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RIPK3-Dependent Necroptosis Activates MCP-1-Mediated Inflammation in Mice after Intracerebral Hemorrhage.

J Stroke Cerebrovasc Dis 2021 Nov 24;31(1):106213. Epub 2021 Nov 24.

Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institutes, Wannan Medical College, Wuhu 241000, Anhui, China; Department of Neurology, Wannan Medical College First Affiliated Hospital, Yijishan Hospital, Wuhu 241000, Anhui, China;; Non-coding RNA Research Center of Wannan Medical College, Wuhu 241000, Anhui, China.. Electronic address:

Background: Recent studies have reported that receptor-interacting protein kinase 3 (RIPK3)-dependent necroptosis is related to the pathological process of intracerebral hemorrhage (ICH). Some studies support the view that inhibiting necroptosis is a key mechanism preventing inflammation. Inflammation is a crucial factor contributing to neurological injuries and unfavorable outcomes after ICH. Read More

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November 2021

To exclude or to accumulate? Revealing the role of the sodium HKT1;5 transporter in plant adaptive responses to varying soil salinity.

Plant Physiol Biochem 2021 Nov 19;169:333-342. Epub 2021 Nov 19.

School of Science, Hawkesbury Institute for the Environment, Western Sydney University, Penrith, NSW, 2751, Australia.

Arid/semi-arid and coastal agricultural areas of the world are especially vulnerable to climate change-driven soil salinity. Salinity tolerance in plants is a complex trait, with salinity negatively affecting crop yield. Plants adopt a range of mechanisms to combat salinity, with many transporter genes being implicated in Na-partitioning processes. Read More

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November 2021

JNK/Itch Axis Mediates the Lipopolysaccharide-Induced Ubiquitin-Proteasome-Dependent Degradation of Ferritin Light Chain in Murine Macrophage Cells.

Inflammation 2021 Nov 27. Epub 2021 Nov 27.

Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Hebei Province, Shijiazhuang, 050024, PR China.

Ferritin, which is composed of a heavy chain and a light chain, plays a critical role in maintaining iron homeostasis by sequestering iron. The ferritin light chain (FTL) is responsible for the stability of the ferritin complex. We have previously shown that overexpression of FTL decreases the levels of the labile iron pool (LIP) and reactive oxygen species (ROS) in lipopolysaccharide (LPS)-treated murine macrophage cells. Read More

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November 2021

Environmental optima for an ecosystem engineer: a multidisciplinary trait-based approach.

Sci Rep 2021 Nov 26;11(1):22986. Epub 2021 Nov 26.

IFREMER, Centre de Bretagne, DYNECO LEBCO, 29280, Plouzané, France.

A complex interplay of biotic and abiotic factors underpins the distribution of species and operates across different levels of biological organization and life history stages. Understanding ecosystem engineer reproductive traits is critical for comprehending and managing the biodiversity-rich habitats they create. Little is known about how the reproduction of the reef-forming worm, Sabellaria alveolata, varies across environmental gradients. Read More

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November 2021

Toward understanding submersed macrophyte Vallisneria natans-microbe partnerships to improve remediation potential for PAH-contaminated sediment.

J Hazard Mater 2021 Nov 22:127767. Epub 2021 Nov 22.

Department of Municipal Engineering, School of Civil Engineering, Southeast University, Nanjing 210096, China.

Rhizodegradation using submersed macrophytes Vallisneria natans (V. natans) is a promising biotechnology with the potential to restore polycyclic aromatic hydrocarbon (PAH)-contaminated sediments. However, how different sediment types influence the rhizoremediation outcome and the characterization of microbial community along the sediment-V. Read More

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November 2021

Evolutionary trade-offs between growth and survival: The delicate balance between reproductive success and longevity in bacteria.

Adv Microb Physiol 2021 13;79:133-162. Epub 2021 Aug 13.

Microbiology & Ryan Institute, School of Natural Sciences, National University of Ireland, Galway, Ireland. Electronic address:

All living cells strive to allocate cellular resources in a way that promotes maximal evolutionary fitness. While there are many competing demands for resources the main decision making process centres on whether to proceed with growth and reproduction or to "hunker down" and invest in protection and survival (or to strike an optimal balance between these two processes). The transcriptional programme active at any given time largely determines which of these competing processes is dominant. Read More

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Efficacy of Telephone Health Coaching Integration with Standard Multidisciplinary Care for Adults with Obesity Attending a Weight Management Service: A Pilot Study.

Nutrients 2021 Nov 15;13(11). Epub 2021 Nov 15.

Metabolic and Weight Loss Program, Department of Endocrinology and Diabetes, Blacktown Hospital, Western Sydney Local Health District, Sydney, NSW 2148, Australia.

Australia has one of the highest prevalences of obesity in the developed world with recognised gaps in patient access to obesity services. This non-randomised before and after study investigated the health benefits and patient acceptability of integrating the Get Healthy Service, a state-funded telephone-delivered coaching service in Australia, as an adjunct to multidisciplinary care for adults attending a public obesity service. Forty-one participants received multidisciplinary care alone while 39 participants were subsequently allocated to receive adjunctive treatment with the Get Healthy Service. Read More

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November 2021

Graphene Quantum Dots and Cu(I) Liquid Crystal for Advanced Electrochemical Detection of Doxorubicine in Aqueous Solutions.

Nanomaterials (Basel) 2021 Oct 21;11(11). Epub 2021 Oct 21.

Department of Applied Chemistry and Engineering of Inorganic Compounds and Environment, Politehnica University of Timisoara, 2 Victoriei Square, 300006 Timisoara, Romania.

Two paste electrodes based on graphene quantum dots and carbon nanotubes (GRQD/CNT) and one modified with a homoleptic liquid crystalline Cu(I) based coordination complex (Cu/GRQD/CNT) were obtained and morphostructurally and electrochemically characterized in comparison with simple CNT electrode (CNT) for doxorubicine (DOX) detection in aqueous solutions. GRQD/CNT showed the best electroanalytical performance by differential pulse voltammetry technique (DPV). Moreover, applying a preconcentration step prior to detection stage, the lowest limit of detection (1 ng/L) and the highest sensitivity (216,105 µA/mg·L) in comparison with reported literature data were obtained. Read More

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October 2021

-Derived Circulating Immune Complexes in Sarcoidosis Patients.

Microorganisms 2021 Oct 21;9(11). Epub 2021 Oct 21.

Department of Human Pathology, Graduate School and Faculty of Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

is a potential etiologic agent of sarcoidosis and a dysregulated immune response to the commensal bacterium is suspected to cause granuloma formation. -derived insoluble immune complexes were recently demonstrated in sinus macrophages of sarcoidosis lymph nodes, suggesting local proliferation of the bacterium in affected organs. In the present study, we developed a method for detecting -derived immune complexes in human blood by measuring the concentration of -specific lipoteichoic acid (PLTA) detectable after an antigen retrieval pretreatment of plasma samples. Read More

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October 2021

The African Swine Fever Virus with MGF360 and MGF505 Deleted Reduces the Apoptosis of Porcine Alveolar Macrophages by Inhibiting the NF-κB Signaling Pathway and Interleukin-1β.

Vaccines (Basel) 2021 Nov 22;9(11). Epub 2021 Nov 22.

Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510462, China.

African swine fever virus (ASFV) poses serious threats to the swine industry. The mortality rate of African swine fever (ASF) is 100%, and there is no effective vaccine currently available. Complex immune escape strategies of ASFV are crucial factors affecting immune prevention and vaccine development. Read More

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November 2021

Modulation of Expression of PVY RNA-Dependent RNA Polymerase (NIb) and Heat Shock Cognate Host Protein HSC70 in Susceptible and Hypersensitive Potato Cultivars.

Vaccines (Basel) 2021 Oct 29;9(11). Epub 2021 Oct 29.

Department of Botany, Faculty of Biology and Biotechnology, Institute of Biology, Warsaw University of Life Sciences-SGGW, Nowoursynowska Street 159, 02-776 Warsaw, Poland.

Potato virus Y (PVY) belongs to the genus Potyvirus and is considered to be one of the most harmful and important plant pathogens. Its RNA-dependent RNA polymerase (RdRp) is known as nuclear inclusion protein b (NIb). The recent findings show that the genome of PVY replicates in the cytoplasm of the plant cell by binding the virus replication complex to the membranous structures of different organelles. Read More

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October 2021

In Vivo Bioluminescence Imaging of HBV Replicating Hepatocytes Allows for the Monitoring of Anti-Viral Immunity.

Viruses 2021 Nov 13;13(11). Epub 2021 Nov 13.

Institute of Molecular Immunology, Klinikum Rechts der Isar, TUM School of Medicine, Technical University of Munich, 80333 Munich, Germany.

Immunity against hepatitis B virus (HBV) infection is complex and not entirely understood so far, including the decisive factors leading to the development of chronic hepatitis B. This lack of a mechanistic understanding of HBV-specific immunity is also caused by a limited number of suitable animal models. Here, we describe the generation of a recombinant adenovirus expressing an HBV 1. Read More

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November 2021

Successive Inoculations of Pigs with Porcine Reproductive and Respiratory Syndrome Virus 1 (PRRSV-1) and Swine H1N2 Influenza Virus Suggest a Mutual Interference between the Two Viral Infections.

Viruses 2021 Oct 27;13(11). Epub 2021 Oct 27.

French Agency for Food, Environmental and Occupational Health and Safety (ANSES), Ploufragan-Plouzané-Niort Laboratory, Swine Virology Immunology Unit, BP53, 22440 Ploufragan, France.

Porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza A virus (swIAV) are major pathogens of the porcine respiratory disease complex, but little is known on their interaction in super-infected pigs. In this study, we investigated clinical, virological and immunological outcomes of successive infections with PRRSV-1 and H1N2 swIAV. Twenty-four specific pathogen-free piglets were distributed into four groups and inoculated either with PRRSV at study day (SD) 0, or with swIAV at SD8, or with PRRSV and swIAV one week apart at SD0 and SD8, respectively, or mock-inoculated. Read More

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October 2021

Association of Hepatitis C Virus Replication with the Catecholamine Biosynthetic Pathway.

Viruses 2021 Oct 23;13(11). Epub 2021 Oct 23.

Laboratory of Molecular Virology, Hellenic Pasteur Institute, 11521 Athens, Greece.

A bidirectional negative relationship between Hepatitis C virus (HCV) replication and gene expression of the catecholamine biosynthetic enzyme L-Dopa decarboxylase (DDC) was previously shown in the liver and attributed at least to an association of DDC with phosphatidylinositol 3-kinase (PI3K). Here, we report that the biosynthesis and uptake of catecholamines restrict HCV replication in hepatocytes, while HCV has developed ways to reduce catecholamine production. By employing gene silencing, chemical inhibition or induction of the catecholamine biosynthetic and metabolic enzymes and transporters, and by applying the substrates or the products of the respective enzymes, we unravel the role of the different steps of the pathway in viral infection. Read More

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October 2021

Iodine and Selenium Biofortification of Chervil Plants Treated with Silicon Nanoparticles.

Plants (Basel) 2021 Nov 20;10(11). Epub 2021 Nov 20.

Department of Agricultural Sciences, University of Naples Federico II, Portici, 80055 Naples, Italy.

Production of functional food with high levels of selenium (Se) and iodine (I) obtained via plant biofortification shows significant difficulties due to the complex interaction between the two elements. Taking into account the known beneficial effect of silicon (Si) on plant growth and development, single and joint foliar biofortification of chervil plants with potassium iodide (150 mg L) and sodium selenate (10 mg L) was carried out in a pot experiment with and without Si nanoparticles foliar supplementation. Compared to control plants, nano-Si (14 mg L) increased shoot biomass in all treatments: by 4. Read More

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November 2021

Exploring the Impacts of Genotype-Management-Environment Interactions on Wheat Productivity, Water Use Efficiency, and Nitrogen Use Efficiency under Rainfed Conditions.

Plants (Basel) 2021 Oct 27;10(11). Epub 2021 Oct 27.

Henan Key Laboratory of Earth System Observation and Modeling, Henan University, Kaifeng 475004, China.

Wheat production under rainfed conditions is restrained by water scarcity, elevated temperatures, and lower nutrient uptake due to possible drought. The complex genotype, management, and environment (G × M × E) interactions can obstruct the selection of suitable high yielding wheat cultivars and nitrogen (N) management practices prerequisite to ensure food security and environmental sustainability in arid regions. The agronomic traits, water use efficiency (WUE), and N use efficiencies were evaluated under favorable and unfavorable weather conditions to explore the impacts of G × M × E on wheat growth and productivity. Read More

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October 2021

Spatial Variation of Epiphytes in the Nan River, Thailand.

Plants (Basel) 2021 Oct 22;10(11). Epub 2021 Oct 22.

Plants of Thailand Research Unit, Department of Botany, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.

is an algal genus known to be ecologically important. It provides habitats for microorganisms known to provide ecological services such as biosynthesis of cobalamin (vitamin B) and nutrient cycling. Most knowledge of microbiomes was obtained from studies of lacustrine species. Read More

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October 2021

Innate-Immunity Genes in Obesity.

J Pers Med 2021 Nov 14;11(11). Epub 2021 Nov 14.

Federal Research Center, Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), 630090 Novosibirsk, Russia.

The main functions of adipose tissue are thought to be storage and mobilization of the body's energy reserves, active and passive thermoregulation, participation in the spatial organization of internal organs, protection of the body from lipotoxicity, and ectopic lipid deposition. After the discovery of adipokines, the endocrine function was added to the above list, and after the identification of crosstalk between adipocytes and immune cells, an immune function was suggested. Nonetheless, it turned out that the mechanisms underlying mutual regulatory relations of adipocytes, preadipocytes, immune cells, and their microenvironment are complex and redundant at many levels. Read More

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November 2021

Evaluating the Expression of Candidate Homeobox Genes and Their Role in Local-Site Inflammation in Mucosal Tissue Obtained from Children with Non-Syndromic Cleft Lip and Palate.

J Pers Med 2021 Nov 2;11(11). Epub 2021 Nov 2.

Department of Morphology, Institute of Anatomy and Anthropology, Rīga Stradiņš University, LV-1007 Riga, Latvia.

Craniofacial development including palatogenesis is a complex process which requires an orchestrated and spatiotemporal expression of various genes and factors for proper embryogenesis and organogenesis. One such group of genes essential for craniofacial development is the homeobox genes, transcriptional factors that are commonly associated with congenital abnormalities. Amongst these genes, and have been recently shown to be involved in the etiology of non-syndromic cleft lip and palate. Read More

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November 2021

Retinoic Acid-Containing Liposomes for the Induction of Antigen-Specific Regulatory T Cells as a Treatment for Autoimmune Diseases.

Pharmaceutics 2021 Nov 17;13(11). Epub 2021 Nov 17.

Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands.

The current treatment of autoimmune and chronic inflammatory diseases entails systemic immune suppression, which is associated with increased susceptibility to infections. To restore immune tolerance and reduce systemic side effects, a targeted approach using tolerogenic dendritic cells (tolDCs) is being explored. tolDCs are characterized by the expression of CD11c, the major histocompatibility complex (MHC)II and low levels of co-stimulatory molecules CD40 and CD86. Read More

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November 2021

In Vivo Investigation of the Ameliorating Effect of Tempol against MIA-Induced Knee Osteoarthritis in Rats: Involvement of TGF-β1/SMAD3/NOX4 Cue.

Molecules 2021 Nov 19;26(22). Epub 2021 Nov 19.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.

Osteoarthritis (OA) is a complex disease characterized by structural, functional, and metabolic deteriorations of the whole joint and periarticular tissues. In the current study, we aimed to investigate the possible effects of tempol on knee OA induced by the chemical chondrotoxic monosodium iodoacetate (MIA) which closely mimics both the pain and structural changes associated with human OA. Rats were administrated oral tempol (100 mg/kg) one week post-MIA injection (3 mg/50 μL saline) at the right knee joints for 21 consecutive days. Read More

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November 2021

Dual Role of SIRT1 in Autophagy and Lipid Metabolism Regulation in Osteoarthritic Chondrocytes.

Medicina (Kaunas) 2021 Nov 4;57(11). Epub 2021 Nov 4.

Laboratory of Cytogenetics and Molecular Genetics, Faculty of Medicine, University of Thessaly, Biopolis, 41500 Larissa, Greece.

: Osteoarthritis (OA) is one of the most common and highly prevalent types of arthritis, also considered a multiphenotypic disease with a strong metabolic component. Ageing is the primary risk factor for OA, while the age-related decline in autophagic activity affects cell function and chondrocyte homeostasis. The aim of this study was to investigate the role of sirtuin 1 (SIRT1) in autophagy dysregulation and lipid metabolism in human OA chondrocytes. Read More

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November 2021

Oxygen, pH, Lactate, and Metabolism-How Old Knowledge and New Insights Might Be Combined for New Wound Treatment.

Medicina (Kaunas) 2021 Nov 1;57(11). Epub 2021 Nov 1.

Department of Surgery, Division of Plastic, Aesthetic and Reconstructive Surgery, Medical University Graz, Auenbruggerplatz 29, 8036 Graz, Austria.

Over time, we have come to recognize a very complex network of physiological changes enabling wound healing. An immunological process enables the body to distinguish damaged cells and begin a cleaning mechanism by separating damaged proteins and cells with matrix metalloproteinases, a complement reaction, and free radicals. A wide variety of cell functions help to rebuild new tissue, dependent on energy provision and oxygen supply. Read More

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November 2021

CRISPR-Based Genetic Switches and Other Complex Circuits: Research and Application.

Life (Basel) 2021 Nov 17;11(11). Epub 2021 Nov 17.

CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

CRISPR-based enzymes have offered a unique capability to the design of genetic switches, with advantages in designability, modularity and orthogonality. CRISPR-based genetic switches operate on multiple levels of life, including transcription and translation. In both prokaryotic and eukaryotic cells, deactivated CRISPR endonuclease and endoribonuclease have served in genetic switches for activating or repressing gene expression, at both transcriptional and translational levels. Read More

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November 2021

A Label-Free Proteomic and Complementary Metabolomic Analysis of Leaves of the Resurrection Plant during Dehydration.

Life (Basel) 2021 Nov 16;11(11). Epub 2021 Nov 16.

Department of Molecular and Cell Biology, University of Cape Town, Private Bag X3, Rondebosch 7701, South Africa.

Vegetative desiccation tolerance, or the ability to survive the loss of ~95% relative water content (RWC), is rare in angiosperms, with these being commonly called resurrection plants. It is a complex multigenic and multi-factorial trait, with its understanding requiring a comprehensive systems biology approach. The aim of the current study was to conduct a label-free proteomic analysis of leaves of the resurrection plant in response to desiccation. Read More

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November 2021

Application of Domain- and Genotype-Specific Models to Infer Post-Transcriptional Regulation of Segmentation Gene Expression in .

Life (Basel) 2021 Nov 13;11(11). Epub 2021 Nov 13.

Mathematical Biology and Bioinformatics Laboratory, Peter the Great Saint Petersburg Polytechnic University, 195251 St. Petersburg, Russia.

Unlike transcriptional regulation, the post-transcriptional mechanisms underlying zygotic segmentation gene expression in early embryo have been insufficiently investigated. Condition-specific post-transcriptional regulation plays an important role in the development of many organisms. Our recent study revealed the domain- and genotype-specific differences between mRNA and the protein expression of , , and genes in cleavage cycle 14A. Read More

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November 2021

Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing.

Pharmaceuticals (Basel) 2021 Oct 29;14(11). Epub 2021 Oct 29.

Department of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.

The normal wound healing process is characterized by a complex, highly integrated cascade of events, requiring the interactions of many cell types, including inflammatory cells, fibroblasts, keratinocytes and endothelial cells, as well as the involvement of growth factors and enzymes. However, several diseases such as diabetes, thermal injury and ischemia could lead to an impaired wound healing process characterized by wound hypoxia, high levels of oxygen radicals, reduced angiogenesis, decreased collagen synthesis and organization. Polydeoxyribonucleotide (PDRN) has been used to improve wound healing through local and systemic administration thanks to its ability to promote cell migration and growth, angiogenesis, and to reduce inflammation on impaired wound healing models in vitro, in vivo and clinical studies. Read More

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October 2021

P-Glycoprotein (ABCB1/MDR1) and BCRP (ABCG2) Limit Brain Accumulation and Cytochrome P450-3A (CYP3A) Restricts Oral Exposure of the RET Inhibitor Selpercatinib (RETEVMO).

Pharmaceuticals (Basel) 2021 Oct 27;14(11). Epub 2021 Oct 27.

Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

Selpercatinib is a targeted, FDA-approved, oral, small-molecule inhibitor for the treatment of rearranged during transfection (RET) proto-oncogene mutation-positive cancer. Using genetically modified mouse models, we investigated the roles of the multidrug efflux transporters ABCB1 and ABCG2, the OATP1A/1B uptake transporters, and the drug-metabolizing CYP3A complex in selpercatinib pharmacokinetics. Selpercatinib was efficiently transported by hABCB1 and mAbcg2, but not hABCG2, and was not a substrate of human OATP1A2, -1B1 or -1B3 in vitro. Read More

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October 2021

BMP7 Increases UCP1-Dependent and Independent Thermogenesis with a Unique Gene Expression Program in Human Neck Area Derived Adipocytes.

Pharmaceuticals (Basel) 2021 Oct 25;14(11). Epub 2021 Oct 25.

Laboratory of Cell Biochemistry, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.

White adipocytes contribute to energy storage, accumulating lipid droplets, whereas brown and beige adipocytes mainly function in dissipating energy as heat primarily via the action of uncoupling protein 1 (UCP1). Bone morphogenic protein 7 (BMP7) was shown to drive brown adipocyte differentiation in murine interscapular adipose tissue. Here, we performed global RNA-sequencing and functional assays on adipocytes obtained from subcutaneous (SC) and deep-neck (DN) depots of human neck and differentiated with or without BMP7. Read More

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October 2021

Chondroitin Sulfate and Fucosylated Chondroitin Sulfate as Stimulators of Hematopoiesis in Cyclophosphamide-Induced Mice.

Pharmaceuticals (Basel) 2021 Oct 24;14(11). Epub 2021 Oct 24.

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119991 Moscow, Russia.

The immunosuppression and inhibition of hematopoiesis are considered to be reasons for the development of complications after intensive chemotherapy and allogeneic hematopoietic stem cell transplantation. Chondroitin sulfate (), isolated from the fish , and fucosylated chondroitin sulfate (), isolated from the sea cucumber , were studied for their roles as stimulators of hematopoiesis in a model of cyclophosphamide-induced immunosuppression in mice. The recombinant protein r G-CSF was applied as a reference. Read More

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October 2021