18,083 results match your criteria competitive interactions

Ferroptosis is involved in the progression of hepatocellular carcinoma through the circ0097009/miR-1261/SLC7A11 axis.

Ann Transl Med 2021 Apr;9(8):675

Department of Minimally Invasive Interventional Radiology, Liver Cancer Study and Service Group, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangzhou, China.

Background: Circular RNAs (circRNAs) are a class of non-coding RNAs that have been demonstrated to play important roles in tumorigenesis. However, how circRNAs regulate the progression of hepatocellular cancer (HCC) remains unclear.

Methods: In the present study, circRNA microarray analyses were performed with HCC tissues to identify circRNAs that are differentially expressed. Read More

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Related parameters of affinity and stability prediction of HLA-A*2402 restricted antigen peptides based on molecular docking.

Ann Transl Med 2021 Apr;9(8):673

Department of Oncology, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Background: Major histocompatibility complex class I (MHC-I) plays an important role in cell immune response, and stable interaction between polypeptides and MHC-I ensures efficient presentation of polypeptide-MHC-I (pMHC-I) molecular complexes to T cells. The aim of this study was to explore ways to improve the affinity and stability of the p-Human Leukocyte Antigen (HLA)-A*2402 complex.

Methods: The peptide sequences of the restricted antigen peptides for HLA-A*2402 and the results of the competitive binding test were retrieved from the literature. Read More

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Click-Coupling to Electrostatically Grafted Polymers Greatly Improves the Stability of a Continuous Monitoring Sensor with Single-Molecule Resolution.

ACS Sens 2021 May 14. Epub 2021 May 14.

Department of Applied Physics, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.

Sensing technologies for the real-time monitoring of biomolecules will allow studies of dynamic changes in biological systems and the development of control strategies based on measured responses. Here, we describe a molecular architecture and coupling process that allow continuous measurements of low-concentration biomolecules over long durations in a sensing technology with single-molecule resolution. The sensor is based on measuring temporal changes of the motion of particles upon binding and unbinding of analyte molecules. Read More

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Allelochemicals of Alexandrium minutum: Kinetics of membrane disruption and photosynthesis inhibition in a co-occurring diatom.

Harmful Algae 2021 Mar 18;103:101997. Epub 2021 Feb 18.

Institut de Biologie Physico-Chimique, Laboratory of Chloroplast Biology and Light Sensing in Microalgae, UMR 7141, Centre National de la Recherche Scientifique (CNRS), Sorbonne université, 75005 Paris, France. Electronic address:

Allelopathy is an efficient strategy by which some microalgae can outcompete other species. Allelochemicals from the toxic dinoflagellate Alexandrium minutum have deleterious effects on diatoms, inhibiting metabolism and photosynthesis and therefore give a competitive advantage to the dinoflagellate. The precise mechanisms of allelochemical interactions and the molecular target of allelochemicals remain however unknown. Read More

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Evaluating Disease Similarity Based on Gene Network Reconstruction and Representation.

Bioinformatics 2021 May 12. Epub 2021 May 12.

College of information and Computer Engineering, Northeast Forestry University, Harbin, 150004, China.

Motivation: Quantifying the associations between diseases is of great significance in increasing our understanding of disease biology, improving disease diagnosis, re-positioning, and developing drugs. Therefore, in recent years, the research of disease similarity has received a lot of attention in the field of bioinformatics. Previous work has shown that the combination of the ontology (such as disease ontology and gene ontology) and disease-gene interactions are worthy to be regarded to elucidate diseases and disease associations. Read More

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Exomer complex regulates protein traffic at the TGN through differential interactions with cargos and clathrin adaptor complexes.

FASEB J 2021 Jun;35(6):e21615

Instituto de Biología Funcional y Genómica (IBFG) and Departamento de Microbiología y Genética, CSIC-Universidad de Salamanca, Salamanca, Spain.

Protein sorting at the trans-Golgi network (TGN) usually requires the assistance of cargo adaptors. However, it remains to be examined how the same complex can mediate both the export and retention of different proteins or how sorting complexes interact among themselves. In Saccharomyces cerevisiae, the exomer complex is involved in the polarized transport of some proteins from the TGN to the plasma membrane (PM). Read More

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Photon management to reduce energy loss in perovskite solar cells.

Chem Soc Rev 2021 May 12. Epub 2021 May 12.

State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, People's Republic of China.

Despite the rapid development of perovskite solar cells (PSCs) over the past few years, the conversion of solar energy into electricity is not efficient enough or cost-competitive yet. The principal energy loss in the conversion of solar energy to electricity fundamentally originates from the non-absorption of low-energy photons ascribed to Shockley-Queisser limits and thermalization losses of high-energy photons. Enhancing the light-harvesting efficiency of the perovskite photoactive layer by developing efficient photo management strategies with functional materials and arrays remains a long-standing challenge. Read More

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Microbial Isolation and Characterization of New Antibiotic-Producing Strains from Decayed Wood.

Methods Mol Biol 2021 ;2296:43-57

INBIOTEC (Instituto de Biotecnología de León), León, Spain.

Microbial drug resistance is increasing over the last years, becoming one of the most important health concerns in the twenty-first century. It encourages the discovery of new antibiotics. Thus, novel antibiotics discovered by exploring different environments that previously have been left out of the scientific focus is a realistic opportunity. Read More

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January 2021

Fine-scale foraging behavior reveals differences in the functional roles of herbivorous reef fishes.

Ecol Evol 2021 May 18;11(9):4898-4908. Epub 2021 Mar 18.

ARC Centre of Excellence for Coral Reef Studies James Cook University Townsville QLD Australia.

Efforts to understand and protect ecosystem functioning have put considerable emphasis on classifying species according to the functions they perform. However, coarse classifications based on diet or feeding mode often oversimplify species' contributions to ecological processes. Behavioral variation among superficially similar species is easily missed but could indicate important differences in competitive interactions and the spatial scale at which species deliver their functions. Read More

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Divide and conquer: Multicolonial structure, nestmate recognition, and antagonistic behaviors in dense populations of the invasive ant .

Ecol Evol 2021 May 18;11(9):4874-4886. Epub 2021 Mar 18.

Department of Entomology Texas A&M University College Station TX USA.

The ecological success of ants has made them abundant in most environments, yet inter- and intraspecific competition usually limit nest density for a given population. Most invasive ant populations circumvent this limitation through a supercolonial structure, eliminating intraspecific competition through a loss of nestmate recognition and lack of aggression toward non-nestmates. Native to South America, has recently invaded many locations worldwide, with invasive populations described as extremely large and dense. Read More

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Male competition reverses female preference for male chemical cues.

Ecol Evol 2021 May 9;11(9):4532-4541. Epub 2021 Mar 9.

Mountain Lake Biological Station and Department of Biology University of Virginia Charlottesville VA USA.

Females must choose among potential mates with different phenotypes in a variety of social contexts. Many male traits are inherent and unchanging, but others are labile to social context. Competition, for example, can cause physiological changes that reflect recent wins and losses that fluctuate throughout time. Read More

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Identifying biotic drivers of population dynamics in a benthic-pelagic community.

Ecol Evol 2021 May 28;11(9):4035-4045. Epub 2021 Mar 28.

Environmental and Marine Biology Åbo Akademi University Turku Finland.

Benthic species and communities are linked to pelagic zooplankton through life-stages encompassing both benthic and pelagic habitats and through a mutual dependency on primary producers as a food source. Many zooplankton taxa contribute to the sedimentary system as benthic eggs. Our main aim was to investigate the nature of the population level biotic interactions between and within these two seemingly independent communities, both dependent on the pelagic primary production, while simultaneously accounting for environmental drivers (salinity, temperature, and oxygen conditions). Read More

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Evolution of Interbacterial Antagonism in Bee Gut Microbiota Reflects Host and Symbiont Diversification.

mSystems 2021 May 11;6(3). Epub 2021 May 11.

The University of Texas at Austin, Department of Integrative Biology, Austin, Texas, USA

Gram-negative bacteria frequently possess type VI secretion systems (T6SSs), protein complexes that are able to inject toxic proteins into nearby cells. Many aspects of T6SS structure and function have been characterized for model species, but less is known about the evolutionary processes that shape T6SS and effector (toxin) diversity in host-associated microbial communities. The bee gut microbiota is a simple community that has codiversified with bees for >80 million years. Read More

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Perennial groundcovers: an emerging technology for soil conservation and the sustainable intensification of agriculture.

Emerg Top Life Sci 2021 May 11. Epub 2021 May 11.

Iowa State University, Ames, IA 50011, U.S.A.

Integrating perennial groundcovers (PGC) - sometimes referred to as living mulches or perennial cover crops - into annual cash-crop systems could address root causes of bare-soil practices that lead to negative impacts on soil and water quality. Perennial groundcovers bring otherwise absent functional traits - namely perenniality - into cash-crop systems to preserve soil and regenerate water, carbon, and nutrient cycles. However, if not optimized, they can also cause competitive interactions and yield loss. Read More

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A randomized trial of safety and pharmacodynamic interactions between a selective glucocorticoid receptor antagonist, PT150, and ethanol in healthy volunteers.

Sci Rep 2021 May 10;11(1):9876. Epub 2021 May 10.

Menninger Department of Psychiatry, Baylor College of Medicine, Houston, USA.

PT150, a novel competitive glucocorticoid receptor (GR) antagonist, has proven safe in animal models, healthy volunteers, and people with depression. Our study is the first to investigate PT150's safety with alcohol use. The primary objective of this study was to evaluate pharmacodynamic interactions between ethanol and PT150 in healthy subjects. Read More

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Ionic Salts@Metal-Organic Frameworks: Remarkable Component to Improve Performance of Fabric Filters to Remove Particulate Matters from Air.

ACS Appl Mater Interfaces 2021 May 10. Epub 2021 May 10.

Department of Chemistry and Green-Nano Materials Research Center, Kyungpook National University, Daegu, 41566, Republic of Korea.

The elimination of particulate matters (PMs) from the air is very important for our sustainability. In this study, highly porous metal-organic frameworks (MOFs) like MIL-101 and UiO-67 were first modified, coated onto cotton, and applied in PM removal via filtration. Ionic salts (ISs) like CaCl and LiCl, after loading onto the MOFs, remarkably increased the PM removal efficiency. Read More

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Elucidating specificity of an allosteric inhibitor WNK476 among WNK isoforms using molecular dynamic simulations.

Chem Biol Drug Des 2021 May 10. Epub 2021 May 10.

Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Khandwa Road, Indore-453552, Madhya Pradesh, India.

Specifically targeting the With-No-Lysine (WNK1) kinase, which is implicated in hypertension, renders a significant challenge in discovering competitive inhibitors due to the highly conserved ATP binding pocket. However, an allosteric inhibitor may impart high specificity against the WNK kinase isoforms since it targets the less conserved site and can provide greater efficacy even under high physiological ATP concentration. In the current study, we have investigated the structural and energetic basis of the specificity of the allosteric inhibitor WNK476 against WNK kinase isoforms by combining molecular dynamics simulations and free energy calculations using molecular mechanics Poisson-Boltzmann surface area (MMPBSA). Read More

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Effects of historical co-infection on host shift abilities of exploitative and competitive viruses.

Evolution 2021 May 10. Epub 2021 May 10.

Department of Ecology and Evolutionary Biology, Yale University, P. O. Box 208106, New Haven, Connecticut, 06520, USA.

Rapid evolution contributes to frequent emergence of RNA viral pathogens on novel hosts. However, accurately predicting which viral genotypes will emerge has been elusive. Prior work with lytic RNA bacteriophage ɸ6 (family Cystoviridae) suggested that evolution under low multiplicity of infection (MOI; proportion of viruses to susceptible cells) selected for greater host exploitation, while evolution under high MOI selected for better intracellular competition against co-infecting viruses. Read More

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Synthesis of orange-emissive silicon nanoparticles as "off-on" fluorescence probe for sensitive and selective detection of l-methionine and copper.

Talanta 2021 Aug 30;231:122369. Epub 2021 Mar 30.

CAS Key Laboratory of Chemistry of Northwestern Plant Resources, Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou, 730000, PR China. Electronic address:

Fluorescent silicon nanoparticles (Si NPs) are of great interest as they are free of heavy ions. However, most of Si NPs exhibit blue or green emission, while orange or red-emitting Si NPs are required for an extensive range of applications. Copper ion (Cu) and l-methionine (L-Met) detection is critically valuable point since their abnormal level is an indicator of various diseases. Read More

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Hierarchies, markets, and collaborative networks in energy governance: Multilevel drivers of renewable energy deployment.

J Environ Manage 2021 May 4;290:112614. Epub 2021 May 4.

Florida State University Askew School of Public Administration, USA. Electronic address:

State renewable portfolio standard (RPS) mandates, competitive wholesale electricity markets, and cooperative regional transmission planning have all been identified as potential drivers of RE production. However, these factors are typically studied in isolation, and studies come to mixed conclusions about their actual effects on RE deployment. In this article, we a) use a novel "networks of action situations" (NAS) approach to examine the way that state RPS mandates, competitive markets, and regional transmission planning interact to jointly affect RE production; and b) ask whether these patterns differ across traditionally regulated and "deregulated" jurisdictions. Read More

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Competitive adsorption of Dibutyl phthalate (DBP) and Di(2-ethylhexyl) phthalate (DEHP) onto fresh and oxidized corncob biochar.

Chemosphere 2021 Apr 23;280:130639. Epub 2021 Apr 23.

College of Natural Resources and Environment, South China Agricultural University, Guangzhou, 510642, PR China; College of Resource and Environmental Engineering, Jiangxi University of Science and Technology, Ganzhou Jiangxi, 341000, PR China.

Phthalates (PAEs) often exist simultaneously in contaminated soil and wastewater systems, and their adsorption to biochar might impact their behavior in the environment. So far, the competitive adsorption of PAEs to biochar has not been reported. In this study, the competitive adsorption of Dibutyl phthalate (DBP) and Di(2-ethylhexyl) phthalate (DEHP) on corncob biochar (fresh and oxidized) was investigated, and experiments of kinetics, isotherms, and thermodynamics were conducted. Read More

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The potential endocrine disruption mechanism of anthelmintic drug niclosamide by activating estrogen receptors and estrogen-related receptors.

Toxicology 2021 May 4;457:152805. Epub 2021 May 4.

College of Resources and Environment, Hunan Agricultural University, Changsha, 410128, PR China. Electronic address:

Niclosamide (NIC), a helminthic drug used widely for controlling schistosomiasis, can reportedly disrupt the endocrine system. However, its underlying mechanisms are still unclear. In this study, we revealed the potential endocrine disruption mechanism of NIC by activating estrogen receptors (ERs) and estrogen-related receptors (ERRs). Read More

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The Role of the Core Attachment Positioning in Triggering Intramolecular Singlet Exciton Fission in Perylene Diimide Tetramers.

J Phys Chem B 2021 May 7. Epub 2021 May 7.

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.

Previous studies have proposed that the presence of a flexible π-bridge linker is crucial in activating intramolecular singlet exciton fission (iSEF) in multichromophoric systems. In this study, we report the photophysical properties of three analogous perylene diimide (PDI) dendritic tetramers showing flexible/twisted π-bridged structures with α- and β-substitutions and a rigid/planar structure with a β-fused ring (βC) connection to a benzodithiophene-thiophene (BDT-Th) core. The rigidity and enhanced planarity of βC lead to significant intramolecular charge transfer and triplet formation via an intersystem crossing pathway. Read More

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Micro-distribution of arsenic and polycyclic aromatic hydrocarbons and their interaction in Pteris vittata L.

Environ Pollut 2021 Apr 29;285:117250. Epub 2021 Apr 29.

Department of Geological & Environmental Sciences, Western Michigan University, Kalamazoo, 49008, USA.

Interactive effects of inorganic arsenic (As) species and polycyclic aromatic hydrocarbons (PAHs) on their uptake, accumulation and translocation in the hyperaccumulator Pteris vittata L. (P. vittata) were studied hydroponically. Read More

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Molecular Modeling of Protein Corona Formation and Its Interactions with Nanoparticles and Cell Membranes for Nanomedicine Applications.

Hwankyu Lee

Pharmaceutics 2021 Apr 29;13(5). Epub 2021 Apr 29.

Department of Chemical Engineering, Dankook University, Yongin-si 16890, Korea.

The conformations and surface properties of nanoparticles have been modified to improve the efficiency of drug delivery. However, when nanoparticles flow through the bloodstream, they interact with various plasma proteins, leading to the formation of protein layers on the nanoparticle surface, called protein corona. Experiments have shown that protein corona modulates nanoparticle size, shape, and surface properties and, thus, influence the aggregation of nanoparticles and their interactions with cell membranes, which can increases or decreases the delivery efficiency. Read More

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A Generic Framework for the PBPK Platform Qualification of PK-Sim and its Application to Predicting CYP3A4-mediated Drug-Drug Interactions.

CPT Pharmacometrics Syst Pharmacol 2021 May 4. Epub 2021 May 4.

Pharmacometrics/Modeling & Simulation, Pharmaceuticals, Research & Development, Bayer AG, Germany.

The success of applications of physiologically-based pharmacokinetic (PBPK) modeling in drug development and drug labeling has triggered regulatory agencies to demand rigorous demonstration of the predictive capability of the specific PBPK platform for a particular intended application purpose. The effort needed to comply with such qualification requirements exceeds the costs for any individual PBPK application. Since changes or updates of a PBPK platform would require re-qualification, a reliable and efficient generic qualification framework is needed. Read More

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On-cell nuclear magnetic resonance spectroscopy to probe cell surface interactions.

Biochem Cell Biol 2021 May 4. Epub 2021 May 4.

Dalhousie University, 3688, Department of Biochemistry & Molecular Biology, Halifax, Canada;

Nuclear magnetic resonance (NMR) spectroscopy allows determination of atomic-level information about intermolecular interactions, molecular structure, and molecular dynamics in the cellular environment. This may be broadly divided into studies focused on obtaining detailed molecular information in the intracellular context ("in-cell") or those focused on characterizing molecules or events at the cell surface ("on-cell"). In this review, we outline some key NMR techniques applied for on-cell NMR studies through both solution-state and solid-state NMR and survey studies that have used these techniques to uncover key information. Read More

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Chemical communication in lizards and a potential role for vasotocin in modulating social interactions.

Integr Comp Biol 2021 May 3. Epub 2021 May 3.

Neuroscience Institute and Center for Behavioral Neuroscience, Georgia State University, 100 Piedmont Avenue SE, Atlanta, GA 30303.

Lizards use chemical communication to mediate many reproductive, competitive, and social behaviors, but the neuroendocrine mechanisms underlying chemical communication in lizards are not well understood and understudied. By implementing a neuroendocrine approach to the study of chemical communication in reptiles, we can address a major gap in our knowledge of the evolutionary mechanisms shaping chemical communication in vertebrates. The neuropeptide arginine vasotocin (AVT) and its mammalian homologue vasopressin are responsible for a broad spectrum of diversity in competitive and reproductive strategies in many vertebrates, mediating social behavior through the chemosensory modality. Read More

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Mycobiomes of Young Beech Trees Are Distinguished by Organ Rather Than by Habitat, and Community Analyses Suggest Competitive Interactions Among Twig Fungi.

Front Microbiol 2021 15;12:646302. Epub 2021 Apr 15.

Department of Plant Physiology, Umeå Plant Science Centre, Umeå University, Umeå, Sweden.

Beech trees () are prominent keystone species of great economic and environmental value for central Europe, hosting a diverse mycobiome. The composition of endophyte communities may depend on tree health, plant organ or tissue, and growth habitat. To evaluate mycobiome communalities at local scales, buds, and twigs were sampled from two young healthy mountain beech stands in Bavaria, Germany, four kilometers apart. Read More

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Synchronization and Coordination of Art Performances in Highly Competitive Contexts: Battle Scenes of Expert Breakdancers.

Front Psychol 2021 15;12:635534. Epub 2021 Apr 15.

Graduate School of Education, The University of Tokyo, Tokyo, Japan.

In the performing arts, such as music and dance performances, people actively interact with each other and show their exciting performances. Some studies have proposed that this interaction is a social origin of the performing arts. Some have further investigated this phenomenon based on the synchronization and coordination theory. Read More

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