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Aspirin Responsiveness at a Dose of 80 mg and Its Impact on Birth Weight when Used in Twin Pregnancies: The GAP Pilot Randomized Trial.

Am J Perinatol 2021 Apr 21. Epub 2021 Apr 21.

Centre de recherche du Centre Hospitalier, Universiatire de Québec-Université Laval, Axe Santé Reproduction Mère et Enfant, Québec, Canada.

Objective:  Daily aspirin, started in the first trimester of pregnancy, is commonly used for the prevention of preeclampsia and fetal growth restriction in multiple gestation. However, the optimal dose remains controversial and the evidence for the use of aspirin in multiple pregnancies is scarce. We aimed to estimate the impact of 80 mg of aspirin in twin pregnancies. Read More

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Air Pollution Is Associated with Cognitive Deterioration of Alzheimer's Disease.

Gerontology 2021 Apr 21:1-9. Epub 2021 Apr 21.

Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Introduction: Dementia is one of the major causes of disability and dependency among older people worldwide. Alz-heimer's disease (AD), the most common cause of dementia among the elderly, has great impact on the health-care system of developed nations. Several risk factors are suggestive of an increased risk of AD, including APOE-ε4, male, age, diabetes mellitus, hypertension, and low social engagement. Read More

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circUBAP2 exacerbates malignant capabilities of NSCLC by targeting KLF4 through miR-3182 modulation.

Aging (Albany NY) 2021 Mar 19;13. Epub 2021 Mar 19.

Department of Thoracic Surgery, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou 350001, Fujian Province, China.

Chemo-resistance and refractoriness remain challenges for Non-small cell lung cancer (NSCLC) patients and the underlying molecular mechanisms haven't been fully explained. In this study, we investigated the influence of circUBAP2 on the NSCLC tumor cells. This study might provide novel therapeutic targets for NSCLC treatment. Read More

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Anterior cingulate cortex neuro-metabolic changes underlying lithium-induced euthymia in bipolar depression: A longitudinal H-MRS study.

Eur Neuropsychopharmacol 2021 Apr 18;49:93-100. Epub 2021 Apr 18.

University of Texas, USA.

The diagnosis and treatment of bipolar depression (BDep) poses complex clinical challenges for psychiatry. Proton magnetic resonance spectroscopy (H-MRS) is a useful imaging tool for investigating in vivo levels of brain neuro-metabolites, critical to understanding the process of mood dysregulation in Bipolar Disorder. Few studies have evaluated longitudinal clinical outcomes in BDep associated with H-MRS metabolic changes. Read More

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3D analysis of facial morphology in Dutch children with cancer.

Comput Methods Programs Biomed 2021 Apr 9;205:106093. Epub 2021 Apr 9.

Department of Human Genetics, KU Leuven, Leuven, Belgium; Big Data Institute and Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, United Kingdom.

Background and Objective; Genetic risk factors for childhood cancer may also influence facial morphology. 3D photography can be used in the recognition of differences in face shape among individuals. In previous research, 3D facial photography was used to identify increased facial asymmetry and greater deviation from normal facial morphology in a group of individuals with distinct morphological features who had childhood cancer compared to healthy controls. Read More

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Macromolecular fraction (MMF) from 3D ultrashort echo time Cones magnetization transfer (3D UTE-Cones-MT) imaging predicts meniscal degeneration and knee osteoarthritis.

Osteoarthritis Cartilage 2021 Apr 18. Epub 2021 Apr 18.

University of California San Diego, San Diego, CA, United States. Electronic address:

Objective: Meniscal degeneration is strongly associated with osteoarthritis (OA). We aimed to evaluate a 3D ultrashort-echo-time Cones magnetization transfer (UTE-Cones-MT) sequence for quantification of macromolecular fraction (MMF) and MT ratio (MTR) in menisci of healthy volunteers and patients with different degrees of OA.

Methods: Patients with mild OA (n=19;37-86 years;10 males) or advanced OA (n=12;52-88 years;4 males) and healthy volunteers (n=17;20-49 years;7 males) were scanned with T2-FSE and UTE-Cones-MT sequences at 3T. Read More

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Mast Cell Tryptase Release Contributes to Disease Progression in Lymphangioleiomyomatosis.

Am J Respir Crit Care Med 2021 Apr 21. Epub 2021 Apr 21.

University of Nottingham, Division of Respiratory Medicine, Biodiscovery Institute and NIHR Biomedical Research Centre, Nottingham, United Kingdom of Great Britain and Northern Ireland;

Rationale: Lymphangioleiomyomatosis is a multisystem disease causing lung cysts and respiratory failure. Loss of tuberous sclerosis complex (TSC) gene function results in a clone of 'LAM cells' with dysregulated mTOR activity. LAM cells and fibroblasts form lung nodules that also contain mast cells although their significance is unknown. Read More

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Impaired Differentiation of COPD Bronchial Epithelial Cells Grown on Bronchial Scaffolds.

Am J Respir Cell Mol Biol 2021 Apr 21. Epub 2021 Apr 21.

AstraZeneca, Gothenburg, Sweden;

Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation, small airway remodeling and emphysema. Airway remodeling in COPD patients involves both the airway epithelium and the subepithelial extracellular matrix (ECM). However, it is currently unknown how epithelial remodeling in COPD airways depends on the relative influence from inherent defects in the epithelial cells and alterations in the ECM. Read More

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Changes in corneal thickness after vitrectomy-Implications for glaucoma practice.

PLoS One 2021 21;16(4):e0249945. Epub 2021 Apr 21.

Glaucoma Services, LV Prasad Eye Institute, Bhubaneswar, India.

Purpose: To evaluate changes in central corneal thickness (CCT) following vitrectomy.

Methods: All consecutive old and new patients referred to glaucoma services for possible secondary glaucoma after vitrectomy and who had undergone corneal pachymetry between July 2013 to June 2020, were included. The eye that developed elevated intraocular pressure (IOP) and was diagnosed clinically as glaucoma after vitrectomy, was labelled as the "affected" eye. Read More

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A Background-Agnostic Framework with Adversarial Training for Abnormal Event Detection in Video.

IEEE Trans Pattern Anal Mach Intell 2021 Apr 21;PP. Epub 2021 Apr 21.

Abnormal event detection is a complex computer vision problem that has attracted significant attention in recent years. Its complexity arises from the commonly-adopted definition of an abnormal event, that is, a rarely occurring event that typically depends on the surrounding context. We propose a background-agnostic framework that learns from training videos containing only normal events. Read More

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Combined Antioxidant-Antibiotic Treatment for Effectively Healing Infected Diabetic Wounds Based on Polymer Vesicles.

ACS Nano 2021 Apr 21. Epub 2021 Apr 21.

Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China.

Infected diabetic wounds are difficult to heal due to high reactive oxygen species (ROS) concentrations and recurrent infections. Such wounds can easily deteriorate into a diabetic ulcer, a chronic diabetic complication with a very high mortality rate. Herein, we propose a combined antioxidant-antibiotic therapy based on poly(ε-caprolactone)--poly(glutamic acid) polymer vesicle to treat infected diabetic wounds. Read More

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Role of Anterior Segment OCT for Descemet Membrane Stripping During Descemet Membrane Endothelial Keratoplasty in Eyes With Congenital Hereditary Endothelial Dystrophy.

Rajesh Fogla

Cornea 2021 Apr;40(4):458-461

Cornea Clinic, Eye Department, Apollo Hospitals, Jubilee Hills, Hyderabad, India.

Purpose: To report the utility of preoperative anterior segment optical coherence tomography (ASOCT) in decision-making for stripping of the Descemet membrane (DM) during Descemet membrane endothelial keratoplasty (DMEK) in eyes with congenital hereditary endothelial dystrophy (CHED).

Methods: ASOCT was performed in eyes with CHED undergoing DMEK. Host DM was retained if the DM appearance was normal on ASOCT. Read More

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Clinical significance of vitamin D in idiopathic normal pressure hydrocephalus.

Acta Neurochir (Wien) 2021 Apr 21. Epub 2021 Apr 21.

Department of Neurosurgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

Background: Although recent studies show vitamin D deficiency is associated with cognitive decline, urinary incontinence, and gait instability, there has been no study on the effect of vitamin D on idiopathic normal pressure hydrocephalus (iNPH) characterized by the classic symptom triad of cognitive decline, urinary incontinence, and gait instability. We investigated the clinical significance of vitamin D in patients with iNPH.

Methods: Between 2017 and 2020, 44 patients who underwent ventriculoperitoneal shunt surgery were divided into low (< 15 ng/mL) and high (≥ 15 ng/mL) vitamin D groups according to the concentration of 25(OH)D, an effective indicator of vitamin D status. Read More

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Acute kidney injury is associated with subtle but quantifiable neurocognitive impairments.

Nephrol Dial Transplant 2021 Apr 21. Epub 2021 Apr 21.

Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.

Background: Acute kidney injury (AKI) is associated with long-term morbidity and mortality. The effects of AKI on neurocognitive functioning remain unknown. Our objective was to quantify neurocognitive impairment after an episode of AKI. Read More

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Mental time travel in patients "cured" from primary central nervous system lymphoma.

J Clin Exp Neuropsychol 2021 Apr 21:1-12. Epub 2021 Apr 21.

Neuropsychological Therapy Centre (NTC)/Clinical Neuropsychology, Faculty of Psychology, Ruhr University Bochum, Bochum, Germany.

: Significant advances in neuro-oncological treatment led to considering neurocognitive functioning and everyday functional needs in patients with long-term survival. Since a potentially lethal disease interrupts normal life and represents a threat to physical and psychological integrity, patients have to cope with the new challenges. Long-term survival and even "cure" is possible in primary central nervous system lymphoma (PCNSL), however, suffering from a life-threatening disease may affect patients´ cognitive processing of past and future (i. Read More

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Association of frailty and pre-frailty with increased risk of mortality among older Canadians.

Health Rep 2021 Apr;32(4):15-26

Health Analysis Division, Statistics Canada, Ottawa, Ontario.

Background: Frailty is a complex syndrome that is associated with aging but not synonymous with the normal aging process. It has been associated with all-cause mortality, but less is known about frailty and mortality from specific causes.

Data And Methods: Data from the 2013 and 2014 Canadian Community Health Survey (CCHS) linked to the Canadian Vital Statistics - Death Database were used to estimate the prevalence of frailty among Canadians aged 65 or older. Read More

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Distinct Illness Representation Profiles Are Associated With Anxiety in Women Testing Positive for Human Papillomavirus.

Ann Behav Med 2021 Apr 21. Epub 2021 Apr 21.

Cancer Prevention Group, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.

Background: Testing positive for human papillomavirus (HPV) at cervical cancer screening has been associated with heightened anxiety. To date, the cognitive determinants of heightened anxiety remain unclear, making it difficult to design effective interventions.

Purpose: This study investigated latent illness representation profiles in women testing positive for HPV with no abnormal cells (normal cytology) and explored associations between these profiles and anxiety. Read More

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Hierarchically porous FeNi@FeNi layered double hydroxide nanostructures: one-step fast electrodeposition and highly efficient electrocatalytic performances for overall water splitting.

Dalton Trans 2021 Apr 21. Epub 2021 Apr 21.

College of Chemistry and Materials Science, Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Provincial Engineering Laboratory for New-Energy Vehicle Battery Energy-Storage Materials, Anhui Normal University, 189 Jiuhua Southern Road, Wuhu, 241002, PR China.

FeNi-layered double hydroxide (LDH) is thought to be an excellent electrocatalyst for oxygen evolution reaction (OER) but it always shows extremely poor electrocatalytic activity toward hydrogen evolution reaction (HER) in alkaline media. Hence, it is significant to improve its HER activity to make it a bifunctional electrocatalyst for the decomposition of water. Here, a simple galvanostatic electrodeposition method was designed for the successful construction of the bifunctional FeNi3@FeNi LDH electrocatalyst. Read More

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Changes in alanine aminotransferase levels after switching from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) in HIV-positive people without viral hepatitis in the Swiss HIV Cohort Study.

HIV Med 2021 Apr 20. Epub 2021 Apr 20.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital, University of Zurich, Zurich, Switzerland.

Objectives: We previously demonstrated an association between tenofovir disoproxil fumarate (TDF) and chronic liver enzyme elevation in the D:A:D study. The objective of the study was to assess changes in alanine aminotransferase (ALT) levels after switching from TDF to tenofovir alafenamide (TAF).

Methods: We included Swiss HIV Cohort Study participants who switched from TDF to TAF with two or more ALT values in the 24 months before and two or more values in the 24 months after replacing TDF with TAF. Read More

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Cross-sectional case-control study of the relationships between pharyngeal compliance and heart rate variability indices in childhood obstructive sleep apnoea.

J Sleep Res 2021 Apr 20:e13337. Epub 2021 Apr 20.

Service de Physiologie Pédiatrique-Centre du Sommeil, Université de Paris, AP-HP, Hôpital Robert Debré, INSERM NeuroDiderot, Paris, France.

A combination of noradrenergic and antimuscarinic agents reduces the apnea-hypopnea index (AHI) in adult patients with obstructive sleep apnoea (OSA) via reduced upper airway collapsibility, suggesting that a shift in the sympathovagal balance improves OSA. The objectives of our present case-control study were to assess heart rate variability (HRV) indices in the stages of sleep in children with and without OSA to evaluate OSA-induced sleep HRV modifications and to assess whether increased collapsibility measured during wakefulness is associated with reduced sympathetic activity during non-rapid eye movement (NREM) sleep. Three groups of 15 children were matched by sex, age, z-score of body mass index and ethnicity: non-OSA (obstructive AHI [OAHI] <2 events/hr), mild (OAHI ≥2 to <5 events/hr) or moderate-severe (OAHI ≥5 events/hr) OSA. Read More

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HO enhances the anticancer activity of TMPyP4 by ROS-mediated mitochondrial dysfunction and DNA damage.

Med Oncol 2021 Apr 21;38(6):59. Epub 2021 Apr 21.

Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, People's Republic of China.

Cancer is one of the diseases that threatens human health and is a leading cause of mortality worldwide. High levels of reactive oxygen species (ROS) have been observed in cancer tissues compared with normal tissues in vivo, and it is not yet known how this influences chemotherapeutic drug action. Cationic porphyrin 5,10,15,20-tetra-(N-methyl-4-pyridyl) porphyrin (TMPyP4) is a photosensitizer used in photodynamic therapy (PDT) and a telomerase inhibitor used in the treatment of telomerase-positive cancer. Read More

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The Role of Biaxial Loading on Smooth Muscle Contractility in the Nulliparous Murine Cervix.

Ann Biomed Eng 2021 Apr 20. Epub 2021 Apr 20.

Department of Biomedical Engineering, Tulane University, 6823 St. Charles Ave, New Orleans, LA, 70118, USA.

Throughout the estrus cycle, the extracellular matrix (ECM) and cervical smooth muscle cells (cSMC) coordinate to accomplish normal physiologic function in the non-pregnant cervix. While previous uniaxial experiments provide fundamental knowledge about cervical contractility and biomechanics, the specimen preparation is disruptive to native organ geometry and does not permit simultaneous assessment of circumferential and axial properties. Thus, a need remains to investigate cervical contractility and passive biomechanics within physiologic multiaxial loading. Read More

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CHFR‑mediated epithelial‑to‑mesenchymal transition promotes metastasis in human breast cancer cells.

Mol Med Rep 2021 Jun 21;23(6). Epub 2021 Apr 21.

Department of Thyroid and Breast Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Luqiao, Zhejiang 318050, P.R. China.

Checkpoint with FHA and RING finger domains (CHFR) is a G phase/mitosis checkpoint. Several studies have reported that CHFR is downregulated in multiple cancer types and serves a tumor suppressor role. However, the biological function of CHFR in breast cancer (BRCA), particularly regarding metastasis, are yet to be elucidated. Read More

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Long non‑coding RNA BANCR promotes proliferation, invasion and migration in esophageal squamous cell carcinoma cells via the Raf/MEK/ERK signaling pathway.

Mol Med Rep 2021 Jun 21;23(6). Epub 2021 Apr 21.

Department of Gastroenterology and Hepatology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.

Esophageal squamous cell carcinoma (ESCC) is a major histological type of esophageal cancer, identified as a leading cause of tumor‑associated death worldwide. In addition, long non‑coding RNA (lncRNA) BRAF‑activated non‑coding RNA (BANCR) expression is increased in the plasma of patients with ESCC, which can be reversed by tumor resection. Thus, the aim of the present study was to investigate the underlying mechanism of BANCR in ESCC progression. Read More

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FOXP3‑induced LINC00885 promotes the proliferation and invasion of cervical cancer cells.

Mol Med Rep 2021 Jun 21;23(6). Epub 2021 Apr 21.

Department of Gynecological Oncology, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi 330006, P.R. China.

Cervical cancer (CC) is the fourth most common type of cancer in women worldwide. LINC00885, a novel oncogenic type of long non‑coding RNA, is upregulated in various types of cancer, but its expression in CC remains unknown. The aim of the present study was to investigate the expression of LINC00885 in CC, and its effect on the proliferation and invasion of CC cells . Read More

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Multimorbidity Accumulation among Middle-Aged Americans: Differences by Race/Ethnicity and Body-Mass Index.

J Gerontol A Biol Sci Med Sci 2021 Apr 21. Epub 2021 Apr 21.

School of Public Health, Oregon Health & Science University, Portland, Oregon, United States.

Background: Obesity and multimorbidity are more prevalent among U.S. racial/ethnic minority groups. Read More

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Liraglutide Regulates the Kidney and Liver in Diabetic Nephropathy Rats through the miR-34a/SIRT1 Pathway.

J Diabetes Res 2021 5;2021:8873956. Epub 2021 Apr 5.

Department of Endocrinology, People's Hospital of Shenzhen Baoan District, The Second School of Clinical Medicine, Southern Medical University, The Second Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China.

Purpose: To explore the regulatory effects of liraglutide on the kidney and liver through the miR-34a/SIRT1 pathway with related factors in diabetic nephropathy (DN) rats.

Methods: DN rats were randomly divided into two groups ( = 10) and were injected with liraglutide or normal saline twice a day. The 24-hour urine microalbumin content and biochemical index levels were measured. Read More

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A Prospective Comparison of Three Strategies for Evaluating Blood Loss in Transurethral Resection of the Prostate.

Biomed Res Int 2021 7;2021:8875380. Epub 2021 Apr 7.

The Department of Urology, Second Affiliated Hospital, Army Medical University, Chongqing 400037, China.

Objective: The aim of the current investigation is to develop a new strategy for evaluating blood loss in the process of transurethral resection of the prostate (TURP).

Methods: 318 patients diagnosed with benign prostatic hyperplasia (BPH) that need TURP were enrolled in this study. Hospitalization information including age, height, weight, surgery time, prostate volume, hemoglobin (Hb) concentration, hematocrit (HCT) percentage, and red blood cell count (RBC) was evaluated for each patient. Read More

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miR-720 Regulates Insulin Secretion by Targeting Rab35.

Biomed Res Int 2021 5;2021:6662612. Epub 2021 Apr 5.

Medical Center of Stomatology, The First Affiliated Hospital, Jinan University, Guangzhou 510630, China.

miRNAs pose a good prospect in the diagnosis and treatment of type 2 diabetes (T2D). This study is aimed at investigating whether miR-720 targets Rab35 to regulate insulin secretion in MIN6 cells and its molecular mechanism and the clinical value of miR-720 as a specific biomarker of T2D. Fifty-five samples of new diagnosis T2D patients and normal control were collected. Read More

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Formulation, Development and Evaluation of Budesonide Oral Nano-sponges Using DOE Approach: Evidences.

Adv Pharm Bull 2021 Feb 5;11(2):286-294. Epub 2020 Aug 5.

School of Pharmacy and Research People's University Bhopal- 462037, MP, India.

The prevalent types of idiopathic inflammatory bowel disease are ulcerative colitis (UC) and Crohn's disease, which affects a large number of populations. Budesonide (BUD) is a glucocorticoid with potent anti-inflammatory activity but low systemic efficacy because of high receptor affinity and rapid diversion. To overcome low efficacy and availability, a novel BUD nano-sponges was formulated using quasi- solvent diffusion and Eudragit S-100 as polymer. Read More

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February 2021