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FDG-PET patterns associated with ideomotor apraxia and imitation apraxia in patients with corticobasal syndrome.

Parkinsonism Relat Disord 2021 Jun 16;88:96-101. Epub 2021 Jun 16.

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

Introduction: Apraxia is a core clinical feature of corticobasal syndrome (CBS). Among the subtypes of apraxia, ideomotor and imitation apraxia are frequently found in CBS. However, little is known about the brain networks that are characteristic of each apraxia subtype or their clinical implication. Read More

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PTEN knockdown attenuates cognitive deficits by inhibiting microglia-mediated neuroinflammation in the hippocampus in a mouse model of perioperative neurocognitive disorder.

Neuroscience 2021 Jun 21. Epub 2021 Jun 21.

Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, People's Republic of China. Electronic address:

Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a crucial regulator of neuronal development, neuronal survival, axonal regeneration, and synaptic plasticity. In this study we examined the potential role of PTEN in cognitive function in a mouse model of perioperative neurocognitive disorder (PND). Adult male C57BL/6J mice received intracerebroventricular injections of small interfering RNA (siRNA) against PTEN or control siRNA 3 days prior to exploratory laparotomy (n=8 per group). Read More

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Gating movements and ion permeation in HCN4 pacemaker channels.

Mol Cell 2021 Jun 18. Epub 2021 Jun 18.

Department of Biosciences, University of Milan, Milan, Italy; Institute of Biophysics-Milano, Consiglio Nazionale delle Ricerche, Rome, Italy. Electronic address:

The HCN1-4 channel family is responsible for the hyperpolarization-activated cation current I/I that controls automaticity in cardiac and neuronal pacemaker cells. We present cryoelectron microscopy (cryo-EM) structures of HCN4 in the presence or absence of bound cAMP, displaying the pore domain in closed and open conformations. Analysis of cAMP-bound and -unbound structures sheds light on how ligand-induced transitions in the channel cytosolic portion mediate the effect of cAMP on channel gating and highlights the regulatory role of a Mg coordination site formed between the C-linker and the S4-S5 linker. Read More

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Military Service Members with Major Lower Extremity Fractures Return to Running with a Passive-dynamic Ankle-foot Orthosis: Comparison with a Normative Population.

Clin Orthop Relat Res 2021 Jun 24. Epub 2021 Jun 24.

Department of Orthopedic Surgery, Scripps Mercy Hospital, San Diego, CA, USA.

Background: Lower extremity fractures represent a high percentage of reported injuries in the United States military and can devastate a service member's career. A passive dynamic ankle-foot orthosis (PD-AFO) with a specialized rehabilitation program was initially designed to treat military service members after complex battlefield lower extremity injuries, returning a select group of motivated individuals back to running. For high-demand users of the PD-AFO, the spatiotemporal gait parameters, agility, and quality of life is not fully understood with respect to uninjured runners. Read More

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Association of rare predicted loss-of-function variants of influenza-related type I IFN genes with critical COVID-19 pneumonia.

J Clin Invest 2021 Jun 24. Epub 2021 Jun 24.

St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockfeller University, New York, United States of America.

To the Editor: Povysil G. et al. report that "rare loss-of-function (LOF) variants in type I interferon (IFN) immunity genes are not associated with severe COVID-19" (1). Read More

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Lack of Associations Between C-Reactive Protein and Mood and Anxiety Symptoms in Adolescents.

J Child Adolesc Psychopharmacol 2021 Jun 24. Epub 2021 Jun 24.

Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, New York, USA.

Increased peripheral inflammation has been consistently documented in both adult and pediatric depression. However, elevated levels of C-reactive protein (CRP), a nonspecific biomarker for inflammation, have been primarily reported in adults; whether CRP plays a similar role in adolescent depression has not been conclusively established. In our prior work, we identified relationships between CRP and reward neurocircuitry in adolescents with psychiatric symptoms ( = 64) but not with depressive symptoms. Read More

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Uncontrolled Extensions of Clinical Trials and the Use of External Controls - scoping opportunities and methods.

Clin Pharmacol Ther 2021 Jun 24. Epub 2021 Jun 24.

Pharmaceutical Outcomes & Policy, Center for Drug Evaluation & Safety, University of Florida.

Increased interest in real-world evidence (RWE) for clinical and regulatory decision making and the need to evaluate long-term benefits and risks of pharmaceutical products raise the importance of understanding the use of external controls (ECs) for uncontrolled extensions of randomized controlled trials (RCTs). We searched clinicaltrials.gov from 2009 to 2019 for uncontrolled extensions and assessed the use of ECs in the trial protocol registry and PubMed. Read More

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Health-related quality of life after posterior vertebral column resection in children: comparison with healthy controls.

Eur J Orthop Surg Traumatol 2021 Jun 24. Epub 2021 Jun 24.

Department of Orthopaedics and Traumatology, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.

Purpose: Vertebral column resection (VCR) is a technique performed for short, angular spinal deformities. Several studies have reported good radiographic results with VCR regarding curve correction. However, only a few studies have reported the impact of this technique on the health-related quality-of-life measures (HRQoL). Read More

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Association of COVID-19 Vaccination and Facial Nerve Palsy: A Case-Control Study.

JAMA Otolaryngol Head Neck Surg 2021 Jun 24. Epub 2021 Jun 24.

Department of Ophthalmology, Shamir Medical Center, Be'er Ya'akov, Israel.

Importance: Peripheral facial nerve (Bell) palsy has been reported and widely suggested as a possible adverse effect of the BNT162b2 (Pfizer-BioNTech) COVID-19 vaccine. Israel is currently the leading country in vaccination rates per capita, exclusively using the BNT162b2 vaccine, and all residents of Israel are obligatory members of a national digital health registry system. These factors enable early analysis of adverse events. Read More

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A single-center retrospective comparison of Duplex ultrasonography versus audible Doppler regarding anterolateral thigh perforator flap harvest and operative times.

Microsurgery 2021 Jun 24. Epub 2021 Jun 24.

Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Heidelberg, Germany.

Introduction: We reported on the superiority of preoperative Duplex mapping ("Duplex") over audible Dopplers ("Doppler") in anterolateral thigh perforator (ALT) free flaps for upper extremity reconstruction. To corroborate our findings on a larger cohort, we conducted this present study focusing on surgical efficiency and patient safety.

Methods: 150 consecutive ALT free flaps were divided into 65 cases of preoperative Duplex versus 85 Doppler controls. Read More

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Physical activity, sports participation and exercise-related constraints in adult women with primary hypothyroidism treated with thyroid hormone replacement therapy.

J Sports Sci 2021 Jun 24:1-10. Epub 2021 Jun 24.

Department of Rehabilitation, Physical Therapy Science and Sport, University Medical Center Utrecht, Utrecht, The Netherlands.

Awareness of physical activity (PA) constraints in patients with primary hypothyroidism on thyroid hormone replacement therapy (THR) is important. Hence, this cross-sectional matched case-control study aimed to determine PA and sports participation (SP) in patients with hypothyroidism on THR in comparison to control subjects. Accordingly, survey questions were selected from the National Survey on Injuries and Physical Activity in the Netherlands (IPAN), supplemented with questions related to self-reported clinical characteristics and exercise-related constraints (ERC) of patients. Read More

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T cells mediate cell non-autonomous arterial aging in mice.

J Physiol 2021 Jun 23. Epub 2021 Jun 23.

Department of Internal Medicine, University of Utah, Salt Lake City, Utah.

Key Points: Increased large artery stiffness and impaired endothelium dependent dilation occur with advanced age. We sought to determine whether T cells mechanistically contribute to age-related arterial dysfunction. We found that old mice exhibited greater proinflammatory T cell accumulation around both the aorta and mesenteric arteries. Read More

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Comparison of dried blood spot and plasma sampling for untargeted metabolomics.

Metabolomics 2021 Jun 23;17(7):62. Epub 2021 Jun 23.

Division of Infectious Diseases, Department of Pediatrics, David Geffen School of Medicine at the University of California, Los Angeles, California, USA.

Introduction: Untargeted metabolomics holds significant promise for biomarker detection and development. In resource-limited settings, a dried blood spot (DBS)-based platform would offer significant advantages over plasma-based approaches that require a cold supply chain.

Objectives: The primary goal of this study was to compare the ability of DBS- and plasma-based assays to characterize maternal metabolites. Read More

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Human histamine H receptors can initiate cardiac arrhythmias in a transgenic mouse.

Naunyn Schmiedebergs Arch Pharmacol 2021 Jun 24. Epub 2021 Jun 24.

Institute for Pharmacology and Toxicology, Medical Faculty, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Histamine is known to lead to arrhythmias in the human heart. A mouse model to mimic these effects has hitherto not been available but might be useful to study the mechanism(s) of H-histamine receptor-induced arrhythmias and may support the search for new antiarrhythmic drugs. In order to establish such a model in mice, we studied here the incidence of cardiac arrhythmias under basal and under stimulated conditions in atrial and ventricular preparations from mice that overexpressed the human H-histamine receptors in a cardiac-specific way (H-TG) in comparison with their wild-type (WT) littermate controls. Read More

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Genetic Signatures From RNA Sequencing of Pediatric Localized Scleroderma Skin.

Front Pediatr 2021 7;9:669116. Epub 2021 Jun 7.

Division of Rheumatology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, United States.

The purpose of this study was to explore the skin transcriptional profile in pediatric localized scleroderma (LS) to provide a better understanding of the altered immune and fibrotic pathways promoting disease. LS is a progressive disease of the skin and underlying tissue that causes significant functional disability and disfigurement, especially in developing children. RNA sequencing (RNAseq) technology allows for improved understanding of relevant cellular expression through transcriptome analysis of phases during LS disease progression (more active/inflammatory vs. Read More

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Gray Matter Abnormalities in Type 1 and Type 2 Diabetes: A Dual Disorder ALE Quantification.

Front Neurosci 2021 7;15:638861. Epub 2021 Jun 7.

Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong.

Diabetes mellitus (DM) is associated with comorbid brain disorders. Neuroimaging studies in DM revealed neuronal degeneration in several cortical and subcortical brain regions. Previous studies indicate more pronounced brain alterations in type 2 diabetes mellitus (T2DM) than in type 1 diabetes mellitus (T1DM). Read More

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Adverse Impact of Rheumatoid Arthritis on Pregnancy Outcomes: A Saudi Arabia Prospective Multicenter Study.

Open Access Rheumatol 2021 15;13:167-175. Epub 2021 Jun 15.

Division of Rheumatology, Department of Medicine, Al Hada Armed Forces Hospital, Taif, Saudi Arabia.

Background: Rheumatoid arthritis (RA) is associated with adverse pregnancy outcomes and postpartum complications, especially with severe disease activity.

Objective: The current study aimed to compare the pregnancy outcomes in patients with RA and healthy controls as well as to assess the impact of disease-related variables, medications and disease activity on pregnancy and neonatal-related outcomes in the Saudi population.

Methods: This prospective multicenter study included pregnant female patients with RA from three tertiary centers in Saudi Arabia. Read More

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Case-control diagnostic accuracy study of a non-sputum CD38-based TAM-TB test from a single milliliter of blood.

Sci Rep 2021 Jun 23;11(1):13190. Epub 2021 Jun 23.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

CD4 T cell phenotyping-based blood assays have the potential to meet WHO target product profiles (TPP) of non-sputum-biomarker-based tests to diagnose tuberculosis (TB). Yet, substantial refinements are required to allow their implementation in clinical settings. This study assessed the real time performance of a simplified T cell activation marker (TAM)-TB assay to detect TB in adults from one millilitre of blood with a 24 h turnaround time. Read More

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Dietary habits in patients with fibromyalgia: a cross-sectional study.

Clin Exp Rheumatol 2021 May-Jun;39 Suppl 130(3):170-173. Epub 2021 Jun 21.

Nutrition, Food Sciences and Gastronomy Department, Universidad de Barcelona, Spain.

Objectives: To the scarce information on dietary habits in fibromyalgia (FM), it is added that there are no comparative studies with other rheumatic diseases. The objective of this study was to characterise the dietary habits of patients with FM by comparing, for the first time, with healthy controls (HC) and rheumatoid arthritis (RA).

Methods: This cross-sectional, observational study was based on data obtained from the Dietfibrom project for FM and from the IMID Consortium for RA and HC. Read More

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A systematic review of resting-state functional connectivity in obesity: Refining current neurobiological frameworks and methodological considerations moving forward.

Rev Endocr Metab Disord 2021 Jun 23. Epub 2021 Jun 23.

Australian Catholic University, Melbourne Campus, VIC, Australia.

Obesity is the second most common cause of preventable morbidity worldwide. Resting-state functional magnetic resonance imaging (fMRI) has been used extensively to characterise altered communication between brain regions in individuals with obesity, though findings from this research have not yet been systematically evaluated within the context of prominent neurobiological frameworks. This systematic review aggregated resting-state fMRI findings in individuals with obesity and evaluated the contribution of these findings to current neurobiological models. Read More

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An Ozonolysis Based Method and Applications for the Non-Lethal Modification of Insect Cuticular Hydrocarbons.

J Chem Ecol 2021 Jun 22. Epub 2021 Jun 22.

Department of Entomology, Michigan State University, East Lansing, MI, USA.

Cuticular hydrocarbons (CHCs) are important, multi-function components of the insect epicuticle. In Drosophila spp., CHCs provide protection from desiccation and serve as semiochemicals for both intra- and interspecific communication. Read More

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Widespread formation of double-stranded RNAs in testis.

Genome Res 2021 Jun 22. Epub 2021 Jun 22.

School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.

The testis transcriptome is highly complex and includes RNAs that potentially hybridize to form double-stranded RNA (dsRNA). We isolated dsRNA using the monoclonal J2 antibody and deep-sequenced the enriched samples from testes of juvenile knockout mice, age-matched controls, and adult animals. Comparison of our data set with recently published data from mouse liver revealed that the dsRNA transcriptome in testis is markedly different from liver: In testis, dsRNA-forming transcripts derive from mRNAs including promoters and immediate downstream regions, whereas in somatic cells they originate more often from introns and intergenic transcription. Read More

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Association of rare predicted loss-of-function variants of influenza-related type I IFN genes with critical COVID-19 pneumonia. Reply.

J Clin Invest 2021 Jun 22. Epub 2021 Jun 22.

Department of Medicine, Columbia University, New York, United States of America.

The authors reply: We appreciate the interest of Dr. Zhang and colleagues in our manuscript. The main difference between our publication and that of Zhang et al. Read More

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CS-VIBE accelerates cranial nerve MR imaging for the diagnosis of facial neuritis: comparison of the diagnostic performance of post-contrast MPRAGE and CS-VIBE.

Eur Radiol 2021 Jun 22. Epub 2021 Jun 22.

Department of Radiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea.

Objective: We aimed to compare the diagnostic performance of post-contrast 3D compressed sensing volume-interpolated breath-hold examination (CS-VIBE) and 3D T1 magnetization-prepared rapid-acquisition gradient-echo (MPRAGE) in detecting facial neuritis.

Materials And Methods: Between February 2019 and September 2019, 60 patients (30 facial palsy patients and 30 controls) who underwent contrast-enhanced cranial nerve MRI with both conventional MPRAGE and CS-VIBE (scan time: 6 min 8 s vs. 2 min 48 s) were included in this retrospective study. Read More

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Association of co-pay elimination with medication adherence and total cost.

Am J Manag Care 2021 Jun;27(6):249-254

Blue Cross and Blue Shield of Louisiana, 5525 Reitz Ave, Baton Rouge, LA 70809. Email:

Objectives: To determine whether elimination of co-pays for prescription drugs affects medication adherence and total health care spending.

Study Design: Retrospective comparative study.

Methods: We conducted a difference-in-differences comparison in the year before and after expansion of a Zero Dollar Co-pay (ZDC) prescription drug benefit in commercially insured Louisiana residents. Read More

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In Search of the SARS-CoV-2 Protection Correlate: Head-to-Head Comparison of Two Quantitative S1 Assays in Pre-characterized Oligo-/Asymptomatic Patients.

Infect Dis Ther 2021 Jun 16:1-14. Epub 2021 Jun 16.

Division of Infectious Diseases and Tropical Medicine, University Hospital, Ludwig-Maximilians-Universität (LMU) Munich, Leopoldstr. 5, 80802 Munich, Germany.

Background: Quantitative serological assays detecting response to SARS-CoV-2 are needed to quantify immunity. This study analyzed the performance and correlation of two quantitative anti-S1 assays in oligo-/asymptomatic individuals from a population-based cohort.

Methods: In total, 362 plasma samples (108 with reverse transcription-polymerase chain reaction [RT-PCR]-positive pharyngeal swabs, 111 negative controls, and 143 with positive serology without confirmation by RT-PCR) were tested with quantitative assays (Euroimmun Anti-SARS-CoV-2 QuantiVac enzyme-linked immunosorbent assay [EI-S1-IgG-quant]) and Roche Elecsys Anti-SARS-CoV-2 S [Ro-RBD-Ig-quant]), which were compared with each other and confirmatory tests, including wild-type virus micro-neutralization (NT) and GenScriptcPass™. Read More

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The comparison of oxidative markers between Covid-19 patients and healthy subjects.

Arch Med Res 2021 Jun 7. Epub 2021 Jun 7.

Nutrition Health Research Center, Hamadan University of Medical Sciences. Hamadan, Iran. Electronic address:

Aim And Background: Covid-19 has been as an important human infectious disease that has affected several countries. Cytokine storm has major role is Covid-19 pathogenesis. The association between inflammation and oxidative stress is well stablished. Read More

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Clinical efficacy of vitamin B in the treatment of mouth ulcer: a systematic review and meta-analysis.

Ann Palliat Med 2021 Jun 16. Epub 2021 Jun 16.

Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, China.

Background: Our study sought to determine the efficacy of vitamin B in treating mouth ulcers.

Methods: The databases PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure (CNKI), and Wanfang were comprehensively searched to identify relevant articles published between 2010 and 2021. Subsequently, the clinical efficacy of vitamin B in the treatment of mouth ulcers was comprehensively and quantitatively evaluated through meta-analysis. Read More

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Intravenous methylprednisolone with or without tocilizumab in patients with severe COVID-19 pneumonia requiring oxygen support: A prospective comparison.

J Infect Public Health 2021 Jun 10;14(8):985-989. Epub 2021 Jun 10.

Health Regulation Sector, Dubai Health Authority, United Arab Emirates. Electronic address:

Background: Cytokine storm is a marker of severity and severe mortality in patients with coronavirus disease 2019 (COVID-19) pneumonia. Immunomodulatory treatments may reduce morbidity and mortality.

Objectives: To determine whether a 7-day course of methylprednisolone (MP) administered with and without tocilizumab improves outcomes in patients with severe COVID-19 (SARS-CoV-2) pneumonia requiring oxygen therapy, relative to historical controls. Read More

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Cost-Effectiveness Comparison of Delivery Modalities for a Dissonance-Based Eating Disorder Prevention Program over 4-Year Follow-Up.

Prev Sci 2021 Jun 21. Epub 2021 Jun 21.

Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.

The cost-effectiveness of delivery methods for an eating disorder prevention program is reported. In an effectiveness trial (enrollment 2013-2015) comparing three formats (clinician-led, peer-led, and Internet-delivered) for delivering the Body Project eating disorder prevention program to college women versus an educational video control, the peer-led method was more effective than the three alternatives at preventing onset of eating disorders over 4-year follow-up. Eating disorder incidence was 19. Read More

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