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High-Dose Compared With Standard-Dose Oxytocin Regimens to Augment Labor in Nulliparous Women: A Randomized Controlled Trial.

Obstet Gynecol 2021 May 6. Epub 2021 May 6.

Yale School of Medicine, New Haven, Connecticut; Northwestern University Feinberg School of Medicine, Northwestern University, and Northwestern Memorial Hospital, Chicago, Illinois; and the University of California, San Francisco, San Francisco, California.

Objective: To evaluate whether a high-dose oxytocin regimen reduces the risk for primary cesarean birth and other obstetric morbidities when compared with standard dosing.

Methods: In a double-blind randomized clinical trial of nulliparous women at or beyond 36 weeks of gestation who were undergoing augmentation of labor, participants were assigned to high-dose (initial and incremental rates of 6 milliunits/min) or standard-dose (initial and incremental rates of 2 milliunits/min) oxytocin regimens. The primary outcome was cesarean birth. Read More

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Conjugate evaluation of sustainable carrying capacity of urban agglomeration and multi-scenario policy regulation.

Sci Total Environ 2021 Apr 28;785:147373. Epub 2021 Apr 28.

College of Resources and Environmental Science, Xinjiang University, Urumqi 830046, China.

The scientific evaluation of carrying capacity and the formulation of adaptive regulation policies are powerful ways to achieve sustainable development goals. In order to quantitatively and accurately diagnose the sustainable development state of urban agglomeration, this paper responds to the "Future Earth" framework; takes the carrying capacity as the breakthrough point; embeds the conjugate thought; considers the elements of the resources, the environment, the ecology, and the development; and establishes the conjugate evaluation model and the evaluation index system of sustainable carrying capacity. In order to solve the actual bottleneck problem of urban agglomeration, this work identifies the key obstacle factors, constructs the multi-scenario dynamic coupling (MSDC) model, recognizes the sensitivity policies, and proposes the adaptive regulation polices. Read More

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Majewski/Microcephalic Osteodysplastic Primordial Dwarfism Type II (MOPDII) with generalised microdontia in the 4th millennium BCE Eastern Mediterranean.

Int J Paleopathol 2021 May 3;33:158-169. Epub 2021 May 3.

Science and Technology in Archaeology and Culture Research Center (STARC), The Cyprus Institute (CyI), Konstantinou Kavafi St, 2121, Aglantzia, Nicosia, Cyprus.

Objective: This research evaluates the occurrence of generalised microdontia and proportionate osteodysplasia in human remains from a Chalcolithic cemetery with early evidence of metalworking in Cyprus (Souskiou-Laona; 3500-2800 BCE).

Materials: Skeletal and dental remains from Tomb 236 Individual A, in comparison with other human remains from Souskiou-Laona (MNI: 203).

Methods: Macroscopic, microscopic, and metric observation of osteodysplasia and microdontia. Read More

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Metanalysis of alloplastic materials versus autologous fat for injection augmentation pharyngoplasty treatment of velopharyngeal insufficiency.

Int J Pediatr Otorhinolaryngol 2021 Apr 28;146:110738. Epub 2021 Apr 28.

Tufts Medical Center, Boston, MA, USA.

Background: Velopharyngeal insufficiency (VPI) can cause resonance, speech and feeding problems. While reconstructive palatoplasty and surgical pharyngoplasty techniques are the mainstay of treatment for severe VPI, injection augmentation pharyngoplasty offers a minimally invasive approach in patients with mild-to-moderate VPI.

Methods: We conducted a systematic review of the literature available on PubMed and Embase from 1990 to 2019 including studies that addressed VPI, incompetence, or dysfunction managed with injection augmentation. Read More

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Guillain-Barré syndrome associated with SARS-CoV-2 infection: A case report with long term follow up.

J Neuroimmunol 2021 Apr 28;356:577590. Epub 2021 Apr 28.

Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, icddr,b, Dhaka 1212, Bangladesh. Electronic address:

A 50-years old male presented with quadriplegia and paresthesia and was diagnosed as Guillain-Barré syndrome (GBS). He was found positive for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) six weeks prior to the onset of weakness. GBS disability score was 4. Read More

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Genome-wide comparison of coronaviruses derived from veterinary animals: A canine and feline perspective.

Comp Immunol Microbiol Infect Dis 2021 Apr 24;76:101654. Epub 2021 Apr 24.

NTT High-Tech Institute, Nguyen Tat Thanh University, 298-300A Nguyen Tat Thanh Street, Ward 13, District 4, Ho Chi Minh City 700000, Viet Nam. Electronic address:

Feline- and canine-derived coronaviruses (FCoVs and CCoVs) are widespread among dog and cat populations. This study was to understand the route of disease origin and viral transmission in veterinary animals and in human through comparative pan-genomic analysis of coronavirus sequences, especially retrieved from genomes of FCoV and CCoV. Average nucleotide identity based on complete genomes might clustered CoV strains according to their infected host, with an exception of type II of CCoV (accession number KC175339) that was clustered closely to virulent FCoVs. Read More

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Coil assisted glue embolization to improve safety and accuracy in endovascular management of Vein of Galen patients.

Clin Neurol Neurosurg 2021 Apr 21;205:106652. Epub 2021 Apr 21.

Army Hospital (Referral & Research), Delhi Cantt, New Delhi 110010, India. Electronic address:

Background: Vein of Galen malformation (VOGM) patients present in neonatal age with cardiac failure or significant neurologic consequences. The most established method of treatment has been transarterial embolization with high concentration glue (N-Butyl Cyano Acrylate) which may be difficult to control due to very high flow rates and may migrate to the venous side with undesirable consequences. We describe our experience in four patients in whom initial coil placement in prominent feeding arteries helped inflow reduction thereby facilitating controlled glue injection with a good result and no incidence of non-target embolization. Read More

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Post-surgery cholesteatoma complicated by facial nerve paralysis: A case report from Afghanistan.

Int J Surg Case Rep 2021 Apr 28;82:105916. Epub 2021 Apr 28.

Medical Research Center, Kateb University, Kabul, Afghanistan. Electronic address:

Introduction: Cholesteatoma is a benign tumoral lesion of squamous epithelial cells in middle ear that can exist as congenital or acquired forms.

Presentation Of Cases: A 35-year-old housewife presented to ENT clinic of a private hospital in Kabul, Afghanistan, with a complete facial nerve paralysis in the right side. In her antecedents, there is a tympanomastoidectomy due to chronic middle ear infection. Read More

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Autoencoder networks extract latent variables and encode these variables in their connectomes.

Neural Netw 2021 Mar 24;141:330-343. Epub 2021 Mar 24.

Applied Mathematics Department, University of Washington, Seattle, WA, United States of America; Computational Neuroscience Center, University of Washington, Seattle, WA, United States of America; Allen Institute for Brain Science, Seattle, WA, United States of America.

Advances in electron microscopy and data processing techniques are leading to increasingly large and complete microscale connectomes. At the same time, advances in artificial neural networks have produced model systems that perform comparably rich computations with perfectly specified connectivity. This raises an exciting scientific opportunity for the study of both biological and artificial neural networks: to infer the underlying circuit function from the structure of its connectivity. Read More

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A simplified cluster model and a tool adapted for collaborative labeling of lung cancer CT scans.

Comput Methods Programs Biomed 2021 Apr 18;206:106111. Epub 2021 Apr 18.

Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department, Petrovka str., 24, Moscow, 127051, Russia; Federal Research Center "Computer Science and Control" of Russian Academy of Sciences, Vavilova str., 44/2, Moscow, 119333, Russia. Electronic address:

Background And Objective: Lung cancer is the most common type of cancer with a high mortality rate. Early detection using medical imaging is critically important for the long-term survival of the patients. Computer-aided diagnosis (CAD) tools can potentially reduce the number of incorrect interpretations of medical image data by radiologists. Read More

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Lymphoid markers predict prognosis of pediatric and adolescent acute myeloid leukemia.

Leuk Res 2021 Apr 30;107:106603. Epub 2021 Apr 30.

Laboratory of Clinical and Experimental Immunology, Healthy and Life Science School Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address:

Acute Myeloid Leukemia (AML) is a complex and highly aggressive disease. To characterize the prognostic factors of pediatric patients with AML relapse, a retrospective cohort study was performed to collect data from children and adolescents, at a hematological oncology reference center, over 11 years. We selected 51 cases of the disease, diagnosed and treated uniformly, divided into two groups: with complete remission (n = 33; 65 %) and with relapse (n = 18; 35 %). Read More

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Pretreatment whole blood Epstein-Barr virus DNA predicts prognosis in Hodgkin lymphoma.

Leuk Res 2021 Apr 30;107:106607. Epub 2021 Apr 30.

Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, 210029, China; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing 210029, China. Electronic address:

The study investigated pretreatment Epstein-Barr virus (EBV) DNA status and its prognostic values in 96 patients newly diagnosed Hodgkin lymphoma (HL). With 13.5 % patients in positive EBV DNA status before therapy, the positive group had inferior progression-free survival (PFS) (P = 0. Read More

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Good treatment-free survival of monoclonal gammopathy of undetermined significance associated pure red cell aplasia after bortezomib plus dexamethasone.

Blood Cells Mol Dis 2021 Apr 27;89:102573. Epub 2021 Apr 27.

Regenerative Medicine Clinic, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China. Electronic address:

Pure red cell aplasia (PRCA) is a rare syndrome characterized by severe anemia and absence of erythroid precursors. PRCA associated to monoclonal gammopathy of undetermined significance (MGUS) is a scarce condition with less than five cases reported so far. There is no agreement on the treatment of MGUS associated PRCA and treatment- free survival (TFS) is an unmet clinical need. Read More

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A novel Ventricular map of Electrograms DUration as a Method to identify areas of slow conduction for ventricular tachycardia ablation. The VEDUM pilot study.

Heart Rhythm 2021 May 3. Epub 2021 May 3.

Arrhythmology Unit, Ospedale San Giovanni Calibita, Fatebenefratelli Isola Tiberina, Rome, Italy.

Background: Bipolar EGM duration is indicative of local activation property and, if prolonged, is useful to discover areas of slow conduction favoring arrhythmias.

Objective: This study aimed to create a map of EGM duration during the VT (VEDUM Map) to verify if the area with the slowest activation is crucial for reentry and could represent a suitable target for rapid VT interruption during ablation.

Methods: Prospectively 30 patients (pts) were enrolled for this study. Read More

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Genomic insights of optrA carrying linezolid resistant Enterococcus faecium using hybrid assembly: First report from India: optrA harbouring linezolid resistant VRE.

J Glob Antimicrob Resist 2021 May 3. Epub 2021 May 3.

Department of Clinical Microbiology, Christian Medical College, Vellore, India.

Objectives: Linezolid resistance in Enterococcus faecium is emerging across the world. In this study, we aimed to characterise two linezolid resistant E. faecium isolates using whole genome sequencing. Read More

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Natural History and Disease Impact of Rome IV versus Rome III Irritable Bowel Syndrome: A Longitudinal Follow-up Study.

Clin Gastroenterol Hepatol 2021 May 3. Epub 2021 May 3.

Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK; Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK. Electronic address:

Objectives: Irritable bowel syndrome (IBS) is a chronic functional bowel disorder diagnosed using the Rome criteria, which have evolved since their original description 30 years ago. Little is known about the effects on the natural history of IBS of moving to the latest iteration, Rome IV, from the previous Rome III criteria. We conducted a 12-month longitudinal follow-up study examining this. Read More

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Effects of porosity on drug release kinetics of swellable and erodible porous pharmaceutical solid dosage forms fabricated by hot melt droplet deposition 3D printing.

Int J Pharm 2021 Apr 29:120626. Epub 2021 Apr 29.

School of Pharmacy, University of East Anglia, Norwich, NR4 7TJ, United Kingdom. Electronic address:

3D printing has the unique ability to produce porous pharmaceutical solid dosage forms on-demand. Although using porosity to alter drug release kinetics has been proposed in the literature, the effects of porosity on the swellable and erodible porous solid dosage forms have not been explored. This study used a model formulation containing hypromellose acetate succinate (HPMCAS), polyethylene oxide (PEO) and paracetamol and a newly developed hot melt droplet deposition 3D printing method, Arburg plastic free-forming (APF), to examine the porosity effects on in vitro drug release. Read More

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Interaction of NHE1 and TRPA1 activity in DRG neurons isolated from adult rats and its role in inflammatory nociception.

Neuroscience 2021 May 3. Epub 2021 May 3.

Departamento de Farmacobiología, Cinvestav, South Campus. Mexico City, Mexico. Electronic address:

Transient receptor potential ankyrin 1 (TRPA1) channel is expressed in a subset of nociceptive neurons. This channel integrates several nociceptive signals. Particularly, it is modulated by intracellular pH (pH). Read More

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An enrichment method for capturing mumps virus whole genome sequences directly from clinical specimens.

J Virol Methods 2021 May 3:114176. Epub 2021 May 3.

Department of Medical Microbiology and Infectious Diseases, Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada. Electronic address:

Recently there has been a significant increase in the number of mumps outbreaks occurring in highly vaccinated populations. These outbreaks are often due to a mumps genotype G virus, where sequencing of the SH gene does not reveal enough genetic diversity to sufficient to resolve outbreaks. This has elevated the need to be able to sequence complete mumps viruses from clinical samples without laborious methods. Read More

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Regenerated interneurons integrate into locomotor circuitry following spinal cord injury.

Exp Neurol 2021 May 3:113737. Epub 2021 May 3.

Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT 84112, USA. Electronic address:

Whereas humans and other adult mammals lack the ability to regain locomotor function after spinal cord injury, zebrafish are able to recover swimming behavior even after complete spinal cord transection. We have previously shown that zebrafish larvae regenerate lost spinal cord neurons within 9 days post-injury (dpi), but it is unknown whether these neurons are physiologically active or integrate into functional circuitry. Here we show that genetically defined premotor interneurons are regenerated in injured spinal cord segments as functional recovery begins. Read More

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Comparative assessment of interventions for treating cutaneous leishmaniasis: A network meta-analysis of randomized clinical trials.

Acta Trop 2021 May 3:105944. Epub 2021 May 3.

Dental Training Department, Ministry of Health, Manama, Kingdom of Bahrain.

Introduction: Various interventions including laser therapy, heat therapy, and several drugs have been trialed in patients with cutaneous leishmaniasis. Due to the lack of an evidence-based comparison of all these interventions, we carried out the present network meta-analysis.

Methods: Electronic databases were searched for randomized clinical trials evaluating the efficacy and safety of any interventions in patients with cutaneous leishmaniasis. Read More

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Comparing verbal and aided single sentence productions in Malayalam-speaking adults with aphasia: a preliminary investigation.

Clin Linguist Phon 2020 Dec 2:1-24. Epub 2020 Dec 2.

Department of Speech-Language Pathology, All India Institute of Speech and Hearing, Mysuru, Karnataka, India.

The primary aim of the study was to investigate the semantic and syntactic aspects of verbal and aided single sentence productions in adults with aphasia and neurotypical adults to determine which mode allowed the exchange of information more effectively. The participants of this study included 20 adults with aphasia and 20 neurotypical adults who were native speakers of Malayalam, an Indo-Dravidian language spoken in the south-western state of Kerala in India. Thirteen action picture stimuli were constructed to elicit single sentences. Read More

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December 2020

Combined Endovascular and Microsurgical Management of a Tentorial Arteriovenous Malformation in a Hybrid Neurovascular Operating Room: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 May 6. Epub 2021 May 6.

Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Tentorial margin arteriovenous malformations (AVMs) at the cerebello-mesencephalic fissure are deep lesions, which can be safely resected via a lateral supracerebellar infratentorial approach. This video illustrates the case of a patient who presented with hemorrhage from a tentorial AVM. He was managed in the hybrid neurovascular operating room with Onyx (Medtronic) embolization of a superior cerebellar artery feeder followed by resection of the AVM, which included cerebellar relaxation from lumbar cerebrospinal fluid (CSF) drainage and lateral positioning. Read More

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A general strategy for semiconductor quantum dot production.

Nanoscale 2021 May 15;13(17):8004-8011. Epub 2021 Apr 15.

CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, P. R. China.

Mass production of semiconductor quantum dots (QDs) from bulk materials is highly desired but far from being satisfactory. Herein, we report a general strategy to mechanically tailor semiconductor bulk materials into QDs. Semiconductor bulk materials are routinely available via simple chemical precipitation. Read More

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Red List assessment of amphibian species of Ecuador: A multidimensional approach for their conservation.

PLoS One 2021 6;16(5):e0251027. Epub 2021 May 6.

Instituto Nacional de Biodiversidad, Casilla, Quito, Ecuador.

Ecuador is one of the most biodiverse countries in the world, but faces severe pressures and threats to its natural ecosystems. Numerous species have declined and require to be objectively evaluated and quantified, as a step towards the development of conservation strategies. Herein, we present an updated National Red List Assessment for amphibian species of Ecuador, with one of the most detailed and complete coverages for any Ecuadorian taxonomic group to date. Read More

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Instructor-led distance learning for training students in cardiopulmonary resuscitation: A randomized controlled study.

PLoS One 2021 6;16(5):e0251277. Epub 2021 May 6.

Department of Emergency Medicine, Dongtan Sacred Heart Hospital, Hallym University, Hwaseong-si, Gyeonggi-do, Republic of Korea.

Study Hypothesis: Cardiopulmonary resuscitation (CPR) training can increase the likelihood of patient survival and better neurological outcomes. However, conventional learning (CL) has cost, time, and space constraints. This study aimed to evaluate whether laypersons who completed instructor-led distance learning (DL) acquired a level of CPR skill comparable to that achieved via CL training. Read More

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Combining Global Positioning System (GPS) with saliva collection among sexual minority adults: A feasibility study.

PLoS One 2021 6;16(5):e0250333. Epub 2021 May 6.

HEALTH Research Institute, University of Houston, Houston, Texas, United States of America.

Background: This is the first study, of which we are aware, to evaluate the feasibility and accessibility of simultaneous use of Global Positioning System (GPS) and saliva collection for biomarker assessment as an objective measure of stress physiology among sexual minority (lesbian, gay, bisexual, queer, and other non-heterosexual identities) individuals. The principal motivation for pairing GPS and saliva collection was to investigate how characteristics of the built and social environments along with participants' daily activity paths affect stress. This can contribute to a better understanding of health and health behaviors in the sexual minority community. Read More

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MEDLINE search retrieval issues: A longitudinal query analysis of five vendor platforms.

PLoS One 2021 6;16(5):e0234221. Epub 2021 May 6.

School of Information Science, University of Kentucky, Lexington, Kentucky, United States of America.

This study compared the results of data collected from a longitudinal query analysis of the MEDLINE database hosted on multiple platforms that include PubMed, EBSCOHost, Ovid, ProQuest, and Web of Science. The goal was to identify variations among the search results on the platforms after controlling for search query syntax. We devised twenty-nine cases of search queries comprised of five semantically equivalent queries per case to search against the five MEDLINE database platforms. Read More

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Modelling optimal vaccination strategy for SARS-CoV-2 in the UK.

PLoS Comput Biol 2021 May 6;17(5):e1008849. Epub 2021 May 6.

The Zeeman Institute for Systems Biology & Infectious Disease Epidemiology Research, School of Life Sciences and Mathematics Institute, University of Warwick, Coventry, United Kingdom.

The COVID-19 outbreak has highlighted our vulnerability to novel infections. Faced with this threat and no effective treatment, in line with many other countries, the UK adopted enforced social distancing (lockdown) to reduce transmission-successfully reducing the reproductive number R below one. However, given the large pool of susceptible individuals that remain, complete relaxation of controls is likely to generate a substantial further outbreak. Read More

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