9,011 results match your criteria compared synthroid

Thyroid hormones in persons with schizophrenia: A systematic review and meta-analysis.

Prog Neuropsychopharmacol Biol Psychiatry 2021 Jul 15;111:110402. Epub 2021 Jul 15.

Department of Psychiatry, Wroclaw Medical University, Pasteura 10 Street, 50-367 Wroclaw, Poland.

There is accumulating evidence that individuals with schizophrenia show altered levels of thyroid hormones. However, a qualitative and quantitative synthesis of findings in this field has not been performed so far. Therefore, we aimed to perform a systematic review and meta-analysis of studies investigating the levels of thyroid-stimulating hormone (TSH), free thyroxine (fT4), total thyroxine (tT4), free triiodothyronine (fT3) and total triiodothyronine (tT3) in multiple-episode schizophrenia (MES) and first-episode psychosis (FEP). Read More

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Changes in thyroid antibody and T lymphocyte subsets after radiofrequency ablation of thyroid nodules in patients with autoimmune thyroiditis.

J Cancer Res Ther 2021 Jul;17(3):638-643

Department of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Settings And Design: The aim was to study the changes in thyroid antibody and T lymphocyte subsets after radiofrequency ablation (RFA) of thyroid nodules in patients with autoimmune thyroiditis.

Subjects And Methods: Patients (n = 135) with autoimmune thyroiditis and thyroid nodules were treated by RFA. The indices of thyroid function and thyroid antibody and T lymphocyte subsets were examined preoperation and on the 1 day and the 1 month after ablation. Read More

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Comparison of Serum Thyroid Hormone Levels in Green-winged Macaws () Using Radio and Chemiluminescent Immunoassays.

J Avian Med Surg 2021 Jul;35(2):187-195

Universidade de Brasília, ICC Sul Campus Universitário Darcy Ribeiro, Faculdade de Agronomia e Medicina Veterinária, Brasília, DF, Brazil 70297-400.

This study compared the use of radioimmunoassay (RIA) and chemiluminescent immunoassay (CLIA) to measure serum thyroid hormone levels in green-winged macaws (). The sample group comprised 20 male and 13 female (n = 33) healthy, captive green-winged macaws of reproductive age but outside of breeding season. Mean free triiodothyronine (T3), total T3, and free thyroxine (T4) measured by CLIA and RIA corresponded to 5. Read More

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Iodine Nutrition and Iodine Supplement Initiation in Association with Thyroid Function in Mildly-to-Moderately Iodine-Deficient Pregnant and Postpartum Women.

J Nutr 2021 Jul 13. Epub 2021 Jul 13.

Seafood, Nutrition and Environmental State, Institute of Marine Research, Bergen, Norway.

Background: Whereas the adverse effects of severe iodine deficiency during pregnancy are well documented, the effects of mild-to-moderate deficiency are not well established.

Objectives: We aimed to explore whether iodine nutrition and timing of iodine supplement initiation are associated with thyroid function in pregnant and postpartum women.

Methods: In this cohort study, 137 pregnant women were enrolled and followed up at gestational weeks (GWs) 18 and 36, and 3 and 6 mo postpartum. Read More

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Serial measurement of thyroid hormones in hospitalised dogs with canine parvoviral enteritis: Incidence of non-thyroidal illness syndrome and its association with outcome and systemic inflammatory response syndrome.

Vet J 2021 Jul 9;274:105715. Epub 2021 Jul 9.

Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

The aim of this study was to serially evaluate the serum concentrations of total thyroxine (tT4), free thyroxine (fT4) and thyroid-stimulating hormone (TSH) in dogs with canine parvoviral enteritis (CPVE) during a 5-day hospitalisation period and assess the association of these hormone concentrations with the outcome and the development of systemic inflammatory response syndrome (SIRS). Dogs with confirmed CPVE that were hospitalised for at least 5 days were included. The thyroid hormones concentrations were measured on days 1, 3 and 5 of hospitalisation. Read More

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Effects of iodine excess on serum thyrotropin-releasing hormone levels and type 2 deiodinase in the hypothalamus of Wistar rats.

Br J Nutr 2021 Jul 12:1-30. Epub 2021 Jul 12.

Department of Endocrinology and Metabolism and the institute of Endocrinology, The First Hospital of China Medical University, Shenyang, Liaoning110001, P. R. China.

Iodine is an important element in thyroid hormone biosynthesis. Thyroid function is regulated by the hypothalamic-pituitary-thyroid axis (HPT). Excessive iodine leads to elevated thyroid stimulating hormone (TSH) levels, but the mechanism is not yet clear. Read More

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Protective Effects of Selenium and Zinc Against Nickel Chloride-Induced Hormonal Changes and Oxidative Damage in Thyroid of Pregnant Rats.

Biol Trace Elem Res 2021 Jul 11. Epub 2021 Jul 11.

Laboratory of Toxicology-Microbiology and Environmental Health (17ES06), Faculty of Sciences of Sfax, University of Sfax, BP1171, 3000, Sfax, Tunisia.

Nickel chloride (NiCl) is a heavy metal that may affect the function of the thyroid. Selenium (Se) and zinc (Zn) are essential trace elements involved in thyroid hormone metabolism. However, little is reported about thyrotoxicity during gestation. Read More

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Warm perches: a novel approach for reducing cold stress effect on production, plasma hormones, and immunity in laying hens.

J Y Hu H W Cheng

Poult Sci 2021 May 29;100(8):101294. Epub 2021 May 29.

USDA-Agricultural Research Service, Livestock Behavior Research Unit, West Lafayette, IN 47907, USA. Electronic address:

Cold temperature is a common environmental stressor that induces pathophysiological stress in birds with profound economic losses. Current methods used for preventing cold stress, such as reducing ventilation and using gas heaters, are facing challenges due to poor indoor air quality and deleterious effects on bird and caretaker health. The aim of this study was to examine if the novel designed warmed perch system, as a thermal device, can reduce cold stress-associated adverse effects on laying hens. Read More

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Thyroid hormone receptor beta sumoylation is required for thyrotropin regulation and thyroid hormone production.

JCI Insight 2021 Jul 8. Epub 2021 Jul 8.

Department of Medicine and Physiology, David Geffen School of Medicine at UCLA, Los Angeles, United States of America.

Thyroid hormone receptor beta (THRB) is post-translationally modified by small ubiquitin-like modifier (SUMO). We generated a mouse model with a mutation that disrupts sumoylation at lysine 146 (K146Q) and resulted in desumoylated THRB as the predominant form in tissues. The THRB K146Q mutant mice had normal serum thyroxine (T4), markedly elevated serum thyrotropin (TSH) (81-fold above control), and enlargement of both the pituitary and the thyroid gland. Read More

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Separating the Wheat from the Chaff: The Use of Upstream Regulator Analysis to Identify True Differential Expression of Single Genes within Transcriptomic Datasets.

Int J Mol Sci 2021 Jun 11;22(12). Epub 2021 Jun 11.

Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H8L1, Canada.

The development of DNA microarray and RNA-sequencing technology has led to an explosion in the generation of transcriptomic differential expression data under a wide range of biologic systems including those recapitulating the monogenic muscular dystrophies. Data generation has increased exponentially due in large part to new platforms, improved cost-effectiveness, and processing speed. However, reproducibility and thus reliability of data remain a central issue, particularly when resource constraints limit experiments to single replicates. Read More

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Comparison of Thyroid Hormone Levels between Women Farmers and Non-Farmers in Banten Indonesia.

Int J Environ Res Public Health 2021 06 19;18(12). Epub 2021 Jun 19.

Department of Occupational Health and Safety, Faculty of Public Health, Mahidol University, Bangkok 10400, Thailand.

Pesticides are suspected of being endocrine disruptors. This cross-sectional study measured serum samples for levels of thyroid hormones including thyroid stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), free T3 (FT3), and free T4 (FT4) among Indonesian female farmers ( = 127) and non-farmers ( = 127). A questionnaire was used to collect information on demographics and risk factors including work characteristics and frequency, and the use of home and agricultural pesticides. Read More

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Oral transmucosal absorption of iodine after intraoral preparation with povidone-iodine prior to oral surgeries: a randomized controlled study in 12 male patients.

Clin Oral Investig 2021 Jul 1. Epub 2021 Jul 1.

Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, The Stomatological Hospital of Chongqing Medical University, Chongqing, China.

Introduction: Absorption of iodine through skin and an increased incidence of thyroid disorders due to iodophor exposure are reported. However, the risk of oral transmucosal absorption of povidone-iodine after intraoral preparation is not clear.

Objective: To investigate the possibility of oral transmucosal absorption of povidone-iodine after intraoral preparation and its effect on thyroxine level in blood. Read More

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Effect of Preeclampsia on Ultrastructure of Thyroid Gland, Hepatic Type 1 Iodothyronine Deiodinase, and Thyroid Hormone Levels in Rats.

Biomed Res Int 2021 20;2021:6681491. Epub 2021 Apr 20.

School of Rehabilitation and Health Preservation, Chengdu University of Traditional Chinese Medicine, Chengdu 610032, China.

Background: Although hypothyroidism during pregnancy may develop grave outcomes for both mothers and offspring, management of which is still a challenge due to the insufficient understanding of this disease. The close correlation between hypothyroidism and preeclampsia is well documented, suggesting that preeclampsia is a potential risk factor for the development of maternal hypothyroidism. However, the exact role of preeclampsia in gestational hypothyroidism is still obscure. Read More

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Free Thyroxine Levels are Associated with Cold Induced Thermogenesis in Healthy Euthyroid Individuals.

Front Endocrinol (Lausanne) 2021 14;12:666595. Epub 2021 Jun 14.

Department of Endocrinology, Diabetes and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.

Thyroid hormone (TH) is an important regulator of mammalian metabolism and facilitates cold induced thermogenesis (CIT) in brown adipose tissue (BAT). Profound hypothyroidism or hyperthyroidism lead to alterations in BAT function and CIT. In euthyroid humans the inter-individual variation of thyroid hormones is relatively large. Read More

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Effects of dietary live yeast supplementation on growth performance and biomarkers of metabolism and inflammation in heat-stressed and nutrient-restricted pigs.

Transl Anim Sci 2021 Apr 27;5(2):txab072. Epub 2021 May 27.

Department of Animal Science, Iowa State University, Ames, IA 50011, USA.

Study objectives were to determine the effects of dietary live yeast ( strain CNCM I-4407; ActisafHR+; 0.25g/kg of feed; Phileo by Lesaffre, Milwaukee, WI) on growth performance and biomarkers of metabolism and inflammation in heat-stressed and nutrient-restricted pigs. Crossbred barrows ( = 96; 79 ± 1 kg body weight []) were blocked by initial BW and randomly assigned to one of six dietary-environmental treatments: 1) thermoneutral () and fed ad libitum the control diet (), 2) TN and fed ad libitum a yeast containing diet (), 3) TN and pair-fed () the control diet (), 4) TN and PF the yeast containing diet (), 5) heat stress () and fed ad libitum the control diet (), or 6) HS and fed ad libitum the yeast diet (). Read More

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High-Normal Serum Thyrotropin Levels Increased the Risk of Non-Alcoholic Fatty Liver Disease in Euthyroid Subjects with Type 2 Diabetes.

Diabetes Metab Syndr Obes 2021 22;14:2841-2849. Epub 2021 Jun 22.

Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, People's Republic of China.

Purpose: The aim of this study was to investigate the association between high-normal thyrotropin (TSH) levels and the prevalence of non-alcoholic fatty liver disease (NAFLD) in euthyroid patients with T2DM.

Methods: A total of 2289 euthyroid adults with T2DM were included in this cross-sectional study conducted at the Third Affiliated Hospital of Sun Yat-sen University from January 2016 to December 2018. NAFLD was diagnosed by abdominal ultrasound. Read More

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Growth hormone replacement improved oocyte quality in a patient with hypopituitarism: a study of follicular fluid.

Ann Endocrinol (Paris) 2021 Jun 26. Epub 2021 Jun 26.

Endocrinology, Diabetes, and Nutrition Department, Amiens University Hospital, Picardy, France; Peritox UMR_I 01, CURS, Jules Verne University of Picardy, Amiens, France. Electronic address:

BACKGROUNDː Growth hormone (GH) is known to be involved in ovarian folliculogenesis and oocyte maturation. In patients with poor ovarian response without growth hormone deficiency (GHD), adjuvant GH treatment improves in-vitro fertilization (IVF) results. Improvement of oocyte quality in IVF by GH replacement was reported in only a few patients with GHD. Read More

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Quality of life comparison in thyroxine hormone withdrawal versus triiodothyronine supplementation prior to radioiodine ablation in differentiated thyroid carcinoma: a prospective cohort study in the Indian population.

Eur Arch Otorhinolaryngol 2021 Jun 24. Epub 2021 Jun 24.

Oncology Apollo Group of Hospitals, Plot #13, Parsik Hill Road, Off Uran Road, Sector - 23, CBD Belapur, Opp. Nerul Wonders Park, Navi Mumbai, Maharashtra, India.

Background: Thyroid withdrawal in preparation for radioiodine ablation (RIA) may have a profound impact on health-related quality of life (HRQL). Cost implications and scheduling limit the use of recombinant TSH and triiodothyronine (T3) with its shorter half-life is a conceptually attractive alternative.

Methods: Prospective cohort study design with patients having withdrawal of thyroxine (n = 37) or T3 supplementation (n = 33). Read More

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Effect of phloretin on growth performance, serum biochemical parameters and antioxidant profile in heat-stressed broilers.

Poult Sci 2021 Apr 24;100(8):101217. Epub 2021 Apr 24.

State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address:

The objective of this work was to evaluate the effect of phloretin on growth performance, serum biochemical parameters, antioxidant profile, glutathione (GSH)-related enzymes, nuclear factor erythroid 2-related 2 (Nrf2) and heat shock protein 70 (HSP70) in heat-stressed broilers. A total of 240, 22-day-old Arbor Acres broilers were divided into 4 groups. The control group was housed at 23. Read More

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Prevalence of Subclinical Hypothyroidism in Chronic Kidney Disease in a Population-based Study: Tehran Thyroid Study.

Int J Endocrinol Metab 2021 Apr 17;19(2):e103750. Epub 2021 Mar 17.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Chronic kidney disease (CKD) is a rising public health concern that has detrimental effects on cardiovascular health and overall survival. Subclinical hypothyroidism (SCH) has been associated with poor outcomes in the general population. It is thought to be more prevalent in CKD subjects, and their coexistence may contribute to poor outcomes in these patients. Read More

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Evaluation of clinical, endocrine and metabolic findings in obese children with and without hepatosteatosis.

J Pediatr Endocrinol Metab 2021 Jun 16. Epub 2021 Jun 16.

Department of Pediatrics,Zeynep Kamil Women and Children's Diseases Training and Research Hospital, Üsküdar, Istanbul, Turkey.

Objectives: Non-alcoholic fatty liver disease (NAFLD) is a common obesity-related comorbidity in childhood. In this study, we aimed to evaluate predictors of NAFLD by comparing clinical, endocrine and metabolic findings in obese children with and without hepatosteatosis.

Methods: Two hundred and eight obese children aged 6-18 years were included. Read More

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Examination of the Dose-Effect Relationship of Radiation-Induced Hypopituitarism: Results of a Case-Control Study.

Adv Radiat Oncol 2021 Jul-Aug;6(4):100693. Epub 2021 Apr 15.

Department of Radiation Oncology.

Purpose: Previous reports have documented a dose-effect relationship for radiation-induced hypopituitarism in patients receiving therapy near or at the base of the skull. We aimed to characterize this long-term endocrinopathy further by examining the effect of dose on both the incidence and severity of toxicity, as well as exploring a possible dose threshold for this effect.

Methods And Materials: Out of an initial 346 patients who had received radiation therapy to the base of the skull, 53 patients with adequate endocrine evaluation were found. Read More

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The effect of vitamin D3 and thyroid hormones on the capillaroscopy-confirmed microangiopathy in pediatric patients with a suspicion of systemic connective tissue disease-a single-center experience with Raynaud phenomenon.

Rheumatol Int 2021 Aug 16;41(8):1485-1493. Epub 2021 Jun 16.

Department of Pediatric Cardiology and Rheumatology, Medical University of Lodz, Sporna 36/50, 91-738, Lodz, Poland.

Raynaud phenomenon (RP) may be the first manifestation of a systemic connective tissue disease (SCTD). Early detection of dysfunction of small vessels called microangiopathy is essential for the diagnostic process. The focus of this single-center, retrospective study was to investigate the potential dependencies between microvascular image and laboratory markers measured in children with RP. Read More

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Novel Gene Mutation Acting as Phenotype Modifier for Novel Compound Heterozygous Gene Mutations Causing Congenital Hypothyroidism.

Thyroid 2021 Jul 16. Epub 2021 Jul 16.

Department of Medicine; University of Miami Miller School of Medicine, Miami, Florida, USA.

A family with congenital hypothyroidism was identified with two novel deleterious compound heterozygous thyroid peroxidase () mutations (, and ). Serum thyroid tests showed higher-than-expected serum-free thyroxine (T4) relative to TT3, while reverse triiodothyronine (rT3) was also elevated. Two siblings manifested a more severe phenotype of developmental delay compared with another sibling and were found to harbor an additional novel heterozygous deleterious iodothyronine deiodinase 1 () mutation (). Read More

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Clinical, biochemical, and radiological follow-up results of children and adolescents with Hashimoto's thyroiditis: a single-center experience.

J Pediatr Endocrinol Metab 2021 Jun 15. Epub 2021 Jun 15.

Division of Pediatric Endocrinology, Faculty of Medicine, İstanbul University - Cerrahpaşa, İstanbul, Turkey.

Objectives: Hashimoto's thyroiditis (HT) is the most common cause of goiter and acquired hypothyroidism in children and adolescents, especially in areas without endemic iodine deficiency. We aimed to evaluate the follow-up results of children and adolescents diagnosed with HT, including clinical, biochemical, and radiological findings and treatment approaches.

Methods: HT patients, who were diagnosed between 2012 and 2018 years in a single-center, were assessed retrospectively. Read More

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Relationship between autoimmune thyroid disease and nephropathy: A clinicopathological study.

Medicine (Baltimore) 2021 Jun;100(23):e26273

Department of Pathology, Shanxi Provincial People's Hospital, Taiyuan City, Shanxi Province, China.

Abstract: The association of nephropathy with autoimmune thyroid disease (AITD) has been reported previously. However, there is limited information on the relationship between thyroid autoantibodies and nephropathy. A retrospective study was conducted using the medical records of 246 patients with nephropathy, 82 of whom had concurrent AITD. Read More

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Association of Vitamin D with Thyroid Status in a Tertiary Care Hospital in North India.

Clin Lab 2021 Jun;67(6)

Background: Vitamin D acts as immunomodulatory molecule and its deficiency has been implicated in various autoimmune diseases including immune mediated hypothyroidism. However, its association with thyroid hormones is ambiguous. The present study was therefore aimed to explore the relationship of vitamin D with thyroid hormone levels in a population enrolled for health care check up in a tertiary care hospital. Read More

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A prospective randomized clinical study of perioperative oral thyroid hormone treatment for children undergoing surgery for congenital heart diseases.

Ann Pediatr Cardiol 2021 Apr-Jun;14(2):170-177. Epub 2021 Feb 16.

Department of Pediatric Cardiothoracic Surgery, Fortis Escorts Heart Institute, New Delhi, India.

Context: Thyroid hormone deficiency is known to occur after cardiac surgery and known as nonthyroid illness (NTI). The beneficial role of perioperative thyroid hormone supplementation in children has been debatable more so with oral supplementation.

Aims: The aim is to evaluate the role of pre-operative oral thyroid hormone therapy in preventing NTI. Read More

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February 2021

Association of lipoproteins and thyroid hormones with cognitive dysfunction in patients with systemic lupus erythematosus.

BMC Rheumatol 2021 Jun 9;5(1):18. Epub 2021 Jun 9.

Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, PR China.

Background: Neuropsychiatric manifestations occur in up to 75% of adult systemic lupus erythematosus (SLE) patients and are one of the major causes of death in SLE patients. Cognitive dysfunction is a typical clinical feature of neuropsychiatric SLE (NPSLE), which seriously affects the quality of life of patients. Dyslipidaemia and thyroid symptoms, which are prevalent in SLE patients, have both been related to neuropsychiatric disturbances, including significant psychiatric and cognitive disturbances. Read More

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A randomised, controlled trial to determine the effect of levothyroxine on Standardbred racehorses.

Equine Vet J 2021 Jun 8. Epub 2021 Jun 8.

Department of Veterinary Clinical Sciences, Purdue University College of Veterinary Medicine, West Lafayette, Indiana, 47907, USA.

Background: The use of thyroid supplement is pervasive in athletic horses although its effects on measures of performance are not known.

Objectives: One purpose of this study was to determine whether supra-physiologic doses of levothyroxine affect the velocities at which blood lactate was greater than 4 mmol/L (V ) and heart rate was over 150 (V ) and 200 (V ) beats per minute respectively. Additionally, a survey of post-race blood samples was also conducted to determine whether high thyroxine concentrations were common in racehorses. Read More

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