Int J Mol Sci 2021 Jul 16;22(14). Epub 2021 Jul 16.
Department of Cell Biology and Genetics, Faculty of Science, Palacký University, Šlechtitelů 27, CZ-783 71 Olomouc, Czech Republic.
A series of new heteroleptic copper(II) complexes of the composition [Cu(L)(bpy)]NO·2MeOH (), [Cu(L)(dimebpy)]NO·2HO (), [Cu(L)(phen)]NO·2MeOH (), [Cu(L)(bphen)]NO·MeOH (), [Cu(L)(dppz)]NO·MeOH () was prepared, where HL = 3-(3,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-6-(3-methylbut-2-ene-1-yl)-4,8-benzo[1,2-:3,4-']dipyran-4-one, (pomiferin) and bpy = 2,2'-bipyridine, dimebpy = 4,4'-dimethyl-2,2'-bipyridine, phen = 1,10-phenanthroline, bphen = 4,7-diphenyl-1,10-phenanthroline, and dppz = dipyrido[3,2-:2',3'-]phenazine. The complexes were characterized using elemental analysis, infrared and Uis spectroscopies, mass spectrometry, thermal analysis and conductivity measurements. The in vitro cytotoxicity, screened against eight human cancer cell lines (breast adenocarcinoma (MCF-7), osteosarcoma (HOS), lung adenocarcinoma (A549), prostate adenocarcinoma (PC-3), ovarian carcinoma (A2780), cisplatin-resistant ovarian carcinoma (A2780R), colorectal adenocarcinoma (Caco-2) and monocytic leukemia (THP-1), revealed the complexes as effective antiproliferative agents, with the IC values of 2. Read More