269,187 results match your criteria compared serum

O-GlcNAcylation inhibits hepatic stellate cell activation.

J Gastroenterol Hepatol 2021 Sep 21. Epub 2021 Sep 21.

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, SAR, China.

Protein O-GlcNAcylation is a critical post-translational modification regulating gene expression and fundamental cell functions. O-GlcNAc transferase (OGT) emerged as a key regulator of liver pathophysiology and disease. In this study, we aimed to evaluate the role of OGT in hepatic stellate cells (HSCs) and its consequent role in liver fibrosis. Read More

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September 2021

Impact of Plasmatic Progesterone on the Day of Frozen Embryo Transfer in Hormone-induced Cycles.

Rev Bras Ginecol Obstet 2021 Aug 21;43(8):608-615. Epub 2021 Sep 21.

Instituto Valenciano de Infertilidad, Lisboa, Portugal.

Objective:  To establish a relationship between serum progesterone values on the day of frozen blastocyst transfer in hormone-replaced cycles with the probability of pregnancy, miscarriage or delivery.

Methods:  This was an ambispective observational study including all frozen-thawed embryo transfer cycles performed at our department following in vitro fecundation from May 2018 to June 2019. The outcomes evaluated were β human chorionic gonadotropin (β-hCG)-positive pregnancy and delivery. Read More

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Impact of seminal and serum zinc on semen quality and hormonal status: A population-based cohort study of Russian young men.

J Trace Elem Med Biol 2021 Sep 7;68:126855. Epub 2021 Sep 7.

Department of Human Molecular Genetics, Federal Research Center 'Institute of Cytology and Genetics', the Siberian Branch of the Russian Academy of Sciences, Prospekt Academician Lavrentyeva 10, Novosibirsk, 630090, Russian Federation. Electronic address:

Background: Trace elements are important factors in human reproductive health. Among them, special attention is paid to zinc, which is an essential trace element and is necessary for the normal functioning of the male reproductive system and the process of spermatogenesis. The aim of the study was to investigate the association between seminal and serum zinc concentrations and semen quality and reproductive hormone levels in population of Russian young men. Read More

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September 2021

Maternal-Neonatal Transfer of SARS CoV-2 IgG Antibodies among Parturient Women Treated with BNT162b2 mRNA Vaccine during Pregnancy.

Am J Obstet Gynecol MFM 2021 Sep 18:100492. Epub 2021 Sep 18.

Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Background: The exclusion of pregnant women from COVID-19 mRNA vaccine trials raised hesitancy regarding the benefit of vaccination of pregnant women, hence little is known about the vaccine's efficacy in this population.

Objective: To determine the maternal-neonatal transplacental transfer of SARS CoV-2 antibodies among vaccinated parturient women. A control group of COVID 19 recovered patients was included in order to compare IgG levels between vaccinated and recovered patients. Read More

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September 2021

Human beta-defensins 2 and 4 are dysregulated in patients with coronavirus disease 19.

Microb Pathog 2021 Sep 18:105205. Epub 2021 Sep 18.

Tropical-Biological Research Unit, College of Science, University of Baghdad, Baghdad, Iraq. Electronic address:

Antimicrobial peptides (AMPs) have recently been proposed as significant immunological factors involved in pathogenesis of coronavirus disease 19 (COVID-19). Human β-defensins (hBDs) are among these AMPs, but the evidence is not well detailed. Therefore, this case-control study analyzed levels of hBD1, hBD2, hBD3 and hBD4 in serum of 103 patients with severe COVID-19 and 105 healthy controls. Read More

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September 2021

Improved Liver Delivery of Primaquine by Phospholipid-Free Small Unilamellar Vesicles with Reduced Hemolytic Toxicity.

Mol Pharm 2021 Sep 21. Epub 2021 Sep 21.

Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

Hemolytic toxicity caused by primaquine (PQ) is a high-risk condition that hampers the wide use of PQ to treat liver-stage malaria. This study demonstrated that phospholipid-free small unilamellar vesicles (PFSUVs) composed of Tween80 and cholesterol could encapsulate and deliver PQ to the hepatocytes with reduced exposure to the red blood cells (RBCs). Nonionic surfactant (Tween80) and cholesterol-forming SUVs with a mean diameter of 50 nm were fabricated for delivering PQ. Read More

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September 2021

The wound healing effect of local leukocyte platelet-rich plasma after total hip arthroplasty: A randomized controlled trial.

Wound Repair Regen 2021 Sep 21. Epub 2021 Sep 21.

Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark.

Rapid wound closure is important after arthroplasty procedures to prevent postoperative complications. Platelets are rich in growth factors and leukocytes contribute to innate immunity. We hypothesized that topical leukocyte platelet-rich plasma (L-PRP) derived from the blood of patients would be beneficial to wound healing. Read More

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September 2021

Adverse effects of oxytetracycline and enrofloxacin on the fertility of Saanen bucks.

Trop Anim Health Prod 2021 Sep 21;53(5):466. Epub 2021 Sep 21.

Departments of Reproduction and Artificial Insemination, Veterinary Faculty, University of Burdur Mehmet Akif Ersoy, 15100, Burdur, Turkey.

This study aimed to determine the adverse effects of oxytetracycline and enrofloxacin application on the fertility of Saanen bucks. For this purpose, twenty-four bucks were divided into three groups. Group I (control group) received only 5 ml of 0. Read More

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September 2021

Elevation of microRNA-214 is associated with progression of liver fibrosis in patients with biliary atresia.

Pediatr Surg Int 2021 Sep 21. Epub 2021 Sep 21.

Department of Pediatric Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Background: MicroRNAs (miRNAs) play an important role in regulating fibrogenesis in the liver. The current study examined the ability of microRNA-214 (miR-214) level in liver and serum samples obtained from patients with BA to predict progressive liver fibrosis in patients with biliary atresia (BA).

Methods: We examined miR-214 level in relation to conventional markers of liver fibrosis, with liver and serum samples from BA patients. Read More

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September 2021

Interleukin-6 and its correlations with maternal characteristics and echocardiographic parameters in pre-eclampsia, gestational hypertension and normotensive pregnancy.

Cardiovasc J Afr 2021 Sep 20;32:1-9. Epub 2021 Sep 20.

Department of Obstetrics and Gynaecology, Medical University - Plovdiv; Clinic of Obstetrics and Gynaecology, UMHAT Sveti Georgi, Plovdiv, Bulgaria.

Background: Pre-eclampsia and gestational hypertension are pregnancy-related disorders with major maternal cardiovascular implications later in life.

Objectives: The aim of this study was to determine interleukin-6 levels in women with pre-eclampsia and gestational hypertension and in healthy pregnant controls, and to examine their correlations with characteristics of the women and echocardiographic findings.

Methods: The ELISA method was used to determine serum interleukin-6 in 36 women with gestational hypertension, 37 women with pre-eclampsia and 50 pregnant controls. Read More

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September 2021

Influence of Narrow-Band Ultra Violet B Phototherapy on Homocysteine Status: A Prospective Study of Patients with Different Cutaneous Disorders.

Photobiomodul Photomed Laser Surg 2021 Sep;39(9):607-611

Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Artificial ultraviolet (UV) radiation is a mainstay in the treatment of a variety of inflammatory skin disorders. Despite existence from a wealth of studies on the impact of narrow-band UVB (NBUVB) on serum levels of nutrients, clinical data on its effect on serum homocysteine (HC) level, which is thought to be a risk factor for cardiovascular disorders, dementia, and depression, are scarce. To assess serum HC status before and after treatment with at least 30 sessions of NBUVB exposure in patients with various cutaneous disorders. Read More

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September 2021

Double-blind, randomized, placebo-controlled pilot study of the phosphodiesterase-3 inhibitor cilostazol as an adjunctive to antidepressants in patients with major depressive disorder.

CNS Neurosci Ther 2021 Sep 21. Epub 2021 Sep 21.

Department of Biochemistry, Faculty of Pharmacy, Menoufia University, Shebin El-Kom, Egypt.

Aims: Cilostazol (CLS) has shown antidepressant effect in cardiovascular patients, post-stroke depression, and animal models through its neurotrophic and antiinflammatory activities. Consequently, we aimed to investigate its safety and efficacy in patients with MDD by conducting double-blind, randomized, placebo-controlled pilot study.

Methods: 80 participants with MDD (DSM-IV criteria) and Hamilton Depression Rating Scale (HDRS) score >20 were treated with CLS 50 mg or placebo twice daily plus escitalopram (ESC) 20 mg once daily for six weeks. Read More

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September 2021

Hepatoprotective effects of supplemented via drinking water against aflatoxin-induced liver damage.

Avian Pathol 2021 Sep 21:1-20. Epub 2021 Sep 21.

Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Felestin Sq., Hamedan, Iran.

The aim of this study was to examine the impact of intake of a lactic acid bacterium; 299v (Lp299v) on aflatoxin-induced hepatotoxicity in broilers. For this, broilers were intoxicated with dietary aflatoxins and simultaneously treated with live Lp299v in drinking water. One-day-old male broilers were divided into 8 groups (n=10/group) as follows; aflatoxin-groups fed basal diet contaminated with aflatoxins (200 or 2000 ppb). Read More

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September 2021

Serum Circ-FAF1/Circ-ELP3: A novel potential biomarker for breast cancer diagnosis.

J Clin Lab Anal 2021 Sep 21:e24008. Epub 2021 Sep 21.

Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Background: Recently, measurement of serum circular RNAs (circRNAs) as a non-invasive tumor marker has been considered more. We designed the present study to investigate the diagnostic efficiency of serum Circ-ELP3 and Circ-FAF1, separately and simultaneously, for diagnosis of patients with breast cancer.

Methods: Seventy-eight female patients diagnosed as primary breast cancer participated in this study. Read More

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September 2021

Monocyte to high-density lipoprotein cholesterol ratio as an independent risk factor for papillary thyroid carcinoma.

J Clin Lab Anal 2021 Sep 21:e24014. Epub 2021 Sep 21.

Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.

Background: Papillary thyroid carcinoma (PTC) is considered to be an inflammatory disease. This study aimed to investigate the association of monocyte to high-density lipoprotein cholesterol ratio (MHR) with PTC.

Methods: Clinical parameters from 300 patients with PTC and 552 patients with benign thyroid nodule were compared. Read More

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September 2021

Serum antibody response against periodontal bacteria and risk of coronary heart disease: systematic review and meta-analysis.

J Clin Periodontol 2021 Sep 20. Epub 2021 Sep 20.

Institute of Dentistry, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen.

Background: The present systematic review and meta-analysis assessed the strength of a reported association between elevated serum anti-periodontal bacterial antibody responses and an increased risk of coronary heart disease (CHD).

Review: Twenty original studies were identified after systematically searching five databases. The majority (n=11) compared serum anti-Porphyromonas gingivalis (Pg) and/or anti-Aggregatibacter actinomycetemcomitans (Aa) IgG antibody responses between CHD patients and control participants. Read More

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September 2021

Comparison of selected serum biochemistry measurements between the Nova Prime Plus VET, Nova pHOx Ultra, and Beckman Coulter AU680 analyzers in dogs.

Vet Clin Pathol 2021 Sep 20. Epub 2021 Sep 20.

Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IL, USA.

Background: Blood gas chemistry analyzers typically produce results faster and use smaller sample volumes than reference chemistry analyzers. However, results may not be comparable between blood gas chemistry analyzers and reference chemistry analyzers or between different models of blood gas chemistry analyzers. This could suggest the use of separate reference intervals and, thus, has implications when making clinical decisions. Read More

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September 2021

The role of the adipose tissue-derived mesenchymal stem cells enriched with melatonin on pancreatic cellular regeneration.

Folia Morphol (Warsz) 2021 Sep 21. Epub 2021 Sep 21.

Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, Egypt.

Background: Adipose tissue-derived mesenchymal stem cells (AD-MSCs) were proved to differentiate into insulin-producing cells (IPCs), but the amount of insulin secreted was relatively low compared to the insulin secreted by mature pancreatic islets. Enrichment of MSCs culture with melatonin (MT) was detected to promote cartilage matrix synthesis, osteogenic and neuronal differentiation. Therefore, the present study was conducted to evaluate the potential role of MT pre-treated AD-MSCs in enhancing the treatment and regeneration of the islet cells of Langerhans in diabetic rats induced by streptozotocin (STZ). Read More

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September 2021

Predictors of Postoperative Pancreatic Fistula (POPF) After Pancreaticoduodenectomy: Clinical Significance of the Mean Platelet Volume (MPV)/Platelet Count Ratio as a New Predictor.

J Gastrointest Surg 2021 Sep 20. Epub 2021 Sep 20.

Department of Surgical Oncology, Faculty of Medicine, Fırat University Medical Faculty Hospital, Elazig, 23200, Turkey.

Purpose: In this study, it was aimed to determine the predictors of clinically relevant postoperative pancreatic fistula (CR-POPF) following pancreaticoduodenectomy (PD) and clinical significance of mean platelet volume (MPV)/total platelet count ratio (MPR) as a new predictor for CR-POPF.

Methods: A total of 105 patients who underwent PD consecutively due to periampullary located diseases were included in the study. Patients were divided into two groups as CR-POPF and no postoperative pancreatic fistula (No-POPF). Read More

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September 2021

Creatinine correction to account for fluid overload in children with acute respiratory distress syndrome treated with extracorporeal membrane oxygenation: an initial exploratory report.

Pediatr Nephrol 2021 Sep 20. Epub 2021 Sep 20.

Department of Intensive Care, Hôpital Universitaire Des Enfants (HUDERF), Université Libre de Bruxelles (ULB), Brussels, Belgium.

Background: Creatinine is distributed between the intracellular and extracellular compartments, and as a result, the measurement of its concentration is strongly related to the fluid status of the patient. An interest has been shown in correcting measured serum creatinine levels according to the fluid balance in order to better specify the degree of acute kidney injury (AKI).

Methods: We conducted a retrospective observational study of 33 children, aged 0 to 5 years, admitted to the pediatric intensive care unit for acute respiratory distress syndrome treated by extracorporeal membrane oxygenation. Read More

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September 2021

Clinical Utility of Serum Holotranscobalamin Measurements in Patients with First-Ever Ischemic Stroke.

Dis Markers 2021 10;2021:9914298. Epub 2021 Sep 10.

Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

Background: Whether holotranscobalamin (holoTC) indicates B12 deficiency more sensitively than total vitamin B12 (B12) is unclear. This study is aimed at determining the impact of serum holoTC level as a risk factor for ischemic stroke and investigating its association with disease severity and short-term outcomes.

Methods: Serum holoTC, total B12, and homocysteine levels were compared between 130 stroke patients and 138 healthy controls. Read More

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September 2021

Clinical Observation on the Improvement of Serum Sex Hormone and Ovarian Function in Premature Ovarian Failure Patients with Deficiency-Cold Syndrome by Combining Wenjing Decoction with Tiaobu Chongren Acupuncture and Moxibustion.

Evid Based Complement Alternat Med 2021 11;2021:3926822. Epub 2021 Sep 11.

Chongqing Red Cross Hospital (Jiangbei District People's Hospital), No. 1, Jialing Village 1, Huaxin Street, Jiangbei District, Chongqing 400020, China.

Objective: To explore the effect of Wenjing Decoction and Tiaobu Chongren acupuncture and moxibustion therapy on serum sex hormones and ovarian function recovery in premature ovarian failure (POF) patients with deficiency-cold syndrome.

Methods: From February 2018 to October 2019, 119 POI patients with deficiency-cold syndrome who met the selection criteria were randomly divided into the control group ( = 59) and the observation group ( = 60). The control group was treated with hormone replacement therapy, and the observation group was treated with Wenjing Decoction and Tiaobu Chongren acupuncture and moxibustion therapy on the basis of the control group. Read More

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September 2021

Intranasal vaccination with a recombinant protein CTA1-DD-RBF protects mice against hRSV infection.

Sci Rep 2021 Sep 20;11(1):18641. Epub 2021 Sep 20.

NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, No. 155, Changbai Road, Changping District, Beijing, 102206, People's Republic of China.

Human respiratory syncytial virus (hRSV) infection is a major pediatric health concern worldwide. Despite more than half a century of efforts, there is still no commercially available vaccine. In this study, we constructed and purified the recombinant protein CTA1-DD-RBF composed of a CTA1-DD mucosal adjuvant and prefusion F protein (RBF) using Escherichia coli BL21 cells. Read More

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September 2021

Lack of gamma delta T cells ameliorates inflammatory response after acute intestinal ischemia reperfusion in mice.

Sci Rep 2021 Sep 20;11(1):18628. Epub 2021 Sep 20.

Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.

T-cells have been demonstrated to modulate ischemia-reperfusion injury (IRI) in the kidney, lung, liver, and intestine. Whereas most T-cell subpopulations contribute primarily to the antigen-specific effector and memory phases of immunity, γδ-T-cells combine adaptive features with rapid, innate-like responses that can place them in the initiation phase of immune reactions. Therefore, we aimed to clarify the role of γδ-T-cells in intestinal IRI. Read More

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September 2021

Efficacy of Intravenous Itraconazole Versus Liposomal Amphotericin B as Empirical Antifungal Therapy in Hematological Malignancy with Persistent Fever and Neutropenia: Study Protocol for a Multicenter, Prospective, Randomized Non-inferiority Trial.

Kurume Med J 2021 Sep 21. Epub 2021 Sep 21.

Department of Hematology, National Hospital Organization Nagoya Medical Center.

Febrile neutropenia, a serious complication that can occur during the treatment of hematological malignancies, can sometimes be fatal owing to fungal infection. Prospective randomized trials indicated the utility of liposomal amphotericin B or caspofungin as an empirical antifungal therapy. Itraconazole, a broad-spectrum tri azole antifungal agent, is poorly absorbed in the intestines after oral absorption and makes it difficult to achieve a stable serum drug concentration. Read More

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September 2021

Development of a Sandwich Chemiluminescence Immunoassay for the Detection of Intact Procollagen Type I N Propeptide with Magnetic Nanosphere Carrier Technology.

J Biomed Nanotechnol 2021 Aug;17(8):1690-1698

Clinical Laboratory Medicine, Anhui University of Science & Technology, Huainan, 232001, China.

The metabolic product of type I collagen synthesis, intact procollagen type I N propeptide (intact PINP), is a potential marker of bone formation and osteoporosis, which is not affected by kidney function. We sought to establish a chemiluminescent immunoassay method for the detection of serum intact PINP with previously prepared paired monoclonal antibodies and to evaluate the diagnostic value of the assay in osteoporosis. Using the capture molecule and monoclonal antibody as detection molecule, a diagnostic reagent was developed to detect intact PINP in serum with magnetic nanosphere carriers by the chemiluminescence method, and its analytical performance in the laboratory was evaluated. Read More

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Preparation of Targeted Mitochondrion Nanoscale-Release Peptides and Their Efficiency on Eukaryotic Cells.

J Biomed Nanotechnol 2021 Aug;17(8):1679-1689

Xi'an Medical University, Xi'an 710021, Shaanxi, PR China.

We established a self-decomposable SiO₂ encapsulated mitochondrial targeting short peptide SS31 drug loading system (SiO₂@SS31) to determine its nano-sustained release characteristics in eukaryotic cells. We explored the protection of SiO₂@SS31 on the 661W cells after oxidative injury by H₂O₂. After the drug loading, we detected the morphology of SiO₂@SS31 by transmission electron microscopy (TEM). Read More

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Effects of Stocking Density on Stress Response and Susceptibility to Infectious Hematopoietic Necrosis Virus in Rainbow Trout.

J Am Assoc Lab Anim Sci 2021 Sep 20. Epub 2021 Sep 20.

The goals of this study were to examine the effect of stocking density on the stress response and disease susceptibility injuvenile rainbow trout (Oncorhynchus mykiss). Fish were sorted into one of 2 stocking densities (high density "HD", 20-40kg/m3) or (low density, "LD", 4-8 kg/m3) and 3 stress indices (cortisol levels in serum and water, and neutrophil: lymphocyte(N:L) ratios from blood smears) were measured at multiple time points over 21 d. Serum cortisol was significantly increased at 1 h in LD samples and at 14 d in HD samples. Read More

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September 2021

Effects of chemerin and homocysteine levels and their associations with occurrence and development of ischemic cerebrovascular disease.

Lipids Health Dis 2021 Sep 20;20(1):108. Epub 2021 Sep 20.

Department of Neurology, Cangzhou Central Hospital, No.16 West Xinhua Road, Hebei, 061000, Cangzhou, China.

Background: The current study was conducted to explore the effects of chemerin and homocysteine (Hcy) levels and their associations with the occurrence and development of ischemic cerebrovascular disease (ICVD).

Methods: There involved a total of 187 patients with ICVD and 190 healthy people for physical examination in Cangzhou Central hospital from January 2020 to April 2021. The participants enrolled were divided into four groups based on the digital subtraction angiography: mild stenosis group (64 cases, stenosis rate 30-49 %), moderate stenosis group (72 cases, stenosis rate 50-69 %), severe stenosis group (51 cases, stenosis rate 70-99 %) and control group (190 cases, in healthy condition). Read More

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September 2021

Effects of mulberry leaf silage on antioxidant and immunomodulatory activity and rumen bacterial community of lambs.

BMC Microbiol 2021 Sep 20;21(1):250. Epub 2021 Sep 20.

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, People's Republic of China.

Background: Rumen is a natural fermentation system and the microorganisms inside can effectively utilize plant bioresource and interact with host metabolism. Here, analysis of rumen microbiome, together with animal performance and serum metabolism in a lamb model were performed to identify the potential use of mulberry leaf silage (MS) to replace alfalfa silage (AS) as a new functional feed resource and to mining the novel specific mulberry leaf associated rumen bacteria interact with host metabolism.

Results: The lambs fed with MS diet showed improved antioxidant capacity and immune function compared to those fed AS diet. Read More

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September 2021