153,339 results match your criteria compared reference

Haemodynamic effects of PAH-targeted therapies in pulmonary hypertension due to lung disease: A systematic review and meta-analysis.

Pulm Pharmacol Ther 2021 May 9:102036. Epub 2021 May 9.

Department of Cardiology, AHEPA University Hospital, Thessaloniki, Greece. Electronic address:

Background: Pulmonary hypertension (PH) is a negative predictor in patients with lung disease and/or hypoxia (group 3 PH). Current guidelines do not endorse the use of targeted therapies for pulmonary arterial hypertension (PAH) in patients with group 3 PH, due to lack of strong evidence. However, a variety of studies have examined the effect of PAH-targeted therapies in group 3 PH with mixed methods and conflicting results. Read More

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Blood-based biomarkers and long-term risk of frailty - experience from the Swedish AMORIS cohort.

J Gerontol A Biol Sci Med Sci 2021 May 12. Epub 2021 May 12.

Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Background: Frailty is associated with reduced quality of life, poor health outcomes, and death. Past studies have investigated how specific biomarkers are associated with frailty but understanding biomarkers in concert with each other and the associated risk of frailty is critical for clinical application.

Methods: Using a sample aged ≥59 years at baseline from the Swedish AMORIS cohort (n=19341), with biomarkers measured at baseline (1985-1996), we conducted latent class analysis with 18 biomarkers and used Cox models to determine the association between class and frailty and all-cause mortality. Read More

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Single-use negative pressure wound therapy reduces costs in closed surgical incisions: UK and US economic evaluation.

J Wound Care 2021 May;30(Sup5):S23-S31

Manchester Metropolitan University, UK.

Objective: Single-use negative pressure wound therapy (sNPWT) following closed surgical incisions has a demonstrable effect in reducing surgical site complications (SSC). However, there is little health economic evidence to support its widespread use. We sought to evaluate the cost-effectiveness of sNPWT compared with standard care in reducing SSCs following closed surgical incisions. Read More

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DeepBSP-a Machine Learning Method for Accurate Prediction of Protein-Ligand Docking Structures.

J Chem Inf Model 2021 May 12. Epub 2021 May 12.

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.

In recent years, machine-learning-based scoring functions have significantly improved the scoring power. However, many of these methods do not perform well in distinguishing the native structure from docked decoy poses due to the lack of decoy structural information in their training data. Here, we developed a machine-learning model, named DeepBSP, that can directly predict the root mean square deviation (rmsd) of a ligand docking pose with reference to its native binding pose. Read More

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Dutch reference values for the Patient-Reported Outcomes Measurement Information System Scale v1.2 - Global Health (PROMIS-GH).

J Patient Rep Outcomes 2021 May 12;5(1):38. Epub 2021 May 12.

Department of Epidemiology and Data Science, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health research institute, de Boelelaan 1089a, 1081 HV, Amsterdam, the Netherlands.

Background: To add context to the impact of medical conditions, it is important to interpret and compare health outcomes across studies and populations. We aimed to determine Dutch reference values for the Patient-Reported Outcomes Measurement Information System Scale v1.2 - Global Health (PROMIS-GH). Read More

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Reduced microglia activity in patients with long-term immunosuppressive therapy after liver transplantation.

Eur J Nucl Med Mol Imaging 2021 May 12. Epub 2021 May 12.

Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Purpose: Calcineurin inhibitors (CNI) can cause long-term impairment of brain function. Possible pathomechanisms include alterations of the cerebral immune system. This study used positron emission tomography (PET) imaging with the translocator protein (TSPO) ligand F-GE-180 to evaluate microglial activation in liver-transplanted patients under different regimens of immunosuppression. Read More

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Accuracy of free-hand humeral head resection planned on 3D-CT models in shoulder arthroplasty: an in vitro analysis.

Arch Orthop Trauma Surg 2021 May 12. Epub 2021 May 12.

Dept of Orthopaedics, Orthopaedic Research Laboratory, University of Utah, Salt Lake City, USA.

Introduction: Three-dimensional planning of humeral head osteotomy in shoulder arthroplasty (SA) is understudied. This study evaluated whether a standard osteotomy technique along the anterosuperior anatomic neck (ASOT) could be surgically reproduced as pre-operatively planned on 3D-CT models.

Material And Methods: Pre-operative planning in 12 cadaver shoulders was performed on a 3D-CT model of the humerus to calculate the planned osteotomy plane (planned OP). Read More

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Association of Left Ventricular Systolic Dysfunction Among Carriers of Truncating Variants in Filamin C With Frequent Ventricular Arrhythmia and End-stage Heart Failure.

JAMA Cardiol 2021 May 12. Epub 2021 May 12.

Heart Failure and Heart Transplantation Unit, Virgen del Rocio University Hospital, Sevilla, Spain.

Importance: Truncating variants in the gene encoding filamin C (FLNCtv) are associated with arrhythmogenic and dilated cardiomyopathies with a reportedly high risk of ventricular arrhythmia.

Objective: To determine the frequency of and risk factors associated with adverse events among FLNCtv carriers compared with individuals carrying TTN truncating variants (TTNtv).

Design, Setting, And Participants: This cohort study recruited 167 consecutive FLNCtv carriers and a control cohort of 244 patients with TTNtv matched for left ventricular ejection fraction (LVEF) from 19 European cardiomyopathy referral units between 1990 and 2018. Read More

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Impact of Carbohydrate Counting Error on Glycemic Control in Open-Loop Management of Type 1 Diabetes: Quantitative Assessment Through an in silico Trial.

J Diabetes Sci Technol 2021 May 12:19322968211012392. Epub 2021 May 12.

Department of Information Engineering, University of Padova, Padova, Italy.

Background: In the management of type 1 diabetes (T1D), systematic and random errors in carb-counting can have an adverse effect on glycemic control. In this study, we performed an in silico trial aiming at quantifying the impact of different levels of carb-counting error on glycemic control.

Methods: The T1D patient decision simulator was used to simulate 7-day glycemic profiles of 100 adults using open-loop therapy. Read More

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Evaluation of novel AI-based extended field-of-view CT reconstructions.

Med Phys 2021 May 12. Epub 2021 May 12.

Department of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Doctor Tanslaan 12, 6229 ET, Maastricht, the Netherlands.

Purpose: Modern CT scanners have an extended-field-of-view (eFoV) reconstructing images up to the bore size, which is relevant for patients with higher BMI or non-isocentric positioning due to fixation devices. However, the accuracy of the image reconstruction in eFoV is not well known since truncated data is used. This study introduces a new deep learning based algorithm for extended field of view reconstruction and evaluates the accuracy of the eFoV reconstruction focusing on aspects relevant for radiotherapy. Read More

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Benchmarking London dispersion corrected density functional theory for noncovalent ion-π interactions.

Phys Chem Chem Phys 2021 May 12. Epub 2021 May 12.

Mulliken Center for Theoretical Chemistry, Institute of Physical and Theoretical Chemistry, University of Bonn, Beringstr. 4, 53115 Bonn, Germany.

The strongly attractive noncovalent interactions of charged atoms or molecules with π-systems are important binding motifs in many chemical and biological systems. These so-called ion-π interactions play a major role in enzymes, molecular recognition, and for the structure of proteins. In this work, a molecular test set termed IONPI19 is compiled for inter- and intramolecular ion-π interactions, which is well balanced between anionic and cationic systems. Read More

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Phase contrast coronary blood velocity mapping with both high temporal and spatial resolution using triggered Golden Angle rotated Spiral k-t Sparse Parallel imaging (GASSP) with shifted binning.

Magn Reson Med 2021 May 12. Epub 2021 May 12.

Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Purpose: High temporal and spatial resolutions are required for coronary blood flow measures. Current spiral breath-hold phase contrast (PC) MRI at 3T focus on either high spatial or high temporal resolution. We propose a golden angle (GA) rotated Spiral k-t Sparse Parallel imaging (GASSP) sequence for both high spatial (0. Read More

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Spectral fitting strategy to overcome the overlap between 2-hydroxyglutarate and lipid resonances at 2.25 ppm.

Magn Reson Med 2021 May 12. Epub 2021 May 12.

Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Purpose: H MRS provides a noninvasive tool for identifying mutations in isocitrate dehydrogenase (IDH). Quantification of the prominent 2-hydroxyglutarate (2HG) resonance at 2.25 ppm is often confounded by the lipid resonance at the same frequency in tumors with elevated lipids. Read More

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Complementing the pulp proteome via sampling with a picosecond infrared laser (PIRL).

Clin Oral Investig 2021 May 12. Epub 2021 May 12.

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany.

Objectives: The aim of this investigation was the detailed analysis of the human pulp proteome using the new picosecond infrared laser (PIRL)-based sampling technique, which is based on a completely different mechanism compared to mechanical sampling. Proteome analysis of healthy pulp can provide data to define changes in the proteome associated with dental disease.

Material And Methods: Immediately after extraction of the entire, undamaged tooth, 15 wisdom teeth were deep frozen in liquid nitrogen and preserved at -80°C. Read More

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Combining hepatic surface nodularity and serum tests better predicts hepatic fibrosis stages in chronic liver disease.

Abdom Radiol (NY) 2021 May 12. Epub 2021 May 12.

Department of Radiology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Republic of Korea.

Purpose: Hepatic surface nodularity quantified on CT images has shown promising results in staging hepatic fibrosis in chronic hepatitis C. The aim of this study was to evaluate hepatic surface nodularity, serum fibrosis indices, and a linear combination of them for staging fibrosis in chronic liver disease, mainly chronic hepatitis B.

Methods: We developed a semiautomated software quantifying hepatic surface nodularity on CT images. Read More

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Differences in Radiation Exposure of CT-Guided Percutaneous Manual and Powered Drill Bone Biopsy.

Cardiovasc Intervent Radiol 2021 May 11. Epub 2021 May 11.

Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstraße 55, 45147, Essen, Germany.

Purpose: Apart from the commonly applied manual needle biopsy, CT-guided percutaneous biopsies of bone lesions can be performed with battery-powered drill biopsy systems. Due to assumably different radiation doses and procedural durations, the aim of this study is to examine radiation exposure and establish local diagnostic reference levels (DRLs) of CT-guided bone biopsies of different anatomical regions.

Methods: In this retrospective study, dose data of 187 patients who underwent CT-guided bone biopsy with a manual or powered drill biopsy system performed at one of three different multi-slice CT were analyzed. Read More

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Prospective Evaluation of the Addition of Polygenic Risk Scores to Breast Cancer Risk Models.

JNCI Cancer Spectr 2021 Jun 2;5(3):pkab021. Epub 2021 Mar 2.

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.

Background: The Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm and the International Breast Cancer Intervention Study breast cancer risk models are used to provide advice on screening intervals and chemoprevention. We evaluated the performance of these models, which now incorporate polygenic risk scores (PRSs), using a prospective cohort study.

Methods: We used a case-cohort design, involving women in the Melbourne Collaborative Cohort Study aged 50-75 years when surveyed in 2003-2007, of whom 408 had a first primary breast cancer diagnosed within 10 years (cases), and 2783 were from the subcohort. Read More

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A Novel TNM Classification for Colorectal Cancers based on the Metro-ticket Paradigm.

J Cancer 2021 5;12(11):3299-3306. Epub 2021 Apr 5.

Department of Gastrointestinal Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China.

Several revisions of the TNM classifications for colorectal cancer (CRC) have acknowledged that the oncological outcomes of stage IIB/IIC CRC are worse than those of stage IIIA. We aimed to develop a novel TNM (nTNM) classification based on the metro-ticket paradigm. We identified eligible CRC patients from the Surveillance, Epidemiology, and End Results database. Read More

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Leukocyte-Reactive Antibodies in Female Blood Donors: The Austrian Experience.

Transfus Med Hemother 2021 Mar 23;48(2):99-108. Epub 2020 Sep 23.

Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.

Introduction: Antibody-mediated transfusion-related acute lung injury (TRALI) is caused by antibodies against human leukocyte antigens (HLAs) or human neutrophil antigens (HNAs), and is one of the most serious complications associated with transfusion medicine. Prevention strategies like testing allo-exposed female blood donors have not yet been introduced nationwide in Austria. To assess the need and feasibility of routine leukocyte antibody testing, the prevalence of leukocyte-reactive antibodies in an Austrian female donor population was been determined using classical cell-based methods which were compared with a high-throughput bead-based method. Read More

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Applicability of a single-use bioreactor compared to a glass bioreactor for the fermentation of filamentous fungi and evaluation of the reproducibility of growth in pellet form.

Eng Life Sci 2021 May 25;21(5):324-339. Epub 2021 Feb 25.

Institute for Biotechnical Process Design Trier University of Applied Sciences, Environmental Campus Birkenfeld Hoppstädten-Weiersbach Germany.

The implementation of single-use technologies offers several major advantages, e.g. prevention of cross-contamination, especially when spore-forming microorganisms are present. Read More

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Tryptophan Operon Diversity Reveals Evolutionary Trends among Geographically Disparate Chlamydia trachomatis Ocular and Urogenital Strains Affecting Tryptophan Repressor and Synthase Function.

mBio 2021 May 11;12(3). Epub 2021 May 11.

Department of Pediatrics, University of California San Francisco, Oakland, California, USA

The obligate intracellular pathogen () is the leading cause of bacterial sexually transmitted infections and blindness globally. To date, urogenital strains are considered tryptophan prototrophs, utilizing indole for tryptophan synthesis within a closed-conformation tetramer comprised of two α (TrpA)- and two β (TrpB)-subunits. In contrast, ocular strains are auxotrophs due to mutations in TrpA, relying on host tryptophan pools for survival. Read More

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Skin Diseases in Elite Athletes.

Int J Sports Med 2021 May 11. Epub 2021 May 11.

Department of Sport Medicine Humboldt University and Charité University School of Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.

An athlete's skin has to cope with various stressors that influence skin integrity. This study investigated the effect of intense sporting activity at a competitive level on skin health, independent of the type of sport. The prevalence of dermatoses in elite athletes who exercise 8 or more hours per week was compared to recreational athletes. Read More

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Neuroendocrine Modulation of Cognitive Performance in the Patients with Fibromyalgia.

Eur Neurol 2021 May 11:1-11. Epub 2021 May 11.

Departments of Neurology (Sleep Disorder), The Affiliated Chaohu Hospital of Anhui Medical University, Hefei, China.

Background: Fibromyalgia (FM) is a chronic widespread pain disorder associated with fatigue, tender points, sleep disturbances, and mood disorders. Symptoms associated with FM also include decreased cognitive function in which the neural basis is poorly understood. Neuroendocrine hormones may be correlated with cognitive performance under some ill conditions. Read More

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Neutron dose coefficients for the lens of the eye.

J Radiol Prot 2021 May 11. Epub 2021 May 11.

Retired, Oak Ridge, Tennessee, UNITED STATES.

International Commission on Radiation Units and Measurements (ICRU) Report Number 95 (ICRU 2020) recommends new definitions of operational quantities as estimators of the International Commission on Radiological Protection (ICRP) radiation protection quantities. As part of the report, dose coefficients for neutron fluences are included for energies from 10-9 MeV through 50 MeV. For lens of the eye dosimetry, several changes in the ICRU recommended quantities are of particular interest. Read More

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Response to systemic therapy in fumarate hydratase-deficient renal cell carcinoma.

Eur J Cancer 2021 May 8;151:106-114. Epub 2021 May 8.

Department of Medical Oncology, Gustave Roussy, Villejuif, France; Réseau National de Référence pour Cancers Rares de l'Adulte PREDIR labellisé par l'INCa, Hôpital Bicêtre, AP-HP, Le Kremlin Bicêtre, France. Electronic address:

Purpose: Fumarate hydratase-deficient (FHdef) renal cell carcinoma (RCC) is a rare entity associated with the hereditary leiomyomatosis and RCC syndrome with no standard therapy approved. The aim of this retrospective study was to evaluate the efficacy of different systemic treatments in this population.

Methods: We performed a multicentre retrospective analysis of Fhdef RCC patients to determine the response to systemic treatments. Read More

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Radiation without endocrine therapy in older women with stage I estrogen-receptor (ER) positive breast cancer is not associated with a higher risk of second breast cancer events.

Int J Radiat Oncol Biol Phys 2021 May 8. Epub 2021 May 8.

Department of Population Health, NYU School of Medicine, New York, NY. Electronic address:

Purpose: The omission of radiation therapy (RT) in elderly women with stage 1 estrogen-receptor positive (ER+) breast cancer receiving endocrine therapy (ET) is an acceptable strategy based on randomized trial data. Less is known about the omission of ET +/- RT.

Patient And Methods: We analyzed SEER-Medicare data for 13,321 women ≥ 66 years with stage I ER+ breast cancer from 2007-2012 who underwent breast conserving surgery. Read More

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Technique for analyzing the transfer of colored cosmetics onto face masks.

Skin Res Technol 2021 May 11. Epub 2021 May 11.

Skin Clinical Trials Center, OATC Inc., Seoul, South Korea.

Background: With the rapid spread of COVID-19, the makeup trend in the cosmetics market is changing as mask-wearing has become a common practice. This study was conducted to establish an objective and reliable method for analyzing the transfer of colored cosmetics onto face masks.

Methods: A total of 24 women participated in this test. Read More

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Establishment of soil strength in a nourished wetland using thin layer placement of dredged sediment.

PLoS One 2021 11;16(5):e0251420. Epub 2021 May 11.

US Army Corps of Engineers, Research and Development Center, Vicksburg, Mississippi, United States of America.

Coastal wetlands are experiencing accelerated rates of fragmentation and degradation due to sea-level rise, sediment deficits, subsidence, and salt-water intrusion. This reduces their ability to provide ecosystem benefits, such as wave attenuation, habitat for migratory birds, and a sink for carbon and nitrogen cycles. A deteriorated back barrier wetland in New Jersey, USA was nourished through thin layer placement (TLP) of dredged sediment in 2016. Read More

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Monthly pork price forecasting method based on Census X12-GM(1,1) combination model.

PLoS One 2021 11;16(5):e0251436. Epub 2021 May 11.

School of Management Engineering, Capital University of Economics and Business, Beijing, China.

Background: In recent years, the price of pork in China continues to fluctuate at a high level. The forecast of pork price becomes more important. Single prediction models are often used for this work, but they are not accurate enough. Read More

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Multiconfigurational Quantum Chemistry Determinations of Absorption Cross Sections (σ) in the Gas Phase and Molar Extinction Coefficients (ε) in Aqueous Solution and Air-Water Interface.

J Chem Theory Comput 2021 May 11. Epub 2021 May 11.

Instituto de Ciencia Molecular, Universitat de València, P.O. Box 22085, València, Spain.

Theoretical determinations of absorption cross sections (σ) in the gas phase and molar extinction coefficients (ε) in condensed phases (water solution, interfaces or surfaces, protein or nucleic acids embeddings, etc.) are of interest when rates of photochemical processes, = ∫ ϕ(λ) σ(λ) (λ) dλ, are needed, where ϕ(λ) and (λ) are the quantum yield of the process and the irradiance of the light source, respectively, as functions of the wavelength λ. Efficient computational strategies based on single-reference quantum-chemistry methods have been developed enabling determinations of line shapes or, in some cases, achieving rovibrational resolution. Read More

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