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Biomechanical Comparison of Three Stabilization Methods for Tibial Tuberosity Fractures in Dogs: A Cadaveric Study.

Vet Comp Orthop Traumatol 2021 May 12. Epub 2021 May 12.

Georgia Department of Agriculture, Animal Industry Division, Atlanta, Georgia, United States.

Objective:  The aim of this study was to compare the biomechanical properties of a hybrid external skeletal fixator (HESF) construct to the placement of paired interfragmentary Kirschner wires alone, and pin and tension band wire (PTBW) fixation for the stabilization of simulated tibial tuberosity fractures in dogs.

Study Design:  Tibias were harvested from 12 skeletally mature dog cadavers weighing 20 to 30 kg. An osteotomy was made through the base of the tibial tuberosity, which was subsequently repaired with either paired Kirschner wires, PTBW fixation or a HESF. Read More

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The epidemiological impact of the NHS COVID-19 App.

Nature 2021 May 12. Epub 2021 May 12.

Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department for Medicine, University of Oxford, Oxford, UK.

The COVID-19 pandemic has seen digital contact tracing emerge around the world to help prevent spread of the disease. A mobile phone app records proximity events between app users, and when a user tests positive for COVID-19, their recent contacts can be notified instantly. Theoretical evidence has supported this new public health intervention, but its epidemiological impact has remained uncertain. Read More

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Development and Clinical Uses of a Mobile Application for Smart Wound Nursing Management.

Adv Skin Wound Care 2021 Jun;34(6):1-6

At Central South University, Changsha, Hunan, China; Qijian Zhang, MS, RN; Weiwei Dai, MS, RN; and Hanzhang Tian, MS, RN, are Enterostomal Therapists at the Wound Center, Xiangya Hospital; Qiongfang Tang, BS, RN, is a Wound Therapist at the Wound Center, Xiangya Hospital; Weihong Huang, MD, is Professor, Mobile Health Ministry of Education - China Mobile Joint Laboratory, Xiangya Hospital; and Shihui Wang, MD, is User Interface Designer, School of Architecture and Art. Acknowledgments: This work was supported in part by the National Key R&D Program of China under Grant 2017YFC0909900 (Integrated Service System of Precision Medicine based on Telemedicine and Mobile Health Network) and the Key R&D Program of Hunan Province China under grant 2017SK2013 (Research and Application of Integrated Medical and Social Care Service Model Supported by Big Data and Mobile Health Technologies). The authors have disclosed no other financial relationships related to this article. Submitted March 10, 2020; accepted in revised form June 19, 2020.

Objective: Establishing a smart platform for wound nursing management is imperative to accelerating the development of this specialty. A mobile application (app) was created based on the clinical needs of wound care to improve working efficiency and wound management, as well as enable information sharing and categorical retrieval of patient records.

Methods: Supported by the National Mobile Laboratory of China, the authors' wound care center collaborated with information technology engineers and user interface designers to establish a multidisciplinary team of experts in wound nursing information management and develop a digital app. Read More

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Comparison of Insulin, Metformin, and Glyburide on Perinatal Complications of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Gynecol Obstet Invest 2021 May 12:1-13. Epub 2021 May 12.

Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Aim: This systematic and meta-analysis was conducted to evaluate the efficacy and safety of insulin, metformin, and glyburide on perinatal complications for gestational diabetes mellitus (GDM).

Methods: Medline (PubMed), EMBASE, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials [CENTRAL], and Cochrane Methodology Register), Web of Science (Science and Social Science Citation Index), and ClinicalTrials (Clinicaltrials.gov) were searched, as well as manual searching. Read More

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Matching-adjusted indirect treatment comparison of ozanimod versus teriflunomide for relapsing multiple sclerosis.

Mult Scler Relat Disord 2021 Apr 25;52:102972. Epub 2021 Apr 25.

Bristol Myers Squibb, 3551 Lawrenceville Rd., Princeton, NJ, 08540 USA.

Background: A growing number of immunomodulating disease-modifying therapies are available for treatment of relapsing multiple sclerosis (RMS). In the absence of randomized head-to-head trials, matching-adjusted indirect comparisons (MAICs) can be used to adjust for cross-trial differences and evaluate the comparative efficacy and safety of these agents. We used MAIC methodology to indirectly compare key outcomes with ozanimod (OZM) and teriflunomide (TERI) in the treatment of RMS. Read More

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Characterization and comparison of mixed-mode and reversed-phase columns; interaction abilities and applicability for peptide separation.

J Chromatogr A 2021 Apr 27;1648:462182. Epub 2021 Apr 27.

Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Hlavova 8, Prague 12843, Czech Republic. Electronic address:

In this work, two mixed-mode columns from a different manufacturers and one marketed as a reversed-phase column were characterized and compared in the terms of their interaction abilities, retentivity, peak symmetry, and applicability for peptide separation. All the tested columns contain octadecyl ligand and positively charged modifier, i.e. Read More

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Ultrasensitive determination of serotonin in human urine by a two dimensional capillary isotachophoresis-capillary zone electrophoresis hyphenated with tandem mass spectrometry.

J Chromatogr A 2021 Apr 27;1648:462190. Epub 2021 Apr 27.

Department of Pharmaceutical Analysis and Nuclear Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Odbojarov 10, SK-832 32 Bratislava, Slovak Republic; Toxicological and Antidoping Center, Faculty of Pharmacy, Comenius University in Bratislava, Odbojarov 10, SK-832 32 Bratislava, Slovak Republic. Electronic address:

A two-dimensional capillary isotachophoresis-capillary zone electrophoresis method hyphenated with tandem mass spectrometry was developed and validated for ultrasensitive quantification of serotonin in real human urine samples. Under optimal conditions, the separation was achieved within 12 min (including on-line sample preparation) with the limit of detection of 34 pg mL (due to a large volume sample injection, here 10 µL, and isotachophoretic preconcentration). This concentration limit represents the lowest value for serotonin in comparison to other previously published separation methods employing mass spectrometry detection and applied to urine matrices. Read More

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Soybean residue based biochar prepared by ball milling assisted alkali activation to activate peroxydisulfate for the degradation of tetracycline.

J Colloid Interface Sci 2021 Apr 19;599:631-641. Epub 2021 Apr 19.

College of Environmental Science and Engineering, Hunan University, Lushan South Road, Yuelu District, Changsha 410082, PR China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Lushan South Road, Yuelu District, Changsha 410082, PR China. Electronic address:

The advanced oxidation process (AOPs) has caused great concern in recent years. Among them, biochar has been widely studied as a catalyst for advanced oxidation process because of its low price and low environmental risk. In this study, a novel ball milling assisted KOH activation biochar (MKBC) was prepared and applied in peroxydisulfate (PDS) activation to degrade tetracycline hydrochloride (TC-H). Read More

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VMAT-like plans for magnetic resonance guided radiotherapy: Addressing unmet needs.

Phys Med 2021 May 9;85:72-78. Epub 2021 May 9.

Fondazione Policlinico Universitario ''A. Gemelli'' IRCCS, Roma, Italy.

Purpose: VMAT delivery technique is currently not applicable to Magnetic Resonance-guided radiotherapy (MRgRT) hybrid systems. Aim of this study is to evaluate an innovative VMAT-like (VML) delivery technique.

Material And Methods: First, planning and dosimetric evaluation of the MRgRT VML treatment have been performed on 10 different disease sites and the results have been compared with the corresponding IMRT plans. Read More

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Depressive and stress symptoms in insomnia patients predict group cognitive-behavioral therapy for insomnia long-term effectiveness: A data-driven analysis.

J Affect Disord 2021 Apr 24;289:117-124. Epub 2021 Apr 24.

Sleep Disorder Center, San Raffaele Hospital Milan, Italy.

Background: Insomnia Disorder is characterized by high degree of phenotypic heterogeneity, that might influence treatment response.

Methods: 123 of 294 insomnia patients initially recruited (66.7% females, age=40. Read More

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The association between transthoracic echocardiogram parameters and white matter hyperintensities.

Clin Neurol Neurosurg 2021 May 4;206:106672. Epub 2021 May 4.

Department of Neurology, University of Utah, Salt Lake City, UT 84132, USA. Electronic address:

Objective: Identify abnormal cardiac chamber size and hemodynamic parameters on transthoracic echocardiogram (TTE) as predictors of advancing cerebral small vessel disease (CSVD) on brain magnetic resonance imaging (MRI).

Materials And Methods: A retrospective chart review of adults with a brain MRI and a 2-dimensional TTE was performed. WMH measured by the Fazekas score served as the primary outcome. Read More

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Bioinformatic prediction and identification of immunogenic epitopes of the antigenic 14-3-3 protein of Echinococcus multilocularis.

Acta Trop 2021 May 9:105955. Epub 2021 May 9.

Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China; Qinghai-Utah Joint Research Key Lab for High Altitude Medicine, Xining 810001, China; Basic Medicine Department, Qinghai University, Xining 810001, China. Electronic address:

Introduction: Alveolar echinococcosis is a high-risk parasitic disease caused by the larval stage of Echinococcus multilocularis. The study aimed to predict and identify the dominant Th1/Th2 and B cell epitopes of the antigen protein 14-3-3 beta:alpha from Echinococcus multilocularis.

Methods: A comparison of the four amino acid sequences of 14-3-3 beta:alpha was respectively derived from Echinococcus multilocularis, Rattus norvegicus, Canis lupus familiaris, and Homo sapiens was carried out by CLUSTALW to provide a basis for excluding similar epitopes. Read More

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α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology.

Cell Rep 2021 May;35(6):109099

Department of Molecular and Cellular Biology, The University of Guelph, Guelph, ON N1G 2W1, Canada; Neurodegenerative Disease Center, Scintillon Institute, 6868 Nancy Ridge Drive, San Diego, CA 92121, USA. Electronic address:

Neuronal loss in Parkinson's disease (PD) is associated with impaired proteostasis and accumulation of α-syn microaggregates in dopaminergic neurons. These microaggregates promote seeding of α-synuclein (α-syn) pathology between synaptically linked neurons. However, the mechanism by which seeding is initiated is not clear. Read More

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Determination of the LD with the chick embryo chorioallantoic membrane (CAM) assay as a promising alternative in nanotoxicological evaluation.

Nanotoxicology 2021 May 12:1-16. Epub 2021 May 12.

Department of Otorhinolaryngology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.

Toxicity tests in rodents are still considered a controversial topic concerning their ethical justifiability. The chick embryo chorioallantoic membrane (CAM) assay may offer a simple and inexpensive alternative. The CAM assay is easy to perform and has low bureaucratic hurdles. Read More

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Prediction of High-Risk Cytogenetic Status in Multiple Myeloma Based on Magnetic Resonance Imaging: Utility of Radiomics and Comparison of Machine Learning Methods.

J Magn Reson Imaging 2021 May 12. Epub 2021 May 12.

Department of Radiology, Peking University Third Hospital, Haidian District, Beijing, People's Republic of China.

Background: Radiomics has shown promising results in the diagnosis, efficacy, and prognostic assessments of multiple myeloma (MM). However, little evidence exists on the utility of radiomics in predicting a high-risk cytogenetic (HRC) status in MM.

Purpose: To develop and test a magnetic resonance imaging (MRI)-based radiomics model for predicting an HRC status in MM patients. Read More

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Effect of Hurricane Irma on daily direct-care nurse staffing in nursing homes.

J Am Geriatr Soc 2021 May 12. Epub 2021 May 12.

Florida Policy Exchange Center of Aging, School of Aging Studies, University of South Florida, Tampa, Florida, USA.

Objectives: To examine the effect of Hurricane Irma on staff-related financial expenditures and daily direct-care nurse staffing levels.

Design: Retrospective cohort study.

Setting: September 3-24, 2017 in the state of Florida, United States. Read More

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Enhanced sophorolipid production and effective conversion of waste frying oil using dual lipophilic substrates.

Biosci Biotechnol Biochem 2021 May 12. Epub 2021 May 12.

Biochemical Laboratory, Saraya Co., Ltd., Osaka, Japan.

A highly efficient sophorolipid (SL) fermentation process using dual lipophilic substrates (DLS) was developed. Using DLS consisting of palm oil and oleic acid in the flask fermentation with SL-producing yeast Starmerella bombicola, the productivity and yield of SL improved 2.4- and 1. Read More

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Clinical and ultrasound characteristics of pediatric lateral neck masses.

PLoS One 2021 12;16(5):e0251563. Epub 2021 May 12.

Department of Plastic and Reconstructive Surgery, Institute of Mother and Child Health Care of Serbia "Dr Vukan Cupic", Belgrade, Serbia.

Lateral neck masses (LNM) often present a diagnostic challenge in the practice of pediatric plastic surgeon. The aim of this study is to investigate the clinical and ultrasound (US) characteristics of pediatric LNM in order to make mutual comparison between their entities and enable the most accurate preoperative diagnosis. A cross-sectional study was conducted among 250 pediatric patients treated by surgical excision or sclerotherapy in our institution in the period from July 2009 to June 2019. Read More

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Media and social media attention to retracted articles according to Altmetric.

PLoS One 2021 12;16(5):e0248625. Epub 2021 May 12.

Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, United States of America.

The number of retracted articles has grown fast. However, the extent to which researchers and the public are made adequately aware of these retractions and how the media and social media respond to them remains unknown. Here, we aimed to evaluate the media and social media attention received by retracted articles and assess also the attention they receive post-retraction versus pre-retraction. Read More

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Outcomes Following Severe Distal Tibial, Ankle, and/or Mid/Hindfoot Trauma: Comparison of Limb Salvage and Transtibial Amputation (OUTLET).


J Bone Joint Surg Am 2021 May 12. Epub 2021 May 12.

Background: Selecting the best treatment for patients with severe terminal lower-limb injury remains a challenge. For some injuries, amputation may result in better outcomes than limb salvage. This study compared the outcomes of patients who underwent limb salvage with those that would have been achieved had they undergone amputation. Read More

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A qualitative analysis of people's experiences with weight-based discrimination.

Psychol Health 2021 May 12:1-18. Epub 2021 May 12.

Department of Psychology, College of Arts and Sciences, Florida State University, Tallahassee, Florida, USA.

Objective: The aim of this study was to describe people's day-to-day experiences with weight-based discrimination and to distill themes that shed new light on this phenomenon.

Design: A qualitative study was conducted in 2019 using a purposive sampling strategy. A racially and ethnically diverse sample of 32 U. Read More

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In vitro comparison of high-definition US, CBCT and periapical radiography in the diagnosis of proximal and recurrent caries.

Dentomaxillofac Radiol 2021 May 12:20210026. Epub 2021 May 12.

Department of Biostatistics, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey.

Objective: To assess the performance of high-definition (HD) US, CBCT and periapical radiography for the visibility of proximal and recurrent caries in teeth with and without restoration.

Methods: A total of 240 molar teeth were divided into eight groups each comprised of 30 teeth. Control groups consisted of teeth without caries (Group 1-4; = 120), whereas diseased groups consisted of teeth with proximal caries (Group 5-8; = 120 teeth). Read More

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Piano-Stool Ruthenium(II) Complexes with Delayed Cytotoxic Activity: Origin of the Lag Time.

Inorg Chem 2021 May 12. Epub 2021 May 12.

Departament de Química Inorgànica i Orgànica, Facultat de Química, Secció de Química Inorgànica, Universitat de Barcelona, Martí i Franquès, 1-11, 08028 Barcelona, Spain.

We have recently reported a series of piano-stool ruthenium(II) complexes of the general formula [RuCl(η-arene)(P(1-pyrenyl)RR)] showing excellent cytotoxic activities (particularly when R = R = methyl). In the present study, new members of this family of compounds have been prepared with the objective to investigate the effect of the steric hindrance of a bulky phosphane ligand, namely diisopropyl(1-pyrenyl)phosphane (), on exchange reactions involving the coordinated halides (X = Cl, I). Two η-arene rings were used, i. Read More

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Seizure in Children Under Five Presenting With Pneumonia in a Critical Care Ward in Bangladesh: Prevalence, Associated Factors, and Outcome.

Pediatr Infect Dis J 2021 May;40(5):389-393

From the International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.

Background: Pneumonia is the leading infectious cause of deaths in children under 5 for the last few decades. Development of seizure in those children is common and associated with increased risk of deaths. We therefore investigated the prevalence, associated factors and outcome of seizure in children hospitalized with pneumonia. Read More

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Diagnostic Values of 8 Different Imaging Modalities for Preoperative Detection of Axillary Lymph Node Metastasis of Breast Cancer: A Bayesian Network Meta-analysis.

Am J Clin Oncol 2021 May 12. Epub 2021 May 12.

Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan Department of Preventive Medicine, School of Medicine, Korea University, Seoul Department of Nuclear Medicine, College of Medicine, Pusan National University Department of Nuclear Medicine BioMedical Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.

Objective: This study aimed to compare diagnostic performances of 8 different imaging modalities for preoperative detection of axillary lymph node (LN) metastasis in patients with breast cancer by performing a network meta-analysis (NMA) using direct comparison studies with 2 or more imaging techniques.

Materials And Methods: PubMed, Cochrane, and Embase were searched for the studies evaluating the performances of 8 different imaging modalities for preoperative axillary LN staging in patients with breast cancer. The NMA was performed in patient-based analyses. Read More

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Value of transcranial color-code Doppler in evaluating intracranial atherosclerotic stenosis in patients with diabetes mellitus type 2: a comparison of transcranial Doppler and computed tomography angiography.

Minerva Endocrinol (Torino) 2021 May 12. Epub 2021 May 12.

Department of Physical Examination, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China -

Background: There are several imaging assessment methods for intracranial atherosclerotic stenosis (ICAS). This study investigated the most efficient method by which to diagnose ICAS in patients with diabetes mellitus.

Methods: One hundred seven patients with type 2 diabetes mellitus were enrolled as the experimental group and 68 healthy subjects were designated as the control group. Read More

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Efficacy and safety of the clearum dialyzer.

Artif Organs 2021 May 12. Epub 2021 May 12.

Department of Biochemistry, Hospital Clínic Barcelona, Barcelona, Spain.

The Clearum dialyzer, built by Medtronic, became commercially available in several European countries in 2020 but there are still no reports of in vivo data. The aim of this study was to evaluate the efficacy and risk of hypoalbuminemia of this dialyzer compared with previously evaluated hemodialysis (HD), expanded hemodialysis (HDx) and postdilution hemodiafiltration (HDF) treatments. A prospective study was carried out in 15 patients. Read More

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Comparing the Drivers of Medical Student Emigration Intention Across Two African Nations.

Med Educ 2021 May 12. Epub 2021 May 12.

University of Pennsylvania, Department of Orthopaedic Surgery, 800 Spruce St, 8th Floor Preston Building, Philadelphia, 19107.

Background: Sub-Saharan Africa faces the highest relative need for health care workers in the world and the emigration of physicians significantly contributes to this deficit. Few studies have explored development of these patterns during medical education. This study investigates career aspirations of medical students in two African nations with similar Human Development Indices, but distinct differences in training structure to better inform retention strategies. Read More

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Radicals and Anions of Siloles and Germoles.

Chemistry 2021 May 12. Epub 2021 May 12.

Technion Israel Institute of Technology, Department of Chemistry, ISRAEL.

The synthesis of persistent sila- and germa-cyclo-penta-dien-yl (silolyl- and germolyl-) radicals by careful stoichiometric reduction of the corresponding halides with potassium is reported. The radicals were characterized by EPR spectroscopy and trapping reactions. The reduction of tris (trimethylsilyl)silyl-substituted halides was successful while smaller substituents (i. Read More

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