18,101 results match your criteria compared il-2

Long-term evaluation of temporomandibular disorders in association with cytokine and autoantibody status in young women.

Cytokine 2021 Apr 30:155551. Epub 2021 Apr 30.

Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, 101 Yunkeun-Dong, Chongro-Ku, Seoul 03080, Republic of Korea. Electronic address:

Temporomandibular disorders (TMD) is a chronic pain disease affecting 4-60% of general population. Its suggested etiology includes mechanical overloading to related structures, psychosocial factors, and genetic vulnerability. However, its pathogenesis is yet to be fully understood, especially in cases with a higher level of pain and more associated comorbidities. Read More

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Composite CD79A/CD40 costimulatory endodomain enhances CD19CAR-T cell proliferation and survival.

Mol Ther 2021 Apr 30. Epub 2021 Apr 30.

Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Adoptively transferred CD19 chimeric antigen receptor (CAR) T-cells have led to impressive clinical outcomes in B-cell malignancies. Beyond induction of remission, the persistence of CAR-T cells is required to prevent relapse and provide long-term disease control. To improve CAR-T cell function and persistence, we developed a composite costimulatory domain of a B-cell signaling moiety, CD79A/CD40, to induce a nuclear translocating signal, NF-κB, to synergize with other T-cell signals and improve CAR-T cell function. Read More

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Effects of music stimulus on behavior response, cortisol level, and horizontal immunity of growing pigs.

J Anim Sci 2021 May;99(5)

Key Laboratory of Swine Facilities Engineering, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Northeast Agricultural University, Harbin, Heilongjiang 150030, P.R. China.

An enriched environment is widely used to improve domestic animals' welfare and promote their natural behaviors. Music can reduce abnormal behavior in humans, nonhuman primates, and rodents. However, little is known about the effects of music on pigs. Read More

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Changes in bone mineral density, 25-hydroxyvitamin D and inflammatory factors in patients with hyperthyroidism.

Exp Ther Med 2021 Jun 14;21(6):617. Epub 2021 Apr 14.

Department of Anesthesiology, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China.

The present study aimed to evaluate changes in bone mineral density, 25-hydroxyvitamin D [25-(OH)D] and inflammatory factors in patients with hyperthyroidism, in order to determine the correlations with the pathogenesis of hyperthyroidism. A total of 55 patients with hyperthyroidism (observation group) and 53 healthy patients (control group) enrolled at Weifang People's Hospital from March 2017 to February 2018 were randomly enrolled. The thyroid function, bone mineral density, 25-(OH)D and inflammatory factors were measured and compared between the two groups. Read More

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Baseline Plasma Inflammatory Profile Is Associated With Response to Neoadjuvant Chemotherapy in Patients With Pancreatic Adenocarcinoma.

J Immunother 2021 Jun;44(5):185-192

Departments of Surgery.

Despite its increased application in pancreatic ductal adenocarcinoma (PDAC), complete response to neoadjuvant therapy (NAT) is rare. Given the critical role of host immunity in regulating cancer, we sought to correlate baseline inflammatory profiles to significant response to NAT. PDAC patients receiving NAT were classified as responders (R) or nonresponders (NR) by carbohydrate antigen 19-9 response, pathologic tumor size, and lymph node status in the resected specimen. Read More

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Effect of Multi-Strain Probiotic Supplementation on URTI Symptoms and Cytokine Production by Monocytes after a Marathon Race: A Randomized, Double-Blind, Placebo Study.

Nutrients 2021 Apr 27;13(5). Epub 2021 Apr 27.

Department of Bioscience, Universidade Federal de São Paulo, Santos 11015-020, Brazil.

(1) Purpose: Performing strenuous exercises negatively impacts the immune and gastrointestinal systems. These alterations cause transient immunodepression, increasing the risk of minor infections, especially in the upper respiratory tract. Recent studies have shown that supplementation of probiotics confers benefits to athletes. Read More

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Assessment of Response to Moderate and High Dose Supplementation of Astaxanthin in Laying Hens.

Animals (Basel) 2021 Apr 16;11(4). Epub 2021 Apr 16.

State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

In this study, we evaluated the impact of moderate and high dose dietary supplementation of astaxanthin on production performance, quality of eggs, and health status of laying hens. The experiment involved 480 laying hens, divided into four groups of eight replicates. The different groups named A1, A2, A3, and A4 were allocated the same diet supplemented with powder to provide 0, 21. Read More

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Cytokine Biosignature of Active and Latent Mycobacterium Tuberculosis Infection in Children.

Pathogens 2021 Apr 24;10(5). Epub 2021 Apr 24.

Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Im-munology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland.

None of the currently used diagnostic tools are efficient enough in diagnosing Mycobacterium tuberculosis (M.tb) infection in children. The study was aimed to identify cytokine biosignatures characterizing active and latent tuberculosis (TB) in children. Read More

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Elevation of Pro-Inflammatory Cytokine Levels Following Intra-Articular Fractures-A Systematic Review.

Cells 2021 Apr 14;10(4). Epub 2021 Apr 14.

Department of Orthopedics and Traumatology, Odense University Hospital, 5000 Odense, Denmark.

Intra-articular fractures are a major cause of post-traumatic osteoarthritis (PTOA). Despite adequate surgical treatment, the long-term risk for PTOA is high. Previous studies reported that joint injuries initiate an inflammatory cascade characterized by an elevation of synovial pro-inflammatory cytokines, which can lead to cartilage degradation and PTOA development. Read More

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Modulates Th1/Th2 Response and Attenuates Airway Inflammation in an Ovalbumin-Sensitized Mouse Allergic Asthma Model.

Life (Basel) 2021 Apr 21;11(5). Epub 2021 Apr 21.

Department of Nutritional Science, Fu-Jen Catholic University, Hsinchuang 24205, Taiwan.

, called fuling, is a famous tonic in traditional Chinese medicine that reportedly possesses various pharmacological properties, including anti-inflammation and immunomodulation. However, few studies have investigated the effects of on allergic diseases, such as allergic asthma. Allergic asthma is caused primarily by Th2 immune response and characterized by airway inflammation. Read More

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Ex Vivo High Salt Activated Tumor-Primed CD4+T Lymphocytes Exert a Potent Anti-Cancer Response.

Cancers (Basel) 2021 Apr 2;13(7). Epub 2021 Apr 2.

Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore 169857, Singapore.

Cell based immunotherapy is rapidly emerging as a promising cancer treatment. A modest increase in salt (sodium chloride) concentration in immune cell cultures is known to induce inflammatory phenotypic differentiation. In our current study, we analyzed the ability of salt treatment to induce ex vivo expansion of tumor-primed CD4 (cluster of differentiation 4)+T cells to an effector phenotype. Read More

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Enhancement of β-Glucan Biological Activity Using a Modified Acid-Base Extraction Method from .

Molecules 2021 Apr 7;26(8). Epub 2021 Apr 7.

Zoology Department, Faculty of Science, New Valley University, El-Kharga 72511, Egypt.

Beta glucan (β-glucan) has promising bioactive properties. Consequently, the use of β-glucan as a food additive is favored with the dual-purpose potential of increasing the fiber content of food products and enhancing their health properties. Our aim was to evaluate the biological activity of β-glucan (antimicrobial, antitoxic, immunostimulatory, and anticancer) extracted from using a modified acid-base extraction method. Read More

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Circulating inflammatory cytokines alter transcriptional activity within fibrotic tissue of Dupuytren's disease patients.

J Orthop Res 2021 Apr 29. Epub 2021 Apr 29.

Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA.

Dupuytren's disease is a benign fibroproliferative disorder of the hand that results in disabling digital contractures that impair function and diminish quality of life. The incidence of this disease has been correlated with chronic inflammatory states, but any direct association between inflammatory cytokines and Dupuytren's disease is not known. We hypothesized that advanced fibroproliferation is associated with increased levels of circulating inflammatory cytokines. Read More

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Compromised levels of CD6 and reduced T cell activation in the aged immune system.

Biomarkers 2021 Apr 29:1-24. Epub 2021 Apr 29.

Department of Biotechnology, Motilal Nehru National Institute of Technology (MNNIT) Allahabad, Prayagraj, India.

The CD6 molecule, a cell surface marker, is involved in immunological synapse formation between T cells and antigen-presenting cells and T lymphocyte activation for adequate immune response. Geriatric individuals fail to mount a satisfactory immunological response against pathogens; thus, insights into the functionality of CD6 may provide information for competence building in elderly immune cells. However, limited information is available regarding the status of CD6 in geriatric individuals. Read More

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[Effect of acupuncture on cancer-related depression: a randomized controlled trial].

Zhongguo Zhen Jiu 2021 Apr;41(4):381-5

Department of Rehabilitation, Hebei Hospital of TCM, Shijiazhuang 050011, China.

Objective: To observe the effect of acupuncture combined with sertraline hydrochloride and sertraline hydrochloride alone on cancer-related depression (CRD), and to explore its action mechanism.

Methods: A total of 120 patients with CRD were randomly divided into an observation group and a control group, 60 cases in each group. Based on the routine treatment of oncology, the patients in the control group were treated with sertraline hydrochloride tablets, 50 mg per time, once a day, and the patients in the observation group were additionally treated with acupuncture at Zhongwan (CV 12), Baihui (GV 20), Shenting (GV 24), Xinshu (BL 15), Ganshu (BL 18), Pishu (BL 20), Shenmen (HT 7), Taichong (LR 3), Taixi (KI 3), 20 to 40 min per time, once a day, 5 times a week. Read More

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HMGB1/TLR4 Signaling Affects Regulatory T Cells in Acute Lung Injury.

J Inflamm Res 2021 19;14:1551-1561. Epub 2021 Apr 19.

Department of Pathophysiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, 230032, People's Republic of China.

Background: High-mobility group box-1 protein (HMGB1) serves as the prototypic damage-associated molecular pattern molecule, and TLR4 is considered a receptor for HMGB1. Regulatory T cells (Tregs) play a crucial role in infectious diseases. The role of HMGB1 in the modulation of Tregs is of great interest. Read More

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Th1/Th2/Th17 cytokine profile in hepatic cystic Echinococcosis patients with different cyst stages.

Parasite Immunol 2021 Apr 23:e12839. Epub 2021 Apr 23.

State Key Laboratory of Pathogenesis, Prevention and Management of High Incidence Diseases in Central Asia, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Aims: The study aimed to investigate possible correlation between expression level of Th1/Th2/Th17-type profile and cyst viability in the systemic and local immunity of hepatic cystic Echinococcosis (CE) patients.

Methods And Results: Expression of Th1-type interleukin (IL)-2, interferon (IFN)-γ, tumour necrosis factor (TNF)-α, Th2-type IL-4, IL-6, IL-10 and Th17-type IL-17A was examined in the serum and liver samples of hepatic CE patients with different cyst stages. Compared with healthy controls, Th1/Th2/Th17-type cytokines were significantly increased in the serum of hepatic CE patients. Read More

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Multifunctionality of CD8 T cells and PD-L1 expression as a biomarker of anti-PD-1 antibody efficacy in advanced melanoma.

J Dermatol 2021 Apr 22. Epub 2021 Apr 22.

Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Anti-programmed cell death protein-1 (PD-1) antibodies have become a standard treatment for advanced melanoma. However, a predictive biomarker for assessing the efficacy of anti-PD-1 antibodies has not been identified. In cancer, CD8 T cells specific for tumor antigens undergo repeated T-cell receptor stimulation due to the persistence of cancer cells and gradually lose their ability to secrete interleukin 2 (IL-2), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ). Read More

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Exosomes Released From Human Bone Marrow-Derived Mesenchymal Stem Cell Attenuate Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation in Mice.

Front Cell Dev Biol 2021 6;9:617589. Epub 2021 Apr 6.

Department of Pediatrics, Rizhao People's Hospital, Rizhao, China.

Objective: Mesenchymal stromal cell-derived exosomes have been applied for the treatment of several immune diseases. This study aimed to explore the effect of human bone marrow-derived mesenchymal stem cell (hBMSC)-derived exosomes on acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (HSCT).

Methods: hBMSC were cultured, and the culture supernatants were then collected to prepare exosomes using total exosome isolation reagent from Invitrogen. Read More

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Outcomes of Interleukin-2 Receptor Antagonist Induction Therapy in Standard-Risk Renal Transplant Recipients Maintained on Tacrolimus: A Systematic Review and Meta-Analysis.

Am J Nephrol 2021 Apr 22:1-13. Epub 2021 Apr 22.

Institute of Medical Sciences, Faculty of Medicine, University of Liverpool, Liverpool, United Kingdom.

Introduction: The additive benefit of interleukin-2 receptor antagonist (IL2-RA) induction in standard-risk kidney transplant recipients, while maintained on tacrolimus-based immunosuppressive therapy, is uncertain.

Methods: We divided the studies included in this meta-analysis into 2 groups: group A (included studies that used same dose of tacrolimus in both arms of each study) and group B (included studies that compared patients who received induction therapy and low-dose tacrolimus vs. those who received no-induction therapy and high dose of tacrolimus). Read More

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Immunotherapeutic strategy based on anti-OX40L and low dose of IL-2 to prolong graft survival in sensitized mice by inducing the generation of CD4 and CD8 Tregs.

Int Immunopharmacol 2021 Apr 20;97:107663. Epub 2021 Apr 20.

Organ Transplantation Center, The Affiliated Hospital of Qingdao University, Qingdao, China; Institute of Transplantationation Science, The Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Alloreactive memory cells play a critical role after a second transplant and are difficult to suppress. This study investigated the effect of an immunotherapeutic strategy that combines anti-OX40L, rapamycin (Rapa), and a low dose of IL-2 in a memory cell-based adoptive model. In this model, the median survival time (MST) of the grafts of the combined treatment group was significantly extended compared to that of the control group and other treatment groups. Read More

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Non-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients.

Sci Rep 2021 Apr 21;11(1):8593. Epub 2021 Apr 21.

Clinical Medicine Department, Miguel Hernández University of Elche, Elche, Spain.

Psoriasis and non-alcoholic fatty liver disease (NAFLD) are both inflammatory diseases. The study objective was to estimate the risk of NAFLD, non-alcoholic steatohepatitis, and liver fibrosis (by liver stiffness and liver biopsy) in patients with psoriasis and to determine the epidemiological, clinical, immunological (TNF-α, IL-2, IL-6, IL-12, IL-17, IL-23, and TGF-β) characteristics, and bacterial translocation. Of the 215 psoriatic patients included, 91 presented NAFLD (prevalence: 42. Read More

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Anti-aging effects of a functional food via the action of gut microbiota and metabolites in aging mice.

Aging (Albany NY) 2021 Apr 20;13. Epub 2021 Apr 20.

Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

Wushen (WS) is a mixed food containing 55 natural products that is beneficial to human health. This study aimed to reveal the preventive effect of WS on aging via a combined analysis of gut microbiome and metabolome. Senescence-accelerated mouse prone 8 (SAMP8) mice were used as aging model and senescence-accelerated mouse resistant 1 (SAMR1) mice as control. Read More

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Age-dependency of terminal ileum tissue resident memory T cell responsiveness profiles to S. Typhi following oral Ty21a immunization in humans.

Immun Ageing 2021 Apr 19;18(1):19. Epub 2021 Apr 19.

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.

Background: The impact of aging on the immune system is unequivocal and results in an altered immune status termed immunosenescence. In humans, the mechanisms of immunosenescence have been examined almost exclusively in blood. However, most immune cells are present in tissue compartments and exhibit differential cell (e. Read More

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Effect of IL-15 addition on asbestos-induced suppression of human cytotoxic T lymphocyte induction.

Environ Health Prev Med 2021 Apr 19;26(1):50. Epub 2021 Apr 19.

Department of Hygiene, Kawasaki Medical School, Kurashiki, 701-0192, Japan.

Background: Asbestos fibers possess tumorigenicity and are thought to cause mesothelioma. We have previously reported that exposure to asbestos fibers causes a reduction in antitumor immunity. Asbestos exposure in the mixed lymphocyte reaction (MLR) showed suppressed induction of cytotoxic T lymphocytes (CTLs), accompanied by a decrease in proliferation of CD8 T cells. Read More

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Growth performance, tissue precipitation, metallothionein and cytokine transcript expression and economics in response to different dietary zinc sources in growing rabbits.

J Anim Physiol Anim Nutr (Berl) 2021 Apr 19. Epub 2021 Apr 19.

Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

The impact of different dietary zinc sources on the growth, serum metabolites, tissue zinc content, economics and relative expression of cytokine and metallothionein genes was evaluated in this study. A total of 120 35-day-old male New Zealand White (NZW) rabbits were randomly distributed into four dietary experimental groups with 10 replicates per group and 3 animals per replicate. The control group was fed basal diet with a Zn-free vitamin-mineral premix; the other three groups received control basal diet supplemented with 50 mg/kg level with zinc oxide (ZnO; as inorganic source), Zn-methionine (Zn-Met; as organic source) and zinc oxide nanoparticles (nano-ZnO). Read More

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Association of Non-Hodgkin lymphoma risk with CYP1A1, GSTM1 and GSTT1 gene variants, in tobacco addicted patients of Pashtun ethnicity of Khyber Pakhtunkhwa, Pakistan.

Pak J Pharm Sci 2020 Nov;33(6):2617-2624

Department of Zoology, University of Peshawar, Peshawar, Pakistan.

The current study determines the possible antitumor and immunomodulatory effects of thymosin against the in vivo and in vitro growth of tumor-derived cell line in mice. Peritoneal phagocytes count, Ehrlich ascites tumor (EAT) cells, T- lymphocytes, and B- lymphocytes activities were determined. In addition, serum level of interleukin 2 (IL-2) and liver functions were measured. Read More

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November 2020

Changes in extracellular cytokines in predicting disease severity and final clinical outcome of patients with blunt chest trauma.

Immunobiology 2021 Mar 27;226(3):152087. Epub 2021 Mar 27.

Division of Trauma Surgery & Critical Care, JPN Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Background: Chest trauma causes substantial morbidity and mortality and its severity is assessed using clinical diagnosis or scoring systems like Injury severity score (ISS) and thoracic trauma severity score (TTSS). Association of inflammatory cytokines with severity of disease and final clinical outcome is not clearly defined in patients with chest trauma. In this study, we thought to evaluate the inflammatory response in serum and bronchoalveolar lavage fluid (BALF) in chest trauma patients and correlate the level of extracellular cytokines with diseases severity and final outcome. Read More

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Protective efficacy of Hla-MntC-SACOL0723 fusion protein adjuvanted in alum and MPL against Staphylococcus aureus sepsis infection in mice.

J Immunol Methods 2021 Apr 13;494:113055. Epub 2021 Apr 13.

Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. Electronic address:

To develop a suitable and effective vaccine against Staphylococcus aureus (S. aureus), we selected the Hla-MntC-SACOL0723 (HMS) recombinant protein with two different formulations of alum and Monophosphoryl lipid A (MPL) adjuvants. In this study, we aimed to evaluate the potentials of alum and MPL adjuvants in stimulating the immune response of HMS vaccine candidate against S. Read More

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Emerging Therapeutics for Immune Tolerance: Tolerogenic Vaccines, T cell Therapy, and IL-2 Therapy.

Front Immunol 2021 29;12:657768. Epub 2021 Mar 29.

Department of Inflammation and Oncology, Amgen Research, Amgen Inc., South San Francisco, CA, United States.

Autoimmune diseases affect roughly 5-10% of the total population, with women affected more than men. The standard treatment for autoimmune or autoinflammatory diseases had long been immunosuppressive agents until the advent of immunomodulatory biologic drugs, which aimed at blocking inflammatory mediators, including proinflammatory cytokines. At the frontier of these biologic drugs are TNF-α blockers. Read More

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