22,252 results match your criteria completed min


Impact of Pharmacologically Left Shifting the Oxygen-Hemoglobin Dissociation Curve on Arterial Blood Gases and Pulmonary Gas Exchange During Maximal Exercise in Hypoxia.

High Alt Med Biol 2021 Jun 21. Epub 2021 Jun 21.

Human Integrative and Environmental Physiology Laboratory, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA.

Stewart, Glenn M., Troy J. Cross, Michael J. Read More

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Talent Identification in Youth Soccer: Prognosis of U17 Soccer Performance on the Basis of General Athleticism and Talent Promotion Interventions in Second-Grade Children.

Front Sports Act Living 2021 4;3:625645. Epub 2021 Jun 4.

Department of Training and Movement Science, Institute of Sport Science, University of Bayreuth, Bayreuth, Germany.

Several talent identification programs in elementary school have implemented motor diagnostics to introduce children to groups of sports, like game sports, or even to particular sports like soccer. However, as in most other sports, in youth soccer, the predictive value of such early testing is still unclear. This prospective study evaluated the midterm prognostic validity of generic motor performance tests. Read More

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Implementing the physical activity vital sign in an academic preventive cardiology clinic.

Prev Med Rep 2021 Sep 2;23:101435. Epub 2021 Jun 2.

University of Massachusetts, Amherst, Amherst, MA 01003, United States.

The aims were to implement physical activity (PA) screening as part of the electronic kiosk check-in process in an adult preventive cardiology clinic and assess factors related to patients' self-reported PA. The 3-question physical activity vital sign (PAVS) was embedded in the Epic electronic medical record and included how many days, minutes and intensity (light, moderate, vigorous) of PA patients conducted on average. This is a data analysis of PAVS data over a 60-day period. Read More

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September 2021

The effects of hemsball on the motor proficiency of students with intellectual disabilities.

Int J Dev Disabil 2018 Oct 13;66(2):104-112. Epub 2018 Oct 13.

Sport Sciences Faculty, Gazi University, Ankara, Turkey.

The effects of hemsball game skills development program on the motor proficiency level of children in the 12-16 age group with mild and moderate intellectual disabilities (ID) have been examined in this study. A total of 50 (25 experimental group +25 control group) students, 23 of which had mild intellectual disabilities (ID) and 27 with moderate ID studying in special education classes in the schools in Afyonkarahisar province in Turkey participated in the study. While no training was given to the control group, the students in the experimental group were subjected to 60 min of applications involving a basic hemsball training program per day for 3 days per week throughout 12 weeks. Read More

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October 2018

Treatment of Moral Injury in U.S. Veterans with PTSD Using a Structured Chaplain Intervention.

J Relig Health 2021 Jun 20. Epub 2021 Jun 20.

Department of Psychiatry & Behavioral Sciences, Deparment of Medicine, Duke University School of Medicine, Durham, NC, USA.

Moral injury is a complex phenomenon characterized by spiritual, psychological, and moral distress caused by actions or acts of omission inconsistent with an individual's moral and ethical values. We present two cases from an ongoing randomized controlled trial of a spiritually integrated structured intervention delivered by chaplains for individuals suffering from moral injury. Chaplains met with Veterans for twelve 50-min sessions that each focused on a specific domain of moral injury. Read More

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Short-term heat acclimation preserves knee extensor torque but does not improve 20 km self-paced cycling performance in the heat.

Eur J Appl Physiol 2021 Jun 19. Epub 2021 Jun 19.

School of Exercise and Nutrition Sciences, Queensland University of Technology (QUT), Brisbane, Australia.

Purpose: This study investigated the effect of 5 days of heat acclimation training on neuromuscular function, intestinal damage, and 20 km cycling (20TT) performance in the heat.

Methods: Eight recreationally trained males completed two 5-day training blocks (cycling 60 min day at 50% peak power output) in a counter-balanced, cross-over design, with a 20TT completed before and after each block. Training was conducted in hot (HA: 34. Read More

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On-line screening of indoleamine 2,3-dioxygenase 1 inhibitors by partial filling capillary electrophoresis combined with rapid polarity switching.

J Chromatogr A 2021 Jun 17;1651:462305. Epub 2021 Jun 17.

Department of Pharmaceutical and Pharmacological Sciences, Pharmaceutical Analysis, KU Leuven - University of Leuven, Leuven, Belgium. Electronic address:

Indoleamine 2,3-dioxygenase 1 (IDO1) has been shown to play an important role in the immune escape process of tumors, and therefore is considered as a promising target for tumor immunotherapy. In this study, off-line and on-line capillary electrophoresis methods were developed for IDO1 inhibitors screening from natural product extracts. The optimized separation conditions of CE were achieved with 32 mM sodium tetraborate (pH 9. Read More

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Preference for the fixed-dose combination of pertuzumab and trastuzumab for subcutaneous injection in patients with HER2-positive early breast cancer (PHranceSCa): A randomised, open-label phase II study.

Eur J Cancer 2021 Jun 16;152:223-232. Epub 2021 Jun 16.

Clinic for Medical Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000, Belgrade, Serbia. Electronic address:

Aim: The aim of the study was to assess patient preference for the fixed-dose combination of pertuzumab and trastuzumab for subcutaneous injection (PH FDC SC) in patients with HER2-positive early breast cancer in PHranceSCa (NCT03674112).

Materials And Methods: Patients who completed neoadjuvant P + H + chemotherapy + surgery were randomised 1:1 to three intravenous (IV) P + H cycles followed by three cycles of PH FDC SC or vice versa (crossover) and then chose subcutaneous (SC) injection or IV infusion to continue up to 18 cycles (continuation). Assessments were via patient and healthcare professional (HCP) questionnaires. Read More

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Trimethoprim/sulfamethoxazole for nocardiosis in solid organ transplant recipients: real-life data from a multicentre retrospective study.

Transpl Infect Dis 2021 Jun 18:e13669. Epub 2021 Jun 18.

Service de Microbiologie, Unité Mobile d'Infectiologie, AP-HP, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015, Paris, France.

Background: Little is known regarding the optimal management of nocardiosis among solid organ transplant (SOT) recipients. It is often suggested to avoid trimethoprim/sulfamethoxazole (TMP-SMX) monotherapy in heavily immunocompromised patients (such as SOT recipients) and/or in case of severe or disseminated nocardiosis. Our aim was to report our experience with TMP-SMX monotherapy in SOT recipients with nocardiosis. Read More

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The ramp and all-out exercise test to determine critical power: validity and robustness to manipulations in body position.

Eur J Appl Physiol 2021 Jun 18. Epub 2021 Jun 18.

School of Health Sciences, Liverpool Hope University, Liverpool, UK.

Purpose: The purpose of the present study was to determine whether a contiguous ramp and all-out exercise test could accurately determine critical power (CP) in a single laboratory visit during both upright and supine cycle exercise.

Methods: Healthy males completed maximal ramp-incremental exercise on a cycle ergometer in the upright (n = 15) and supine positions (n = 8), with task failure immediately followed by a 3-min all-out phase for determination of end-test power (EP). On separate days, participants undertook four constant-power tests in either the upright or supine positions with the limit of tolerance ranging from ~ 2 to 15 min for determination of CP. Read More

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A nurse-led, telehealth-driven hepatitis C management initiative in regional Victoria: Cascade of care from referral to cure.

J Telemed Telecare 2021 Jun 18:1357633X211024108. Epub 2021 Jun 18.

Department of Gastroenterology, Eastern Health, Australia.

Introduction: Elimination of hepatitis C virus stands as an unresolved World Health Organization target, and is associated with complications including cirrhosis and hepatocellular carcinoma. Hepatitis C virus management has been revolutionised following the widespread availability of direct-acting antiviral agents in Australia since 2016; however, large proportions of the population remain untreated. Telehealth-based service delivery is an accessible and effective alternative, and we aimed to assess qualitative and clinical outcomes in a clinical nurse consultant-led regional telehealth model. Read More

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Impact of Hypoxic Exercise Recovery on Skeletal Muscle Glycogen and Gene Expression.

High Alt Med Biol 2021 Jun 17. Epub 2021 Jun 17.

School of Integrative Physiology and Athletic Training, University of Montana, Missoula, Montana, USA.

Slivka, Dustin, Charles Dumke, Walter Hailes, and Brent Ruby. Impact of hypoxic exercise recovery on skeletal muscle glycogen and gene expression. 00:000-000, 2021. Read More

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Assessing Vocal Chanting as an Online Psychosocial Intervention.

Front Psychol 2021 1;12:647632. Epub 2021 Jun 1.

School of Psychological Sciences, Faculty of Medicine, Health, and Human Sciences, Macquarie University, Sydney, NSW, Australia.

The ancient practice of chanting typically takes place within a community as a part of a live ceremony or ritual. Research suggests that chanting leads to improved mood, reduced stress, and increased wellbeing. During the global pandemic, many chanting practices were moved online in order to adhere to social distancing recommendations. Read More

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The effects of hydration status and ice-water dousing on physiological and performance indices during a simulated soccer match in the heat.

J Sci Med Sport 2021 May 24. Epub 2021 May 24.

Korey Stringer Institute, Department of Kinesiology, University of Connecticut, USA.

Objectives: To assess the effects of hydration status and ice-water dousing on physiological and performance parameters.

Design: Randomized, crossover.

Methods: Twelve athletes (mean[M] ± standard deviation[SD]; age, 20 ± 1 years; height, 174 ± 8 cm; body mass, 72. Read More

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How long do mood induction procedure (MIP) primes really last? Implications for cognitive vulnerability research.

J Affect Disord 2021 May 26;292:328-336. Epub 2021 May 26.

Department of Psychology, Western University, London, Canada. Electronic address:

Background: Mood Induction Procedures (MIPs) are used widely in research on cognitive vulnerability to depression. Although empirical evidence supports certain MIPs as effective, little research has evaluated whether MIP-induced sad moods are sufficiently persistent. This study aimed to determine (1) how long an MIP-induced mood lasts according to commonly used operational definitions and (2) whether these findings vary according to the type of MIP used. Read More

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Acute caffeine ingestion improves 3-km run performance, cognitive function, and psychological state of young recreational runners.

Pharmacol Biochem Behav 2021 Jun 15;207:173219. Epub 2021 Jun 15.

Laboratory of Pharmacology, UR12 ES13, Faculty of Medicine, University of Sfax, Tunisia.

The current study aimed to assess the effects of caffeine administration on performance time, cognition, psychomotor state, and blood levels of oxidative stress markers following a 3-km run competition. Thirteen recreational runners performed two test sessions in a double-blind randomized order after placebo or 3 mg/kg of body mass of caffeine. At each session, subjects completed a 3-km running competition around a 400 m outdoor athletics track. Read More

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Renoprotective Effect of the Mineralocorticoid Receptor Antagonist Esaxerenone.

Circ Rep 2021 May 12;3(6):333-337. Epub 2021 May 12.

Second Department of Internal Medicine, University of Toyama Toyama Japan.

The effects of mineralocorticoid receptor antagonists, including the newly introduced esaxerenone, on renal function remain uncertain. This retrospective study was performed on patients who received esaxerenone for resistant hypertension between November 2019 and June 2020. Trends in the estimated glomerular filtration rate (eGFR) were compared between the 6-month period before esaxerenone treatment (pre-treatment period) and the 6-month treatment period on esaxerenone. Read More

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Effect of a Probiotic Combination in an Experimental Mouse Model and Clinical Patients With Chronic Kidney Disease: A Pilot Study.

Front Nutr 2021 31;8:661794. Epub 2021 May 31.

Department of Pediatrics, National Cheng Kung University Hospital, Tainan, Taiwan.

The aim of the present study was to evaluate whether probiotic administration could slow declining renal function. C57BL/6 mice (6-8 weeks of age, male) were fed a diet supplemented with adenine to induce chronic kidney disease (CKD). The experimental groups were additionally supplemented with 10 colony-forming units (CFU)/day (high-dose) and 10 CFU/day (low-dose) probiotics containing (TYCA06), subspecies (BLI-02), and (VDD088). Read More

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Rapid and sensitive detection of potato cyst nematode by loop-mediated isothermal amplification assay.

3 Biotech 2021 Jun 24;11(6):294. Epub 2021 May 24.

Division of Nematology, ICAR-Indian Agricultural Research Institute, New Delhi, 110012 India.

Cyst nematodes of the species and are devastating parasites of the potato crop. Early detection of cyst nematodes in the field is critical for adopting an appropriate management strategy. A specific and sensitive loop-mediated isothermal amplification (LAMP) assay using four oligonucleotide primers has been developed to amplify the internal transcribed spacer region (ITS) of ribosomal DNA of potato cyst nematode The PCN-LAMP reaction could be completed within 75 min at 68 °C followed by termination at 85 °C for 7 min. Read More

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The feasibility and technical strategy of a fascia space priority approach in laparoscopic lateral lymph node dissection for advanced middle and low rectal cancer: a retrospective multicentre study.

Wideochir Inne Tech Maloinwazyjne 2021 Jun 9;16(2):312-320. Epub 2021 Apr 9.

Department of Colorectal Surgery, Tianjin Union Medical Centre, Tianjin, China.

Introduction: Laparoscopic lateral lymph node dissection (LLND) is an important treatment for patients with lateral lymph node metastasis.

Aim: To assess the technical feasibility and investigate the surgical outcomes after LLND using the fascia space priority approach for patients with advanced middle and low rectal cancer.

Material And Methods: Consecutive patients undergoing laparoscopic LLND using the fascia space priority approach from June 2017 to June 2020 were identified from 12 medical centres in mainland China. Read More

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Gum chewing while walking increases walking distance and energy expenditure: A randomized, single-blind, controlled, cross-over study.

J Exerc Sci Fit 2021 Jul 7;19(3):189-194. Epub 2021 May 7.

Faculty of Sport Sciences, Waseda University, Saitama, Japan.

Background/objective: Gum chewing while walking increases walking distance and energy expenditure in middle-aged male and female individuals. This study aimed to examine the effects of gum chewing while walking on walking distance and energy metabolism in male and female individuals of various age groups.

Methods: Fifty participants (25 male and 25 female individuals) aged 22-69 years completed two trials in a random order. Read More

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Association Between Postoperative Long-Term Heart Rate Variability and Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery: A Prospective Cohort Study.

Front Aging Neurosci 2021 31;13:646253. Epub 2021 May 31.

Department of Anesthesiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Background: Postoperative delirium (POD) is a common complication after orthopedic surgery in elderly patients. The elderly may experience drastic changes in autonomic nervous system (ANS) activity and circadian rhythm disorders after surgery. Therefore, we intend to explore the relationship between postoperative long-term heart rate (HR) variability (HRV), as a measure of ANS activity and circadian rhythm, and occurrence of POD in elderly patients. Read More

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Repeated Exposure to Illusory Sense of Body Ownership and Agency Over a Moving Virtual Body Improves Executive Functioning and Increases Prefrontal Cortex Activity in the Elderly.

Front Hum Neurosci 2021 31;15:674326. Epub 2021 May 31.

Department of Advanced Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

We previously showed that the illusory sense of ownership and agency over a moving body in immersive virtual reality (displayed in a first-person perspective) can trigger subjective and physiological reactions on the real subject's body and, therefore, an acute improvement of cognitive functions after a single session of high-intensity intermittent exercise performed exclusively by one's own virtual body, similar to what happens when we actually do physical activity. As well as confirming previous results, here, we aimed at finding in the elderly an increased improvement after a longer virtual training with similar characteristics. Forty-two healthy older subjects (28 females, average age = 71. Read More

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Joint association of physical activity and sleep difficulties with the incidence of hypertension in mid-age Australian women.

Maturitas 2021 Jul 18;149:1-7. Epub 2021 Apr 18.

School of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, QLD 4072, Australia.

Introduction: Little is known about the joint effects of physical activity and sleep difficulties on hypertension. The aim of this study was to examine the joint associations of physical activity and sleep difficulties with the incidence of hypertension in mid-aged women.

Study Design: Prospective cohort study. Read More

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Carotid body chemosensitivity is not attenuated during cold water diving.

Am J Physiol Regul Integr Comp Physiol 2021 06 16. Epub 2021 Jun 16.

Center for Research and Education in Special Environments, University at Buffalo, State University of New York, Buffalo, NY, United States.

Introduction: Tonic carotid body (CB) activity is reduced during exposure to cold and hyperoxia. We tested the hypotheses that cold water diving lowers CB chemosensitivity and augments CO retention more than thermoneutral diving.

Methods: Thirteen subjects (age: 26±4 y; BMI: 26±2 kg/m) completed two, four-hour head out water immersion protocols in a hyperbaric chamber (1. Read More

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A Health Technician-delivered Brief Intervention linked to AUDIT for reduction of alcohol use in Chilean primary care: a randomized controlled trial.

Addict Sci Clin Pract 2021 06 15;16(1):39. Epub 2021 Jun 15.

School of Medicine, Department of Public Health, Pontificia Universidad Católica de Chile, Alameda 340, 8331150, Santiago, Chile.

Background: Because of the shortage of health professionals in Chilean primary care, Health Technicians (HT) are providing Brief Interventions (BI) for risky alcohol consumption. We compared the efficacy of two AUDIT-linked interventions provided by HTs: an informative leaflet and a BI plus leaflet.

Methods: This is a parallel-group randomized controlled trial with 1:1 randomization. Read More

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Rapid and specific detection of apple chlorotic leaf spot virus in pear by reverse-transcription recombinase polymerase amplification.

Acta Virol 2021 ;65(2):237-241

Apple chlorotic leaf spot virus (ACLSV) is an important virus infecting fruit trees. It causes serious economic losses in the global production of fruit trees belonging to the genera Prunus and Malus and can be vegetatively transmitted during propagation. In this study, an isothermal reverse transcription-recombinase polymerase amplification (RT-RPA) assay method was developed for detecting ACLSV in pear leaves. Read More

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Effect of morning versus evening exercise training on sleep, physical activity, fitness, fatigue and quality of life in overweight and obese adults.

Chronobiol Int 2021 Jun 15:1-12. Epub 2021 Jun 15.

Laboratory Physical Activity Impact on Health (IAPS), Toulon University, Toulon, France.

This study compares the effectiveness of a 12-week moderate exercise training program (METP), performed in the morning versus the evening, on sleep, physical activity, physical fitness, sleepiness, fatigue and health-related quality of life (HRQoL) in overweight and obese patients. Sedentary and inactive overweight/obese adults (n = 36) were included in METP and randomized into two groups: morning group (GM) and evening group (GE). Twenty-eight participants successfully completed METP (3 × 90 min exercise session per week for 12 weeks, completion rates >80%). Read More

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Evaluating the Feasibility and Acceptability of the Lifestyle Enhancement for ADHD Program.

J Pediatr Psychol 2021 Jun 12. Epub 2021 Jun 12.

Seattle Children's Research Institute, USA.

Objective : To evaluate the feasibility and acceptability of the Lifestyle Enhancement for Attention Deficit Hyperactivity Disorder (ADHD) Program (LEAP), a novel parent behavior management training program that promotes physical activity (PA) and positive health behaviors and is enhanced with mobile health technology (Garmin) and a social media (Facebook) curriculum for parents of children with ADHD.

Methods : The study included parents of children ages 5-10 years diagnosed with ADHD who did not engage in the recommended >60 min/day of moderate to vigorous PA based on parent report at baseline. Parents participated in the 8-week LEAP group and joined a private Facebook group. Read More

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Embedding supervised exercise training for men on androgen deprivation therapy into standard prostate cancer care: a feasibility and acceptability study (the STAMINA trial).

Sci Rep 2021 06 14;11(1):12470. Epub 2021 Jun 14.

Allied Health Professionals, Radiotherapy and Oncology, Sheffield Hallam University, Sheffield, UK.

Lifestyle interventions involving exercise training offset the adverse effects of androgen deprivation therapy in men with prostate cancer. Yet provision of integrated exercise pathways in cancer care is sparse. This study assessed the feasibility and acceptability of an embedded supervised exercise training intervention into standard prostate cancer care in a single-arm, multicentre prospective cohort study. Read More

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