1,479,912 results match your criteria complex treatment

Comprehensive analysis of BTN3A1 in cancers: mining of omics data and validation in patient samples and cellular models.

FEBS Open Bio 2021 Jul 22. Epub 2021 Jul 22.

State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Butyrophilin 3A1 (BTN3A1), a major histocompatibility complex (MHC)-associated gene that encodes a membrane protein with 2 extracellular immunoglobulin domains and an intracellular B30.2 domain, is critical in T-cell activation and adaptive immune response. Here, the expression of BTN3A1 in cancers was analyzed in 8 databases comprising 86,733 patients of 33 cancers and the findings were validated in patient samples and cell models. Read More

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Relatively Low Rate of Heterotopic Ossification Following Primary Total Knee Arthroplasty: A Systematic Review and Meta-analysis.

J Am Acad Orthop Surg Glob Res Rev 2021 07 22;5(7). Epub 2021 Jul 22.

From the Stavros Niarchos Foundation Complex Joint Reconstruction Center, Hospital for Special Surgery, New York, NY (Dr. Gkiatas, Mr. Xiang, Mr. Windsor, Dr. Malahias, Dr. Tarity, and Dr. Sculco), and the School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece (Mr. Karasavvidis).

Background: Heterotopic ossification (HO) is abnormal growth of ectopic bone and negatively affects the outcomes after total knee arthroplasty (TKA). This systematic review and meta-analysis were performed to characterize the prevalence and severity of HO after primary TKA.

Methods: A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Read More

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The Management of Orbital Roof Fractures and Defects: A Review.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

Orbital and Oculoplastics Department, Sussex Eye Hospital, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom Department of Neurosurgery, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom Department of Radiology, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom Department of Head & Neck Prosthetics, Queen Victoria Hospital NHS Foundation Trust, East Grinstead, United Kingdom.

Purpose: To explore the anatomy, etiopathogenesis, diagnosis and classification, current evidence on intervention and the surgical management of orbital roof fractures and defects (ORFD) for oculoplastic surgeons presented with such cases.

Methods: A review of the current literature through the MEDLINE database using the following search terms: "orbital roof fracture (+treatment/management)," "orbital roof defect (+treatment/management)," "orbital roof erosion (+treatment/management)," "orbital roof repair," "orbital roof," "orbital fracture," "pediatric orbital roof (defect/fracture/erosion)," "orbital anatomy," and "orbital roof anatomy" was conducted. As relatively little has been published on this topic, inclusion criteria were broad and peer-reviewed articles judged to be of clinical importance, relevant to the aims of this review, were included. Read More

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Corrective Proximal Humerus Osteotomy with Blade Plate Osteosynthesis in Adolescents: A Report of 2 Cases.

JBJS Case Connect 2021 07 22;11(3). Epub 2021 Jul 22.

Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, New York.

Case: Two cases are presented to highlight the indications, surgical technique, and early clinical outcomes associated with proximal humerus corrective osteotomy using a 90° cannulated blade plate in adolescent patients.

Conclusion: A complex deformity of the proximal humerus in the adolescent patient poses an uncommon yet debilitating clinical condition that is challenging to manage. We report a unique method for surgical correction and fixation using an infant hip osteotomy 90° blade plate that restores native shoulder anatomy, improves function, and has led to early clinical success. Read More

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Multiple-Session Subthreshold Micropulse Laser Therapy for Exudative Perifoveal Vascular Anomalous Complex: a case report.

Retin Cases Brief Rep 2021 Jul 16. Epub 2021 Jul 16.

Department of Ophthalmology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, South Korea.

Purpose: To report a case of exudative perifoveal vascular anomalous complex treated with a 532 nm subthreshold micropulse laser unresponsive to intravitreal injections.

Methods: A case report.

Results: A 65-year-old woman presented with blurred vision in left eye for 1 month. Read More

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Prediction and Prevention of Spontaneous Preterm Birth: ACOG Practice Bulletin, Number 234.


Obstet Gynecol 2021 Aug;138(2):e65-e90

Preterm birth is among the most complex and important challenges in obstetrics. Despite decades of research and clinical advancement, approximately 1 in 10 newborns in the United States is born prematurely. These newborns account for approximately three-quarters of perinatal mortality and more than one half of long-term neonatal morbidity, at significant social and economic cost (1-3). Read More

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Prediction and Prevention of Spontaneous Preterm Birth: ACOG Practice Bulletin Summary, Number 234.


Obstet Gynecol 2021 Aug;138(2):320-323

Preterm birth is among the most complex and important challenges in obstetrics. Despite decades of research and clinical advancement, approximately 1 in 10 newborns in the United States is born prematurely. These newborns account for approximately three-quarters of perinatal mortality and more than one half of long-term neonatal morbidity, at significant social and economic cost (1-3). Read More

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A Case of Hypophosphatemia due to Oncogenic Osteomalacia in a Patient with Natural Killer T-Cell Lymphoma.

Kidney Blood Press Res 2021 Jul 22:1-5. Epub 2021 Jul 22.

Ochsner Clinical School/The University of Queensland, Brisbane, Queensland, Australia.

Introduction: Oncogenic osteomalacia (Onc-Ost) is a paraneoplastic phenomenon characterized by hypophosphatemia due to elevated fibroblast growth factor-23 (FGF-23). Onc-Ost has been previously reported in patients with germ line mesenchymal tumors and solid organ malignancies. This is the first report of aggressive natural killer (NK) T-cell lymphoma presenting as Onc-Ost. Read More

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Complexities at the Au/ZrS(001) interface probed by X-ray photoemission spectroscopy.

J Phys Condens Matter 2021 Jul 22. Epub 2021 Jul 22.

Department of Physics and Astronomy and Center for Materials Research and Analysis, University of Nebraska- Lincoln, Jorgensen Hall, 855 North 16th Str., NE 68588-0299, Lincoln, 68588-0299, UNITED STATES.

Interaction between the Au adlayers and ZrS(001) has been examined via X-ray photoemission spectroscopy (XPS). The angle-resolved XPS (ARXPS) measurements reveal that ZrS(001) is disulfide (S) terminated and the Au thickness-dependent XPS indicates that the observed band bending, for low Au coverage, is consistent with formation of a Schottky barrier at the Au/ZrS(001) interface. This band bending, however, appears to be suppressed as the thickness of Au adlayer is increased, indicating varying interfacial interactions at the Au/ZrS(001) interface. Read More

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Biohybrid generators based on living plants and artificial leaves: Influence of leaf motion and real wind outdoor energy harvesting.

Bioinspir Biomim 2021 Jul 22. Epub 2021 Jul 22.

Center for Micro-Biorobotics, Italian Institute of Technology (IIT), Viale Rinaldo Piaggio 34, Pontedera, 56025, ITALY.

Plants translate wind energy into leaf fluttering and branch motion by reversible tissue deformation. Simultaneously, the plant's outermost structure, i.e. Read More

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A qualitative study exploring the career mindset of a group of early career academic nurses as they deployed 'Habits of Mind' to sustain their career journey.

Nurse Educ Pract 2021 Jul 14;55:103149. Epub 2021 Jul 14.

Vice-Chancellor and Principal, The Vice-Chancellor's Unit, Building 36, University of Wollongong, Australia. Electronic address:

Aim: This study aimed to explore the qualities that sustain a career mindset in a group of early career academics in one Australian university.

Background: Building an academic career is a lengthy, convoluted and complex journey requiring a mindset prepared to make informed and timely decisions. Success is predicated to a large extent on the ability of persons to process information effectively before actions are taken. Read More

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Clinical sympathy - A mixed method study of the relationship between the clinical nurse educator and the graduate nurse.

Nurse Educ Pract 2021 Jul 14;55:103150. Epub 2021 Jul 14.

School of Medicine, University of Notre Dame Australia, Henry Street, Fremantle 6160, Western Australia, Australia.

Aim/objective: This paper sought to investigate the influence of the supernumerary clinical nurse educator role on the newly qualified graduate nurses' professional development and successful transition to competent and confident practitioners in the acute care hospital environment.

Background: The novice nurses learning in the inpatient clinical environment is affected by increasing patient acuity, complex conditions and organisational expectations. The supernumerary clinical nurse educator is uniquely positioned to prioritise these nurses' education through protected and available time to support adaption in the workplace culture and retention in the organisation. Read More

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Insights for applying erythrosine B as a green fluorescence probe for estimation of anticancer tamoxifen and its analog; clomiphene in nanogram concentration.

M M Tolba M M Salim

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 12;263:120156. Epub 2021 Jul 12.

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University - Egypt, New Damietta 34511, Egypt. Electronic address:

The growth of tumor tissue is extremely pervasive among post-menopausal women. Commonly, from the clinical application, adjuvant selective estrogen receptor modulators such as tamoxifen are prescribed for prohibiting metastatic breast cancer, while its analog, clomiphene, is used to treat infertility in women. Lately, the significance of green chemistry on our environment was through reducing the influence of hazardous chemicals. Read More

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A systematic review of loneliness in bereavement: Current research and future directions.

Curr Opin Psychol 2021 Jun 19;43:48-64. Epub 2021 Jun 19.

Department of Clinical Psychology, Utrecht University, Utrecht, the Netherlands; Department of Clinical Psychology & Experimental Psychopathology, University of Groningen, Groningen, the Netherlands.

Bereaved people suffer from loneliness and loneliness is associated with poor mental health. In this study, this topic is reviewed. An agenda is suggested for future research. Read More

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Male involvement in promotion of safe motherhood in low- and middle-income countries: A scoping review.

Midwifery 2021 Jul 14;103:103089. Epub 2021 Jul 14.

Centre for Midwifery, Maternal & Perinatal Health, Faculty of Health and Social Sciences, Bournemouth University, 10 St Paul's Ln, Boscombe BH8 8AJ, United Kingdom. Electronic address:

Background: Maternal health programmes that focus on the woman alone are limiting in LMICs as pregnant women often relate to maternity services through a complex social web that reflects power struggles within the kinship and the community.

Methods: A scoping review was conducted to explore the rationale for male involvement in maternal health in LMICs. This review was guided by the question: What is the current state of knowledge regarding the inclusion of men in maternal health services in LMICs? The literature search was conducted using mySearch, Bournemouth University`s iteration of the EBSCO Discovery Service (EDS) tool. Read More

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Review: The development of the gastrointestinal tract microbiota and intervention in neonatal ruminants.

Animal 2021 Jul 19;15(8):100316. Epub 2021 Jul 19.

Department of Animal Science, College of Animal Sciences, Jilin University, Changchun 130062, China. Electronic address:

The complex microbiome colonizing the gastrointestinal tract (GIT) of ruminants plays an important role in the development of the immune system, nutrient absorption and metabolism. Hence, understanding GIT microbiota colonization in neonatal ruminants has positive impacts on host health and productivity. Microbes rapidly colonize the GIT after birth and gradually develop into a complex microbial community, which allows the possibility of GIT microbiome manipulation to enhance newborn health and growth and perhaps induce lasting effects in adult ruminants. Read More

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Methylcellulose/tannic acid complex particles coated on alginate hydrogel scaffold via Pickering for removal of methylene blue from aqueous and quinoline from non-aqueous media.

Chemosphere 2021 Jul 17;286(Pt 1):131597. Epub 2021 Jul 17.

Department of Energy Science and Technology, Environmental Waste Recycle Institute, Myongji University, Yongin, Gyeonggi-do 17058, Republic of Korea. Electronic address:

Adsorbents reported for liquid phase decontamination under both aqueous and non-aqueous media are all dispersed phase sorbents that further require a tedious separation step post adsorption. Herein, a monolith, highly porous, and mechanically robust scaffold was synthesized for the adsorption of pollutants from both aqueous and non-aqueous media with facile separation and regeneration. Methylcellulose-tannic acid complex particles were prepared and systematically decorated on the surface of interpenetrating polymer network (IPN) scaffold via Pickering emulsion. Read More

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Child maltreatment and the development of psychopathology: The role of developmental timing and chronicity.

Child Abuse Negl 2021 Jul 20;120:105215. Epub 2021 Jul 20.

Mt. Hope Family Center, University of Rochester, United States of America; Center for the Study and Prevention of Suicide, Department of Psychiatry, University of Rochester Medical Center, United States of America.

Background: The effects of child maltreatment (CM) on psychopathology are well-established, yet the complex effects of timing and chronicity of maltreatment exposure on the development of psychopathology are still unclear.

Objective: To elucidate developmental pathways from distinct dimensions of CM (chronicity and timing) to psychopathology during emerging adulthood using data from a longitudinal, multi-method study.

Participants And Setting: Children with and without maltreatment exposure were recruited at wave 1 (ages 10-12) to participate in a research summer camp. Read More

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Endoscopic Endonasal Approach for Giant Pituitary Adenoma Occupying The Entire Third Ventricle: Surgical Results and A Review of Literature.

World Neurosurg 2021 Jul 19. Epub 2021 Jul 19.

Department of Neurosurgery , Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India - 695011. Electronic address:

Background: Pituitary macroadenomas, occasionally, disrupt the sellar diaphragm and extend directly to the third ventricle causing hydrocephalus.

Objective: We present the results of a single stage extended endoscopic approach for managing giant pituitary adenomas occupying the entire third ventricle.

Methods: A retrospective study of all giant pituitary adenomas, occupying the entire third ventricle, operated via the endoscopic endonasal approach between January 2016 and December 2020 was performed. Read More

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Biomechanical strategies to reach a compromise between stiffness and flexibility in hind femora of desert locusts.

Acta Biomater 2021 Jul 19. Epub 2021 Jul 19.

Functional Morphology and Biomechanics, Institute of Zoology, Kiel University, Kiel, Germany; Division of Mechanical Engineering and Design, School of Engineering, London South Bank University, London, UK.

Insect cuticle can reach a wide range of material properties, which is thought to be the result of adaptations to applied mechanical stresses. Biomechanical mechanisms behind these property variations remain largely unknown. To fill this gap, here we performed a comprehensive study by simultaneous investigation of the microstructure, sclerotization and the elasticity modulus of the specialized cuticle of the femora of desert locusts. Read More

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Population seroprevalence of SARS-CoV-2 antibodies in Anambra state, South-East, Nigeria.

Int J Infect Dis 2021 Jul 19. Epub 2021 Jul 19.

State Ministry of Health, Jerome Udoji Secretariat Complex, Aroma Awka, Anambra State, Nigeria.

Objective: The objective of this study was to determine the proportion of Anambra State population that had been infected by the SARS-CoV-2 virus and developed antibodies before the second wave.

Methods: The WHO-recommended health facility-based cross-sectional approach was adapted for this survey. Between 8 and 15 December 2020, 3142 participants across the 21 local government areas (LGAs) of the state, aged one year and over, attending randomly selected health facilities were recruited. Read More

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The complex interplay of gut microbiota with the five most common cancer types: From carcinogenesis to therapeutics to prognosis.

Crit Rev Oncol Hematol 2021 Jul 19:103429. Epub 2021 Jul 19.

NICM Health Research Institute, Western Sydney University, Penrith, NSW 2747, Australia. Electronic address:

The association between human gut microbiota and cancers has been an evolving field of biomedical research in recent years. The gut microbiota is composed of the microorganisms residing in the gastrointestinal system that interact with the host to regulate behaviours and biochemical processes within the gut. This symbiotic physiological interaction between the gut and the microbiota plays a significant role in the modulation of gut homeostasis, in which perturbations to the microbiota, also known as dysbiosis can lead to the onset of diseases, including cancer. Read More

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Molecular and epidemiological investigation of a colistin-resistant OXA-23/NDM-1-producing Acinetobacter baumannii outbreak in Southwest Indian Ocean.

Int J Antimicrob Agents 2021 Jul 19:106402. Epub 2021 Jul 19.

Centre National de Référence de la Résistance aux Antibiotiques, Centre Hospitalier Universitaire de Besançon, Besançon, France.; Laboratoire de Bactériologie, UMR CNRS 6249 Chrono-Environnement, Faculté de Médecine-Pharmacie, Université Bourgogne Franche-Comté, Besançon, France.. Electronic address:

Dual resistance to colistin and carbapenems is a milestone reached by certain extensively-drug resistant (XDR) Gram-negative bacteria. The present study describes the first outbreak of XDR colistin- and carbapenem-resistant OXA-23/NDM-1-producing Acinetobacter baumannii (CCRAB) in European overseas territory of Reunion Island (France, Indian Ocean). Between April 2019 and June 2020, 13 patients admitted to the University Hospital of Reunion Island were involved in the outbreak, of whom 8 were infected and 6 died. Read More

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Clofazimine for treatment of multidrug-resistant non-tuberculous mycobacteria.

Pulm Pharmacol Ther 2021 Jul 19:102058. Epub 2021 Jul 19.

Department of Medicine and Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia. Electronic address:

Background: /Question: Nontuberculous mycobacteria (NTM) infections are increasingly detected but difficult to cure given complex drug-resistance patterns. Select U.S. Read More

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Lysophosphatidylcholine induces apoptosis and inflammatory damage in brain microvascular endothelial cells via GPR4-mediated NLRP3 inflammasome activation.

Toxicol In Vitro 2021 Jul 19:105227. Epub 2021 Jul 19.

Department of Neurology, University of Chinese Academy of Sciences Shenzhen Hospital (Guang ming), No. 39 Huaxia Road, Guangming District, Shenzhen 518107, China. Electronic address:

Lysophosphatidylcholine (LPC), as the main active component of oxidized low-density lipoproteins (ox-LDLs), has significant effects in cerebrovascular disease. However, the complex mechanism by which LPC functions in brain microvascular endothelial cells (BMECs) is not clearly understood. In this study, BMECs were transfected with G protein-coupled receptor 4 (GPR4) siRNA or an NLRP3-overexpression plasmid, and GPR4 expression was identified by RT-qPCR and western blotting; IL-1β, IL-18, and IL-33 levels were evaluated by ELISA. Read More

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Visuomotor control dynamics of quiet standing under single and dual task conditions in younger and older adults.

Gregory S Walsh

Neurosci Lett 2021 Jul 19:136122. Epub 2021 Jul 19.

Department of Sport, Health Sciences and Social Work, Oxford Brookes University, Oxford, UK. Electronic address:

Visual input facilitates stable postural control; however, ageing alters visual gaze strategies and visual input processing times. Understanding the complex interaction between visual gaze behaviour and the effects of age may inform future interventions to improve postural control in older adults. The purpose of this study was to determine effects of age and dual task on gaze and postural sway dynamics, and the sway-gaze complexity coupling to explore the coupling between sensory input and motor output. Read More

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Nuclear IL-33 plays an important role in IL-31-mediated downregulation of filaggrin, keratin 1, and keratin 10 by regulating STAT3 activation in human keratinocytes.

J Invest Dermatol 2021 Jul 19. Epub 2021 Jul 19.

Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan.

Interleukin (IL)-33, a chromatin-associated multifunctional cytokine, is implicated in the pathogenesis of atopic dermatitis (AD), an inflammatory skin disorder characterized by skin barrier dysfunction. IL-33 accumulates in the nuclei of epidermal keratinocytes in AD lesions. However, it is unclear whether nuclear IL-33 directly contributes to the pathogenesis of AD. Read More

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Rac-dependent Feedforward Autoactivation of NOX2 leads to Oxidative Burst.

J Biol Chem 2021 Jul 19:100982. Epub 2021 Jul 19.

Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019. Electronic address:

NADPH oxidase 2 (NOX2) produces the superoxide anion radical (O), which has functions in both cell signaling and immune defense. NOX2 is a multimeric-protein complex consisting of several protein subunits including the GTPase Rac. NOX2 uniquely facilitates an oxidative burst, which is described by initially slow O production which increases over time. Read More

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The functional cross talk between cancer cells and cancer associated fibroblasts from a cancer mechanics perspective.

Biochim Biophys Acta Mol Cell Res 2021 Jul 19:119103. Epub 2021 Jul 19.

Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran. Electronic address:

The function of biological tissues in health and disease is regulated at cellular level and is highly influenced by the physical microenvironment, through the interaction of forces between cells and ECM, which are perceived through mechanosensing pathways. In cancer, both chemical and physical signaling cascades and their interactions are involved during cell-cell and cell-ECM communications to meet requirements of tumor growth. Among stroma cells, cancer associated fibroblasts (CAFs) play key role in tumor growth and pave the way for cancer cells to initiate metastasis and invasion to other tissues, and without recruitment of CAFs, the process of cancer invasion is dysfunctional. Read More

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Liquid-liquid phase separation as a common organizing principle of intracellular space and biomembranes providing dynamic adaptive responses.

Biochim Biophys Acta Mol Cell Res 2021 Jul 19:119102. Epub 2021 Jul 19.

Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Institutskiy pereulok, 9, Dolgoprudny, 141700, Russia; Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC07, Tampa, FL 33612, USA. Electronic address:

This work is devoted to the phenomenon of liquid-liquid phase separation (LLPS), which has come to be recognized as fundamental organizing principle of living cells. We distinguish separation processes with different dimensions. Well-known 3D-condensation occurs in aqueous solution and leads to membraneless organelle (MLOs) formation. Read More

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