been reported. Because of the "indenyl effect", transition-metal indenyl complexes usually show enhanced reactivity in substitution and related reactions. Read More

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November 2021

Fabrication of magnetic nickel incorporated carbon nanofibers for superfast adsorption of sulfadiazine: Performance and mechanisms exploration.

J Hazard Mater 2022 Feb 15;423(Pt B):127219. Epub 2021 Sep 15.

Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, Xiangtan University, Xiangtan 411105, PR China.

Herein, novel magnetic nickel incorporated carbon nanofibers ([email protected]) were successfully synthesized via electrostatic spinning method for sulfadiazine (SDZ) adsorption. We combined computational and experimental tools to clarify the distinct nature of SDZ on [email protected] Extensive computations and characterizations of SDZ-Ni adsorption complexes evidenced that Ni atoms were indispensable for SDZ adsorption and increasing the number of Ni atoms in [email protected] significantly improved SDZ adsorption due to the lower adsorption energy (E). Read More

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February 2022

Photo-modulated supramolecular self-assembly of -nitrobenzyl ester-based alkynylplatinum(II) 2,6-bis(-alkylbenzimidazol-2'-yl)pyridine complexes.

Chem Commun (Camb) 2021 Nov 29. Epub 2021 Nov 29.

Institute of Molecular Functional Materials and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China.

The enhanced supramolecular self-assembly behaviors of photo-caged platinum(II) complexes have been triggered by applying light as the external stimulus. Distinct morphological transformation of the nanoaggregates has been observed in the photo-caged complexes before and after UV irradiation. Read More

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November 2021

Antiproliferative, antimigratory, and prooxidative potential of novel platinum(IV) complexes and resveratrol on breast cancer (MDA-MB-231) and choriocarcinoma (JEG-3) cell lines.

Drug Dev Res 2021 Nov 26. Epub 2021 Nov 26.

Faculty of Science, Department of Biology and Ecology, University of Kragujevac, Kragujevac, Serbia.

Platinum(IV) complexes offer the potential to overcome cisplatin resistance of cancer cells, with possible improved selectivity. Resveratrol, a natural polyphenol with anticancer and antioxidant capacity, could limit the possible side effects of chemotherapeutics on healthy cells. This study investigates the effects of platinum(IV) complexes containing some esters of the ethylenediamine-N,N'-di-S,S-(2,2'-dibenzyl)acetate acid (H -S,S-eddba), and resveratrol on proliferation, migration, and redox balance of breast cancer (MDA-MB-231), choriocarcinoma (JEG-3), and human lung fibroblast (MRC-5) cell line. Read More

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November 2021

Supramolecular Surface Functionalization of Iron Oxide Nanoparticles with α-Cyclodextrin-Based Cationic Star Polymer for Magnetically-Enhanced Gene Delivery.

Pharmaceutics 2021 Nov 6;13(11). Epub 2021 Nov 6.

Department of Materials Science and Engineering, National University of Singapore, 7 Engineering Drive 1, Singapore 117574, Singapore.

Supramolecular polymers formed through host-guest complexation have inspired many interesting developments of functional materials for biological and biomedical applications. Here, we report a novel design of a non-viral gene delivery system composed of a cationic star polymer forming supramolecular complexes with the surface oleyl groups of superparamagnetic iron oxide nanoparticles (SPIONs), for magnetically enhanced delivery of DNA into mammalian cells. The cationic star polymer was synthesized by grafting multiple oligoethylenimine (OEI) chains onto an α-cyclodextrin (α-CD) core. Read More

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November 2021

Potassium Complexes of Quercetin-5'-Sulfonic Acid and Neutral O-Donor Ligands: Synthesis, Crystal Structure, Thermal Analysis, Spectroscopic Characterization and Physicochemical Properties.

Materials (Basel) 2021 Nov 11;14(22). Epub 2021 Nov 11.

Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sklodowska University, 20-031 Lublin, Poland.

The coordination ability of QSA ligand towards potassium cations was investigated. Potassium complex of quercetin-5'-sulfonate of the general formula [KQSA(HO)] was obtained. The [KQSA(HO)] () was a starting compound for solvothermal syntheses of acetone () and dimethylsulfoxide () complexes. Read More

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November 2021

Enhancing Cr(VI) bio-reduction by conductive materials and enrichment of functional microbes under anaerobic conditions.

Chemosphere 2022 Jan 3;287(Pt 2):132150. Epub 2021 Sep 3.

School of Minerals Processing and Bioengineering, Key Laboratory of Biohydrometallurgy of Ministry of Education, Central South University, Changsha, 410083, China. Electronic address:

A few studies reported the impact of mineral conductivity properties on contaminant-mineral-microbe interactions and microbial community structure changes in the interaction process. To fill the gap, conductive minerals (magnetite/hematite) and an insulative mineral (quartz) were introduced into Cr(VI) reduction systems to investigate the effect of mineral conductivity properties on Cr(VI) removal. Results showed that conductive minerals enhanced Cr(VI) reduction rate as compared to insulative minerals. Read More

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January 2022

SNAP25 mutation disrupts metabolic homeostasis, steroid hormone production and central neurobehavior.

Biochim Biophys Acta Mol Basis Dis 2021 Nov 24;1868(2):166304. Epub 2021 Nov 24.

Division of Endocrinology, Gerontology and Metabolism, Stanford University School of Medicine, Stanford, CA, United States; Geriatric Research, Education, and Clinical Center, Veterans Administration Palo Alto Health Care System, Palo Alto, CA, United States. Electronic address:

Objective: SNAP-25 is one of the key proteins involved in formation of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes that are at the core of hormonal secretion and synaptic transmission. Altered expression or function of SNAP-25 can contribute to the development of neuropsychiatric and metabolic disease. A dominant negative (DN) I67T missense mutation in the b-isoform of SNAP-25 (DN-SNAP25mut) mice leads to abnormal interactions within the SNARE complex and impaired exocytotic vesicle recycling, yet the significance of this mutation to any association between the central nervous system and metabolic homeostasis is unknown. Read More

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November 2021

Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from to overcome kanamycin resistance.

RSC Med Chem 2021 Nov 5;12(11):1894-1909. Epub 2021 Oct 5.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky 789 South Limestone Street Lexington KY 40536 USA

Tuberculosis (TB), caused by (), is a deadly bacterial disease. Drug-resistant strains of make eradication of TB a daunting task. Overexpression of the enhanced intracellular survival (Eis) protein by confers resistance to the second-line antibiotic kanamycin (KAN). Read More

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November 2021

Mitochondrial complex II and V activity is enhanced in pediatric acute myeloid leukemia.

Am J Blood Res 2021 15;11(5):534-543. Epub 2021 Oct 15.

Department of Medical Oncology, Dr. B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences New Delhi, India.

Background: Mitochondrial bioenergetic alterations are commonly observed metabolic adaptation in malignancies including acute myeloid leukemia (AML). Mitochondrial DNA alterations are well known in pediatric AML with possible prognostic significance; however, mitochondrial complex activity and its impact on disease outcome have not been previously explored. The aim of this study was to evaluate the mitochondrial complex II and complex V activity and its prognostic significance in pediatric AML patients. Read More

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October 2021

Mitochondria and traffic-related air pollution linked coronary artery calcification: exploring the missing link.

Rev Environ Health 2021 Dec 19;36(4):545-563. Epub 2021 Jan 19.

Vascular Biology Lab, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India.

The continuing increase in the exposure to Traffic-related air pollution (TRAP) in the general population is predicted to result in a higher incidence of non-communicable diseases like cardiovascular disease. The chronic exposure of air particulate matter from TRAP upon the vascular system leads to the enhancement of deposition of calcium in the vasculature leading to coronary artery calcification (CAC), triggered by inflammatory reactions and endothelial dysfunction. This calcification forms within the intimal and medial layers of vasculature and the underlying mechanism that connects the trigger from TRAP is not well explored. Read More

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December 2021

Injectable self-healing hydrogel with siRNA delivery property for sustained STING silencing and enhanced therapy of intervertebral disc degeneration.

Bioact Mater 2022 Mar 10;9:29-43. Epub 2021 Aug 10.

Center for Human Tissues and Organs Degeneration, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, Guangdong, PR China.

Inflammatory responses of nucleus pulposus (NP) can induce imbalanced anabolism and catabolism of extracellular matrix, and the cytosolic dsDNA accumulation and STING-NF-κB pathway activation found in NP inflammation are considered as fairly important cause of intervertebral disc (IVD) degeneration. Herein, we constructed a siSTING delivery hydrogel of aldehyde hyaluronic acid (HA-CHO) and poly(amidoamine) PAMAM/siRNA complex to intervene the abnormal STING signal for IVD degeneration treatment, where the formation of dynamic Schiff base bonds in the system ([email protected]) was able to overcome the shortcomings such as low cellular uptake, short half-life, and rapid degradation of siRNA-based strategy. PAMAM not only formed complexes with siRNA to promote siRNA transfection, but also served as dynamic crosslinker to construct hydrogel, and the injectable and self-healing hydrogel efficiently and steadily silenced STING expression in NP cells. Read More

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Genome-wide cancer-specific chromatin accessibility patterns derived from archival processed xenograft tumors.

Genome Res 2021 Nov 23. Epub 2021 Nov 23.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

Chromatin accessibility states that influence gene expression and other nuclear processes can be altered in disease. The constellation of transcription factors and chromatin regulatory complexes in cells results in characteristic patterns of chromatin accessibility. The study of these patterns in tissues has been limited because existing chromatin accessibility assays are ineffective for archival formalin-fixed, paraffin-embedded (FFPE) tissues. Read More

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November 2021

Enantioselective recognition of chiral acids by supramolecular interactions with chiral AIEgens.

Chem Commun (Camb) 2021 Nov 23. Epub 2021 Nov 23.

Shenzhen Institute of Aggregate Science and Technology, School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China.

Novel chiral AIEgens bearing optically pure amino groups were synthesized and showed excellent discrimination for a series of chiral acidic compounds and amino acids. Interestingly, after supramolecular assembly with 4-sulfocalix[4]arene, the obtained complexes showed enhanced enantioselectivity for chiral acids. Read More

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November 2021

Enhanced Sampling Approach to the Induced-Fit Docking Problem in Protein-Ligand Binding: The Case of Mono-ADP-Ribosylation Hydrolase Inhibitors.

J Chem Theory Comput 2021 Nov 23. Epub 2021 Nov 23.

Institute for Advanced Simulations (IAS)-5/Institute for Neuroscience and Medicine (INM)-9, Forschungszentrum Jülich, 52428 Jülich, Germany.

Enhanced sampling methods can predict free-energy landscapes associated with protein/ligand binding, characterizing the involved intermolecular interactions in a precise way. However, these approaches can be challenged by induced-fit effects. Here, we present a variant of volume-based metadynamics tailored to tackle this problem in a general and efficient way. Read More

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November 2021

Nitrite/Nitrous Acid Generation from the Reaction of Nitrate and Fe(II) Promoted by Photolysis of Iron-Organic Complexes.

Environ Sci Technol 2021 Nov 23. Epub 2021 Nov 23.

School of Energy and Environment, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong 999077, China.

Gaseous nitrous acid (HONO) has the potential to greatly contribute to the atmospheric oxidation capacity. Increased attention has been paid to in-particle nitrite or nitrous acid, N(III), as one of the HONO sources. However, sources and formation mechanisms of N(III) remain uncertain. Read More

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November 2021

Mechanical strength enhancement by grain size reduction in a soft colloidal polycrystal.

Soft Matter 2021 Nov 23. Epub 2021 Nov 23.

Matière et Systèmes Complexes (MSC), UMR 7057 CNRS and Université de Paris, 10 rue Alice Domon et Léonie Duquet, 75205 Paris Cedex 13, France.

It has long been known that the mechanical strength of finely grained solid state polycrystals could be enhanced when the grain size is reduced. Indeed, the equation linking the yield stress and the inverse square root of grain size was introduced in the 1950s by Hall and Petch. Since then this relationship has been widely used to engineer structural metals and alloys. Read More

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November 2021