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Survival Probabilities and Predictors of Major Depressive Episode Incidence Among Individuals With Various Types of Substance Use Disorders.

J Clin Psychiatry 2021 Jul 27;82(5). Epub 2021 Jul 27.

Addictions Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

This study aimed to estimate the survival probabilities related to the occurrence of major depressive episodes (MDEs) after the onset of substance use disorders (SUDs) using data from the 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions-III.

The Alcohol Use Disorder and Associated Disabilities Interview Schedule-5 was used to diagnose SUD, and psychiatric diagnoses were based on the , Fifth Edition. Individuals with incidents of various SUDs with no prior history of MDEs (n = 5,987 with alcohol use disorder [AUD], 1,353 with cannabis use disorder [CUD], 351 with opioid use disorder [OUD], 827 with stimulant use disorder [STUD], and 5,363 with nicotine use disorder [NUD]) were included. Read More

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Impact of pharmacist involvement on medication safety in interprofessional transfer of care activity.

N Z Med J 2021 Jul 30;134(1539):9-20. Epub 2021 Jul 30.

Associate Dean Medical Education, University of Otago, Christchurch, Specialist Respiratory Physician, Canterbury District Health Board.

Aim: Any transition of patient care is a high-risk time for communication error. This paper explores whether the presence of a pharmacist as part of an interprofessional group provides additional benefit and safety in transitions of care.

Method: Six pharmacy interns and newly qualified pharmacists joined participants from seven other health professional training programmes to take part in an interprofessional education activity. Read More

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Association between Comorbidities and Preserved Ratio Impaired Spirometry: Using the Korean National Health and Nutrition Examination Survey IV-VI.

Respiration 2021 Jul 28:1-9. Epub 2021 Jul 28.

Department of Public Health Science, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.

Background: Preserved ratio impaired spirometry (PRISm) patients have more frequent respiratory symptoms and an increased risk of mortality. However, studies on comorbidities in these patients are lacking.

Objectives: We investigated the association between PRISm and comorbidities using the Korea National Health and Nutrition Examination Survey (KNHANES). Read More

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Influence of environmental enrichment on circulating white blood cell counts and behavior of female turkeys.

Poult Sci 2021 Jun 30;100(9):101360. Epub 2021 Jun 30.

Clinic for Poultry, University of Veterinary Medicine Hannover, Hannover 30559, Germany. Electronic address:

Under commercial conditions turkeys are housed in large groups in poorly structured environments. This leads to stress and subsequently to pecking and cannibalism. Environmental enrichment is suggested to reduce stress and feather pecking, thus leading to an increase of the overall flock health. Read More

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How dirty are the pens in health-care environment༟An easily overlooked detail of hand hygiene.

Am J Infect Control 2021 Jul 25. Epub 2021 Jul 25.

Department of General Surgery, Beijing Shijitan Hospital, Capital Medical University/ Peking University Ninth School of Clinical Medicine, Beijing, China. Electronic address:

Pens, common in hospitals, may be a potential vehicle for cross-infection. In this study, the number of pathogens on different pens and the positive rates of several common multi-drug-resistant bacteria were calculated and compared according to the nature of use and material. In addition, the effect of pens on bacterial transmission was explored through simulation experiments. Read More

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Characteristics of work-related eye trauma in construction and manufacturing industries.

Clin Exp Optom 2021 Jul 28:1-6. Epub 2021 Jul 28.

Former President of Turkish Social Security Institution, Ankara, Turkey.

Clinical Relevance: Knowledge of work-related eye trauma in the construction and manufacturing industries will facilitate planning of policies and practices to protect against such occurrences.

Background: The aim of this study was to compare demographic, epidemiological, and clinical characteristics of work-related eye trauma in workers in the construction and manufacturing industries.

Methods: Medical board disability reports of subjects who experienced work-related eye trauma were investigated in this retrospective comparative study. Read More

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Risdiplam-Treated Infants with Type 1 Spinal Muscular Atrophy versus Historical Controls.

N Engl J Med 2021 Jul;385(5):427-435

From the Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston (B.T.D.); the Developmental Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan (R.M., G.B.), and the Center of Translational and Experimental Myology, IRCCS Istituto Giannina Gaslini, Genoa (C.B.) - both in Italy; the Department of Developmental Neurology, Medical University of Gdańsk, Gdańsk, Poland (M.M.-B.); the Paediatric Gait Analysis Service of New South Wales, the Children's Hospital at Westmead and the University of Sydney, Sydney (K.R.); the Department of Pediatrics, Peking University First Hospital, Beijing (H.X.), and Children's Hospital of Fudan University, Shanghai (Y.W.) - both in China; the Department of Neurology, Faculdade de Medicina, Universidade de São Paulo, São Paulo (E.Z.); the Dubowitz Neuromuscular Centre, National Institute for Health Research Great Ormond Street Hospital Biomedical Research Centre, University College London Great Ormond Street Institute of Child Health, and Great Ormond Street Hospital for Children NHS Foundation Trust, London (G.B.), Roche Products, Welwyn Garden City (M.E.-K.), and the Muscular Dystrophy UK Oxford Neuromuscular Centre, the Department of Paediatrics, University of Oxford, Oxford (L.S.) - all in the United Kingdom; Russian Children Neuromuscular Center, Veltischev Clinical Pediatric Research Institute, Pirogov Russian National Research Medical University, Moscow (D.V.); Pharma Development, Safety (M.G.), Product Development Medical Affairs - Neuroscience and Rare Disease (K.G., P.F.), and Pharma Development Neurology (R.S.S.), F. Hoffmann-La Roche, and Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel (O.K., H.K.) - both in Basel, Switzerland; the Division of Child Neurology, Centre de Références des Maladies Neuromusculaires, the Department of Pediatrics, University Hospital Liege, University of Liege, Liege, Belgium (L.S.); and I-Motion, Institut de Myologie, Assistance Publique Hôpitaux de Paris, Hôpital Armand Trousseau, Paris (L.S.).

Background: Type 1 spinal muscular atrophy (SMA) is a progressive neuromuscular disease characterized by an onset at 6 months of age or younger, an inability to sit without support, and deficient levels of survival of motor neuron (SMN) protein. Risdiplam is an orally administered small molecule that modifies pre-messenger RNA splicing and increases levels of functional SMN protein in blood.

Methods: We conducted an open-label study of risdiplam in infants with type 1 SMA who were 1 to 7 months of age at enrollment. Read More

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RIP3-mediated necroptosis increases neuropathic pain via microglia activation: necrostatin-1 has therapeutic potential.

FEBS Open Bio 2021 Jul 28. Epub 2021 Jul 28.

Department of Anesthesiology, Ningbo Medical Treatment Center Lihuili Hospital, Ningbo, Zhejiang, 315040, China.

Neuropathic pain (NP) is a clinical symptom that accompanies many diseases. We investigated the effect of receptor-interacting protein kinase 3 (RIP3)-regulated necroptosis on NP, and explore its relationship with microglia, in order to provide a theoretical basis for further research and provide new insights into the treatment of NP. In this study, the spared nerve injury (SNI) model was used along with intervention with necrostatin and the inhibitor of necroptosis necrostatin-1 (Nec-1). Read More

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Expression and prognostic significance of vascular endothelial growth factor-A (VEGF-A) and its receptor in canine prostate cancer.

Prostate 2021 Jul 28. Epub 2021 Jul 28.

Department of Veterinary Surgery and Anesthesiology, School of Veterinary Medicine and Animal Science, São Paulo State University-UNESP, Botucatu, Sao Paulo, Brazil.

Background: Vascular endothelial growth factor-A (VEGF-A) and its receptor, VEGF receptor-2 (VEGFR-2), represent a complex family of angiogenic molecules consisting of different ligands and receptors. Due to the importance of VEGF-A/VEGFR-2 signaling in tumor proliferation and angiogenesis, this study aimed to evaluate the protein and gene expression levels of VEGF-A and VEGFR-2 in canine prostate cancer (PC).

Methods: We analyzed VEGF-A and VEGFR-2 expression in 87 PC samples by immunohistochemistry and quantitative-polymerase chain reaction. Read More

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Impact of the coronavirus disease 2019 on the diagnoses of Hansen's disease in Brazil.

Rev Soc Bras Med Trop 2021 23;54:e02512021. Epub 2021 Jul 23.

Universidade José do Rosário Vellano, Centro de Reabilitação de Anomalias Craniofaciais, Alfenas, MG, Brasil.

Introduction: Coronavirus disease 2019 (COVID-19) has limited the access of patients with Hansen's disease (HD) to care due to changes in routine health services.

Methods: To ascertain this, we compared the number of HD cases diagnosed before and after the COVID-19 pandemic.

Results: The decrease in HD cases in Brazil reached 18,223 (-48. Read More

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Circular RNA circEGFR regulates tumor progression via the miR-106a-5p/DDX5 axis in colorectal cancer.

Braz J Med Biol Res 2021 23;54(8):e10940. Epub 2021 Jul 23.

Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Recently, an increasing number of studies have reported that dysregulation of circular RNA (circRNA) expression plays critical roles in the progression of several cancers, including colorectal cancer (CRC). However, the detailed molecular mechanisms of circRNAs involvement in CRC remain largely unknown. Here, we confirmed that the level of circEGFR was significantly increased in CRC tissues compared to matched adjacent non-tumor tissues, and a high level of circEGFR was correlated with poor clinicopathological characteristics and poor prognosis in patients with CRC. Read More

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Three Decades of Contact Lens-associated Microbial Keratitis in a Referral Hospital in São Paulo, Brazil.

Arq Bras Oftalmol 2021 Jul 14. Epub 2021 Jul 14.

Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Hospital São Paulo, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Purpose: The aim of this study was to analyze patient data and the laboratory results of corneal samples collected from patients followed at the Ophthalmology Department, Hospital São Paulo, Brazil over a 30-year period, and correlate the analize with contact lens wearing.

Methods: Corneal samples from patients diagnosed clinically with microbial keratitis between January 1987 and December 2016 were included in this study. Cultures that were positive for bacteria, fungi, and Acanthamoeba spp. Read More

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Exercise Training Improves Functions of Endothelial Progenitor Cells in Patients with Metabolic Syndrome.

Arq Bras Cardiol 2021 Jul;117(1):108-117

Qinhuangdao First Hospital,Qinhuangdao - China.

Background: Endothelial progenitor cells (EPCs) play an important role in maintaining endothelial function. Metabolic syndrome (MetS) is associated with EPC dysfunction. Although physical exercise has a beneficial impact on EPC activity, its mechanism is not completely clear yet. Read More

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HDI, Technological and Human Resources in the Diagnosis and Treatment of Malformations of the Circulatory System in Brazil.

Arq Bras Cardiol 2021 Jul;117(1):63-71

Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ - Brasil.

Background: In 2015, the number of infants with congenital malformations (CMs) per 100 000 live births (LBs) was 2368 (7.6%) worldwide, of whom 10.6% died in the first year of life, 43% due to malformations of the circulatory system (MCSs), a scenario similar to what occurs in Brazil. Read More

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Efficacy of the Chinese version interpretation bias modification training in an unselected sample: A randomized trial.

PLoS One 2021 28;16(7):e0255224. Epub 2021 Jul 28.

Faculty of Psychology, Naval Medical University, Shanghai, China.

Training individuals to interpret ambiguous information in positive ways might be an effective method of reducing social anxiety. However, little research had been carried out in Chinese samples, and the effect of interpretation training on other processes such as attentional bias also remained unclear. This study examined the effect of interpretation bias modification program (IMP) on interpretation bias, social anxiety and attentional bias, and the possible mediation effects. Read More

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Can lung ultrasound score accurately predict the need for surfactant  replacement in preterm neonates? A systematic review and meta-analysis protocol.

PLoS One 2021 28;16(7):e0255332. Epub 2021 Jul 28.

Division of Neonatology, Department of Translational Medical Sciences, University Federico II, Naples, Italy.

Respiratory distress syndrome (RDS) is a leading cause of morbidity and mortality in preterm infants due to primary surfactant deficiency. Surfactant replacement has greatly improved the short and long term prognosis of RDS but its administration criteria remain uncertain. Lung ultrasound has been recently shown as a non-invasive, repeatable, bedside tool to estimate parenchymal aeration using a semiquantitative score (LUS). Read More

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Early but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19.

PLoS One 2021 28;16(7):e0254453. Epub 2021 Jul 28.

Section of Infectious Diseases, Department of Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.

Background: Limited therapeutic options exist for coronavirus disease 2019 (COVID-19). COVID-19 convalescent plasma (CCP) is a potential therapeutic, but there is limited data for patients with moderate-to-severe disease.

Research Question: What are outcomes associated with administration of CCP in patients with moderate-to-severe COVID-19 infection?

Study Design And Methods: We conducted a propensity score-matched analysis of patients with moderate-to-severe COVID-19. Read More

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Prevalence of unmasked and improperly masked behavior in indoor public areas during the COVID-19 pandemic: Analysis of a stratified random sample from Louisville, Kentucky.

PLoS One 2021 28;16(7):e0248324. Epub 2021 Jul 28.

Department of Epidemiology and Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, Kentucky, United States of America.

Wearing a facial mask can limit COVID-19 transmission. Measurements of communities' mask use behavior have mostly relied on self-report. This study's objective was to devise a method to measure the prevalence of improper mask use and no mask use in indoor public areas without relying on self-report. Read More

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Beneficial effects of dietary supplementation with green tea catechins and cocoa flavanols on aging-related regressive changes in the mouse neuromuscular system.

Aging (Albany NY) 2021 Jul 28;13(undefined). Epub 2021 Jul 28.

Unitat de Neurobiologia Cel·lular, Departament de Medicina Experimental, Facultat de Medicina, Universitat de Lleida and Institut de Recerca Biomèdica de Lleida (IRBLleida), Lleida, Spain.

Besides skeletal muscle wasting, sarcopenia entails morphological and molecular changes in distinct components of the neuromuscular system, including spinal cord motoneurons (MNs) and neuromuscular junctions (NMJs); moreover, noticeable microgliosis has also been observed around aged MNs. Here we examined the impact of two flavonoid-enriched diets containing either green tea extract (GTE) catechins or cocoa flavanols on age-associated regressive changes in the neuromuscular system of C57BL/6J mice. Compared to control mice, GTE- and cocoa-supplementation significantly improved the survival rate of mice, reduced the proportion of fibers with lipofuscin aggregates and central nuclei, and increased the density of satellite cells in skeletal muscles. Read More

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A semi-automated measurement of muscle fiber size using the Imaris software.

Am J Physiol Cell Physiol 2021 Jul 28. Epub 2021 Jul 28.

Faculty of Biology, Technion Institute of Technology, Haifa, Israel.

The size and shape of skeletal muscle fibers are affected by various physiological and pathological conditions, such as muscle atrophy, hypertrophy, regeneration, and dystrophies. Hence, muscle fiber cross-sectional area (CSA) is an important determinant of muscle health and plasticity. We adapted the Imaris software to automatically segment muscle fibers based on fluorescent labeling of the plasma membrane, and measure muscle fiber CSA. Read More

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A Retrospective Examination of the Impact of Pharmacotherapy on Parent-Child Interaction Therapy.

J Child Adolesc Psychopharmacol 2021 Jul 28. Epub 2021 Jul 28.

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.

Parent-child interaction therapy (PCIT) is an evidence-based approach for children aged 2-7 years with disruptive behavior problems. This study examined the effectiveness of PCIT with and without concurrent pharmacotherapy. A convenience sample was collected from a retrospective chart review of preschool-aged children treated with PCIT at the Mayo Clinic Young Child Clinic between 2016 and 2020. Read More

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Airflow-Assisted Impact of Drops of Various Viscosities: The Role of Viscous Dissipation, Normal Imposed Pressure, and Shear Flow of Air.

Langmuir 2021 Jul 28. Epub 2021 Jul 28.

Department of Mechanical Engineering, Indian Institute of Technology (ISM), Dhanbad 826 004, India.

The role of liquid viscosity on the spreading for an airflow-assisted impact of drops on a surface is investigated. The spreading diameter is found to increase with the Reynolds number of the airflow () for a given viscosity and impact Weber number () compared to the still air. The increment is higher at a low for viscous drops, whereas the effect of dominates at the intermediate as the viscosity decreases. Read More

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Evaluating the antibacterial effect of synthesized herbal toothpastes and their efficacy for dentine tubule occlusion: Scanning electron microscopy and energy-dispersive X-ray spectroscopy analysis.

Microsc Res Tech 2021 Jul 28. Epub 2021 Jul 28.

Department of Microbiology and Virology, Kerman University of Medical Sciences, Kerman, Iran.

The tubule occlusion of two newly developed herbal toothpastes was examined. They were prepared based on the mixture of pomegranate peel and Equisetum arvense extracts with strontium acetate. The antimicrobial activity of pomegranate peel and E. Read More

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Hepatopulmonary syndrome is related to the development of acute-on-chronic liver failure and poor prognosis in cirrhotic patients.

Hepatol Int 2021 Jul 28. Epub 2021 Jul 28.

Department of Internal Medicine, Division of Gastroenterology and Hepatology, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, 20, Ilsanro, Wonju, 26426, Republic of Korea.

Background And Aims: Long-term prospective data on hepatopulmonary syndrome (HPS) from a large number of patients, especially in Asian patients, are lacking. We evaluated the long-term prognosis of HPS and the development of acute-on-chronic liver failure (ACLF), and related factors.

Methods: A total of 142 patients with cirrhosis who underwent saline-agitated contrast echocardiography for the diagnosis of HPS were enrolled and observed prospectively from 2014 to 2019. Read More

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Effect of Curcumol on NOD-Like Receptor Thermoprotein Domain 3 Inflammasomes in Liver Fibrosis of Mice.

Chin J Integr Med 2021 Jul 28. Epub 2021 Jul 28.

Department of Physiology, College of Basic Medicine, Guangxi University of Chinese Medicine, Nanning, 530021, China.

Objective: To investigate the effect of curcumol on NOD-like receptor thermoprotein domain 3 (NLRP3) inflammasomes, and analyze the mechanism underlying curcumol against liver fibrosis.

Methods: Thirty Kunming mice were divided into a control group, a model group and a curcumol group according to a random number table, 10 mice in each group. Mice were intraperitoneally injected with 40% carbon tetrachloride (CCl:peanut oil, 2:3 preparation) at 5 mL/kg for 6 weeks, twice a week, for developing a liver fibrosis model. Read More

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Technical and procedural comparison of two different cryoballoon ablation systems in patients with atrial fibrillation.

J Interv Card Electrophysiol 2021 Jul 28. Epub 2021 Jul 28.

Cardiology/Electrophysiology, University of Basel Hospital, Petersgraben 4 4031, Basel, Switzerland.

Purpose: The aim was to report procedural and technical differences of a novel cryoballoon (NCB) ablation catheter for pulmonary vein isolation (PVI) compared to the standard cryoballoon (SCB) catheter.

Methods: Consecutive patients with atrial fibrillation (AF) undergoing PVI using the NCB and the SCB were included. Procedural parameters, technical differences, acute efficacy, and safety are reported. Read More

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Ultrasound-guided internal jugular venipuncture using pocket-sized versus standard ultrasound devices: a prospective non-inferiority trial.

J Med Ultrason (2001) 2021 Jul 28. Epub 2021 Jul 28.

Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.

Purpose: Pocket-sized ultrasound devices (PUDs) are commonly adopted for bedside use despite their inferior performance compared with standard ultrasound devices (SUDs). We investigated the non-inferiority of PUDs versus SUDs for ultrasound-guided internal jugular venipuncture.

Methods: All patients undergoing scheduled surgery with general anesthesia and internal jugular vein catheter placement were prospectively included in this randomized non-inferiority trial to compare the qualities of the internal jugular venipuncture between the PUD group (Group P) and SUD group (Group S). Read More

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A comparison between Asians and Caucasians in the dimensions of the femoral isthmus based on a 3D-CT analysis of 1189 adult femurs.

Eur J Trauma Emerg Surg 2021 Jul 28. Epub 2021 Jul 28.

Department of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

Introduction: For successful intramedullary implant placement at the femur, such as nailing in unstable proximal femur fractures, the use of an implant that at least reaches or exceeds the femoral isthmus and yields sufficient thickness is recommended. A number of complications after intramedullary femoral nailing have been reported, particularly in Asians. To understand the anatomical features of the proximal femur and their ethnic differences, we aimed to accurately calculate the femoral isthmus dimensions and proximal distance of Asians and Caucasians. Read More

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Albiflorin alleviates cognitive dysfunction in STZ-induced rats.

Aging (Albany NY) 2021 Jul 28;13(undefined). Epub 2021 Jul 28.

Department of Endocrinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.

Background: To explore the effect of albiflorin (AL) on streptozotocin (STZ)-induced Alzheimer's disease (AD) in rats.

Methods: A mouse model of diabetic encephalopathy was established by intraperitoneal injection of 1%STZ. Step down test and water maze test were used to test the cognitive function of rats. Read More

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Effect of Extrinsic Warming of Low-Osmolality CT Contrast Media (Iohexol 350) on Extravasations and Patient Reaction Rates: A Retrospective Study.

AJR Am J Roentgenol 2021 Jul 28. Epub 2021 Jul 28.

Department of Radiology, Valleywise Health Medical Center, 2601 E Roosevelt St, Phoenix, AZ 85008.

Extrinsic warming of iodinated CT contrast media to body temperature reduces viscosity and injection pressures. However, studies examining the effect of extrinsic warming on clinical adverse events are limited in number and provide conflicting results. Therefore, consensus practice recommendations have been sparse. Read More

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