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The impact of antisperm antibodies on human male reproductive function: an update.

Reproduction 2021 Aug 1. Epub 2021 Aug 1.

S Amaral, University of Coimbra, University of Coimbra Center for Neuroscience and Cell Biology, Coimbra, Portugal.

Immune infertility occurs due to the presence of antisperm antibodies (ASA). This type of infertility has a relatively low prevalence (2.6-6. Read More

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Feasibility of Magnetic Resonance Angiography in Patients With Legg-Calvé-Perthes Disease.

J Pediatr Orthop 2021 Aug 2. Epub 2021 Aug 2.

Instituto de Ortopedia e Traumatologia Instituto de Radiologia, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo Instituto Remo Meu Rumo Hospital Israelita Albert Einstein, São Paulo, Brazil AdventHealth Central Florida, Orlando, FL Scottish Rite for Children, Dallas, TX.

Background: The etiology of Legg-Calvé-Perthes disease (LCPD) remains unknown; however, interruption of medial circumflex femoral artery (MCFA) supply to the femoral head is the key pathogenic factor. The main purpose of this study is to determine the feasibility of using magnetic resonance angiography (MRA) to evaluate the course of the MCFA in the normal and affected hips of patients with unilateral LCPD.

Methods: We analyzed 24 patients with unilateral LCPD using a time-resolved imaging of contrast kinetics magnetic resonance angiography (TRICKS-MRA). Read More

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Pharmacist involvement in the inhaler choice improves lung function in patients with COPD: a prospective single-arm study.

J Pharm Health Care Sci 2021 Aug 2;7(1):28. Epub 2021 Aug 2.

Department of Pharmacy, Kyoto-Katsura Hospital, 17, Yamadahiraocho, Kyoto-shi Nishikyo-ku, Kyoto, 615-8256, Japan.

Background: Currently, in Japan, shifting tasks from physician to hospital pharmacist is being developed to reduce physician workload and improve the quality of pharmacotherapy. This study aimed to investigate the effects of pharmacist involvement in the choice of inhaler as the task on the clinical outcomes of patients with chronic obstructive pulmonary disease (COPD).

Methods: This prospective, single-center, single-arm study included 36 outpatients with newly diagnosed COPD indicating inhaler therapy. Read More

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Autoantibodies against NMDA receptor 1 modify rather than cause encephalitis.

Mol Psychiatry 2021 Jul 30. Epub 2021 Jul 30.

Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany.

The etiology and pathogenesis of "anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis" and the role of autoantibodies (AB) in this condition are still obscure. While NMDAR1-AB exert NMDAR-antagonistic properties by receptor internalization, no firm evidence exists to date that NMDAR1-AB by themselves induce brain inflammation/encephalitis. NMDAR1-AB of all immunoglobulin classes are highly frequent across mammals with multiple possible inducers and boosters. Read More

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(Eco)toxicological tests for assessing impacts of chemical stress to aquatic ecosystems: Facts, challenges, and future.

Sci Total Environ 2021 Jul 1;795:148776. Epub 2021 Jul 1.

Aquatic Ecology and Water Quality Management group, Wageningen University, P.O. Box 47, 6700 AA Wageningen, the Netherlands; Wageningen Environmental Research, P.O. Box 47, 6700 AA Wageningen, the Netherlands.

Monitoring of chemicals in the aquatic environment by chemical analysis alone cannot completely assess and predict the effects of chemicals on aquatic species and ecosystems. This is primarily because of the increasing number of (unknown) chemical stressors and mixture effects present in the environment. In addition, the ability of ecological indices to identify underlying stressors causing negative ecological effects is limited. Read More

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Sensitivity of cohesin-chromatin association to high-salt treatment corroborates non-topological mode of loop extrusion.

Epigenetics Chromatin 2021 Jul 28;14(1):36. Epub 2021 Jul 28.

Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.

Cohesin is a key organizer of chromatin folding in eukaryotic cells. The two main activities of this ring-shaped protein complex are the maintenance of sister chromatid cohesion and the establishment of long-range DNA-DNA interactions through the process of loop extrusion. Although the basic principles of both cohesion and loop extrusion have been described, we still do not understand several crucial mechanistic details. Read More

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Modification of the Fetal Profile Line to Measure Reversal of Forehead Slope after Early Repair of Frontoethmoidal Encephalocele.

J Neurol Surg B Skull Base 2021 Jul 24;82(Suppl 3):e300-e305. Epub 2020 Jan 24.

Department of Neurological Surgery, University of Minnesota School of Medicine, Minneapolis, Minnesota, United States.

 Congenital frontoethmoidal encephaloceles are associated with a shallow sloping forehead. We (1) sought to determine if early repair reverses abnormal forehead slope, and (2) assessed a modification of the fetal profile (FP) line to assess results.  Study of two cases. Read More

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Myocardial Tissue Characterization in Heart Failure with Preserved Ejection Fraction: From Histopathology and Cardiac Magnetic Resonance Findings to Therapeutic Targets.

Int J Mol Sci 2021 Jul 17;22(14). Epub 2021 Jul 17.

Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy.

Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome responsible for high mortality and morbidity rates. It has an ever growing social and economic impact and a deeper knowledge of molecular and pathophysiological basis is essential for the ideal management of HFpEF patients. The association between HFpEF and traditional cardiovascular risk factors is known. Read More

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Inactivation of EMILIN-1 by Proteolysis and Secretion in Small Extracellular Vesicles Favors Melanoma Progression and Metastasis.

Int J Mol Sci 2021 Jul 9;22(14). Epub 2021 Jul 9.

Microenvironment and Metastasis Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Center (CNIO), 28029 Madrid, Spain.

Several studies have demonstrated that melanoma-derived extracellular vesicles (EVs) are involved in lymph node metastasis; however, the molecular mechanisms involved are not completely defined. Here, we found that EMILIN-1 is proteolyzed and secreted in small EVs (sEVs) as a novel mechanism to reduce its intracellular levels favoring metastasis in mouse melanoma lymph node metastatic cells. Interestingly, we observed that EMILIN-1 has intrinsic tumor and metastasis suppressive-like properties reducing effective migration, cell viability, primary tumor growth, and metastasis. Read More

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[Infection Control in Anesthesia].

Anasthesiol Intensivmed Notfallmed Schmerzther 2021 Jul 23;56(7-08):474-484. Epub 2021 Jul 23.

The anaesthesiological care of patients in the operating room involves many activities that can lead to an infection. Hand hygiene is the most effective single measure for the prevention of nosocomial infections. Hand disinfectant dispensers should be placed within easy reach. Read More

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Asymmetric nuclear division in neural stem cells generates sibling nuclei that differ in size, envelope composition, and chromatin organization.

Curr Biol 2021 Jul 15. Epub 2021 Jul 15.

MRC Laboratory for Molecular Cell Biology, University College London, London, UK; Institute for the Physics of Living Systems, University College London, London, UK; MRC Laboratory of Molecular Cell Biology, Cambridge, UK. Electronic address:

Although nuclei are the defining features of eukaryotes, we still do not fully understand how the nuclear compartment is duplicated and partitioned during division. This is especially the case for organisms that do not completely disassemble their nuclear envelope upon entry into mitosis. In studying this process in Drosophila neural stem cells, which undergo asymmetric divisions, we find that the nuclear compartment boundary persists during mitosis thanks to the maintenance of a supporting nuclear lamina. Read More

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Crystal structure and functional characterization of an oligosaccharide dehydrogenase from Pycnoporus cinnabarinus provides insights into fungal breakdown of lignocellulose.

Biotechnol Biofuels 2021 Jul 22;14(1):161. Epub 2021 Jul 22.

INRAE, Aix Marseille Université, BBF UMR1163 Biodiversité et Biotechnologie Fongiques, 163 Avenue de Luminy, 13009, Marseille, France.

Background: Fungal glucose dehydrogenases (GDHs) are FAD-dependent enzymes belonging to the glucose-methanol-choline oxidoreductase superfamily. These enzymes are classified in the "Auxiliary Activity" family 3 (AA3) of the Carbohydrate-Active enZymes database, and more specifically in subfamily AA3_2, that also includes the closely related flavoenzymes aryl-alcohol oxidase and glucose 1-oxidase. Based on sequence similarity to known fungal GDHs, an AA3_2 enzyme active on glucose was identified in the genome of Pycnoporus cinnabarinus, a model Basidiomycete able to completely degrade lignin. Read More

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Controlling the flow balance: In vitro characterization of a pulsatile total artificial heart in preload and afterload sensitivity.

Artif Organs 2021 Jul 20. Epub 2021 Jul 20.

Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Aachen, Germany.

The objective of this study is to identify the preload and afterload sensitivity of the ReinHeart TAH 2.0. For adequate left-right flow balance, the concept of a reduced right stroke volume (by about 10%) and active adaption of the right diastole duration are evaluated concerning the controllability of the flow balance. Read More

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Radiation Recall Dermatitis in Patients Treated With Immune Checkpoint Inhibitors: A Case Report and Literature Review.

Cureus 2021 Jun 9;13(6):e15548. Epub 2021 Jun 9.

Radiation Oncology, Hacettepe University Medical School, Ankara, TUR.

Radiation recall dermatitis (RRD) is defined as a skin reaction in the previously irradiated area triggered by a systemic agent's administration. The use of immune checkpoint inhibitors (ICI) alone and in combination with other treatments is increasing in many cancers. ICI-associated radiation recall reactions such as dermatitis, pneumonia, and myelitis have been reported so far. Read More

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Diaphragm Pacing in Patients with Spinal Cord Injury: A European Experience.

Respiration 2021 Jul 16:1-7. Epub 2021 Jul 16.

Fundación Institut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Barcelona, Spain.

Background: Patients with high spinal cord injury (SCI) are unable to breathe on their own and require mechanical ventilation (MV). The long-term use of MV is associated with increased morbidity and mortality. In patients with intact phrenic nerve function, patients can be partially or completely removed from MV by directly stimulating the diaphragm motor points with a diaphragm pacing system (DPS). Read More

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Monte Carlo simulations in the unconstrained ensemble.

Phys Rev E 2021 Jun;103(6):L061303

SISSA, via Bonomea 265 and INFN, Sezione di Trieste, 34136 Trieste, Italy.

The unconstrained ensemble describes completely open systems whose control parameters are the chemical potential, pressure, and temperature. For macroscopic systems with short-range interactions, thermodynamics prevents the simultaneous use of these intensive variables as control parameters, because they are not independent and cannot account for the system size. When the range of the interactions is comparable with the size of the system, however, these variables are not truly intensive and may become independent, so equilibrium states defined by the values of these parameters may exist. Read More

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Strategies for the Identification and Prevention of Survey Fraud: Data Analysis of a Web-Based Survey.

JMIR Cancer 2021 Jul 16;7(3):e30730. Epub 2021 Jul 16.

Healthcare Delivery Research, Medstar Health Research Institute, Washington, DC, United States.

Background: To assess the impact of COVID-19 on cancer survivors, we fielded a survey promoted via email and social media in winter 2020. Examination of the data showed suspicious patterns that warranted serious review.

Objective: The aim of this paper is to review the methods used to identify and prevent fraudulent survey responses. Read More

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Palliative surgery and the surgeon's role in the palliative care team: a review.

Ann Palliat Med 2021 Jun 23. Epub 2021 Jun 23.

Department of Surgery, Brown University, Lifespan Health System and Warren Alpert Medical School, Providence, RI, USA.

This review focuses on the role of palliative surgery in the care of the palliative care patient, and the appropriate role of the surgeon. The surgeon has much to bring to the palliative care team. The surgeon's role goes beyond the technical requirements of the palliative procedure, which itself must be strictly defined, and has recognized utility for improving quality of life in selected patients. Read More

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Overexpression of Neutrophil MMP-9 and HIF-1α May Contribute to the Finger-Like Projections Formation and Histo-Pathogenesis in Nasal Inverted Papilloma.

J Inflamm Res 2021 6;14:2979-2991. Epub 2021 Jul 6.

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.

Background: Nasal inverted papilloma (NIP) is defined based on its histological characteristic of inverted epithelium growth into the stroma. The inversion can result in epithelial growth in the underlying connective tissue stroma when the basement membrane completely separates from the epithelial layer. To date, such inversion mechanism underlying NIP's pathological phenomenon is unknown. Read More

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Arthroscopic Management of Giant Cell Tumor of the Calcaneus.

Foot Ankle Spec 2021 Jul 14:19386400211029120. Epub 2021 Jul 14.

Department of Orthopaedic and Traumatology, Sanglah Hospital; Faculty of Medicine, University of Udayana, Bali, Indonesia.

Giant cell tumor of the calcaneal bone is a very rare entity and generally seen in the 30 to 40 years age group. We report a case of a 17-year-old male with giant cell tumor of the calcaneus, presented with left heel pain without another obvious physical abnormality. Radiographs showed a lobulated, well-defined, lytic lesion of the calcaneus with narrow transitional zone without periosteal reaction, no extraosseal spread, and no lung metastases. Read More

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Can cropland management practices lower net greenhouse emissions without compromising yield?

Glob Chang Biol 2021 Jul 9. Epub 2021 Jul 9.

Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK.

Smart cropland management practices can mitigate greenhouse gas (GHG) emissions while safeguarding food security. However, the integrated effects on net greenhouse gas budget (NGHGB) and grain yield from different management practices remain poorly defined and vary with environmental and application conditions. Here, we conducted a global meta-analysis on 347 observation sets of non-CO GHG (CH and N O) emissions and grain yield, and 412 observations of soil organic carbon sequestration rate (SOCSR). Read More

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Water-biomolecule clusters studied by photoemission spectroscopy and multilevel atomistic simulations: hydration or solvation?

Phys Chem Chem Phys 2021 Jul;23(28):15049-15058

Normandie Univ., ENSICAEN, UNICAEN, CEA, CNRS, CIMAP, 14000 Caen, France.

The properties of mixed water-uracil nanoaggregates have been probed by core electron-photoemission measurements to investigate supramolecular assembly in the gas phase driven by weak interactions. The interpretation of the measurements has been assisted by multilevel atomistic simulations, based on semi-empirical tight-binding and DFT-based methods. Our protocol established a positive-feedback loop between experimental and computational techniques, which has enabled a sound and detailed atomistic description of such complex heterogeneous molecular aggregates. Read More

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Metabolic Differentiation of Co-occurring Accumulibacter Clades Revealed through Genome-Resolved Metatranscriptomics.

mSystems 2021 Jul 6:e0047421. Epub 2021 Jul 6.

Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Natural microbial communities consist of closely related taxa that may exhibit phenotypic differences and inhabit distinct niches. However, connecting genetic diversity to ecological properties remains a challenge in microbial ecology due to the lack of pure cultures across the microbial tree of life. " Accumulibacter phosphatis" (Accumulibacter) is a polyphosphate-accumulating organism that contributes to the enhanced biological phosphorus removal (EBPR) biotechnological process for removing excess phosphorus from wastewater and preventing eutrophication from downstream receiving waters. Read More

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A prospective study of carcinoid crisis with no perioperative octreotide.

Surgery 2021 Jul 3. Epub 2021 Jul 3.

Division of Surgical Oncology, Department of Surgery, Oregon Health & Science University, Portland, OR. Electronic address:

Background: Carcinoid crises, defined as the sudden onset of hemodynamic instability in patients with neuroendocrine tumors undergoing operation, are associated with significantly increased risk of postoperative complications. Octreotide has been used prophylactically to reduce crisis rates as well as therapeutically to treat crises that still occur. However, studies using octreotide still report crisis rates of 3. Read More

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AAPM Task Group 241: A medical physicist's guide to MRI-guided focused ultrasound body systems.

Med Phys 2021 Jul 5. Epub 2021 Jul 5.

National Cancer Institute, National Institutes of Health, Rockville, MD, USA.

Magnetic resonance-guided focused ultrasound (MRgFUS) is a completely non-invasive technology that has been approved by FDA to treat several diseases. This report, prepared by the American Association of Physicist in Medicine (AAPM) Task Group 241, provides background on MRgFUS technology with a focus on clinical body MRgFUS systems. The report addresses the issues of interest to the medical physics community, specific to the body MRgFUS system configuration, and provides recommendations on how to successfully implement and maintain a clinical MRgFUS program. Read More

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Persistent symptoms in adult patients one year after COVID-19: a prospective cohort study.

Clin Infect Dis 2021 Jul 5. Epub 2021 Jul 5.

Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, Germany.

Background: Long COVID is defined as the persistence of symptoms beyond 3 months after SARS-CoV-2 infection. To better understand the long-term course and etiology of symptoms we analyzed a cohort of COVID-19 patients prospectively.

Methods: Patients were included at 5 months after acute COVID-19 in this prospective, non-interventional follow-up study. Read More

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Clinical outcome of endoscopic therapy in patients with symptomatic pancreas divisum: a Dutch cohort study.

Endosc Int Open 2021 Jul 21;9(7):E1164-E1170. Epub 2021 Jun 21.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

Although the majority of patients with pancreas divisum (PDiv) are asymptomatic, a subgroup present with recurrent pancreatitis or pain for which endoscopic therapy may be indicated. The aim of this study was to evaluate success rates and long-term outcomes of endoscopic treatment in patients with symptomatic PDiv. A multicenter, retrospective cohort study was performed. Read More

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The Impact of Radiotherapy in Children and Adolescents with Metastatic Rhabdomyosarcoma.

Int J Radiat Oncol Biol Phys 2021 Jul 1. Epub 2021 Jul 1.

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands; Department of Pediatric Oncology, Emma Children's Hospital-Academic Medical Center (EKZ-AMC), Amsterdam, The Netherlands.

Purpose: There is limited evidence to define the role of radiotherapy in children with metastatic rhabdomyosarcoma (mRMS). In the international XXXX study, children with mRMS or non-RMS soft tissue sarcoma were randomized to receive standard chemotherapy with/without bevacizumab, with radiotherapy recommended to all disease sites after chemotherapy cycle 6. We retrospectively evaluated the impact of radiotherapy on survival in the mRMS cohort. Read More

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[Establishment of chromatographic fingerprint of and its applications in animal source identification and quality grade discrimination].

Se Pu 2020 Dec;38(12):1440-1448

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

, or "Chuanshanjia" in Chinese, is a traditional Chinese medicine (TCM) for promoting blood circulation and reducing swelling and discharge; the only animal source used in TCM is the scales of . However, in today's pharmaceutical market, there are many scales from other species of the same genus that are difficult to distinguish from . High-quality and low-quality scales are also severely confused. Read More

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December 2020

Resolution of Idiopathic Epidural Lipomatosis after Bariatric Surgery: Case Report and Literature Review.

Asian J Neurosurg 2021 Jan-Mar;16(1):217-220. Epub 2021 Feb 23.

Department of Spine Surgery, Specialist Terrefort Clinic, Bruges, France.

Spinal epidural lipomatosis (SEL) is traditionally a rare disorder defined as an abnormal accumulation of unencapsulated epidural fat. SEL can be classified into idiopathic and secondary. We report a 46-year-old obese male with idiopathic epidural lipomatosis with a clinical picture of bilateral L5 and S1 radiculopathy, with an L5 and S1 distribution. Read More

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February 2021